An artful science : activism, non-violence, and radical democracy in Cold War Britain

Funding: The author would like to acknowledge the Royal Historical Society’s small grants programme for enabling me to complete the research underpinning this article.The Direct Action Committee (DAC, 1958–62) and its parent, the Non-Violent Research Group (NVRG 1949–62) occupy a minor position in British postwar peace historiography where they are generally depicted as a well-meaning fringe group whose political naivety limited their impact. This perspective assumes that success means inaugurating a mass movement or forcing a policy change. It overlooks the group's objections to these strategies and underplays the research dimension of their activities. This article argues that while unilateral disarmament was the DAC's short-term priority, it was always connected to a larger goal of cultivating non-violence as a practical political philosophy and theory of social change. During the 1950s, the group developed an ‘artful science’ of activism which included a poetics of protest inspired by the Gandhian concept of satyagraha. Later, their fieldwork experiences further informed a prosaic theory of activism attentive to the everyday business of organizing as a vital space for building democratic capacity.Peer reviewe

Rethinking the Socialist Intellectual in the British First New Left

The first British New Left formed in response to a crisis in international and British socialism. Although never a formal movement, its associated members set themselves the tasks of, first, confronting the rapid change transforming social life at both global and national scales, and second, articulating a new political culture able to accommodate the good and resist the bad of it. As part of this process, a series of intense debates took place on the role of the socialist intellectual in stimulating such a culture. In this article, I consider three of the NL’s main protagonists, EP Thompson, Stuart Hall, and Raphael Samuel, and the different positions they took on this issue. I argue here that while all made important contributions to the argument, Samuel’s practice as an intellectual, currently the least well known of the three, is worth closer attention for its relevance to contemporary educational debates

Acting Local, Thinking Global in Post-War British Anarchism

Internationalism has always been a major strand of anarchist political thought where it works on several levels. It has described their commitment to dynamic cosmopolitanism but also dictated revolutionary strategy and structured their social alternatives. In the post-war years, however, many anarchist thinkers, confronting the implications of the atomic bomb for state power and global governance, acknowledged the need for strategic revision. Retreating from the idea of revolution as a series of national armed uprisings, they shifted, instead, towards endorsing an ‘act local, think global’ approach to policy. But what did it mean to think global? This article focuses on British post-war anarchists and explores their spectrum of approaches to this strategy shift. While it recognises a common move towards more permeable notions of the local-global dynamic, it also argues for a richer differentiation among their responses than is usually acknowledged

Intellectual lives, performance and persona:the making of a people's historian

The most important aspect of British historian Raphael Samuel (1934-1996) was his entire way of being a historian. Samuel, a former youth member of the Communist Party of Great Britain, is best known as a founder of the first British New Left (1956-62), the driving force behind the first History Workshop movement (1963-79), which pioneered a distinctive 'history-from-below', and as the author of Theatres of Memory (1994), an idiosyncratic exploration of the past in contemporary culture. Despite all this, he did not advance an especially ground-breaking historical argument or historiographical theory. He set his sights elsewhere, on the democratisation of history making. To achieve this end, he created a distinctive persona as a people's historian through which he projected a radical transformation of what it meant to study history. Yet posterity was both condescending and neglectful, and until recently the full

An activist stagecraft: Performative politics and the first new left 1956-1962

The First British New Left (NL) (1956–1962) formed around two journals, The New Reasoner (NR) edited by E.P.Thompson and John Saville, and the Universities and Left Review (ULR) edited by Stuart Hall, Gabriel Pearson, Raphael Samuel and Charles Taylor. Both sought a ‘new’ socialism which, based on a loose concept of socialist humanism, restored the role of the individual and revitalised a popular left movement. Early commentators critiqued its lack of robust theory and organisational structure. More recently, others have proposed that, particularly amongst the ULR cohort, with this ‘new’ socialism emerged a ‘new’ activist politics. Building on this, I examine the ULR’s activism as a performative politics which stressed active participation over theory and dissolved any distinction between means and ends. Whilst Thompson and Hall have tended to be considered the main protagonists in shaping this, I argue that it was Samuel, an experienced organiser, who was most responsible for shaping their early agenda. His role has been neglected because he wrote no ‘position piece’ but, appropriately for an activist politics, expressed his ideas through his actions. ‘Reading’ his performances, then, illuminates more fully both the scope and the limits of this activist politics

Why alternative teenagers self-harm: exploring the link between non-suicidal self-injury, attempted suicide and adolescent identity

Background: The term ‘self-harm’ encompasses both attempted suicide and non-suicidal self-injury (NSSI). Specific adolescent subpopulations such as ethnic or sexual minorities, and more controversially, those who identify as ‘Alternative’ (Goth, Emo) have been proposed as being more likely to self-harm, while other groups such as ‘Jocks’ are linked with protective coping behaviours (for example exercise). NSSI has autonomic (it reduces negative emotions) and social (it communicates distress or facilitates group ‘bonding’) functions. This study explores the links between such aspects of self-harm, primarily NSSI, and youth subculture.<p></p> Methods: An anonymous survey was carried out of 452 15 year old German school students. Measures included: identification with different youth cultures, i.e. Alternative (Goth, Emo, Punk), Nerd (academic) or Jock (athletic); social background, e.g. socioeconomic status; and experience of victimisation. Self-harm (suicide and NSSI) was assessed using Self-harm Behavior Questionnaire and the Functional Assessment of Self-Mutilation (FASM).<p></p> Results: An “Alternative” identity was directly (r ≈ 0.3) and a “Jock” identity inversely (r ≈ -0.1) correlated with self-harm. “Alternative” teenagers self-injured more frequently (NSSI 45.5% vs. 18.8%), repeatedly self-injured, and were 4–8 times more likely to attempt suicide (even after adjusting for social background) than their non-Alternative peers. They were also more likely to self-injure for autonomic, communicative and social reasons than other adolescents.<p></p> Conclusions: About half of ‘Alternative’ adolescents’ self-injure, primarily to regulate emotions and communicate distress. However, a minority self-injure to reinforce their group identity, i.e. ‘To feel more a part of a group’

An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity

The severity of disease following infection with SARS-CoV-2 is determined by viral replication kinetics and host immunity, with early T cell responses and/or suppression of viraemia driving a favourable outcome. Recent studies uncovered a role for cholesterol metabolism in the SARS-CoV-2 life cycle and in T cell function. Here we show that blockade of the enzyme Acyl-CoA:cholesterol acyltransferase (ACAT) with Avasimibe inhibits SARS-CoV-2 pseudoparticle infection and disrupts the association of ACE2 and GM1 lipid rafts on the cell membrane, perturbing viral attachment. Imaging SARS-CoV-2 RNAs at the single cell level using a viral replicon model identifies the capacity of Avasimibe to limit the establishment of replication complexes required for RNA replication. Genetic studies to transiently silence or overexpress ACAT isoforms confirmed a role for ACAT in SARS-CoV-2 infection. Furthermore, Avasimibe boosts the expansion of functional SARS-CoV-2-specific T cells from the blood of patients sampled during the acute phase of infection. Thus, re-purposing of ACAT inhibitors provides a compelling therapeutic strategy for the treatment of COVID-19 to achieve both antiviral and immunomodulatory effects. Trial registration: NCT04318314

An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity

The severity of disease following infection with SARS-CoV-2 is determined by viral replication kinetics and host immunity, with early T cell responses and/or suppression of viraemia driving a favourable outcome. Recent studies uncovered a role for cholesterol metabolism in the SARS-CoV-2 life cycle and in T cell function. Here we show that blockade of the enzyme Acyl-CoA:cholesterol acyltransferase (ACAT) with Avasimibe inhibits SARS-CoV-2 pseudoparticle infection and disrupts the association of ACE2 and GM1 lipid rafts on the cell membrane, perturbing viral attachment. Imaging SARS-CoV-2 RNAs at the single cell level using a viral replicon model identifies the capacity of Avasimibe to limit the establishment of replication complexes required for RNA replication. Genetic studies to transiently silence or overexpress ACAT isoforms confirmed a role for ACAT in SARS-CoV-2 infection. Furthermore, Avasimibe boosts the expansion of functional SARS-CoV-2-specific T cells from the blood of patients sampled during the acute phase of infection. Thus, re-purposing of ACAT inhibitors provides a compelling therapeutic strategy for the treatment of COVID-19 to achieve both antiviral and immunomodulatory effects. Trial registration: NCT04318314

Fungal decomposition of river organic matter accelerated by decreasing glacier cover

Climate change is altering the structure and functioning of river ecosystems worldwide. In mountain rivers, glacier retreat has been shown to result in systematic changes in aquatic invertebrate biodiversity, but the effects of ice loss on other biological taxa and on whole-ecosystem functions are less well understood. Using data from mountain rivers spanning six countries on four continents, we show that decreasing glacier cover leads to consistent fungal-driven increases in the decomposition rate of cellulose, the world’s most abundant organic polymer. Cellulose decomposition rates were associated with greater abundance of aquatic fungi and the fungal cellulose-degrading Cellobiohydrolase I (cbhI) gene, illustrating the potential for predicting ecosystem-level functions from gene-level data. Clear associations between fungal genes, populations and communities and ecosystem functioning in mountain rivers indicate that ongoing global decreases in glacier cover can be expected to change vital ecosystem functions, including carbon cycle processes

The ethics of ‘Trials within Cohorts’ (TwiCs): 2nd international symposium - London, UK. 7-8 November 2016

On 7-8 th November 2016, 60 people with an interest in the ‘ Trials within Cohorts ’ (TwiCs) approach for randomised controlled trial design met in London. The purpose of this 2 nd TwiCs international symposium was to share perspectives and experiences on ethical aspects of the TwiCs design, discuss how TwiCs relate to the current ethical frame- work, provide a forum in which to discuss and debate ethical issues and identify future directions for conceptual and empirical research. The symposium was supported by the Wellcome Trust and the NIHR CLAHRC Yorkshire and Humber and organised by members of the TwiCs network led by Clare Relton and attended by people from the UK, the Netherlands, Norway, Canada and USA. The two-day sympo- sium enabled an international group to meet and share experiences of the TwiCs design (also known as the ‘ cohort multiple RCT design ’ ), and to discuss plans for future research. Over the two days, invited plenary talks were interspersed by discussions, posters and mini pre- sentations from bioethicists, triallists and health research regulators. Key findings of the symposium were: (1) It is possible to make a compelling case to ethics committees that TwiCs designs are ap- propriate and ethical; (2) The importance of wider considerations around the ethics of inefficient trial designs; and (3) some questions about the ethical requirements for content and timing of informed consent for a study using the TwiCs design need to be decided on a case-by-case basis