U.S. and U.K. Interest Rates 1890 - 1934: New Evidence on Structural Breaks

This paper presents econometric evidence on whether the founding of the Federal Reserve in 1914 caused a structural change from level-stationarity to difference-stationarity in U.S. and U.K. short-term nominal interest rates. We develop new econometric tests that allow for parameter transitions to test for a break of this kind and undertake a grid search analysis of dates and speeds for the change. We find that U.S. nominal interest rates most likely evolved rapidly to difference-stationarity in June 1917. For the U.K. we fail to reject the null that U.K. interest rate series follow a difference stationary process over the entire period 1890-1934. Our analysis differs from previous research on this topic in that we take care to explore statistical uncertainty around parameter estimates, and incorporate higher order dynamics into our econometric analysis.

Characterisation of the TBR1 interactome: variants associated with neurodevelopmental disorders disrupt novel protein interactions

TBR1 is a neuron-specific transcription factor involved in brain development and implicated in a neurodevelopmental disorder (NDD) combining features of autism spectrum disorder (ASD), intellectual disability (ID) and speech delay. TBR1 has been previously shown to interact with a small number of transcription factors and co-factors also involved in NDDs (including CASK, FOXP1/2/4 and BCL11A), suggesting that the wider TBR1 interactome may have a significant bearing on normal and abnormal brain development. Here we have identified approximately 250 putative TBR1-interaction partners by affinity purification coupled to mass spectrometry. As well as known TBR1-interactors such as CASK, the identified partners include transcription factors and chromatin modifiers, along with ASD- and ID-related proteins. Five interaction candidates were independently validated using bioluminescence resonance energy transfer assays. We went on to test the interaction of these candidates with TBR1 protein variants implicated in cases of NDD. The assays uncovered disturbed interactions for NDD-associated variants and identified two distinct protein-binding domains of TBR1 that have essential roles in protein–protein interaction

Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders

FOXP transcription factors play important roles in neurodevelopment, but little is known about how their transcriptional activity is regulated. FOXP proteins cooperatively regulate gene expression by forming homo- and hetero-dimers with each other. Physical as

The Ontology of Biological Attributes (OBA)-computational traits for the life sciences.

Existing phenotype ontologies were originally developed to represent phenotypes that manifest as a character state in relation to a wild-type or other reference. However, these do not include the phenotypic trait or attribute categories required for the annotation of genome-wide association studies (GWAS), Quantitative Trait Loci (QTL) mappings or any population-focussed measurable trait data. The integration of trait and biological attribute information with an ever increasing body of chemical, environmental and biological data greatly facilitates computational analyses and it is also highly relevant to biomedical and clinical applications. The Ontology of Biological Attributes (OBA) is a formalised, species-independent collection of interoperable phenotypic trait categories that is intended to fulfil a data integration role. OBA is a standardised representational framework for observable attributes that are characteristics of biological entities, organisms, or parts of organisms. OBA has a modular design which provides several benefits for users and data integrators, including an automated and meaningful classification of trait terms computed on the basis of logical inferences drawn from domain-specific ontologies for cells, anatomical and other relevant entities. The logical axioms in OBA also provide a previously missing bridge that can computationally link Mendelian phenotypes with GWAS and quantitative traits. The term components in OBA provide semantic links and enable knowledge and data integration across specialised research community boundaries, thereby breaking silos

A View from the Top: International Politics, Norms and the Worldwide Growth of NGOs

This article provides a top-down explanation for the rapid growth of nongovernmental organizations (NGOs) in the postwar period, focusing on two aspects of political globalization. First, I argue that international political opportunities in the form of funding and political access have expanded enormously in the postwar period and provided a structural environment highly conducive to NGO growth. Secondly, I present a norm-based argument and trace the rise of a pro-NGO norm in the 1980s and 1990s among donor states and intergovernmental organizations (IGOs), which has actively promoted the spread of NGOs to non-Western countries. The article ends with a brief discussion of the symbiotic relationship among NGOs, IGOs, and states promoting international cooperation

Surfing the Waves of Accountable Compassion: A qualitative study of the emerging trauma-informed culture within North Wales Youth Justice Service

The thesis describes a qualitative study of trauma-informed practice which draws on accounts of a sample of justice involved children and service providers in North Wales, in order to explore the practicalities of working within a trauma-informed paradigm and how it fits with key principles which exist within the Youth Justice Service (YJS). The study, which was theoretically informed by symbolic interactionism and hermeneutic phenomenology, used qualitative methods comprising semi-structured interviews with justice involved children as well as interviews and focus groups with service providers. The study findings indicate that there is a shift to moving towards working via a trauma-informed lens, and aims to embed trauma-informed practice into the fabric of the YJS. Certain elements within the YJS, namely the child-practitioner relationship, are more advanced with regard to being trauma-informed in comparison to other areas, some of which are external to the YJS. The thesis argues that in order to weave trauma-informed approaches and a culture of understanding into the identity of the YJS, consideration is required with regards to cultural hang-overs, stemming from previous practice, vicarious trauma and the position of relational practice. In conclusion, the thesis suggests that a trauma-informed cultural shift has many benefits for justice-involved children, not only in addressing their behaviour and the emotions potentially lurking behind it, but also in healing and helping to process past experiences. The experiences and contributions from participants in this study collectively advocate utilising a trauma-informed lens across the YJS. However, a cultural change requires careful management and consideration in order to protect staff, particularly from the imprint of trauma narratives and support children holistically. Where this is neglected, the path to trauma-informed could divert to trauma-organised