Interference in interacting quantum dots with spin

We study spectral and transport properties of interacting quantum dots with spin. Two particular model systems are investigated: Lateral multilevel and two parallel quantum dots. In both cases different paths through the system can give rise to interference. We demonstrate that this strengthens the multilevel Kondo effect for which a simple two-stage mechanism is proposed. In parallel dots we show under which conditions the peak of an interference-induced orbital Kondo effect can be split.Comment: 8 pages, 8 figure

TENOGENIC DIFFERENTIATION PROTOCOL IN XENOGENIC-FREE MEDIA ENHANCES TENDON-RELATED MARKER EXPRESSION IN ADIPOSE-DERIVED STEM CELLS

Tendon injuries are common and current therapies often are unsuccessful. Cell-based therapy using mesenchymal stem cells (MSCs) seems to be the most promising approach to heal tendon. Moreover, providing safe and regulated cell therapy products to patients requires adherence to good manufacturing practices (GMP). Adipose-derived stem cells (n=4) were cultured in 6-well plates coated with type-I collagen in a chemically defined serum-free medium (SF) or a xenogenic-free human pooled platelet lysate medium (hPL). At passage 4, ASCs were induced to tendon lineage for 14 days using 100ng/ml CTGF, 10ng/ml TGFβ3, 50ng/ml BMP12 and 50µg/ml ascorbic acid in the SF (SF-TENO) or in the hPL (hPL-TENO) medium. Cells cultured without any supplements are used as control. Morphological appearance, cell viability and FACS were performed in undifferentiated cells to evaluate the xenogenic-free culture conditions; the gene and protein expression were performed by RT-PCR and immunofluorescence to evaluate to expression of stem cell- and tendon-related markers upon cell differentiation. SF-CTRL and hPL-CTRL showed similar viability and MSC's surface proteins and expressed the stemness markers NANOG, OCT4 and Ki67. Moreover, both SF-TENO and hPL-TENO expressed significant higher levels of SCX, COL1A1, COL3A1, COMP, MMP3 and MMP13 genes already at 3d (p<0.05) respect to CTRLs. Scleraxis and collagen were also detected in both SF-TENO and hPL-TENO at protein level in higher amount than CTRLs. In conclusion, ASCs exposed to CTGF, BMP12, TGFb3 and AA in both serum and xenogenic-free media possess similar tenogenic differentiation ability moving forward the GMP-compliant approaches for the clinical use of ASCs

Model-based design of a pseudo-cogenerative heating system for e-boat battery cold start

Full-electric boats are an expression of recent advancements in the area of vessel electrifi-cation. The installed batteries can suffer from poor cold-start performance, especially in the frigid season and at higher latitudes, leading to driving power limitations immediately after startup. At state, the leading solution is to adopt a dedicated heater placed on the common cooling/heating circuit; this implies poor volume, weight, and cost figures, given the very limited duty cycle of such a part. The Heater-in-Converter (HiC) technology allows removing this specialized component, ex-ploiting the power electronics converters already available on board: HiC modulates their efficiency to produce valuable heat (pseudo-cogeneration). In this work, we use the model-based approach to design this system, which requires heating power minimization to fulfill power electronics limitations, while guaranteeing the user-expected startup time to full power. A multistage model is used to get the yearly vessel temperature distribution from latitude information and some additional data. Then, a lumped parameter for the cooling/heating circuit is used to determine the minimum required power as a function of the properties of the thermal interface material used for the battery coupling. The design is validated on a 1:5 test bench (battery power and energy), which demonstrates how the technology can be to scaled up to also fit different boats and battery sizes

Distribution of landslides reconstructed from inventory data and estimation of landslide susceptibility in Hungary

The complexity of landslides makes it difficult to predict the spatial distribution of landslide susceptibility and hazard. Although in most European countries the basic preconditions for the occurrence of mass movements (rocks and topography) have been mapped in detail, the triggering factors (e.g. precipitation or earthquakes) are much less predictable. A detailed nation-wide inventory for Hungary provides a unique base for landslide susceptibility mapping. As the methodology for the assessment the technique applied in the ELSUS 1000 project was selected. The micro-regions of Hungary were identified where mass movements contribute to land degradation. The paper provides a statistical evaluation of the distribution of landslides, depicts landslide susceptibility on maps and reveals the role of anthropogenic factors in the generation of mass movements. The mid-resolution elevation model (SRTM1), land cover data (CLC50) and surface geology database (Mining and Geological Survey of Hungary) allowed for the derivation of a landslide susceptibility map more detailed than before. Along with its background information the map reflects and explains the differences in landslide susceptibility among the individual hilly and mountainous regions

The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development.

Ca(2+) contributes to a myriad of important cellular processes in all organisms, including the apicomplexans, Plasmodium and Toxoplasma. Due to its varied and essential roles, free Ca(2+) is tightly regulated by complex mechanisms. These mechanisms are therefore of interest as putative drug targets. One pathway in Ca(2+) homeostatic control in apicomplexans uses a Ca(2+)/H(+) exchanger (a member of the cation exchanger family, CAX). The P. falciparum CAX (PfCAX) has recently been characterised in asexual blood stage parasites. To determine the physiological importance of apicomplexan CAXs, tagging and knock-out strategies were undertaken in the genetically tractable T. gondii and P. berghei parasites. In addition, a yeast heterologous expression system was used to study the function of apicomplexan CAXs. Tagging of T. gondii and P. berghei CAXs (TgCAX and PbCAX) under control of their endogenous promoters could not demonstrate measureable expression of either CAX in tachyzoites and asexual blood stages, respectively. These results were consistent with the ability of parasites to tolerate knock-outs of the genes for TgCAX and PbCAX at these developmental stages. In contrast, PbCAX expression was detectable during sexual stages of development in female gametocytes/gametes, zygotes and ookinetes, where it was dispersed in membranous networks within the cytosol (with minimal mitochondrial localisation). Furthermore, genetically disrupted parasites failed to develop further from "round" form zygotes, suggesting that PbCAX is essential for ookinete development and differentiation. This impeded phenotype could be rescued by removal of extracellular Ca(2+). Therefore, PbCAX provides a mechanism for free living parasites to multiply within the ionic microenvironment of the mosquito midgut. Ca(2+) homeostasis mediated by PbCAX is critical and suggests plasmodial CAXs may be targeted in approaches designed to block parasite transmission

Recognition and Assessment of Geomorphosites in Malta at the Il-Majjistral Nature and History Park

The Il-Majjistral Nature and History Park, located on the northwestern coast of the Island of Malta, is a protected area with natural, cultural and tourist interests. The Park, which was registered in 2008, is characterised by a landscape dominated by limestone and clay. Geomorphological features are highly controlled by the presence of faults and rock masses characterised by different physical and mechanical properties. Coastal cliffs, bays and sandy beaches are the most outstanding geomorphological features of the Park, creating a breathtaking landscape which is an attraction for a number of visitors. In the framework of an international research project, a study for the identification, selection and enhancement of the rich geomorphological heritage of the area has been carried out. In particular, a recognition and a quantitative assessment of geomorphosites on the basis of two different methodologies has been developed, and the results have been compared to establish the reliability of the methodologies. The results represent the first step and the necessary basic knowledge for possible enhancement of geomorphosites in Malta and the promotion of tourism activities at the Il-Majjistral Nature and History Park through the auspices of environmental agencies

Advanced SAR interferometric analysis to support geomorphological interpretation of slow-moving coastal landslides (Malta, Mediterranean Sea)

An advanced SAR interferometric analysis has been combined with a methodology for the automatic classification of radar reflectors phase histories to interpret slope-failure kinematics and trend of displacements of slow-moving landslides. To accomplish this goal, the large dataset of radar images, acquired in more than 20 years by the two European Space Agency (ESA) missions ERS-1/2 and ENVISAT, was exploited. The analysis was performed over the northern sector of Island of Malta (central Mediterranean Sea), where extensive landslides occur. The study was assisted by field surveys and with the analysis of existing thematic maps and landslide inventories. The outcomes allowed definition of a model capable of describing the geomorphological evolution of slow-moving landslides, providing a key for interpreting such phenomena that, due to their slowness, are usually scarcely investigated

Landslide susceptibility modeling assisted by Persistent Scatterers Interferometry (PSI): an example from the northwestern coast of Malta

Persistent Scatterers Interferometry (PSI) techniques are widely employed in geosciences to detect and monitor landslides with high accuracy over large areas, but they also suffer from physical and technological constraints that restrict their field of application. These limitations prevent us from collecting information from several critical areas within the investigated region. In this paper, we present a novel approach that exploits the results of PSI analysis for the implementation of a statistical model for landslide susceptibility. The attempt is to identify active mass movements by means of PSI and to avoid, as input data, time-/cost-consuming and seldom updated landslide inventories. The study has been performed along the northwestern coast of Malta (central Mediterranean Sea), where the peculiar geological and geomorphological settings favor the occurrence of a series of extensive slow-moving landslides. Most of these consist in rock spreads, evolving into block slides, with large limestone blocks characterized by scarce vegetation and proper inclination, which represent suitable natural radar reflectors for applying PSI. Based on geomorphometric analyses and geomorphological investigations, a series of landslide predisposing factors were selected and a susceptibility map created. The result was validated by means of cross-validation technique, field surveys and global navigation satellite system in situ monitoring activities. The final outcome shows a good reliability and could represent an adequate response to the increasing demand for effective and lowcost tools for landslide susceptibility assessment

Effects of transient water mass redistribution associated with a tsunami wave on Earth’s pole path

We have quantified the effects of a water mass redistribution associated with the propagation of a tsunami wave on the Earth’s pole path and on the Length-Of-Day (LOD) and applied our modeling results to the tsunami following the 2004 giant Sumatra earthquake. We compared the result of our simulations on the instantaneous rotational axis variations with the preliminary instrumental evidence on the pole path perturbation (which has not been confirmed) registered just after the occurrence of the earthquake. The detected perturbation in the pole path showed a step-like discontinuity that cannot be attributed to the effect of a seismic dislocation. Our results show that the tsunami induced instantaneous rotational pole perturbation is indeed characterized by a step-like discontinuity compatible with the observations but its magnitude is almost one hundred times smaller than the detected one. The LOD variation induced by the water mass redistribution turns out to be not significant because the total effect is smaller than current measurements uncertainties