Evaluación in vitro de la filtración apical de dos cementos y dos procedimientos de obturación con y sin la adición de un adhesivo dentinario

El objetivo de este trabajo fue analizar la filtración apical de dos cementos y dos procedimientos de obturación con y sin la adición de un adhesivo dentinario. Para ello se usaron 80 raíces de dientes monoradiculares que fueron instrumentadas mediante el sistema HERO. De las 80 raíces que fueron instrumetnadas se formaron 8 grupos, seis de estos fueron grupos experimentales, mientras que los dos restantes se usaron como grupos control. En el grupo 1 se incluyeron 10 raíces que fueron obturadas con cemento EndoREZ y punta única, el grupo 2 fue obturado con EndoREZ, punta única y la adición de un adhesivo, el grupo 3 con cemeno EndoREZ y condensación lateral, el grupo 4 con EndoREZ, condensacion lateral y adhesivo, el grupo 5 con cemento AH Plus y condensación lateral y el grupo 6 con AH Plus, condensación lateral y adhesivo. En el grupo 7 (control positivo) se incluyeron 10 raíces que fueron instrumentadas pero que no se obturaron. En el grupo 8 (control negativo) se incluyeron 10 raíces las cuales fueron totalmente cubiertas por dos capas de laca de uñas. Todos los dientes fueron sumergidos en azul de metileno durante 48 h, después de lo cual todos los especimenes fueron limpiados con agua y almacenados en medio húmero a 37°C. La evaluación se realizó mediante transparencia de los dientes lo scuales fueron examinados mediante un estéreomicroscopio a 60 aumentos. No se hallaron diferencias en cuanto a la filtración. El uso de un adhesivo dentinario tampoco mejoró el sellado del ápice

One-loop corrections for WW to HH in Higgs EFT with the electroweak chiral Lagrangian

In this work, we present the computation of the one-loop electroweak radiative corrections to the scattering process WW → HH within the context of the Higgs Effective Field Theory (HEFT). We assume that the fermionic interactions are like in the Standard Model, whereas the beyond Standard Model interactions in the bosonic sector are given by the electroweak chiral Lagrangian (EChL). The computation of the one-loop amplitude and the renormalization program is performed in terms of the involved one-particle-irreducible (1PI) functions and using Rζ covariant gauges. The renormalization of 1PI functions at arbitrary external momenta is a more ambitious program than just renormalizing the amplitude with on-shell external legs, and it has the advantage that they can be used in several scattering amplitudes. In fact, we use here some of the 1PI functions already computed in our previous work (devoted to WZ → WZ). We will complement them here with the computation of the new 1PI functions required for WW → HH. From this renormalization procedure, we will also derive the full set of renormalized coefficients of the EChL that are relevant for this scattering process. In the last part, we will present the numerical results for the EChL predictions of the one-loop level cross section, σ(WW → HH)|1-loop, as a function of the center-of-mass energy, showing the relative size of the one-loop radiative corrections with respect to the tree-level prediction in terms of the EChL coefficients. The results of the one-loop corrections to WW → HH for the SM case will be also presented, for comparison with the EChL case, following the same computational method - i.e., by means of the renormalization of 1PI function

Primary monocytes regulate endothelial cell survival through secretion of Angiopoietin-1 and activation of endothelial Tie2

Objective—Monocyte recruitment and interaction with the endothelium is imperative to vascular recovery. Tie2 plays a key role in endothelial health and vascular remodeling. We studied monocyte-mediated Tie2/angiopoietin signaling following interaction of primary monocytes with endothelial cells and its role in endothelial cell survival. Methods and Results—The direct interaction of primary monocytes with subconfluent endothelial cells resulted in transient secretion of angiopoietin-1 from monocytes and the activation of endothelial Tie2. This effect was abolished by preactivation of monocytes with tumor necrosis factor-α. Although primary monocytes contained high levels of both angiopoietin 1 and 2, endothelial cells contained primarily angiopoietin 2. Seeding of monocytes on serum-starved endothelial cells reduced caspase-3 activity by 46±5.1%, and 52±5.8% after tumor necrosis factor-α treatment and decreased detected single-stranded DNA levels by 41±4.2% and 40±3.5%, respectively. This protective effect of monocytes on endothelial cells was reversed by Tie2 silencing with specific short interfering RNA. The antiapoptotic effect of monocytes was further supported by the activation of cell survival signaling pathways involving phosphatidylinositol 3-kinase, STAT3, and AKT. Conclusion—Monocytes and endothelial cells form a unique Tie2/angiopoietin-1 signaling system that affects endothelial cell survival and may play critical a role in vascular remodeling and homeostasis

Capillary glucose concentration during oral glucose tolerance test for the diagnosis of gestational diabetes

Objective: To assess concordance between two point-of-care testing (POCT) devices and the standard laboratory method in screening for gestational diabetes mellitus (GDM) in Huesca. Methods: Pregnant women who met criteria for an oral glucose tolerance test (OGTT) and attended the laboratory between October 2017 and November 2018 were recruited in this prospective observational study. Glucose was measured in venous (laboratory) and capillary blood (Accu-Chek or Contour Next glucometers). GDM was diagnosed attending to NDDG criteria for venous samples or capillary-specific cut-off. Linear regression, Passing–Bablok, Bland–Altman, and the kappa coefficient were used to study concordance between POCT and laboratory method. Results: Data from 109 women were analyzed (57 for Accu-Chek, 52 for Contour Next). Statistical analyses showed good agreement between both POCT and laboratory method. There were no statistical differences in fasting glucose measurements between capillary and venous samples and both POCT devices meet the ISO 15197 standard. Accu-Chek showed good agreement (k=0.629) regarding the laboratory method in classifying GDM, with an acceptable inter-evaluator bias of 3.5% (P<0.001). Conclusion: POCT can be used to obtain fasting values and reduce overall waiting times for patients. Additionally, Accu-Chek can be used to diagnose GDM in remote areas applying specific cut-off values

Creación hotel rural "El Muro"

En este trabajo se refleja la creación de principio a fin de un Hotel Rural en la Villa de Arróniz, Comunidad Foral de Navarra

Comparación de tres metodologías de análisis sísmico de túnel NATM en suelos finos de Santiago

Seismic design of tunnels is often based on simplified models through analytical expressions for elemental geometries and structural softwares which not include soil stress path due to construction stages and the distance of the front of the excavation, resulting in overestimating the tunnels stresses. However, the development of finite differences or finite elements software has provided new tools that solve these problems and allow evaluating the seismic response through seismic records. This article compares the seismic response of NATM tunnels in soft soil of Santiago through the seismic distortion method of soil applied in a structural analysis software and a finite difference software for soil - structure interaction. Additionally, a seismic record is applied to the last case. The results of these analyses are compared in terms of seismic response of soils and structural design according to current Chilean practice

Crucial Role of the Co Cations on the Destabilization of the Ferrimagnetic Alignment in Co-Ferrite Nanoparticles with Tunable Structural Defects

The key role of the structural defects on the magnetic properties of cobalt ferrite nanoparticles (NPs) is investigated by complementary local probes: element- and site-specific X-ray magnetic circular dichroism (XMCD) combined with high-resolution transmission electron microscopy of individual NPs. A series of monodisperse samples of 8 nm NPs with a tunable amount of structural defects were prepared by thermal decomposition of Fe(III) and Co(II) acetylacetonates in the presence of a variable concentration of 1,2-hexadecanediol. The particles show a partial inverse spinel structure, and their stoichiometry and cation distribution are comparable along the series. Element-specific XMCD hysteresis loops at all the cationic sites show a decrease in squareness and an increase in both the closure field and the high-field susceptibility as the NPs become more structurally defective, suggesting the progressive loss of the collinear ferrimagnetism. However, the Co2+ cations in octahedral sites are significantly more affected by the structural defects than the rest of the cations. This is because structural defects cause local distortions of the crystal field acting on the orbital component of the cations, yielding effective local anisotropy axes that cause a prevalent Co2+ spin canting through the spin–orbit coupling, owing to the relatively large value of the partially unquenched moment of these cations, as found by XMCD. All in all, our results emphasize the crucial role of the Co2+ cations on the destabilization of the collinear ferrimagnetism with the inclusion of structural defects in cobalt ferrite NPs

Urinary incontinence related to perineal muscle strength in the first trimester of pregnancy: cross-sectional study

Objective To analyze pelvic floor muscle strength (PFMS), urinary continence and quality of life related to urinary incontinence (UI) of women in the first trimester of pregnancy. Method Cross-sectional study with a sample of 500 women who started prenatal care in a complementary healthcare facility in Guarulhos, state of São Paulo, from 2012 and 2013. Pelvic floor muscle strength was evaluated through perineometry. The pregnant women who presented UI answered the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). Results It was found that maternal age (OR=1.06; CI95% 1.02-1.11) and prior UI (OR=15.12; 95%CI 8.19-27.92) are the variables that, in tandem, best explain the occurrence of UI at the beginning of pregnancy. The mean score on the ICIQ-SF was 8.2 (SD=3.9), considered a moderate impact on quality of life. Conclusion Older pregnant women with prior UI are more likely to have UI in the first trimester of pregnancy.
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Practical Dosimetry of 131I in Patients with Thyroid Carcinoma

Radioiodine treatments of patients with well-differentiated thyroid carcinoma have generally been safe and beneficial. Safety can be ensured while efficacy is increased through practical methods of dosimetry that measure body retention of 131I. Prescriptions for therapeutic 131I can be decreased when the retention level is high and increased when the level is low. Assays of serum free T4 will alert the physician to possible increased radiation to blood and bone marrow, and appreciable concentrations of free T4 are indications to reduce the therapeutic 131I. Carcinomas ≥1 cm in diameter that are not visible on diagnostic scintigraphy are unlikely to respond to the commonly prescribed mCi of 131I. Biologic responses to commonly prescribed levels of therapeutic 131I, as seen in toxic changes of normal tissues and in indices of tumor size, will be the final dosimeters. With lower levels of prescribed diagnostic 131I, stunning should not impair dosimetry. Thus, readily obtained measurements make dosimetry a practical method for improving carcinoma therapy with 131I.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63166/1/10849780252824118.pd

Understanding factors associated with the translation of cardiovascular research: A multinational case study approach

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.This article has been made available through the Brunel Open Access Publishing Fund.Background: Funders of health research increasingly seek to understand how best to allocate resources in order to achieve maximum value from their funding. We built an international consortium and developed a multinational case study approach to assess benefits arising from health research. We used that to facilitate analysis of factors in the production of research that might be associated with translating research findings into wider impacts, and the complexities involved. Methods: We built on the Payback Framework and expanded its application through conducting co-ordinated case studies on the payback from cardiovascular and stroke research in Australia, Canada and the United Kingdom. We selected a stratified random sample of projects from leading medical research funders. We devised a series of innovative steps to: minimize the effect of researcher bias; rate the level of impacts identified in the case studies; and interrogate case study narratives to identify factors that correlated with achieving high or low levels of impact. Results: Twenty-nine detailed case studies produced many and diverse impacts. Over the 15 to 20 years examined, basic biomedical research has a greater impact than clinical research in terms of academic impacts such as knowledge production and research capacity building. Clinical research has greater levels of wider impact on health policies, practice, and generating health gains. There was no correlation between knowledge production and wider impacts. We identified various factors associated with high impact. Interaction between researchers and practitioners and the public is associated with achieving high academic impact and translation into wider impacts, as is basic research conducted with a clinical focus. Strategic thinking by clinical researchers, in terms of thinking through pathways by which research could potentially be translated into practice, is associated with high wider impact. Finally, we identified the complexity of factors behind research translation that can arise in a single case. Conclusions: We can systematically assess research impacts and use the findings to promote translation. Research funders can justify funding research of diverse types, but they should not assume academic impacts are proxies for wider impacts. They should encourage researchers to consider pathways towards impact and engage potential research users in research processes. © 2014 Wooding et al.; licensee BioMed Central Ltd.RAND Europe and HERG, with subsequent funding from the NHFA, the HSFC and the CIHR. This research was also partially supported by the Policy Research Programme in the English Department of Health