Cribratge de lesions precursores del càncer anal amb citologia en homes que mantenen sexe amb homes i viuen amb el VIH

Càncer anal; Cribratge; Infectat pel VIHCáncer de ano; Cribado; Infectado por el VIHAnal cancer; Screening; HIV-infectedS’han identificat nou guies de pràctica clínica amb recomanacions pel cribratge de lesions precursores de càncer anal, no obstant no hi havia un consens amb l’ús exclusiu de la citologia, ni en la freqüència ni en la derivació. Els programes de cribratge de lesions precursores de càncer anal amb citologia poden reduir la incidència i prevalença d’aquest càncer en HSH que viuen amb VIH. No obstant això, no hi ha estudis de cost-efectivitat realitzats al nostre entorn. Els estudis detectats mostren resultats contradictoris i amb limitacions en la modelització i selecció de paràmetres. Pel que fa a les recomanacions no sembla haver-hi un consens i l’evidència és sustentada per opinions d’experts. Els estudis futurs haurien de ser poder avaluar íntegrament els programes de cribratge.Se han identificado nueve guías de práctica clínica con recomendaciones para el cribado de lesiones precursoras de cáncer anal, no obstante no había un consenso con el uso exclusivo de la citología, ni en la frecuencia ni en la derivación. Los programas de cribado de lesiones precursoras de cáncer anal con citología pueden reducir la incidencia y prevalencia de este cáncer en HSH que viven con VIH. No obstante, no hay estudios de coste-efectividad realizados en nuestro entorno. Los estudios detectados muestran resultados contradictorios y con limitaciones en la modelización y selección de parámetros. En cuanto a las recomendaciones no parece haber un consenso y la evidencia es sustentada por opiniones de expertos. Los estudios futuros deberían ser poder evaluar íntegramente los programas de cribado.Nine clinical practice guidelines have been identified with recommendations for screening precursor lesions of cancer, however there was no consensus on the exclusive use of cytology, neither in frequency nor referral. Screening programs for cancer precursor lesions with cytology can reduce the incidence and prevalence of this cancer in MSM living with HIV. However, there are no cost-effectiveness studies carried out in our environment. The studies detected show contradictory results, limitations in the modeling and selection of parameters. Regarding the recommendations, there seems to be no consensus and the evidence is supported by expert opinions. Future studies should be able to fully evaluate screening programs

Research / children's health

The article provides detailed information from a study that suggests environmental exposure to airborne manganese (Mn) is neurotoxic, especially when inhaled, and is inversely associated with intellectual function in young school-age children. Entering into the body through the lungs, airborne Mn may access the brain directly through olfactory uptake. This cross-sectional study measured the environmental exposure to airborne Mn resulting from mining and processing in Hidalgo State in central Mexico, and explored its association with the intellectual function of school-age children

Strategic and competitive advantages of the agricultural sector in Querétaro, Mexico

Objective: Characterize the agricultural production of the state of Querétaro during 2018 to facilitate business decision-making and propose public and private strategies for the development of high-value agrifood production projects. Design/methodology/approach: The analysis was carried out from bibliometric exploration and statistical data collection from different agrifood information platforms. Results: The municipalities of Pedro Escobedo, Colón, San Juan del Río, and El Marqués have established crops of grains, vegetables, forage grasses, and roses, through productive projects of private initiative with an agribusiness vision, due to the use of knowledge, technological innovations, and market intelligence. Limitations of the study/implications: Lack of information to establish the current agricultural vocation of the state of Querétaro. Findings/conclusions: Based on the perspectives of specialized markets at the national and international level, the state of Querétaro has several strategic and competitive advantages for the establishment of high-impact agricultural projects.Objective: To characterize agricultural production in the state of Querétaro, Mexico, during 2018 in order to provide information that can facilitate business decision-making and lay out public and private strategies for the development of high-value projects in agrifood production. Design/Methodology/Approach: The analysis was conducted through bibliometric exploration and collection of statistical data, available on different public-access agrifood statistics information platforms. Results: The municipalities of Pedro Escobedo, Colón, San Juan del Río, and El Marqués established grain, vegetable, foraging grass, and rose crops through private sector productive projects with an agribusiness perspective, using available knowledge, technological innovation, and market intelligence. Study Limitations/Implications: A lack of information to allow establishing the current agricultural vocation of the state of Queretaro. Findings/Conclusions: Based on the perspectives of specialized markets at the national and international level, Querétaro possesses diverse strategic and competitive advantages for the establishment of high-impact agricultural projects

Refundar un orden: la dictadura cívico-militar, el terrorismo de Estado, la reestructuración económica y las políticas culturales juveniles

Fil: Canciani Vivanco, Verónica. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Floridia, Yanina. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Giraudo, Marina. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: González, Alejandra Soledad. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Morón, Silvia. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Ortiz, Laura. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades; Argentina.Fil: Ortiz, Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Philp, María Marta. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales. Centro de Estudios Avanzados; Argentina.Fil: Philp, María Marta. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Reche, Federico. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones María Saleme de Burnichon; Argentina.Fil: Reche, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Libro que compila capítulos de Historia de Córdoba desde los primeros pobladores hasta la historia reciente; fue producto de un convenio interinstitucional entre la FFyH (a través de la escuela de historia) y el ministerio de educación de la provincia de Córdoba, vía Olimpíadas de historia de Córdoba y la SICyPE. Participé del convenio en calidad de equipo interinstitucional y como autora de capítulos. resumen del capítulo: En América Latina, desde los años sesenta y primera mitad de los setenta se impusieron Dictaduras de Seguridad Nacional en diferentes países como respuesta a la creciente impugnación y crítica del orden que los movimientos sociales y políticos venían realizando. Al identificar estos cuestionamientos con la existencia de un enemigo interno, estas dictaduras militares con fuertes apoyos civiles se enmarcaron en la Doctrina de Seguridad Nacional que alentaba la guerra al comunismo internacional. Esas dictaduras se caracterizaron por ser las más represivas y feroces de la historia reciente y por sus decididas vocaciones por intervenir en la sociedad, la política y la economía para refundar un orden nuevo, en reemplazo del anterior vigente hasta entonces al que entendían viciado y degradado. A su vez, eran expresión de una vocación marcadamente intervencionista de las fuerzas armadas que se autopercibían como garantes del orden y autónomas del poder civil. En Argentina, tanto la dictadura inaugurada en 1966 con el Golpe de Onganía como la iniciada el 24 de marzo de 1976 participan de este universo de definiciones. Sin embargo muestran también diferencias: durante la “Revolución Argentina” se produjo un aumento de la conflictividad social y se forzó una salida electoral, mientras la dictadura del ’76 aumentó su capacidad destructiva e impuso una represión sistemática inusitada, al tiempo que desmontó mecanismos previos de organización del mundo económico, político y social para dar lugar al diseño e implementación de un nuevo orden que se garantizó con el terror. En este capítulo pretendemos dar respuesta a una pregunta principal: ¿Qué tipo de orden se propusieron desmantelar y cuáles fueron las características de aquel que construyeron como su reemplazo? ¿Qué estrategias y mecanismo utilizaron y cuáles fueron las diferentes respuestas sociales ante esta transformación? Este capítulo se escribió desde agosto de 2017 a marzo de 2018. Requirió la conformación del equipo de autores, la selección de contenidos y sucesivas entregas al equipo que coordina la publicación. Se encuentra en revisión final y será publicado en el segundo semestre de 2018. Por lo tanto, se consigna publicada porque el soporte no la opción en evaluación final para publicar. pero queremos dar cuenta de un trabajo de escritura de largo aliento, multiautoría y dentro de una propuesta interinstitucional de trabajo.https://ffyh.unc.edu.ar/editorial/itinerarios-recorridos-por-la-historia-de-cordoba/Fil: Canciani Vivanco, Verónica. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Floridia, Yanina. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Giraudo, Marina. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: González, Alejandra Soledad. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Morón, Silvia. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Ortiz, Laura. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades; Argentina.Fil: Ortiz, Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Philp, María Marta. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales. Centro de Estudios Avanzados; Argentina.Fil: Philp, María Marta. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Reche, Federico. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones María Saleme de Burnichon; Argentina.Fil: Reche, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Otras Historia y Arqueologí

Competitive management for export of roses from Mexico to Canada

Objective: The aim of this study was to assess the dynamics of the international rose market between Mexico and Canada and propose effective management strategies that could be applied in rural economic units to strengthen the position of Mexican roses in the Canadian market. Design/methodology/approach: The methodological process used the deductive approach. First, an in-depth analysis of the rose market in Canada was carried out, and competitive management strategies subsequently were determined. The information was collected on agri-food documentary and statistical information platforms at the national and international levels. Results: Mexico has excellent agri-environmental conditions, efficient international logistics, solid infrastructure, a current trade agreement with Canada (T-MEC), and outstanding experience in the agricultural production of roses. Additionally, there is important demand in the Canadian rose market, which has so far been dominated primarily in recent years by Colombia and Ecuador. Limitations on study/implications: It is a research that can be used as a reference for any agricultural producer, rural production company, or international trade company that wants to enter the rose market and export from Mexico to Canada. Findings/conclusions: Finally, this study shows the importance of taking advantage of available commercial opportunities and promoting synergy between the public and private sectors to promote the growth of the rose agroindustry in Mexico and contribute to the economic development of the country. With a smart approach and strategic execution, Mexico has the potential to become a prominent player in Canada's rose export market in the coming years. Keywords: Agribusiness, social welfare, international trade, cut flowers, competitive management.between Mexico and Canada and to propose competitive management strategies that could be implemented in the rural economic units to consolidate the presence of Mexican roses in the Canadian market. Design/methodology/approach: The methodological process to fulfill the objectives of this study uses the deductive approach, since we start from an analysis of the rose market in Canada in order to determine the competitive management strategies. Gathering information was conducted in platforms of agrifood documental information and statistics in the national and international spheres. Results: Mexico has excellent agro-environmental conditions, efficient international logistics, solid infrastructure, a valid trade agreement with Canada (T-MEC), and outstanding experience in agricultural production of roses. In addition, there is a significant demand in the Canadian rose market that has been dominated in recent years and until today by Colombia and Ecuador. Limitations on study/implications: It is a study that could be used as reference for any agricultural producer, rural production society, of international trade company that wants to penetrate the rose market and its exports from Mexico to Canada. Findings/conclusions: Finally, this study evidences the importance of taking advantage of the available commercial opportunities and to promote synergy between the public and private sectors to drive the growth of agroindustry of roses in Mexico and to contribute to economic development of the country. With an intelligent approach and strategic execution, Mexico has the potential of becoming a prominent actor in the export market of roses to Canada in the coming years

Phase II clinical trial of nab-paclitaxel plus gemcitabine in elderly patients with previously untreated locally advanced or metastatic pancreatic adenocarcinoma: the BIBABRAX study

[Purpose] To evaluate the health-related quality of life (HRQoL), global health status (GHS), and deterioration-free survival of an elderly population (> 70 years) with unresectable locally advanced (LAPC) or metastatic pancreatic cancer (mPC) treated with nab-paclitaxel in combination with gemcitabine.[Methods] In this open-label, single-arm, multicenter, phase II trial, patients received 4-week cycles of intravenous (i.v.) nab-paclitaxel at a dose of 125 mg/m2, followed by i.v. injections of gemcitabine at a dose of 1000 mg/m2 on days 1, 8 and 15 until disease progression or unacceptable toxicity was observed. The primary outcome was the HRQoL (deterioration-free rate at 3 months as evaluated with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30.[Results] Eighty patients (median age: 74.6 years) were enrolled (56 with mPC, 24 with LAPC). The percentage of patients who had not experienced deterioration at 3 months was 54.3% (95% CI 41.6–67.0%). The median (interquartile range) time until definite deterioration was 1.6 (1.1–3.7) months. The objective response rate and clinical benefit rate were achieved by 11 (13.8%, 95% CI 6.2–21.3%) and 54 patients (67.5%, 95% CI 57.2–77.8%), respectively. The median overall survival was 9.2 months (95% CI 6.9–11.5), and the median progression-free survival was 7.2 months (95% CI 5.8–8.5). Only fatigue and neutropenia demonstrated a grade 3–4 toxicity incidence > 20%.[Conclusions] Our study confirms the clinical benefit of the combination of nab-paclitaxel and gemcitabine in an elderly population with pancreatic cancer in terms of improved survival and clinical response. However, we were unable to confirm a benefit in terms of quality-of-life.The BIBABRAX study was funded by Celgene. Medical writing assistance in the preparation of this paper was provided by Apices with financial support from Celgene.Peer reviewe

Between-site reliability of startle prepulse inhibition across two early psychosis consortia

Prepulse inhibition (PPI) and reactivity of the acoustic startle response are widely used biobehavioral markers in psychopathology research. Previous studies have demonstrated that PPI and startle reactivity exhibit substantial within-site stability; between-site stability, however, has not been established. In two separate consortia investigating biomarkers of early psychosis, traveling subjects studies were performed as part of quality assurance procedures in order to assess the fidelity of data across sites. In the North American Prodromal Longitudinal Studies (NAPLS) Consortium, 8 normal subjects traveled to each of the 8 NAPLS sites and were tested twice at each site on the startle PPI paradigm. In preparation for a binational study, 10 healthy subjects were assessed twice in both San Diego and Mexico City. Intraclass correlations between and within sites were significant for PPI and startle response parameters, confirming the reliability of startle measures across sites in both consortia. There were between site differences in startle magnitude in the NAPLS study that did not appear to be related to methods or equipment. In planning multi-site studies, it is essential to institute quality assurance procedures early and establish between site reliability to assure comparable data across sites

Estudio de la atención involuntaria, mediante potenciales relacionados con eventos, en pacientes con enfermedad de Parkinson /

\ua0tesis que para obtener el grado de Doctor en Psicología, presenta Rodolfo Solís Vivanco ; asesor Ricardo Garcell Josefina, Roberto Agustín Prado Alcalá, Mario Arturo Rodríguez Camacho, María Asunción Corsi Cabrera, Irma Yolanda Del Río Portilla. 127, [17] páginas :\ua0ilustraciones. Doctorado en Psicología\ua0UNAM, Facultad de Psicología,\ua0201

Eficacia del ranibizumab intravítreo posterior al cerclaje escleral como método preventivo del redesprendimiento de retina secundario a vítreorretinopatía proliferativa

Ciencias Médica