The dynamical equivalence of modified gravity revisited

We revisit the dynamical equivalence between different representations of vacuum modified gravity models in view of Legendre transformations. The equivalence is discussed for both bulk and boundary space, by including in our analysis the relevant Gibbons-Hawking terms. In the f(R) case, the Legendre transformed action coincides with the usual Einstein frame one. We then re-express the R+f(G) action, where G is the Gauss-Bonnet term, as a second order theory with a new set of field variables, four tensor fields and one scalar and study its dynamics. For completeness, we also calculate the conformal transformation of the full Jordan frame R+f(G) action. All the appropriate Gibbons-Hawking terms are calculated explicitly.Comment: 17 pages; v3: Revised version. New comments added in Sections 3 & 5. New results added in Section 6. Version to appear in Class. Quantum Gravit

Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS.

Vaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in single-cell biology have been instrumental in uncovering pre-vaccination immune cell types and genomic features (i.e., the baseline immune state, BIS) that have been associated with vaccine responsiveness. Here, we review clinical factors that shape the BIS, and the characteristics of the BIS associated with responsiveness to frequently studied vaccines (i.e., influenza, COVID-19, bacterial pneumonia, malaria). Finally, we discuss potential strategies to enhance vaccine responsiveness in high-risk groups, focusing specifically on older adults

Regulation of L1 expression and retrotransposition by melatonin and its receptor: implications for cancer risk associated with light exposure at night.

Expression of long interspersed element-1 (L1) is upregulated in many human malignancies. L1 can introduce genomic instability via insertional mutagenesis and DNA double-strand breaks, both of which may promote cancer. Light exposure at night, a recently recognized carcinogen, is associated with an increased risk of cancer in shift workers. We report that melatonin receptor 1 inhibits mobilization of L1 in cultured cells through downregulation of L1 mRNA and ORF1 protein. The addition of melatonin receptor antagonists abolishes the MT1 effect on retrotransposition in a dose-dependent manner. Furthermore, melatonin-rich, but not melatonin-poor, human blood collected at different times during the circadian cycle suppresses endogenous L1 mRNA during in situ perfusion of tissue-isolated xenografts of human cancer. Supplementation of human blood with exogenous melatonin or melatonin receptor antagonist during the in situ perfusion establishes a receptor-mediated action of melatonin on L1 expression. Combined tissue culture and in vivo data support that environmental light exposure of the host regulates expression of L1 elements in tumors. Our data imply that light-induced suppression of melatonin production in shift workers may increase L1-induced genomic instability in their genomes and suggest a possible connection between L1 activity and increased incidence of cancer associated with circadian disruption

Clustering of Ly-alpha emitters around luminous quasars at z = 2-3: an alternative probe of reionization on galaxy formation

Narrowband observations have detected no Ly-alpha emission within a 70 pMpc^3 volume centered on the z = 2.168 quasar PKS 0424-131. This is in contrast to surveys of Ly-alpha emitters in the field at similar redshifts and flux limits, which indicate that tens of sources should be visible within the same volume. The observed difference indicates that the quasar environment has a significant influence on the observed density of Ly-alpha emitters. To quantify this effect we have constructed a semi-analytic model to simulate the effect of a luminous quasar on nearby Ly-alpha emitters. We find the null detection around PKS 0424-131 implies that the minimum isothermal temperature of Ly-alpha emitter host halos is greater than 3.4 x 10^6 K (68% level), corresponding to a virial mass of ~1.2 x 10^12 M_solar. This indicates that the intense UV emission of the quasar may be suppressing the star formation in nearby galaxies. Our study illustrates that low redshift quasar environments may serve as a surrogate for studying the radiative suppression of galaxy formation during the epoch of reionization.Comment: 9 pages, 5 figures, submitted to MNRA

The State of the Region: Hampton Roads 2006

This is Old Dominion University\u27s seventh annual State of the Region report. While it represents the work of many people connected in various ways to the university, the report does not constitute an official viewpoint of Old Dominion, or it\u27s president, Roseann Runte. The report maintains the goal of stimulating thought and discussion that ultimately will make Hampton Roads an even better place to live. We are proud of our region\u27s many successes, but realize that it is possible to improve our performance. In order to do so, we must have accurate information about where we are and a sound understanding of the policy options open to us.https://digitalcommons.odu.edu/economics_books/1012/thumbnail.jp

Electromagnetic modelling of the SKA-LOW AAVS2 prototype

The computational electromagnetic modelling of a large radio telescope prototype array for the Square Kilometer Array is described. The numerical models, using the Method of Moments, are characterised by a very large number of unknowns, requiring the use of fast solution methods and high performance computing platforms. Good agreement has been obtained between results obtained on two different commercial codes. Results for both embedded element patterns and the station beam are shown. The use of the computed embedded element patterns for array calibration is briefly addressed

Registered Replication Report on Fischer, Castel, Dodd, and Pratt (2003)

The attentional spatial-numerical association of response codes (Att-SNARC) effect (Fischer, Castel, Dodd, & Pratt, 2003)—the finding that participants are quicker to detect left-side targets when the targets are preceded by small numbers and quicker to detect right-side targets when they are preceded by large numbers—has been used as evidence for embodied number representations and to support strong claims about the link between number and space (e.g., a mental number line). We attempted to replicate Experiment 2 of Fischer et al. by collecting data from 1,105 participants at 17 labs. Across all 1,105 participants and four interstimulus-interval conditions, the proportion of times the effect we observed was positive (i.e., directionally consistent with the original effect) was 50. Further, the effects we observed both within and across labs were minuscule and incompatible with those observed by Fischer et al. Given this, we conclude that we failed to replicate the effect reported by Fischer et al. In addition, our analysis of several participant-level moderators (finger-counting habits, reading and writing direction, handedness, and mathematics fluency and mathematics anxiety) revealed no substantial moderating effects. Our results indicate that the Att-SNARC effect cannot be used as evidence to support strong claims about the link between number and space

Characterization of the SKA1-Low prototype station Aperture Array Verification System 2

The low frequency component of the Square Kilometre Array (SKA1-Low) will be an aperture phased array located at the Murchison Radio-astronomy Observatory (MRO) site in Western Australia. It will be composed of 512 stations, each consisting of 256 log-periodic dual-polarized antennas, and will operate in the low frequency range (50 to 350 MHz) of the SKA bandwidth. The Aperture Array Verification System 2 (AAVS2), operational since late 2019, is the last full-size engineering prototype station deployed at the MRO site before the start of the SKA1-Low construction phase. The aim of this paper is to characterize the station performance through commissioning observations at six different frequencies (55, 70, 110, 160, 230, and 320 MHz) collected during its first year of activities. We describe the calibration procedure, present the resulting all-sky images and their analysis, and discuss the station calibratability and system stability. Using the difference imaging method, we also derive estimates of the SKA1-Low sensitivity for the same frequencies and compare them with those obtained through electromagnetic simulations across the entire telescope bandwidth, finding good agreement (within 13%). Moreover, our estimates exceed the SKA1-Low requirements at all considered frequencies by up to a factor of ∼2.3. Our results are very promising and allow for an initial validation of the AAVS2 prototype station performance, which is an important step toward the coming SKA1-Low telescope construction and science

Registered Replication Report on Fischer, Castel, Dodd, and Pratt (2003)

The attentional spatial-numerical association of response codes (Att-SNARC) effect (Fischer, Castel, Dodd, & Pratt, 2003)—the finding that participants are quicker to detect left-side targets when the targets are preceded by small numbers and quicker to detect right-side targets when they are preceded by large numbers—has been used as evidence for embodied number representations and to support strong claims about the link between number and space (e.g., a mental number line). We attempted to replicate Experiment 2 of Fischer et al. by collecting data from 1,105 participants at 17 labs. Across all 1,105 participants and four interstimulus-interval conditions, the proportion of times the effect we observed was positive (i.e., directionally consistent with the original effect) was .50. Further, the effects we observed both within and across labs were minuscule and incompatible with those observed by Fischer et al. Given this, we conclude that we failed to replicate the effect reported by Fischer et al. In addition, our analysis of several participant-level moderators (finger-counting habits, reading and writing direction, handedness, and mathematics fluency and mathematics anxiety) revealed no substantial moderating effects. Our results indicate that the Att-SNARC effect cannot be used as evidence to support strong claims about the link between number and space