3,048 research outputs found
Quantifying identifiability in independent component analysis
We are interested in consistent estimation of the mixing matrix in the ICA
model, when the error distribution is close to (but different from) Gaussian.
In particular, we consider independent samples from the ICA model , where we assume that the coordinates of are independent
and identically distributed according to a contaminated Gaussian distribution,
and the amount of contamination is allowed to depend on . We then
investigate how the ability to consistently estimate the mixing matrix depends
on the amount of contamination. Our results suggest that in an asymptotic
sense, if the amount of contamination decreases at rate or faster,
then the mixing matrix is only identifiable up to transpose products. These
results also have implications for causal inference from linear structural
equation models with near-Gaussian additive noise.Comment: 22 pages, 2 figure
PRISTINA'S DEVELOPMENT STRATEGY OF 2013-2016: AN ANALYSIS OF THE SITUATION IN THE EDUCATIONAL, CULTURAL, YOUTH, AND SPORT SECTOR
Sustainable economic development is done through Development Strategy. Development strategies have some priorities which include encouraging other participants, stakeholders, and those that have impact on the investment to act in accordance with the vision. This is accomplished by working together to establish priorities in the correct way. Also, this is undoubtedly the key to success. Economic development is essential for the survival of all municipalities. Economic growth which is accomplished as a result of an economic development plan, promotes new capital in municipalities. Hence, this is becoming an integral part of the strategic process at the national level. This enables the creation of a better environment and economic competition locally. Local economic development is the process by which local communities (public, businesses, and non-governmental organizations) are working towards the achievement of sustainable economic development and provides an increased level of employment, welfare, and quality of life for all (World Bank, 2009). Local economic development is one of the most important areas to increase the quality of life of the citizens and create a favourable environment for business development (Riinvest, 2002). Development Strategy comes as a response to rapid changes, keeping containment conditions by which interest groups will have the constructive approach in evaluating the situation. Also, the position towards the strategy which takes the specific actions is placed into consideration. This therefore ensures that the changes in the city are not dramatic. Municipalities must learn how to compete and how to deploy themselves in order to ensure quality of life, jobs, and services, which then influences the attraction of investments. Strategy is often a prerequisite for financing municipal projects through government grants, FDI, banks, publicprivate partnerships, or EU funds. During this process, the municipality creates partnerships, both within and outside the municipality. The stronger these partnerships are, the greater the chances of a municipality to secure future development. The strategy in itself provides the opportunity for the community to continuously improve the investment climate. It is a general observation that development strategy should have no overarching plan. Furthermore, it must contain some strategic steps in order for it to increase the system as a whole. Thus, this is done through the mechanisms of different national levels such as changes in the status of the city, public and private investment, public-private initiatives etc
PRISTINA'S DEVELOPMENT STRATEGY OF 2013-2016: AN ANALYSIS OF THE SITUATION IN THE EDUCATIONAL, CULTURAL, YOUTH, AND SPORT SECTOR
Sustainable economic development is done through Development Strategy. Development strategies have some priorities which include encouraging other participants, stakeholders, and those that have impact on the investment to act in accordance with the vision. This is accomplished by working together to establish priorities in the correct way. Also, this is undoubtedly the key to success. Economic development is essential for the survival of all municipalities. Economic growth which is accomplished as a result of an economic development plan, promotes new capital in municipalities. Hence, this is becoming an integral part of the strategic process at the national level. This enables the creation of a better environment and economic competition locally. Local economic development is the process by which local communities (public, businesses, and non-governmental organizations) are working towards the achievement of sustainable economic development and provides an increased level of employment, welfare, and quality of life for all (World Bank, 2009). Local economic development is one of the most important areas to increase the quality of life of the citizens and create a favourable environment for business development (Riinvest, 2002). Development Strategy comes as a response to rapid changes, keeping containment conditions by which interest groups will have the constructive approach in evaluating the situation. Also, the position towards the strategy which takes the specific actions is placed into consideration. This therefore ensures that the changes in the city are not dramatic. Municipalities must learn how to compete and how to deploy themselves in order to ensure quality of life, jobs, and services, which then influences the attraction of investments. Strategy is often a prerequisite for financing municipal projects through government grants, FDI, banks, publicprivate partnerships, or EU funds. During this process, the municipality creates partnerships, both within and outside the municipality. The stronger these partnerships are, the greater the chances of a municipality to secure future development. The strategy in itself provides the opportunity for the community to continuously improve the investment climate. It is a general observation that development strategy should have no overarching plan. Furthermore, it must contain some strategic steps in order for it to increase the system as a whole. Thus, this is done through the mechanisms of different national levels such as changes in the status of the city, public and private investment, public-private initiatives etc
A Logistic Regression/Markov Chain Model for NCAA Basketball
Each year, more than $3 billion is wagered on the NCAA Division I men’s basketball tournament. Most of that money is wagered in pools where the object is to correctly predict winners of each game, with emphasis on the last four teams remaining (the Final Four). In this paper, we present a combined logistic regression/Markov chain model for predicting the outcome of NCAA tournament games given only basic input data. Over the past 6 years, our model has been significantly more successful than the other common methods such as tournament seedings, the AP and ESPN/USA Today polls, the RPI, and the Sagarin ratings
Quantum Critical Scaling in a Moderately Doped Antiferromagnet
Using high temperature expansions for the equal time correlator and
static susceptibility for the t-J model, we present evidence for
quantum critical (QC), , behavior at intermediate temperatures in a
broad range of ratio, doping, and temperatures. We find that the
dynamical susceptibility is very close to the universal scaling function
computable for the asymptotic QC regime, and that the dominant energy scale is
temperature. Our results are in excellent agreement with measurements of the
spin-echo decay rate, , in LaCuO, and provide qualitative
understanding of both and nuclear relaxation rates in
doped cuprates.Comment: 11 pages, REVTeX v3.0, PostScript file for 3 figures is attached,
UIUC-P-93-07-068. In this revised version, we calculate the scaling functions
and thus present new and more direct evidence in favor of our original
conclusion
Layer- and bulk roton excitations of 4He in porous media
We examine the energetics of bulk and layer-roton excitations of 4He in
various porous medial such as aerogel, Geltech, or Vycor, in order to find out
what conclusions can be drawn from experiments on the energetics about the
physisorption mechanism. The energy of the layer-roton minimum depends
sensitively on the substrate strength, thus providing a mechanism for a direct
measurement of this quantity. On the other hand, bulk-like roton excitations
are largely independent of the interaction between the medium and the helium
atoms, but the dependence of their energy on the degree of filling reflects the
internal structure of the matrix and can reveal features of 4He at negative
pressures. While bulk-like rotons are very similar to their true bulk
counterparts, the layer modes are not in close relation to two-dimensional
rotons and should be regarded as a third, completely independent kind of
excitation
Pan-squamous genomic profiling stratified by anatomic tumor site and viral association
Background: Squamous cell carcinomas (SCC) have diverse anatomic etiologies but may share common genomic biomarkers. We profiled 7,871 unique SCCs across nine anatomic sites to investigate commonality in genomic alterations (GA), tumor mutational burden (TMB), human papillomavirus (HPV) association, and mutational signatures.
Methods: Tissue from over 8,100 unique SCC samples originating from nine anatomic sites (anogenital (anus, cervix, penis, vagina, vulva), esophagus, head and neck, lung, and skin) were sequenced by hybrid capture-based comprehensive genomic profiling to evaluate GA and TMB. About 3% of non-cutaneous SCC samples had UV signatures, indicative of potential primary site misdiagnoses, and were filtered from the analysis. Detection of HPV, including high-risk strains 16, 18, 31, 33, and 45, was implemented through de novo assembly of non-human sequencing reads and BLASTn comparison against all viral nucleotide sequences in the NCBI database.
Results: The proportion of HPV+ patients by anatomic site varied, with the highest being anal (91%) and cervical (83%). The mutational landscape of each cohort was similar, regardless of anatomic origin, but clustered based on HPV status. The largest differences in GA frequency as stratified by HPV- vs. HPV+ were TP53 (87% vs. 12%), CDKN2A (45% vs. 6%), and PIK3CA (22% vs. 33%). The median TMB in cases originating from HPV-associated sites was similar, regardless of HPV status. Higher median TMB was observed in lung and skin cases, which exhibited significant enrichment of mutational signatures indicative of tobacco- and UV-induced DNA damage, respectively.
Conclusions: HPV+ and HPV- SCC populations have distinct genomic profiles and, for the latter, anatomic site is correlated with TMB distribution, secondary to associated carcinogen exposure. As such, biomarkers such as TMB and UV signature can provide unexpected insight into site of origin misdiagnoses and may correlate with benefit from immune checkpoint inhibitors
First Detection of the White-Dwarf Cooling Sequence of the Galactic Bulge
We present Hubble Space Telescope data of the low-reddening Sagittarius
window in the Galactic bulge. The Sagittarius Window Eclipsing Extrasolar
Planet Search field (3'x3'), together with three more Advanced Camera for
Surveys and eight Wide Field Camera 3 fields, were observed in the F606W and
F814W filters, approximately every two weeks for two years, with the principal
aim of detecting a hidden population of isolated black holes and neutron stars
through astrometric microlensing. Proper motions were measured with an accuracy
of ~0.1 mas/yr (~4 km/s) at F606W~25.5 mag, and better than ~0.5 mas/yr (20
km/s) at F606W~28 mag, in both axes. Proper-motion measurements allowed us to
separate disk and bulge stars and obtain a clean bulge color-magnitude diagram.
We then identified for the first time a white dwarf (WD) cooling sequence in
the Galactic bulge, together with a dozen candidate extreme horizontal branch
stars. The comparison between theory and observations shows that a substantial
fraction of the WDs (30%) are systematically redder than the cooling tracks for
CO-core H-rich and He-rich envelope WDs. This evidence would suggest the
presence of a significant number of low-mass WDs and WD - main sequence
binaries in the bulge. This hypothesis is further supported by the finding of
two dwarf novae in outburst, two short-period (P < 1 d) ellipsoidal variables,
and a few candidate cataclysmic variables in the same field.Comment: 9 pages, 5 figures, accepted for publication on Ap
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