53 research outputs found
A systematic review and meta-analysis to determine the contribution of mr imaging to the diagnosis of foetal brain abnormalities In Utero.
- Author
- AC Rossi
- Anthea Sutton
- BR Benacerraf
- C D'Ercole
- C Doneda
- C Rubod
- Cara Mooney
- CF Hagmann
- D Moher
- D Paladini
- D Prayer
- Debbie Jarvis
- Diana Papaioannou
- DM Twickler
- DR Elbourne
- EH Whitby
- EH Whitby
- EM Simon
- G Benoist
- G Egana-Ugrinovic
- G Malinger
- G Malinger
- G Malinger
- G Papaioannou
- GB Wang
- GG Colleoni
- H Amini
- HT Phua
- IA Hosny
- J Garcia-Flores
- J Higgins
- JH Chung
- JPT Higgins
- JS We
- Judith Cohen
- KM Ismail
- L Manganaro
- LS Corp
- M Doorn van
- M Hamisa
- M Resta
- MC Frates
- Mike Bradburn
- MP Becker
- OA Glenn
- P Peruzzi
- Paul D. Griffiths
- PF Whiting
- R DerSimonian
- R Rajeswaran
- RA Kubik-Huch
- S Kul
- S Lipitz
- SA Nabavizadeh
- SN Saleem
- W Blaicher
- WT Yuh
- Y Patenaude
- YS Sohn
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 21/09/2016
- Field of study
OBJECTIVES: This systematic review was undertaken to define the diagnostic performance of in utero MR (iuMR) imaging when attempting to confirm, exclude or provide additional information compared with the information provided by prenatal ultrasound scans (USS) when there is a suspicion of foetal brain abnormality. METHODS: Electronic databases were searched as well as relevant journals and conference proceedings. Reference lists of applicable studies were also explored. Data extraction was conducted by two reviewers independently to identify relevant studies for inclusion in the review. Inclusion criteria were original research that reported the findings of prenatal USS and iuMR imaging and findings in terms of accuracy as judged by an outcome reference diagnosis for foetal brain abnormalities. RESULTS: 34 studies met the inclusion criteria which allowed diagnostic accuracy to be calculated in 959 cases, all of which had an outcome reference diagnosis determined by postnatal imaging, surgery or autopsy. iuMR imaging gave the correct diagnosis in 91Â % which was an increase of 16Â % above that achieved by USS alone. CONCLUSION: iuMR imaging makes a significant contribution to the diagnosis of foetal brain abnormalities, increasing the diagnostic accuracy achievable by USS alone. KEY POINTS: âą Ultrasound is the primary modality for monitoring foetal brain development during pregnancy âą iuMRI used together with ultrasound is more accurate for detecting foetal brain abnormalities âą iuMR imaging is most helpful for detecting midline brain abnormalities âą The moderate heterogeneity of reviewed studies may compromise findings
Lawson criterion for ignition exceeded in an inertial fusion experiment
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- Zobrist T
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- Zylstra AB
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 06/07/2022
- Field of study
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37Â MJ of fusion for 1.92Â MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion
The neurobiological link between OCD and ADHD
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Zhu B
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- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A DĂĄvalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
- A-L BarabĂĄsi
- AA Andreadis
- AA Borisy
- AA Farooqui
- AA Qutub
- AA Qutub
- AA Vlessis
- AB Nathens
- AB Parsons
- AB Parsons
- AB Thompson
- AB Thomson
- AC Bayne
- AC Bharti
- AC Cave
- AC Mello Filho
- AD d'Hardemare
- AD de Silva
- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
- ADL van der
- AE Aust
- AE Baue
- AE Finefrock
- AE Heazell
- AE Heazell
- AE Kartikasari
- AEC Ihekwaba
- AEC Ihekwaba
- AF Tramontano
- AH Berg
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- YZ Fang
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- Z Cai
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- Z Tong
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- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Molecular signatures for CCN1, p21 and p27 in progressive mantle cell lymphoma
- Author
- A Besson
- A Jedsadayanmata
- A Moros
- A MĂŒller
- A Ray
- AB Queiroz
- AC QueirĂłs
- Afak Rasheed Salman Zaidi
- AM Abukhdeir
- AS Dobroff
- B Perbal
- B Perbal
- C Ceccarelli
- C Ciccarelli
- C Denicourt
- C Gillett
- C Renty de
- C Royo
- C Rudolph
- C-C Niu
- CA Tucker
- Charlotte Burt
- CM Garrett-Engele
- D Jeong
- D Sohn
- D Xie
- D Xie
- E Campo
- E Zucca
- F Kipkeew
- F Samaniego
- G Baretton
- G Bretones
- G Chen
- G Ferrandina
- G Maity
- GD Roodman
- H Rauert-Wunderlich
- H Toyoshima
- H Zhao
- I Haque
- I Perez-Roger
- I Tamura
- I Timmerbeul
- IB Roninson
- J Camps
- J Choi
- J Dotterweich
- J Jandova
- J LaBaer
- J Lukas
- J O'Kelly
- J Wells
- J-M Jung
- JA Menendez
- JA Nemes
- JC Crockett
- JJ Molenaar
- JR Nevins
- K Sawai
- K Thompson
- KB D'Antonio
- KF Izban
- L Bartholin
- L McCallum
- L Quintanilla-Martinez
- L Quintanilla-Martinez
- L Zhang
- L-F Qin
- LF Lau
- LJ Crawford
- Lynn McCallum
- M Dreyling
- M Hall
- M PĂ©rez-SayĂĄns
- M-T Lin
- M-T Lin
- ML Kireeva
- MR Smith
- MT Piccolo
- N Kapranos
- N Planque
- N Planque
- N Planque
- ND Perkins
- O Saglam
- OA OâConnor
- P Balsas
- P Brennan
- P Feng
- P Gelebart
- P Jares
- P Jeannot
- P PĂ©rez-GalĂĄn
- R Kridel
- R Mathur
- RD Cassaday
- RK Assoian
- S BeĂ
- S Coats
- S Gery
- S Kruck
- S Ohkoshi
- S Roy
- S Waga
- S-J Leu
- S-Y Peng
- Sadie Dresman
- SE Holloway
- SH Swerdlow
- Simon Rule
- SJ Jim Leu
- SK Johnson
- T Abbas
- T Bai
- T Hirama
- T Komiya
- T-Y Cheng
- TJ Duncan
- TK Zirbes
- TM Nordgren
- UR Pendurthi
- V Devgan
- V Romanov
- V Todorovicç
- VP Yakubenko
- W Chien
- W He
- W Si
- X Lu
- X Tong
- X Tong
- Y Chen
- Y Li
- Y Liu
- Y Lu
- Y Zhang
- YH Min
- Z Lu
- Z Sun
- Z-Q Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 21/11/2018
- Field of study
Mantle cell lymphoma (MCL) is a comparatively rare non-Hodgkinâs lymphoma characterised by overexpression of cyclin D1.Many patients present with or progress to advanced stage disease within 3 years. MCL is considered an incurable disease withmedian survival between 3 and 4 years. We have investigated the role(s) of CCN1 (CYR61) and cell cycle regulators inprogressive MCL. We have used the human MCL cell lines REC1 G519 > JVM2 cells by RQ-PCR, depicting a decrease in CCN1expression with disease progression. Investigation of CCN1 isoform expression by western blotting showed that whilst expres-sion of full-length CCN1 was barely altered in the cell lines, expression of truncated forms (18â20 and 28â30 kDa) decreasedwith disease progression. We have then demonstrated that cyclin D1 and cyclin dependent kinase inhibitors (p21CIP1and p27KIP1)are also involved in disease progression. Cyclin D1 was highly expressed in REC1 cells (OD: 1.0), reduced to one fifth in G519cells (OD: 0.2) and not detected by western blotting in JVM2 cells. p27KIP1followed a similar profile of expression as cyclin D1.Conversely, p21CIP1was absent in the REC1 cells and showed increasing expression in G519 and JVM2 cells. Subcellularlocalization detected p21CIP1/p27KIP1primarily within the cytoplasm and absent from the nucleus, consistent with altered roles in treatment resistance. Dysregulation of the CCN1 truncated forms are associated with MCL progression. In conjunction withreduced expression of cyclin D1 and increased expression of p21, this molecular signature may depict aggressive disease andtreatment resistance
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
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- Wise SK
- Wise SK
- Won HK
- Wong AYS
- Wong D
- Wong IW
- Wong IW
- Wong SJ
- Wood AJ
- Wood AJ
- Woodard T
- Woodhouse BM
- Woods CM
- Woodworth BA
- Woodworth BA
- Woodworth BA
- Woodworth BA
- Woodworth BA.
- Workman AD
- Workman AD
- Workman AD
- Workman AD
- Workman AD
- Workman AD
- Wormald PJ
- Wormald PJ
- Wright ED
- Wu AW
- Wu AW
- Wu D
- Wu D
- Wu D
- Wu J
- Wu YâX
- Wuister AM
- WuokkoâLandĂ©n A
- Xia Z
- Xian M
- Xu J
- Xu JJ
- Xu M
- Xu Y
- Xu Z
- Yamada T
- Yamasaki A
- Yan C
- Yan CH
- Yan CH
- Yan CH
- Yan CH
- Yan CH
- Yan M
- Yan M
- Yancey KL
- Yancey KL
- Yang C
- Yang C
- Yaniv D
- Yaniv D
- Yao Y
- Yarmohammadi H
- Yatsunenko T
- Yayik AM
- Yel L
- Yelverton JC
- Yilmaz S
- Yip J
- Yip J
- Yohai RA
- Yoo F
- Yoo HS
- Yoon H
- Yoon HY
- Yoshida K
- Young J
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- Young Jang T
- Young LC
- Yousefi J
- Yu MS
- Yu X
- Yu XM
- Zabner J
- Zacharek M
- Zainine R
- Zajac AE
- Zalmanovici Trestioreanu A
- Zalmanovici Trestioreanu A
- Zariwala MA
- Zeiger J
- Zeng M
- Zeng M
- Zhai GT
- Zhang L
- Zhang ML
- Zhang N
- Zhang N
- Zhang N
- Zhang Q
- Zhang S
- Zhang S
- Zhang S
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhao CY
- Zhao K
- Zhao K
- Zhao L
- Zhao YC
- Zhao YC
- Zheng C
- Zheng Z
- Zhou B
- Zia S
- Ziegler CGK
- ZielinskaâBlizniewska H
- Zou L
- Zuckerman JD
- Zurlo JJ
- Zuskin E
- Äulig J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICARâRS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICARâRSâ2021 as well as updates to the original 140 topics. This executive summary consolidates the evidenceâbased findings of the document. Methods: ICARâRS presents over 180 topics in the forms of evidenceâbased reviews with recommendations (EBRRs), evidenceâbased reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICARâRSâ2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidenceâbased management algorithm is provided. Conclusion: This ICARâRSâ2021 executive summary provides a compilation of the evidenceâbased recommendations for medical and surgical treatment of the most common forms of RS
Cognitive inflexibility in obsessive-compulsive disorder and major depression is associated with distinct neural correlates
- Author
- AB Smith
- AD Barber
- AD Craig
- AR Aron
- AR Aron
- AT Beck
- BM Gu
- Chris Vriend
- CR Genovese
- D Joel
- D Perani
- DC Krawczyk
- Dick J. Veltman
- DM Veale
- E Sanavio
- G Valerius
- Gert-Jan Hendriks
- GJ DiGirolamo
- GJ Siegle
- H Ruge
- Harry B. M. Uylings
- IH Gotlib
- J Levine
- J Radua
- J Woolley
- Kenji Hashimoto
- KJ Friston
- KP Ebmeier
- L Clark
- L Menzies
- LA Page
- LH Watkins
- M Hamilton
- M Zimmerman
- MA Goodarzi
- Marjan M. A. Nielen
- MF Rushworth
- MH Sohn
- MM Nielen
- MM Nielen
- MP Paulus
- N Medford
- N Ramnani
- NA Fineberg
- NJ van der Wee
- O Monchi
- OA van den Heuvel
- OA van den Heuvel
- Odile A. van den Heuvel
- P van Oppen
- Peter L. Remijnse
- PL Remijnse
- PL Remijnse
- PL Remijnse
- PT Ninan
- R Cools
- R Elliott
- R Halari
- R Purcell
- RD Rogers
- RD Rogers
- RJ Dolan
- S Monsell
- S Moritz
- S Pu
- SA Montgomery
- SR Chamberlain
- SR Chamberlain
- SR Chamberlain
- T Overbeek
- TW Robbins
- W De Baene
- WC Drevets
- Witte J G. Hoogendijk
- WK Goodman
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2013
- Field of study
Contains fulltext :
118166.pdf (publisher's version ) (Open Access)Obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) are frequently co-morbid, and dysfunctional frontal-striatal circuits have been implicated in both disorders. Neurobiological distinctions between OCD and MDD are insufficiently clear, and comparative neuroimaging studies are extremely scarce. OCD and MDD may be characterized by cognitive rigidity at the phenotype level, and frontal-striatal brain circuits constitute the neural substrate of intact cognitive flexibility. In the present study, 18 non-medicated MDD-free patients with OCD, 19 non-medicated OCD-free patients with MDD, and 29 matched healthy controls underwent functional magnetic resonance imaging during performance of a self-paced letter/digit task switching paradigm. Results showed that both patient groups responded slower relative to controls during repeat events, but only in OCD patients slowing was associated with decreased error rates. During switching, patients with OCD showed increased activation of the putamen, anterior cingulate and insula, whereas MDD patients recruited inferior parietal cortex and precuneus to a lesser extent. Patients with OCD and MDD commonly failed to reveal anterior prefrontal cortex activation during switching. This study shows subtle behavioral abnormalities on a measure of cognitive flexibility in MDD and OCD, associated with differential frontal-striatal brain dysfunction in both disorders. These findings may add to the development of biological markers that more precisely characterize frequently co-morbid neuropsychiatric disorders such as OCD and MDD
Regulation of root patterns in mammalian teeth
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Vecuronium pharmacokinetics and pharmacodynamics during hypothermic cardiopulmonary bypass in infants and children
- Author
- AA dâHollander
- AA dâHollander
- AJ Koska
- AM Beaufort
- C Meistelman
- C Rosow
- CA Shanks
- CA Taylor
- DA Rosen
- Davinia Withington
- DM Fisher
- DM Fisher
- DM Fisher
- DP Lynam
- France Varin
- François Donati
- G Meakin
- Guillaume Menard
- I Rebeyka
- J Ducharme
- Jennifer Harris
- JS Walker
- K Leslie
- LI Eriksson
- M Gibaldi
- M Kansanaho
- M Koizumi
- MJ Avram
- NJ Smeulers
- NJ Smeulers
- NM Denny
- NR Searle
- OA Meretoja
- OA Meretoja
- OA Meretoja
- OA Meretoja
- P McDonagh
- PJ Flynn
- PJ Flynn
- Pradeep Kulkarni
- RJ Thornton
- RT Mathie
- SA Feldman
- SA Feldman
- SS Sorooshian
- T Heier
- T Heier
- W Buzello
- W Buzello
- W Buzello
- WA Buylaert
- YJ Sohn
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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