Differences on risk of cesarean section after labour induction according different portuguese hospitals

To assess if the risk of caesarean section (CS) after labour induction (LI) differs between hospitals and which extent this association may explain differences in CS rates. Methods: Participants (6688 Portuguese women) were consecutively recruited in five public hospitals (level III) during the assembling of a birth-cohort. Personal interviews were used to obtain data on socio-demographic characteristics, gynecological history and obstetric events. The risk (computed as odds ratio (OR) and 95% confidence Interval (95%CI)) of CS were considered according to hospital and adjusted for socio-demographic and obstetric characteristics. An interaction term (hospital and LI) was considered in the final model. Results: The proportion of LI by hospital ranged from 15.8% to 53.5% (p<0.001) and the proportion of CS varied between 22.2% and 35.6% (p<0.001). Women with LI presented an higher adjusted rate of CS (OR=1.71; 95%CI:1.48-1.99). There was a statistically significant interaction between hospital and IL on the risk of CS (p=0.002). After stratification by hospital and adjustment to characteristics of mother, the risk of CS for women with LI in comparison with those without LI was higher for three hospitals (OR=3.15; 95%CI:1.98-5.04, OR=1.84; 95% CI:1.38-2.46 and OR=2.04; 95%CI:1.52-2.73) but no such effect was found in the remaining two. Conclusions: Different associations between LI and CS across hospitals probably result from different management of LI. These differences may partially explain discrepancies in CS rates across hospitals.Instituto de Saúde pública da Universidade do Porto, Serviço de Higiene e Epidemiologia da Faculdade de Medicina da Universidade do Porto, Ministério da Saúde - associação Regional de ´saúde do Nort

O impacto do trabalho por turnos rotativos na vida familiar dos trabalhadores do setor do retalho alimentar

O trabalho por turnos rotativos é um tipo de regime horário de trabalho que está, de ano para ano, em crescimento em Portugal. É um tipo de horário que permite que os serviços estejam em funcionamento ou 24h por dia ou, pelo menos, o maior número de horas possível. O setor do retalho alimentar é um dos setores que utiliza este tipo de horário de trabalho, permitindo que hiper e supermercado se mantenham abertos raticamente durante o dia inteiro. O trabalho por turnos rotativos apresenta vantagens como a compensação remuneratória, no entanto também apresenta diversas dificuldades no que diz respeito à conciliação com a vida familiar e, por exemplo, o facto de incluir trabalho ao fim de semana, mais concretamente, ao domingo.N/

Epitaxial graphene immunosensor for human chorionic gonadotropin

Human chorionic gonadotropin (hCG), a 37 kDa glycoprotein hormone, is a key diagnostic marker of pregnancy and has been cited as an important biomarker in relation to cancerous tumors found in the prostate, ovaries and bladder.A novel chemically-modified epitaxial graphene diagnostic sensor has been developed for ultrasensitive detection of the biomarker hCG. Multi-layer epitaxial graphene (MEG), grown on silicon carbide substrates, was patterned using electron beam lithography to produce channel based devices. The MEG channels have been amine terminated using 3-Aminopropyl-triethoxysilane (APTES) in order to attach the anti-hCG antibody to the channel.Detection of binding of hCG with its graphene-bound antibody was monitored by measuring reduction of the channel current of the graphene biosensor. The sensitivity of the sensor device was investigated using varying concentrations of hCG, with changes in the channel resistance of the sensor observed upon exposure to hCG. The detection limit of the sensor was 0.62 ng/mL and the sensor showed a linear response to hCG in the range 0.62–5.62 ng/mL with a response of 142 Ω/ng/mL. At concentrations above 5.62 ng/mL the sensor begins to saturate

Polineuropatia Amiloidótica Familiar: Estudo da Eficácia de um tratamento combinado em animais transgénicos V30M/Hsf1

A Polineuropatia amiloidótica familiar (PAF) é uma doença neurodegenerativa fatal com transmissão hereditária autossómica dominante. A substituição de uma valina por uma metionina na posição 30 (V30M) é a mutação da proteína transtirretina (TTR) é uma das principais variantes que conduz à deposição extracelular, multi-sistémica, de agregados fibrilares e não fibrilares de TTR. O transplante hepático é o tratamento comumente utilizado no tratamento da PAF, no entanto, na última década vários fármacos têm sido estudados como possíveis alternativas terapêuticas. Neste estudo propusemo-nos a avaliar a deposição de transtirretina no sistema vascular cerebral, leptomeninges e sistema gastrointestinal, assim como, a concentração de TTR no plasma em animais transgénicos para mutação humana da TTR (V30M), sem TTR endógena, deficientes para o Heat shock transcription factor 1 V30M/Hsf1, após a administração de um tratamento combinado. Para determinar a eficácia deste tratamento neste modelo animal foram utilizadas técnicas imunohistoquímicas, de imunofluorescência, western blot e imunodifusão radial. Os resultados obtidos no sistema gastrointestinal revelam que o tratamento combinado foi eficaz na disrupção e remoção de depósitos fibrilares. No cérebro (sistema vascular cerebral), os animais tratados apresentaram uma tendência para a diminuição de deposição de agregados de TTR. Foi igualmente observado que a transtirretina plasmática encontrava-se aumentada em animais tratados. Em suma, o tratamento combinado revelou ser eficaz na disrupção de fibrilas amilóides e remoção de agregados não fibrilares no sistema gastrointestinal. No sistema vascular cerebral, os animais tratados apresentaram uma tendência para a diminuição de deposição de agregados de TTR, sugerindo que tratamento combinado pode ter atuado nestes animais. O status nutricional dos animais tratados melhorou, sugerido pela elevação de TTR plasmática, comparativamente aos animais controlo

Physician burnout in primary care during the COVID-19 pandemic: a cross-sectional study in Portugal

Primary care physicians have been present on the frontline during the ongoing pandemic, adding new tasks to already high workloads. Our aim was to evaluate burnout in primary care physicians during the COVID-19 pandemic, as well as associated contributing factors. Cross-sectional study with an online questionnaire disseminated through social media, applying the snowball technique. The target population was primary care physicians working in Portugal during the first outbreak of the COVID-19 pandemic. In addition to sociodemographic data, the questionnaire collected responses to the Copenhagen Burnout Inventory (CBI), the Resilience Scale and the Depression, Anxiety, and Stress Scales (DASS-21). Data were collected from May 9 to June 8, 2020, a period comprising the declaration of a national calamity and then state of emergency, and the subsequent ease of lockdown measures. Levels of burnout in 3 different dimensions (personal, work, and patient-related), resilience, stress, depression, and anxiety were assessed. Logistic regression analyses were conducted to identify factors associated with burnout levels. Results: Among the 214 physician respondents, burnout levels were high in the 3 dimensions. A strong association was found between gender, years of professional experience, depression and anxiety, and burnout levels. Physician burnout in primary care is high and has increased during the pandemic. More studies are needed in the long term to provide a comprehensive assessment of COVID-19’simpact on burnout levels and how to best approach and mitigate it during such unprecedented times.info:eu-repo/semantics/publishedVersio

Estimación de la composición de la canal por ultrsonidos y por el modelo comunitario de clasificación de canales ligeras

El modelo comunitario de clasificación de canales de corderos definida en el REGLAMENTO (CEE) nº 2 137/92 se basa en la conformación y en la importancia de la capa de grasa subcutánea. No obstante, autoriza que los estados miembros definan otros criterios de clasificación para canales con menos de 13 kilogramos de peso, tales como: peso, color de la carne y capa de grasa subcutánea. Por otro lado, el REGLAMENTO (CEE) n°: 2967/85 establece que el desarrollo de métodos objetivos de clasificación de canales debe basarse en la estimación del porcentaje de carne magra en la canal. debiendo los métodos poseer un coeficiente de determinación (R2) superior a 0,64 y una desviación estándar residual {DER) inferior a 2,5% para que su utilización sea autorizada (Cadavez et al., 2000). El objetivo de este estudio fue evaluar la precisión de modelos de estimación de la composición de la canal utilizando como variables independientes: 1. el peso de la canal caliente (PCC} y medidas de ultrasonidos realizadas in vivo y 2. el PCC y la clase de cobertura grasa (CCG) definida en el modelo comunitario de clasificación de canales de corderos ligeros

Method of detecting bacterial infection in a biological sample

A method of indicating the presence of a bacterial infection in a biological sample is provided. The method detects a marker for infection by providing a device, the device including a biosensor, an interaction arising be tween the biosensor and the marker when the marker is present in the biological sample. Contacting at least a part of the biological sample with the biosensor of the device, therefore, provides analysis of the biological sample with respect to the marker by detecting for the interaction between the biosensor and the marker. A preferred marker is the enzyme amylase.peer-reviewe

Method of detecting bacterial infection in a biological sample

A method of indicating the presence of a bacterial infection in a biological sample is provided. The method detects a marker for infection by providing a device, the device including a biosensor, an interaction arising between the biosensor and the marker when the marker is present in the biological sample. Contacting at least a part of the biological sample with the biosensor of the device, therefore, provides analysis of the biological sample with respect to the marker by detecting for the interaction between the biosensor and the marker. A preferred marker is the enzyme amylase.peer-reviewe