Younger age at onset and sex predict celiac disease in children and adolescents with type 1 diabetes. An Italian multicenter study

WSTĘP. Celem badania była ocena chorobowości w przypadku, potwierdzonej w biopsji, choroby trzewnej u włoskich dzieci i młodzieży, chorych na cukrzycę typu 1 oraz określenie zależności między wiekiem, w którym ujawniła się cukrzyca typu 1, a rozpoznaniem choroby trzewnej. MATERIAŁ I METODY. Badanie obejmowało grupę kliniczną dzieci i młodzieży w okresie dojrzewania, chorych na cukrzycę typu 1, leczonych w 25 ośrodkach we Włoszech. Co roku wykonywano u nich badania przesiewowe w kierunku celiakii, przy użyciu przeciwciał przeciwgliadynowych IgA/IgG i przeciwciał IgA przeciwko endomysium. WYNIKI. Potwierdzoną w biopsji chorobę trzewną stwierdzono u 292 z 4322 dzieci i młodzieży [chorobowość 6,8%, 95-procentowy przedział ufności (CI, confidendial interval) 6,0-7,6]; ryzyko wystąpienia choroby trzewnej było wyższe u dziewcząt niż u chłopców [współczynnik ryzyka (OR, odds ratio) 1,93; 1,51-2,47]. W 89% przypadków cukrzycę rozpoznano przed ujawnieniem się choroby trzewnej. Analiza regresji logistycznej wykazała, że młody wiek, płeć żeńska i zaburzenia czynności tarczycy były niezależnie związane z ryzykiem zachorowania na cukrzycę lub chorobę trzewną. W porównaniu z osobami, u których cukrzyca ujawniła się powyżej 9. roku życia, u osób, u których początek choroby wystąpił poniżej 4. roku życia, OR wynosił 3,27 (2,20-4,85). WNIOSKI. W niniejszej pracy wykazano, że: 1) chorobowość w przypadku potwierdzonej biopsją choroby trzewnej u dzieci i młodzieży jest wysoka (6,8%); 2) ryzyko wystąpienia obu schorzeń jest 3-krotnie wyższe u dzieci i młodzieży z cukrzycą typu 1, u których ujawniła się ona przed ukończeniem 4. roku życia niż w przypadku, kiedy początek choroby wystąpił powyżej 9. roku życia; 3) ryzyko wystąpienia obu schorzeń u dziewcząt jest wyższe niż u chłopców.INTRODUCTION. To estimate the prevalence of biopsy- confirmed celiac disease in Italian children and adolescents with type 1 diabetes and to assess whether age at onset of type 1 diabetes is independently associated with diagnosis of celiac disease. MATERIAL AND METHODS. The study group was a clinic-based cohort of children and adolescents with type 1 diabetes cared for in 25 Italian centers for childhood diabetes. Yearly screening for celiac disease was performed using IgA/IgG anti-gliadin and IgA anti-endomysium antibodies. RESULTS. Of the 4,322 children and adolescents (age 11.8 ± 4.2 years) identified with type 1 diabetes, biopsy-confirmed celiac disease was diagnosed in 292 (prevalence 6.8%, 95% confidence interval [CI] 6.0–7.6), with a higher risk seen in girls than in boys (odds ratio [OR] 1.93, 1.51–2.47). In 89% of these, diabetes was diagnosed before celiac disease. In logistic regression analyses, being younger at onset of diabetes, being female, and having a diagnosis of a thyroid disorder were independently associated with the risk of having diabetes and celiac disease. In comparison with subjects who were older than 9 years at onset of diabetes, subjects who were younger than 4 years at onset had an OR of 3.27 (2.20–4.85). CONCLUSIONS. We have provided evidence that 1) the prevalence of biopsy-confirmed celiac disease in children and adolescents with type 1 diabetes is high (6.8%); 2) the risk of having both diseases is threefold higher in children diagnosed with type 1 diabetes at age 9 years; and 3) girls have a higher risk of having both diseases than boys

Brightness enhancement in pulsed-operated perovskite light-emitting transistors

Perovskite light-emitting field-effect transistors (PeLEFETs) provide a versatile device architecture to control transport and electroluminescence properties of hybrid perovskites, enabling injection of high charge carrier density and spatial control of the radiative recombination zone. Ionic screening and organic cation polarization effects typical of metal-halide perovskites, however, critically affect PeLEFET efficiency and reliability. In this work, we demonstrate a new device operation mode based on high-frequency modulation of the applied voltages, which allows significant reduction of ionic drift/screening in methylammonium lead iodide light-emitting transistors. In optimized top contact PeLEFETs, AC operation results in brighter and more uniform electroluminescence compared to DC-driven devices, whereas high-frequency modulation enables electroluminescence emission up to room temperature.Ministry of Education (MOE)National Research Foundation (NRF)The research was supported by the Singapore Ministry of Education (grant nos. MOE2016-T1-1-164 and MOE2011- T3-1-005) and the Singapore National Research Foundation (CRP award no. NRF-CRP14-2014-03)

Reshaping Hybrid Perovskites Emission with Flexible Polymer Microcavities

Thanks to versatile optoelectronic properties solution processable perovskites have attracted increasing interest as active materials in photovoltaic and light emitting devices. However, the deposition of perovskite thin films necessitates wide range solvents that are incompatible with many other solution-processable media, including polymers that are usually dissolved by the perovskite solvents. In this work, we demonstrate that hybrid perovskite thin films can be coupled with all polymer planar photonic crystals with different approaches to achieve emission intensity enhancement and reshaping using different approaches. The possibility to control and modify the emission spectrum of a solution processable perovskite via a simple spun-cast polymer structure is indeed of great interest in optoelectronic applications requiring high color purity or emission directionality. Furthermore, thanks to the ease of fabrication and scalability of solution-processed photonic crystals, this approach could enable industrial scale production of low-cost, large area, lightweight and flexible polymer-perovskite lighting devices, which may be tuned without resorting to compositional engineering

Reshaping Hybrid Perovskites Emission with Flexible Polymer Microcavities

Thanks to versatile optoelectronic properties solution processable perovskites have attracted increasing interest as active materials in photovoltaic and light emitting devices. However, the deposition of perovskite thin films necessitates wide range solvents that are incompatible with many other solution-processable media, including polymers that are usually dissolved by the perovskite solvents. In this work, we demonstrate that hybrid perovskite thin films can be coupled with all polymer planar photonic crystals with different approaches to achieve emission intensity enhancement and reshaping using different approaches. The possibility to control and modify the emission spectrum of a solution processable perovskite via a simple spun-cast polymer structure is indeed of great interest in optoelectronic applications requiring high color purity or emission directionality. Furthermore, thanks to the ease of fabrication and scalability of solution-processed photonic crystals, this approach could enable industrial scale production of low-cost, large area, lightweight and flexible polymer-perovskite lighting devices, which may be tuned without resorting to compositional engineering

Ruxolitinib for pulmonary extramedullary hematopoiesis in myelofibrosis

Here we report an uncommon case of a patient with MF and pulmonary EMH treated with ruxolitini

The LINC-NIRVANA patrol camera

LINC-NIRVANA is the IR Fizeau interferometric imager of the Large Binocular Telescope (LBT) in Arizona. Here we describe in particular the design, realization and preliminary tests of the so-called Patrol Camera. It can image (in the range 600-900 nm) the same 2 arcmin FoV seen by the Medium- High-Wavefront Sensor (MHWS), adequately sampled to provide the MHWS star enlargers with the positions of the FoV stars with an accuracy of 0.1 arcsec. To this aim a diffraction-limited performance is not required, while a distortion free focal plane is needed to provide a suitable astrometric output. Two identical systems will be realized, one for each single arm, which corresponds to each single telescope. We give here the details concerning the optical and mechanical design, as well as the CCD and the control system. The interfaces with LINC-NIRVANA are also presented both in terms of matching the carbon fiber optical bench and developing of suitable software procedures. Since the major components have been already gathered, the laboratory tests and the integration are currently in progress

Safety profile of Erwinia asparaginase treatment in adults with newly diagnosed acute lymphoblastic leukemia: a retrospective monocenter study

Safety profile of Erwinia asparaginase treatment in adults with newly diagnosed acute lymphoblastic leukemia: a retrospective monocenter study

Differences in presenting features, outcome and prognostic models in patients with primary myelofibrosis and post-polycythemia vera and/or post-essential thrombocythemia myelofibrosis treated with ruxolitinib. New perspective of the MYSEC-PM in a large multicenter study⁎

39nonenonePalandri, Francesca*; Palumbo, Giuseppe A.; Iurlo, Alessandra; Polverelli, Nicola; Benevolo, Giulia; Breccia, Massimo; Abruzzese, Elisabetta; Tiribelli, Mario; Bonifacio, Massimiliano; Tieghi, Alessia; Isidori, Alessandro; Martino, Bruno; Sgherza, Nicola; D'Adda, Mariella; Bergamaschi, Micaela; Crugnola, Monica; Cavazzini, Francesco; Bosi, Costanza; Binotto, Gianni; Auteri, Giuseppe; Latagliata, Roberto; Ibatici, Adalberto; Scaffidi, Luigi; Penna, Domenico; Cattaneo, Daniele; Soci, Francesco; Trawinska, Malgorzata; Russo, Domenico; Cuneo, Antonio; Semenzato, Giampietro; Di Raimondo, Francesco; Aversa, Franco; Lemoli, Roberto M.; Heidel, Florian; Reggiani, Maria L.B.; Bartoletti, Daniela; Cavo, Michele; Catani, Lucia; Vianelli, NicolaPalandri, Francesca; Palumbo, Giuseppe A.; Iurlo, Alessandra; Polverelli, Nicola; Benevolo, Giulia; Breccia, Massimo; Abruzzese, Elisabetta; Tiribelli, Mario; Bonifacio, Massimiliano; Tieghi, Alessia; Isidori, Alessandro; Martino, Bruno; Sgherza, Nicola; D'Adda, Mariella; Bergamaschi, Micaela; Crugnola, Monica; Cavazzini, Francesco; Bosi, Costanza; Binotto, Gianni; Auteri, Giuseppe; Latagliata, Roberto; Ibatici, Adalberto; Scaffidi, Luigi; Penna, Domenico; Cattaneo, Daniele; Soci, Francesco; Trawinska, Malgorzata; Russo, Domenico; Cuneo, Antonio; Semenzato, Giampietro; Di Raimondo, Francesco; Aversa, Franco; Lemoli, Roberto M.; Heidel, Florian; Reggiani, Maria L. B.; Bartoletti, Daniela; Cavo, Michele; Catani, Lucia; Vianelli, Nicol