Corepressor diversification by alternative mRNA splicing is species specific.

BackgroundSMRT and NCoR are corepressor paralogs that help mediate transcriptional repression by a variety of transcription factors, including the nuclear hormone receptors. The functions of both corepressors are extensively diversified in mice by alternative mRNA splicing, generating a series of protein variants that differ in different tissues and that exert different, even diametrically opposite, biochemical and biological effects from one another.ResultsWe report here that the alternative splicing previously reported for SMRT appears to be a relatively recent evolutionary phenomenon, with only one of these previously identified sites utilized in a teleost fish and a limited additional number of the additional known sites utilized in a bird, reptile, and marsupial. In contrast, extensive SMRT alternative splicing at these sites was detected among the placental mammals. The alternative splicing of NCoR previously identified in mice (and shown to regulate lipid and carbohydrate metabolism) is likely to have arisen separately and after that of SMRT, and includes an example of convergent evolution.ConclusionsWe propose that the functions of both SMRT and NCoR have been diversified by alternative splicing during evolution to allow customization for different purposes in different tissues and different species

Preliminary Survey of the Terrestrial Isopods (Isopoda), Millipedes (Diplopoda), Harvestmen (Opiliones), and Spiders (Araneae) of Toft Point Natural Area, Door County, Wisconsin

Toft Point Natural Area is a National Natural Landmark owned and managed by the University of Wisconsin – Green Bay and located on the Lake Michigan shore of Wisconsin’s Door Peninsula. With twelve biotic communities on 700 acres, Toft Point contains considerable biological diversity. We conducted a preliminary survey of the arachnids (spiders and harvestmen, excluding mites and pseudoscorpions), millipedes (diplopods), and terrestrial isopods (Isopoda: Oniscoidea). Sampling occurred on three dates in 2001 using leaf litter collection with Berlese extraction and a timed collection by hand that incorporated a variety of techniques. Specimens from a 1992 survey and assorted collecting events were also used to compile a species list. The list includes five isopods, four millipedes, six harvestmen, and 113 spiders, including 16 new state records (two millipedes and 14 spiders) and 90 new Door County records. Litter collection and sampling in wetland habitats were both especially productive

Planetary geometry handbook: Venus positional data, 1988 - 2020, volume 2

Graphical data necessary for the analysis of planetary exploration missions to Venus are presented. Positional and geometric information spanning the time period from 1988 through 2020 is provided. The data and the usage are explained

Planetary geometry handbook: Mars positional data, 1990 - 2020, volume 3

Graphical data necessary for the analysis of planetary exploration missions to Mars are presented. Positional and geometric information spanning the time period from 1990 through 2020 is provided. The data and usage are explained

Planetary geometry handbook: Jupiter positional data, 1985 - 2020, volume 4

Graphical data necessary for the analysis of planetary exploration missions to Jupiter are presented. Positional and geometric information spanning the time period from 1985 through 2020 is provided. The data and their usage are explained

Hybrid carcinoma of the salivary gland: salivary duct adenocarcinoma adenoid cystic carcinoma

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73933/1/j.1365-2559.1999.00761.x.pd

Fertility studies on Strongsville soil

Caption title.Mode of access: Internet