Fast Ion Effects During Test Blanket Module Simulation Experiments in DIII-D

Fast beam-ion losses were studied in DIII-D in the presence of a scaled mockup of two Test Blanket Modules (TBM) for ITER. Heating of the protective tiles on the front of the TBM surface was found when neutral beams were injected and the TBM fields were engaged. The fast-ion core confinement was not significantly affected. Different orbit-following codes predict the formation of a hot spot on the TBM surface arising from beam-ions deposited near the edge of the plasma. The codes are in good agreement with each other on the total power deposited at the hot spot predicting an increase in power with decreasing separation between the plasma edge and the TBM surface. A thermal analysis of the heat flow through the tiles shows that the simulated power can account for the measured tile temperature rise. The thermal analysis, however, is very sensitive to the details of the localization of the hot spot which is predicted to be different among the various codes

Feasibility study of intelligent autonomous determination of the bladder voiding need to treat bedwetting using ultrasound and smartphone ML techniques

Unsatisfactory cure rates for the treatment of nocturnal enuresis (NE), i.e. bed-wetting, have led to the need to explore alternative modalities. New treatment methods that focus on preventing enuretic episodes by means of a pre-void alerting system could improve outcomes for children with NE in many aspects. No such technology exists currently to monitor the bladder to alarm before bed-wetting. The aim of this study is to carry out the feasibility of building, refining and evaluating a new, safe, comfortable and non-invasive wearable autonomous intelligent electronic device to monitor the bladder using a single-element low-powered low-frequency ultrasound with the help of Machine Learning techniques and to treat NE by warning the patient at the pre-void stage, enhancing quality of life for these children starting from the first use. The sensitivity and specificity values are 0.89 and 0.93 respectively for determining imminent voiding need. The results indicate that customised imminent voiding need based on the expansion of the bladder can be determined by applying a single-element transducer on a bladder in intermittent manner. The acquired results can be improved further with a comfortable non-invasive device by adding several more features to the current features employed in this pilot study

Simulation of localized fast-ion heat loads in test blanket module simulation experiments on DIII-D

Infrared imaging of hot spots induced by localized magnetic perturbations using the test blanket module (TBM) mock-up on DIII-D is in good agreement with beam-ion loss simulations. The hot spots were seen on the carbon protective tiles surrounding the TBM as they reached temperatures over 1000 °C. The localization of the hot spots on the protective tiles is in fair agreement with fast-ion loss simulations using a range of codes: ASCOT, SPIRAL and OFMCs while the codes predicted peak heat loads that are within 30% of the measured ones. The orbit calculations take into account the birth profile of the beam ions as well as the scattering and slowing down of the ions as they interact with the localized TBM field. The close agreement between orbit calculations and measurements validate the analysis of beam-ion loss calculations for ITER where ferritic material inside the tritium breeding TBMs is expected to produce localized hot spots on the first wall. © 2013 IAEA, Vienna

Simulation of localized fast-ion heat loads in test blanket module simulation experiments on DIII-D

Infrared imaging of hot spots induced by localized magnetic perturbations using the test blanket module (TBM) mock-up on DIII-D is in good agreement with beam-ion loss simulations. The hot spots were seen on the carbon protective tiles surrounding the TBM as they reached temperatures over 1000 °C. The localization of the hot spots on the protective tiles is in fair agreement with fast-ion loss simulations using a range of codes: ASCOT, SPIRAL and OFMCs while the codes predicted peak heat loads that are within 30% of the measured ones. The orbit calculations take into account the birth profile of the beam ions as well as the scattering and slowing down of the ions as they interact with the localized TBM field. The close agreement between orbit calculations and measurements validate the analysis of beam-ion loss calculations for ITER where ferritic material inside the tritium breeding TBMs is expected to produce localized hot spots on the first wall. © 2013 IAEA, Vienna

Fast-ion effects during test blanket module simulation experiments in DIII-D

Fast beam-ion losses were studied in DIII-D in the presence of a scaled mock-up of two test blanket modules (TBM) for ITER. Heating of the protective tiles on the front of the TBM surface was found when neutral beams were injected and the TBM fields were engaged. The fast-ion core confinement was not significantly affected. Different orbit-following codes predict the formation of a hot spot on the TBM surface arising from beam ions deposited near the edge of the plasma. The codes are in good agreement with each other on the total power deposited at the hot spot, predicting an increase in power with decreasing separation between the plasma edge and the TBM surface. A thermal analysis of the heat flow through the tiles shows that the simulated power can account for the measured tile temperature rise. The thermal analysis, however, is very sensitive to the details of the localization of the hot spot, which is predicted to be different among the various codes. © 2011 IAEA, Vienna

vIL-10-overexpressing human MSCs modulate naïve and activated T lymphocytes following induction of collagenase-induced osteoarthritis

Recent efforts in osteoarthritis (OA) research have highlighted synovial inflammation and involvement of immune cells in disease onset and progression. We sought to establish the in-vivo immune response in collagenase-induced OA and investigate the ability of human mesenchymal stem cells (hMSCs) overexpressing viral interleukin 10 (vIL-10) to modulate immune populations and delay/prevent disease progression. Eight-week-old male C57BL/6 mice were injected with 1 U type VII collagenase over two consecutive days. At day 7, 20,000 hMSCs overexpressing vIL-10 were injected into the affected knee. Control groups comprised of vehicle, 20,000 untransduced or adNull-transduced MSCs or virus alone. Six weeks later knees were harvested for histological analysis and popliteal and inguinal lymph nodes for flow cytometric analysis. At this time there was no significant difference in knee OA scores between any of the groups. A trend toward more damage in animals treated with hMSCs was observed. Interestingly there was a significant reduction in the amount of activated CD4 and CD8 T cells in the vIL-10-expressing hMSC group. vIL-10-overexpressing hMSCs can induce long-term reduction in activated T cells in draining lymph nodes of mice with collagenase-induced OA. This could lead to reduced OA severity or disease progression over the long term.peer-reviewe