A Separable Model for Dynamic Networks

Models of dynamic networks --- networks that evolve over time --- have manifold applications. We develop a discrete-time generative model for social network evolution that inherits the richness and flexibility of the class of exponential-family random graph models. The model --- a Separable Temporal ERGM (STERGM) --- facilitates separable modeling of the tie duration distributions and the structural dynamics of tie formation. We develop likelihood-based inference for the model, and provide computational algorithms for maximum likelihood estimation. We illustrate the interpretability of the model in analyzing a longitudinal network of friendship ties within a school.Comment: 28 pages (including a 4-page appendix); a substantial rewrite, with many corrections, changes in terminology, and a different analysis for the exampl

Competing periodicities in fractionally filled one-dimensional bands

We present a variable temperature Scanning Tunneling Microscopy and Spectroscopy (STM and STS) study of the Si(553)-Au atomic chain reconstruction. This quasi one-dimensional (1D) system undergoes at least two charge density wave (CDW) transitions at low temperature, which can be attributed to electronic instabilities in the fractionally-filled 1D bands of the high-symmetry phase. Upon cooling, Si(553)-Au first undergoes a single-band Peierls distortion, resulting in period doubling along the imaged chains. This Peierls state is ultimately overcome by a competing tripleperiod CDW, which in turn is accompanied by a x2 periodicity in between the chains. These locked-in periodicities indicate small charge transfer between the nearly half-filled and quarter-filled 1D bands. The presence and the mobility of atomic scale dislocations in the x3 CDW state indicates the possibility of manipulating phase solitons carrying a (spin,charge) of (1/2,+-e/3) or (0,+-2e/3).Comment: submitted, accepted for publication in Phys. Rev. Let

Stromal control of oncogenic traits expressed in response to the overexpression of GLI2, a pleiotropic oncogene.

Hedgehog signaling is often activated in tumors, yet it remains unclear how GLI2, a transcription factor activated by this pathway, acts as an oncogene. We show that GLI2 is a pleiotropic oncogene. The overexpression induces genomic instability and blocks differentiation, likely mediated in part by enhanced expression of the stem cell gene SOX2. GLI2 also induces transforming growth factor (TGF)B1-dependent transdifferentiation of foreskin and tongue, but not gingival fibroblasts into myofibroblasts, creating an environment permissive for invasion by keratinocytes, which are in various stages of differentiation having downregulated GLI2. Thus, upregulated GLI2 expression is sufficient to induce a number of the acquired characteristics of tumor cells; however, the stroma, in a tissue-specific manner, determines whether certain GLI2 oncogenic traits are expressed

Resolved Spectroscopy of the Narrow-Line Region in NGC 1068. I. The Nature of the Continuum Emission

We present the first long-slit spectra of the Seyfert 2 galaxy NGC 1068 obtained by the Space Telescope Imaging Spectrograph (STIS); the spectra cover the wavelength range 1150 - 10,270 Angstroms at a spatial resolution of 0.05 - 0.1 arcsec and a spectral resolving power of 1000. In this first paper, we concentrate on the far-UV to near-IR continuum emission from the continuum ``hot spot'' and surrounding regions extending out to +/- 6 arcsec (+/-432 pc) at a position angle of 202 degrees In addition to the broad emission lines detected by spectropolarimetry, the hot spot shows the ``little blue bump'' in the 2000 - 4000 Ang. range, which is due to Fe II and Balmer continuum emission. The continuum shape of the hot spot is indistinguishable from that of NGC 4151 and other Seyfert 1 galaxies. Thus, the hot spot is reflected emission from the hidden nucleus, due to electron scattering (as opposed to wavelength-dependent dust scattering). The hot spot is ~0.3 arcsec in extent and accounts for 20% of the scattered light in the inner 500 pc. We are able to deconvolve the extended continuum emission in this region into two components: electron-scattered light from the hidden nucleus (which dominates in the UV) and stellar light (which dominates in the optical and near-IR). The scattered light is heavily concentrated towards the hot spot, is stronger in the northeast, and is enhanced in regions of strong narrow-line emission. The stellar component is more extended, concentrated southwest of the hot spot, dominated by an old (> 2 x 10 Gyr) stellar population, and includes a nuclear stellar cluster which is ~200 pc in extent.Comment: 32 pages, Latex, includes 11 figures (postscript), to appear in the Astrophysical Journa

Formation of atom wires on vicinal silicon

The formation of atomic wires via pseudomorphic step-edge decoration on vicinal silicon surfaces has been analyzed for Ga on the Si(112) surface using Scanning Tunneling Microscopy and Density Functional Theory calculations. Based on a chemical potential analysis involving more than thirty candidate structures and considering various fabrication procedures, it is concluded that pseudomorphic growth on stepped Si(112), both under equilibrium and non-equilibrium conditions, must favor formation of Ga zig-zag chains rather than linear atom chains. The surface is non-metallic and presents quasi-one dimensional character in the lowest conduction band.Comment: submitte

Recent advances in the assessment and treatment of falls in Parkinson's disease

Falls are among the most incapacitating features of Parkinson's disease. Prevention of falls requires a systematic assessment of all contributing factors (with emphasis on freezing of gait and frontal executive dysfunction), and a multidisciplinary treatment approach tailored to the specific pathophysiology of falls for each individual patient

IUE observations of Fe 2 galaxies

Repeated observations of the Seyfert 1 galaxies I Zw 1 and II Zw 136, which have very strong Fe II emission lines in the optical region, were made at low resolution with the IUE Satellite. The ultraviolet spectra are very similar: both are variable and show broad emission features of Fe II (especially the UV multiplets 1, 33, 60, 62, and 63) as well as the emission lines usually strong in Seyferts and quasars. The data strongly support the hypothesis that the optical Fe II emission lines are primarily due to collisional excitation and that resonance fluorescence makes only a minor contribution to the excitation of these lines

Ga-induced atom wire formation and passivation of stepped Si(112)

We present an in-depth analysis of the atomic and electronic structure of the quasi one-dimensional (1D) surface reconstruction of Ga on Si(112) based on Scanning Tunneling Microscopy and Spectroscopy (STM and STS), Rutherford Backscattering Spectrometry (RBS) and Density Functional Theory (DFT) calculations. A new structural model of the Si(112)6 x 1-Ga surface is inferred. It consists of Ga zig-zag chains that are intersected by quasi-periodic vacancy lines or misfit dislocations. The experimentally observed meandering of the vacancy lines is caused by the co-existence of competing 6 x 1 and 5 x 1 unit cells and by the orientational disorder of symmetry breaking Si-Ga dimers inside the vacancy lines. The Ga atoms are fully coordinated, and the surface is chemically passivated. STS data reveal a semiconducting surface and show excellent agreement with calculated Local Density of States (LDOS) and STS curves. The energy gain obtained by fully passivating the surface calls the idea of step-edge decoration as a viable growth method toward 1D metallic structures into question.Comment: Submitted, 13 pages, accepted in Phys. Rev. B, notational change in Fig.

Transfer of lumbosacral load to iliac bones and legs Part 2: Loading of the sacroiliac joints when lifting in a stooped posture

We developed a biomechanical model of load transfer by the sacroiliac joints in relation to posture. A description is given of two ways in which the transfer of lumbar load to the pelvis in a stooped posture can take place. One way concerns ligament and muscle forces that act on the sacrum, raising the tendency of the sacrum to flex in relation to the hip bones. The other refers to ligament and muscle forces acting on the iliac crests, raising the tendency of the sacrum to shift in caudal direction in relation to the hip bones. Both loading modes deal with the self-bracing mechanism that comes into action to prevent shear in the sacroiliac joints. When a person is lifting a load while in a stooped posture, the force raised by gravity acting in a plane perpendicular to the spine and the sacrum becomes of interest. In this situation a belt such as used by weight lifters may contribute to the stability of the sacroiliac joints. Verification of the biomechanical model is based on anatomical studies and on load application to human specimens. Magnetic resonance imaging pictures have been taken to verify geometry in vivo