Image and Video Disclosure of Substance Use on Social Media Websites

The present study examines young adults’ use of social media websites, such as MySpace, Facebook, and YouTube, to post public images and videos of themselves depicting alcohol consumption, inebriated behavior, or recreational marijuana use. A content analysis revealed that the majority of image and video representations of alcohol consumption depicted females in social gatherings while images and videos depicting marijuana use depicted solitary males. Videos typically were viewed frequently and gained positive ratings. Among a sample of college students, one-third of participants reported having posted a picture depicting substance use on a social networking site, with 97 percent aware that others engage in this phenomenon. Students’ perceptions of alcohol-related postings were generally positive or seen as a matter of individual choice while marijuana-related postings were generally viewed more negatively

Study of flow boiling characteristics of R134a in annulus of enhanced surface tubing

The paper presents an experimental study of the flow-boiling heat-transfer characteristics of R12 and R134a in the annulus of a horizontal enhanced-surface-tubing evaporator. The test section has an inner-tube bore diameter of 17.5 mm, an envelope diameter of 28.6 mm and an outer smooth tube of 32.3 mm inside diameter. The ranges of heat flux and mass velocity covered in the tests were 5–25 kW/m2 and 180–290 kg/m2/s, respectively, at a pressure of 365 kPa. In order to establish the flow regime conditions at the inlet to the test section, the test rig allows for the visualization of refrigerant flow through the preheater. The experiments show two regions of heat transfer: a nucleate boiling region where the heat transfer depends mainly on heat flux, and a forced convective region where the heat transfer depends only on the refrigerant flow rate

Resistant starch as a dietary intervention to limit the progression of diabetic kidney disease

Diabetes is the leading cause of kidney disease, and as the number of individuals with diabetes increases there is a concomitant increase in the prevalence of diabetic kidney disease (DKD). Diabetes contributes to the development of DKD through a number of pathways, including inflammation, oxidative stress, and the gut-kidney axis, which may be amenable to dietary therapy. Resistant starch (RS) is a dietary fibre that alters the gut microbial consortium, leading to an increase in the microbial production of short chain fatty acids. Evidence from animal and human studies indicate that short chain fatty acids are able to attenuate inflammatory and oxidative stress pathways, which may mitigate the progression of DKD. In this review, we evaluate and summarise the evidence from both preclinical models of DKD and clinical trials that have utilised RS as a dietary therapy to limit the progression of DKD

Gaussian Approximation Potentials: the accuracy of quantum mechanics, without the electrons

We introduce a class of interatomic potential models that can be automatically generated from data consisting of the energies and forces experienced by atoms, derived from quantum mechanical calculations. The resulting model does not have a fixed functional form and hence is capable of modeling complex potential energy landscapes. It is systematically improvable with more data. We apply the method to bulk carbon, silicon and germanium and test it by calculating properties of the crystals at high temperatures. Using the interatomic potential to generate the long molecular dynamics trajectories required for such calculations saves orders of magnitude in computational cost.Comment: v3-4: added new material and reference

The Multiple Meanings of “Hybrid”: Studying Adult Student Experiences in Hybrid (Web-Enhanced) Classes While Learning How to do Qualitative Research

This paper has a two-fold or “hybrid” purpose: (1) to discuss the results of a qualitative study of adult students experiences of web-enhanced or hybrid classes, and (2) to briefly discuss the process of learning to do qualitative research while conducting this study in a qualitative research methods class

Knot selection in sparse Gaussian processes with a variational objective function

Sparse, knot‐based Gaussian processes have enjoyed considerable success as scalable approximations of full Gaussian processes. Certain sparse models can be derived through specific variational approximations to the true posterior, and knots can be selected to minimize the Kullback‐Leibler divergence between the approximate and true posterior. While this has been a successful approach, simultaneous optimization of knots can be slow due to the number of parameters being optimized. Furthermore, there have been few proposed methods for selecting the number of knots, and no experimental results exist in the literature. We propose using a one‐at‐a‐time knot selection algorithm based on Bayesian optimization to select the number and locations of knots. We showcase the competitive performance of this method relative to optimization of knots simultaneously on three benchmark datasets, but at a fraction of the computational cost

Loss of microbial diversity and pathogen domination of the gut microbiota in critically ill patients

Among long-stay critically ill patients in the adult intensive care unit (ICU), there are often marked changes in the complexity of the gut microbiota. However, it remains unclear whether such patients might benefit from enhanced surveillance or from interventions targeting the gut microbiota or the pathogens therein. We therefore undertook a prospective observational study of 24 ICU patients, in which serial faecal samples were subjected to shotgun metagenomic sequencing, phylogenetic profiling and microbial genome analyses. Two-thirds of the patients experienced a marked drop in gut microbial diversity (to an inverse Simpson's index of <4) at some stage during their stay in the ICU, often accompanied by the absence or loss of potentially beneficial bacteria. Intravenous administration of the broad-spectrum antimicrobial agent meropenem was significantly associated with loss of gut microbial diversity, but the administration of other antibiotics, including piperacillin/tazobactam, failed to trigger statistically detectable changes in microbial diversity. In three-quarters of ICU patients, we documented episodes of gut domination by pathogenic strains, with evidence of cryptic nosocomial transmission of Enterococcus faecium. In some patients, we also saw an increase in the relative abundance of apparent commensal organisms in the gut microbiome, including the archaeal species Methanobrevibacter smithii. In conclusion, we have documented a dramatic absence of microbial diversity and pathogen domination of the gut microbiota in a high proportion of critically ill patients using shotgun metagenomics