1,664 research outputs found
The molecular gas in the supernova remnant IC443
Although a few highly perturbed regions characterized by gas motions with velocities larger than 20 km/s have been discovered during the last several years in the supernova remnant (SNR) IC 443, the nature of these perturbed clumps and their relationship to the quiescent molecular gas near the SNR remains unknown. In part, this is due to a lack of large-scale, high angular resolution observations. Therefore, a systematic survey of this SNR in the CO (J=1 yields 0) line has been conducted, covering a roughly 50' x 50' region spaced by 2'. The observations were made with the 14 m telescope of the Five College Radio Astronomy Observatory (FCRAO), which has a resolution of 45" and a single sideband receiver temperature of 200 K at 2.6 mm wavelength. Five new clumps were discovered, bringing the total number of known perturbed regions to eight. To study the physical structure of these clumps in more detail, more complete maps of the clumps have been made in both the CO(J=1 yields 0) and (J=2 yields 1) transitions with the FCRAO telescope. These maps show that the extent of perturbed gas in a typical clump is several arcmin, or a few pc at a distance of 1.5 kpc
Microstructure Effects on Daily Return Volatility in Financial Markets
We simulate a series of daily returns from intraday price movements initiated
by microstructure elements. Significant evidence is found that daily returns
and daily return volatility exhibit first order autocorrelation, but trading
volume and daily return volatility are not correlated, while intraday
volatility is. We also consider GARCH effects in daily return series and show
that estimates using daily returns are biased from the influence of the level
of prices. Using daily price changes instead, we find evidence of a significant
GARCH component. These results suggest that microstructure elements have a
considerable influence on the return generating process.Comment: 15 pages, as presented at the Complexity Workshop in Aix-en-Provenc
Star Formation in Bright Rimmed Clouds. I. Millimeter and Submillimeter Molecular Line Surveys
We present the results of the first detailed millimeter and submillimeter
molecular line survey of bright rimmed clouds, observed at FCRAO in the CO
(J=1-0), C18O (J=1-0), HCO+ (J=1-0), H13CO+ (J=1-0), and N2H+ (J=1-0)
transitions, and at the HHT in the CO (J=2-1), HCO+ (J=3-2), HCO+ (J=4-3),
H13CO+ (J=3-2), and H13CO+ (J=4-3) molecular line transitions. The source list
is composed of a selection of bright rimmed clouds from the catalog of such
objects compiled by Sugitani et al. (1991). We also present observations of
three Bok globules done for comparison with the bright rimmed clouds. We find
that the appearance of the millimeter CO and HCO+ emission is dominated by the
morphology of the shock front in the bright rimmed clouds. The HCO+ (J=1-0)
emission tends to trace the swept up gas ridge and overdense regions which may
be triggered to collapse as a result of sequential star formation. Five of the
seven bright rimmed clouds we observe seem to have an outflow, however only one
shows the spectral line blue-asymmetric signature that is indicative of infall,
in the optically thick HCO+ emission. We also present evidence that in bright
rimmed clouds the nearby shock front may heat the core from outside-in thereby
washing out the normally observed line infall signatures seen in isolated star
forming regions. We find that the derived core masses of these bright rimmed
clouds are similar to other low and intermediate mass star forming regions.Comment: 67 pages, including 35 figures and 6 tables. Accepted for publication
in ApJ. Version with embedded full-resolution figures available at
http://www.astro.umass.edu/~devries/brc1
Embedded Stellar Clusters in the W3/W4/W5 Molecular Cloud Complex
We analyze the embedded stellar content in the vicinity of the W3/W4/W5 HII
regions using the FCRAO Outer Galaxy 12CO(J=1-0) Survey, the IRAS Point Source
Catalog, published radio continuum surveys, and new near-infrared and molecular
line observations. Thirty-four IRAS Point Sources are identified that have
far-infrared colors characteristic of embedded star forming regions, and we
have obtained K' mosaics and 13CO(J=1-0) maps for 32 of them. Ten of the IRAS
sources are associated with an OB star and 19 with a stellar cluster, although
three OB stars are not identified with a cluster. Half of the embedded stellar
population identified in the K' images is found in just the 5 richest clusters,
and 61% is contained in IRAS sources associated with an embedded OB star. Thus
rich clusters around OB stars contribute substantially to the stellar
population currently forming in the W3/W4/W5 region. Approximately 39% of the
cluster population is embedded in small clouds with an average mass of ~130 Mo
that are located as far as 100 pc from the W3/W4/W5 cloud complex. We speculate
that these small clouds are fragments of a cloud complex dispersed by previous
episodes of massive star formation. Finally, we find that 4 of the 5 known
embedded massive star forming sites in the W3 molecular cloud are found along
the interface with the W4 HII region despite the fact that most of the
molecular mass is contained in the interior regions of the cloud. These
observations are consistent with the classical notion that the W4 HII region
has triggered massive star formation along the eastern edge of the W3 molecular
cloud.Comment: to appear in ApJS, see http://astro.caltech.edu/~jmc/papers/w
One-carbon metabolism in cancer
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells. As such, anti-folates, drugs that target one-carbon metabolism, have long been used in the treatment of cancer. Amino acids, such as serine are a major one-carbon source, and cancer cells are particularly susceptible to deprivation of one-carbon units by serine restriction or inhibition of de novo serine synthesis. Recent work has also begun to decipher the specific pathways and sub-cellular compartments that are important for one-carbon metabolism in cancer cells. In this review we summarise the historical understanding of one-carbon metabolism in cancer, describe the recent findings regarding the generation and usage of one-carbon units and explore possible future therapeutics that could exploit the dependency of cancer cells on one-carbon metabolism
Molecular evolution of the membrane associated progesterone receptor in the Brachionus plicatilis (Rotifera, Monogononta) species complex
Author Posting. © Springer, 2010. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Hydrobiologia 662 (2011): 99-106, doi:10.1007/s10750-010-0484-4.Many studies have investigated physiological roles of the membrane associated progesterone
receptor (MAPR), but little is known of its evolution. Marked variations in response to
exogenous progesterone have been reported for four brachionid rotifer species, suggesting
differences in progesterone signaling and reception. Here we report sequence variation for the
MAPR gene in the Brachionus plicatilis species complex. Phylogenetic analysis of this receptor
is compared with relatedness based on cytochrome c oxidase subunit 1 sequences.
Nonsynonymous to synonymous site substitution rate ratios, amino acid divergence, and
variations in predicted phosphorylation sites are examined to assess evolution of the MAPR
among brachionid clades.National Science Foundation grant BE/GenEn MCB-0412674E to TWS and DMW, and an NSF
IGERT fellowship to HAS under DGE 0114400, supported this work
Probing MHD Shocks with high-J CO observations: W28F
Context. Observing supernova remnants (SNRs) and modelling the shocks they
are associated with is the best way to quantify the energy SNRs re-distribute
back into the Interstellar Medium (ISM). Aims. We present comparisons of shock
models with CO observations in the F knot of the W28 supernova remnant. These
comparisons constitute a valuable tool to constrain both the shock
characteristics and pre-shock conditions. Methods. New CO observations from the
shocked regions with the APEX and SOFIA telescopes are presented and combined.
The integrated intensities are compared to the outputs of a grid of models,
which were combined from an MHD shock code that calculates the dynamical and
chemical structure of these regions, and a radiative transfer module based on
the 'large velocity gradient' (LVG) approximation. Results. We base our
modelling method on the higher J CO transitions, which unambiguously trace the
passage of a shock wave. We provide fits for the blue- and red-lobe components
of the observed shocks. We find that only stationary, C-type shock models can
reproduce the observed levels of CO emission. Our best models are found for a
pre-shock density of 104 cm-3, with the magnetic field strength varying between
45 and 100 {\mu}G, and a higher shock velocity for the so-called blue shock
(\sim25 km s-1) than for the red one (\sim20 km s-1). Our models also
satisfactorily account for the pure rotational H2 emission that is observed
with Spitzer.Comment: 8 pages, 6 figures, 1 table, accepted for A&A SOFIA/GREAT Special
Issu
Water Abundance in Molecular Cloud Cores
We present Submillimeter Wave Astronomy Satellite (SWAS) observations of the
1_{10}-1_{01} transition of ortho-water at 557 GHz toward 12 molecular cloud
cores. The water emission was detected in NGC 7538, Rho Oph A, NGC 2024, CRL
2591, W3, W3(OH), Mon R2, and W33, and was not detected in TMC-1, L134N, and
B335. We also present a small map of the water emission in S140. Observations
of the H_2^{18}O line were obtained toward S140 and NGC 7538, but no emission
was detected. The abundance of ortho-water relative to H_2 in the giant
molecular cloud cores was found to vary between 6x10^{-10} and 1x10^{-8}. Five
of the cloud cores in our sample have previous water detections; however, in
all cases the emission is thought to arise from hot cores with small angular
extents. The water abundance estimated for the hot core gas is at least 100
times larger than in the gas probed by SWAS. The most stringent upper limit on
the ortho-water abundance in dark clouds is provided in TMC-1, where the
3-sigma upper limit on the ortho-water fractional abundance is 7x10^{-8}.Comment: 5 pages, 3 Postscript figures, uses aastex.cls, emulateapj5.sty
(included), and apjfonts.sty (included
The Distribution of Water Emission in M17SW
We present a 17-point map of the M17SW cloud core in the 1_{10}-1_{01}
transition of ortho-water at 557 GHz obtained with the Submillimeter Wave
Astronomy Satellite. Water emission was detected in 11 of the 17 observed
positions. The line widths of the water emission vary between 4 and 9 km
s^{-1}, and are similar to other emission lines that arise in the M17SW core. A
direct comparison is made between the spatial extent of the water emission and
the ^{13}CO J = 5\to4 emission; the good agreement suggests that the water
emission arises in the same warm, dense gas as the ^{13}CO emission. A spectrum
of the H_2^{18}O line was also obtained at the center position of the cloud
core, but no emission was detected. We estimate that the average abundance of
ortho-water relative to H_2 within the M17 dense core is approximately
1x10^{-9}, 30 times smaller than the average for the Orion core. Toward the H
II region/molecular cloud interface in M17SW the ortho-water abundance may be
about 5 times larger than in the dense core.Comment: 4 pages, 3 Postscript figures, uses aastex.cls, emulateapj5.sty
(included), and apjfonts.sty (included
- …