Treatment of a life-threatening dapsone intoxication

The case report describes a case of a severe dapsone (more than 200 tablets dapsone 100 mg) and mild methotrexate intoxication (10 tablets methotrexate 10 mg) as an attempt to commit suicide, resulting in severe cyanosis with elevation in methemoglobin concentration, treated with methylene blue, ascorbic acid, folinic acid, multidose activated charcoal and hemodialysis. Measurements of blood gases, dapsone and methotrexate levels were performed. Furthermore a hepatitis, pulmonary artery thrombus and a strange taste sensation were diagnosed, probably related to dapsone. The patient recovered and was discharged from hospital after five days. Acute intoxication from excessive dapsone intake is uncommon and clear treatment guidelines are lacking. We here report the treatment modalities as a result of a dapsone intoxication, including the effects on the overall condition of the patient.</p

Responses to gestational weight management guidance: a thematic analysis of comments made by women in online parenting forums

Background: The National Institute for Health and Clinical Excellence (NICE) published guidance on weight management in pregnancy in July 2010[1], and this received considerable press coverage across a range of media. This offered an opportunity to examine how gestational weight management guidance was received by UK women. Methods: A thematic analysis was conducted of 400 posts made in UK-based parenting internet forums in the week following the publication of the NICE guidance. This allowed us to examine the naturally occurring comments from 202 women who posted about the guidance on public forums. Results: Three main themes were identified and explored: i) Perceived control/responsibility ii) Risk perception iii) Confused messages. Conclusions: Women differed in their perceptions of the level of control that they had over being overweight with some feeling responsible and motivated to maintain a healthy lifestyle. Others felt there were multiple factors influencing their weight issues beyond their control. There were reports of feeling guilty about the impact of weight on the growing baby and experiencing significant obesity stigma from the public and health professionals. Information about the risks of overweight and obesity in pregnancy were difficult messages for women to hear, and for health professionals to deliver. Women reported being confused by the messages that they received. Health messages need to be delivered sensitively to women, and health professionals need support and training to do this. Risk information should always be accompanied with clear advice and support to help women to manage their weight in pregnancy. Keywords: internet-mediated research, gestational weight gain, parenting forums, NICE, women, views, risk perception</p

\u201cLogically, We Quite Agree with the IARC\u201d: Negotiating Interpersonal Meaning in a Corpus of Scientific Texts

This chapter extends the scope of a previous study (Fusari 2017 and in press 2018) of the reception, by a range of scientific journals featured in the database Elsevier Science Direct, of a 2015 report (IARC 2015) in which the International Agency for Research on Cancer officially incorporated red meat in Group 2A carcinogens (probably carcinogenic to humans) and processed meat in Group 1 (carcinogenic to humans). For this study, we have built a 384,491 words corpus, fully POS-tagged, and partially parsed using a systemic functional grammatical formalism. While the previous stages in this project concentrated on ideational meaning, addressing the use of mass vs. countable nouns, nominalization, the experiential structure of the Noun Group, and patterns of Transitivity, this new step moves beyond representation (Glenn 2004; Gupta 2006; Stibbe 2014; Cook 2015), to explore interpersonal meaning. This area of meaning is less widely studied with corpus approaches, largely because of the greater difficulty, both technical and epistemological, of analysing Tenor with a corpus-assisted approach (Fuoli 2018). Our aim is to analyze how the roles of the various Participants (IARC, scientific community, general public) in the discursive construction of meat carcinogenicity are negotiated. To achieve this aim, we rely on the notions of Attitude, Engagement and stance, in terms of both Appraisal theory (Martin &amp; White 2005) and interactional metadiscourse (Hyland 2005; 2017; Jiang &amp; Hyland 2017). We concentrate specifically on attitudinal Values, Graduation, comment Adjuncts, modal verbs and personal pronouns. The results show that the scientific literature exemplified in this corpus does not aim to settle the meat/cancer controversy once and for all, but rather to \u201cpersuade readers [i.e. other members of the relevant discourse communities] of the scientific acceptability of the knowledge claims presented\u201d (Allen, Qin &amp; Lancaster 1994, p. 280). Therefore, the discursive construction of meat carcinogenicity should not be seen only in terms of relating objective facts and hard data about the levels of risk involved, but also in terms of \u201cdialogism\u201d (O\u2019Hallaron, Palincsar &amp; Schleppegrell 2015), which is equally - if not more - important to reach a shared interpretation (Fern\ue1ndez Polo 2018) of scientific facts