Another algorithm for reducing bandwidth and profile of a sparse matrix

The paper describes a new bandwidth reduction method for sparse matrices which promises to be both fast and effective in comparison with known methods. The algorithm operates on the undirected graph corresponding to the incidence matrix induced by the original sparse matrix, and separates into three distinct phases: (1) determination of a spanning tree of maximum length, (2) modification of the spanning tree into a free level structure of small width, (3) level-by-level numbering of the level structure. The final numbering produced corresponds to a renumbering of the rows and columns of a sparse matrix so as to concentrate non-zero elements of the matrix in a band about the main diagonal

Innovation and the co-creation of value in construction

Construction businesses balance market and project risks in resourcing innovation and value creation. Technical, technological and management innovation are considered using the marketing lens of the service-dominant logic. The co-creation of value is a primary concept, which is largely unexplored in construction, especially related to innovation. Co-created by main contractors and clients is defined as value generated in context and use. The paper is part of a programme of work, applying an interpretative qualitative approach. The method for data collection was semi-structured interviews, derived from six major international main contractors. Thirty-nine interviews were conducted with a range of senior management, functional heads and project managers responsible for identifying innovation and value creation opportunities. The overall findings fall into three main areas. First, management perceived construction to be suppliers of technical expertise. Second, projects are perceived in terms of expert inputs. Third, associated tasks are conducted to meet programme schedules and requirements. Opportunities to co-create value are largely pursued reactively and opportunities to innovate through top down or project induced capabilities are largely overlooked. Where innovation occurred it was largely initiated through a combination of co-creation drivers supported by management pull factors rather than innovation drivers and a technology push

Self-Reactivity and the Expression of Memory Markers Vary Independently in MRL-Mp+/+ and MRL-Mp-lpr/lpr Mice

MRL-Mp-lpr/lpr mice contain phenotypically abnormal populations of T cells, and exhibit an SLE-like autoimmune disease in which autoantibodies are a prominent feature. We analyzed the phenotype and T-cell receptor Vß expression pattern in CD4+ T cells of this mutant mouse strain to detect abnormalities that could explain the autoimmunity. The CD4+ T cells contain two distinct abnormal populations. One of these expresses B220 and HSA, and in these and other respects closely resembles the accumulating CD4–CD8– population. The other expresses a high level of CD44 (Pgp-1), and a high level of the 16A epitope of CD45, and so resembles post-activation T cells. Both of these cell types are exclusive to MRL-Mp-lpr/lpr. We also identified V ß5- and V ß11-positive CD4+ T cells, in both MRL-Mp-lpr/lpr and MRL-Mp-+/+ mice. We conclude that autoimmune T cells can be detected in these mice, but that they are not the cause of the accumulation of abnormal CD4+ and CD4–CD8–cells

Not just who you are, but who you were before : social identification, identity incompatibility and performance-undermining learning behaviour in higher education

The current study builds on links between academic social identification and learning behaviours and extends these models by also considering the level of compatibility between the student identity and the pre‐existing self‐concept. This is a crucial extension, in the context of broadening access to higher education and fostering belonging and learning in nontraditional students. Further, where previous work focused on learning behaviours that enhance performance (often learning approaches), we also consider performance‐undermining behaviours (self‐handicapping and procrastination). These effects are explored in survey responses from an undergraduate student sample (N = 121) from UK and broader European samples. Participants were predominantly female (69%) and native English speakers (87%). Three models of the relationships between these variables were tested using Mplus. Results indicate that performance‐undermining behaviours are predicted by identity incompatibility, but not identification level; deep learning approaches are predicted by identification level, but not identity incompatibility. This provides first evidence that identity incompatibility is not just a moderator of the identification‐learning relationships but, in fact, a separate identity process for consideration. We also present initial evidence for a mediation model, where in the identity variables are related to procrastination and self‐handicapping via learning approaches.PostprintPeer reviewe

Calculating self-concept structure indices, including Linville’s H : toward standardization and replication

The structure of the self and its relationship with wellbeing are of interest to researchers in many areas of psychology, including social, clinical and differential. Psychologists seeking to calculate the self-concept structure indices associated with the self-complexity framework have long been faced with a computation bottleneck. The complex formulae, variable approaches and lack of availability of ready-to-use programs that allow streamlined calculation of dimensionality (Linville’s H), complexity (Sakaki’s SC), overlap (OL) and compartmentalisation (Shower’s Phi) means that the research area has been limited in both research speed and participation. The low volume of studies and the computational disincentive for replications have led to a situation where the evidence on self-complexity and related constructs is equivocal. In this article, we discuss approaches to calculating self-concept structure, providing a practical guide for researchers who would like to implement the published formulas or use existing computational tools, made available by the authors. This tutorial will allow both efficiency and broader access for researchers seeking to examine constructs related to self-concept structure. We hope that these contributions might foster a new wave of data collection in this area, allowing for clarity on the utility and implications of dimensionality and complexity in the self-concept.Publisher PDFPeer reviewe

Continuous Acquisition of MHC:Peptide Complexes by Recipient Cells Contributes to the Generation of Anti-Graft CD8+ T Cell Immunity

Understanding the evolution of the direct and indirect pathways of allorecognition following tissue transplantation is essential in the design of tolerance‐promoting protocols. On the basis that donor bone marrow–derived antigen‐presenting cells are eliminated within days of transplantation, it has been argued that the indirect response represents the major threat to long‐term transplant survival, and is consequently the key target for regulation. However, the detection of MHC transfer between cells, and particularly the capture of MHC:peptide complexes by dendritic cells (DCs), led us to propose a third, semidirect, pathway of MHC allorecognition. Persistence of this pathway would lead to sustained activation of direct‐pathway T cells, arguably persisting for the life of the transplant. In this study, we focused on the contribution of acquired MHC‐class I on recipient DCs during the life span of a skin graft. We observed that MHC‐class I acquisition by recipient DCs occurs for at least 1 month following transplantation and may be the main source of alloantigen that drives CD8(+) cytotoxic T cell responses. In addition, acquired MHC‐class I:peptide complexes stimulate T cell responses in vivo, further emphasizing the need to regulate both pathways to induce indefinite survival of the graft

Learning behaviour and learning outcomes : the roles for social influence and field of study

Research has demonstrated a significant role of discipline social identification in predicting learning approaches, even controlling for individual differences. Smyth et al. (Educ Psychol 35(1):53–72, 2015. doi:10.1080/01443410.2013.822962) suggest that learners share discipline-based social identifications, and that this identification, in combination with relevant norms, influences the adoption of learning approaches. The current paper extends this analysis in two directions. First, the effect of broad field of study is examined for systematic differences across content domains. Secondly, the model examines effects on student perceptions of teaching quality and intentions to continue within a discipline. Results provide support for Smyth et al.’s (2015) model, demonstrating links between discipline identification, perceived norms, learning approaches and outcomes. Strongly identified students, students who perceived deep learning norms and students taking a deep learning approach all reported more positive outcomes. Disciplinary variations in responses to learning approaches and outcomes were also found, broadly in line with that found in the Biglan–Becher literature.PostprintPeer reviewe

Electrochemistry and application of a novel monosubstituted squarate electron-transfer mediator in a glucose oxidase-doped poly(phenol) sensor

Electrosynthetic poly(phenol) nanofilms were deposited in situ on platinum electrodes in the presence and absence of glucose oxidase. The synthesis charges and currents of the nonconducting polymer films were recorded at various applied potentials for films grown from 25–100 mM phenol concentrations. Film parameters such as the standard rate constant for film deposition, film thickness, and surface concentration of the poly(phenol) films were evaluated from the cyclic and step voltammograms of the polymerization process. A novel electron-transfer mediator consisting of monosubstituted 4-hydroxycyclobut-3-ene-1,2-dione (squarate) was used as a mediator for Pt/poly(phenol) nano-film/GOx amperometric glucose biosensors. Amperometric responses for 3-diphenylamino-4-hydroxycyclobut-3-ene-1,2- dione (diphenylaminosquarate: E°′ = of +328 mV/Ag-AgCl at pH 7.0)-mediated systems were measured by both steady-state amperometric and cyclic voltammetry. The sensor sensitivity was calculated to be 558 nA cm –2 (µM) –1