2,868 research outputs found

    Stereotypical Enemies: American Frontiersmen and Mexican Caricatures in the Literature of an Expanding White Nation

    Get PDF
    11 Yo no soy ya americano, pero comprendo ingles 11 : I am no longer an American, but I do understand English. This ever-popular ranchero, the 11 Ba11 ad of Joaquin Murretta, 11 is a defiant assertion of the Mexican 1s dignity as well as a justification for blood revenge. The Mexican, the Mexican-American, the Spanish-American, or the Chicano has always been self-assured of his cultural identity. But in American popular literature the Spanish-speaking have not fared well. Fiction and non-fiction written by Anglo-Saxons for Anglo-Saxons has traditionally shut out the Mexican, except as a knife-toting, over-emotional, happygo- lucky thief. In other words, students of American popular culture know the Mexican only as a negative stereotype. Assured of his positive identity as a superior person, the white American is given little reason to question the validity of traditional race and national character types. Such was my case in 1967, when I was employed by the Community Action Agency in a small Colorado town. Typical of that group of rational, fair-minded social workers, I was conscious of the obvious ramifications of abusive race codifications-- Mex, spic, greaser, etc. However, I remained unconscious of just how complete my Anglo-Saxon racist conditioning had been until that day my employer, Mr. Orlando Salazar, spoke out against the then popular Frito-Lay television commercial--The Frito Bandito. I thought the commercial 11 cute, 11 and said as much. Salazar angrily retorted that there was nothing 11 cute11 about dramatizing the Mexican as an inept, comical thief--especially as his children were being "kindly" identified as little Frito Banditos. Salazar was right. Lo, the poor Anglo whose reason dictates one set of values and whose cultural conditioning dictates quite another. This investigation of the historical and literary antecedents of the stereotypical "superior" Anglo-Saxon and the "inferior" Mexican was largely motivated by my desire to comprehend the nature of the stereotypes and to understand how an why they have been preserved to plague the twentieth-century American with paradox and conflict.Englis

    Retention characteristics of some antibiotic and anti-retroviral compounds in hydrophilic interaction chromatography using isocratic elution, and gradient elution with repeatable partial equilibration

    Get PDF
    © 2018 Elsevier B.V. The separation of some zwitterionic, basic and neutral antibiotic and antiretroviral compounds was studied using hydrophilic interaction chromatography (HILIC) on bare silica, bonded amide and urea superficially porous phases. The differences in the selectivity and retentivity of these stationary phases were evaluated for compounds with widely different physicochemical properties (logD −3.43 to 2.41 at ww pH 3.0). The mobile phase was acetonitrile-ammonium formate buffered at low ww pH. Compounds containing quinolone and serine groups showed poor peak shapes on all columns, attributed to metal-oxide interactions with system metals. Peak shapes were improved by addition of citrate buffers. Gradient elution, particularly with regard to column equilibration, was also studied due to the large differences in retention factors observed under isocratic conditions. Full equilibration in HILIC was slow for both ionogenic and neutral solutes, requiring as much as ∼40 column volumes. However, highly repeatable partial equilibration, suitable for gradient elution, was achieved in only a few minutes. Pronounced selectivity differences in the separations were shown dependent on the partial equilibration time

    Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias

    Get PDF
    Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA). We studied the effects of 26 drugs and 3 drug combinations on 2 commercially available iPSC-CM types using high-throughput voltage-sensitive dye and microelectrode-array assays being studied for the CiPA initiative and compared the results with clinical QT prolongation and torsade de pointes (TdP) risk. Concentration-dependent analysis comparing iPSC-CMs to clinical trial results demonstrated good correlation between drug-induced rate-corrected action potential duration and field potential duration (APDc and FPDc) prolongation and clinical trial QTc prolongation. Of 20 drugs studied that exhibit clinical QTc prolongation, 17 caused APDc prolongation (16 in Cor.4U and 13 in iCell cardiomyocytes) and 16 caused FPDc prolongation (16 in Cor.4U and 10 in iCell cardiomyocytes). Of 14 drugs that cause TdP, arrhythmias occurred with 10 drugs. Lack of arrhythmic beating in iPSC-CMs for the four remaining drugs could be due to differences in relative levels of expression of individual ion channels. iPSC-CMs responded consistently to human ether-a-go-go potassium channel blocking drugs (APD prolongation and arrhythmias) and calcium channel blocking drugs (APD shortening and prevention of arrhythmias), with a more variable response to late sodium current blocking drugs. Current results confirm the potential of iPSC-CMs for proarrhythmia prediction under CiPA, where iPSC-CM results would serve as a check to ion channel and in silico modeling prediction of proarrhythmic risk. A multi-site validation study is warranted

    Ursinus College Alumni Journal, Winter 1946

    Get PDF
    Dean • President\u27s page • Record enrollment in 76th year • Necrology • Dean Kline dies in 83rd year • Livingood honored • Dr. Niblo attends Episcopal convention • Music room developed • Faculty increased • Revue of sports • Seeders appointed head basketball coach • Student activities • Letters to the alumni • Old Timers\u27 Day • Alumni committees appointed • Re-education of Germany • News about ourselves • Dr. Haines: Teacher and author • News around town • Recipient of Rotary Club award • Dr. Markley completes term of service • 1946 and football • As the placement office sees us • Men\u27s basketball schedulehttps://digitalcommons.ursinus.edu/alumnijournal/1026/thumbnail.jp

    Multiple Victimization & Sexual Revictimization

    Get PDF
    Committing multiple victimization and sexual revictimization towards others can be labeled inhuman crimes that cause various forms of trauma to victims. In return, this results in higher mortality and tarnishes the connections between members of society. Five thousand three hundred people were used as a sample amount for the survey. The researcher wanted to know how people experiencing multiple victimizations and sexual revictimization can cause strain to one’s social life. The researcher also wanted to explore the connections to higher mortality rates as a result of the multiple victimizations and/or sexual revictimization to an individual. Results show that typical victims are those with little income and with an age range of 18 – 25; however, typical victims of sexual revictimization are usually outdoors during high-crime hours and with an age range of 18 – 25. With a lack of support, information and professionals with adequate experience to help those experiencing these offenses, victims resort to drugs, sex, and crime to ease their pain, making them feel alone in the world

    Ursinus College Alumni Journal, Summer 1947

    Get PDF
    Word of appreciation • Old Timers\u27 Day • President\u27s page • Alumni Association tables special committee\u27s report • Student union chosen as war memorial • Women\u27s Club • Dr. Clawson new Ursinus Dean • Board of Directors creates new committee, adds five members • Campus to be used for astronomical observation • Kuhrt Wieneke named coach of football • Three resign from faculty • Fourteen members added to faculty • Dr. Distler addresses graduating class • Sports: Men\u27s basketball; baseball; men\u27s tennis; track; women\u27s swimming; women\u27s basketball; women\u27s tennis • Local alumni associations meet • Work progressing on alumni register • Summer assembly • News about ourselves • Necrology • News around townhttps://digitalcommons.ursinus.edu/alumnijournal/1031/thumbnail.jp

    Mitochondrial DNA clocks and the phylogeny of Danaus butterflies

    Get PDF
    Molecular clocks based on sequence change in mitochondrial (mt) DNA have been useful for placing molecular phytogenies in their historical context, thereby enhancing evolutionary insight. Nonetheless, despite their importance to phylogeographers, the methodology is controversial. Here we report on two mitochondrial clocks for the butterfly genus Danaus based on sequences from the cytochrome c oxidase subunit I (COI) and small subunit 12S rRNA (12S) genes. Both clocks are, within the context of Danaus, reliable time-keepers, mutually consistent and, respectively, in agreement with a crustacean COI clock and a molluscan 12S clock. Though we have no fossils with which directly to calibrate sequence divergence rates for Danaus, the 12S molluscan and COI crustacean clocks chosen for comparison were calibrated to radiometrically dated geomorphological events. Our results indicate that the Danaus COI clock evolves approximately four times faster than the 12S clock. Differences between rates of sequence change in terminal sister-taxa are small and likelihood ratio tests do not reject a hypothesis that evolution has been clock-like. The species Danaus chrysippus is paraphyletic and, therefore, invalid. Danaus probably split from its sister-genus Tirumala around 4.9 ± 0.3 million years ago in the early Pliocene

    2016 Decadal Update of the NASA ESTO Lidar Technologies Investment Strategy

    Get PDF
    We describe the 2016 update of the NASA Earth Science Technology Office (ESTO) investment strategy in the area of lidar technologies as pertaining to NASAs Earth Science measurement goals in the next decade

    The role of religion in the longer-range future, April 6, 7, and 8, 2006

    Full text link
    This repository item contains a single issue of the Pardee Conference Series, a publication series that began publishing in 2006 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future. This conference that took place during April 6, 7, and 8, 2006. Co-organized by David Fromkin, Director, Frederick S. Pardee Center for the Study of the Longer-Range Future, and Ray L. Hart, Dean ad interim Boston University School of TheologyThe conference brought together some 40 experts from various disciplines to ponder upon the “great dilemma” of how science, religion, and the human future interact. In particular, different panels looked at trends in what is happening to religion around the world, questions about how religion is impacting the current political and economic order, and how the social dynamics unleashed by science and by religion can be reconciled.Carnegie Council on Ethics and International Affair
    corecore