Memorandum for the National Security Council

Memorandum for the National Security Council regarding attached paper discussing objectives and problems and policy solution in the Inter-American Region

Paying More for the American Dream - The Subprime Shakeout and Its Impact on Lower-Income and Minority Communities

A joint report by: California Reinvestment Coalition, Community Reinvestment Association of North Carolina, Empire Justice Center, Massachusetts Affordable Housing Alliance, Neighborhood Economic Development Advocacy Project, Ohio Fair Lending Coalition, and Woodstock Institut

Intellectual functioning in clinically confirmed fetal valproate syndrome

Background: An increased risk of impaired intelligence (IQ) has been documented in valproate-exposed children, but investigations have not previously focused on those with a clinical diagnosis of Fetal Valproate Syndrome (FVS). Methods: This cross sectional observational study recruited individuals with a diagnosis of FVS and completed standardized assessments of intellectual abilities making comparisons to a normative comparison group. Both mean difference (MD) and prevalence of scores below the lower average range were analyzed. Results: The mean full-scale IQ in 31 individuals with FVS (mean age 14.97; range 6–27 years) was 19 points lower (19.55, 95% CI −24.94 to 14.15), and IQ scores <70 were present in 26%. The mean differences for verbal comprehension (21.07, 95% CI −25.84 to −16.29), working memory (19.77, 95% CI −25.00 to −14.55) and processing speed (16.87, 95% CI −22.24 to −11.50) performances were poorer than expected with the mean differences over one standard deviation from the comparison group. Sixty one percent of cases demonstrated disproportionately lower verbal comprehension ability. There were no significant group differences for IQ in high vs. moderate dose valproate or mono vs. polytherapy. There were no differences in IQ between those with and those without a major congenital malformation. The requirement for educational intervention was high at 74%. Conclusion: Intellectual difficulties are a central feature of FVS and are more severe in their presentation in individuals with a diagnosis of valproate embryopathy. Individuals with FVS who present with the characteristic facial presentation should be considered at high risk of cognitive difficulties regardless of the dose of valproate exposure or the presence of a major congenital malformation

Paying More for the American Dream III: Promoting Responsible Lending to Lower-Income Communities and Communities of Color

This report analyzes 2007 Home Mortgage Disclosure Act data and finds that, in low- and moderate-income communities, depositories with CRA obligations originate a far smaller share of higher-cost loans than lenders not subject to CRA. It also finds that lenders covered by CRA are much less likely to make higher-cost loans in communities of color than lenders not covered by CRA

Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child (Review).

Accumulating evidence suggests an association between prenatal exposure to antiepileptic drugs (AEDs) and increased risk of both physical anomalies and neurodevelopmental impairment. Neurodevelopmental impairment is characterised by either a specific deficit or a constellation of deficits across cognitive, motor and social skills and can be transient or continuous into adulthood. It is of paramount importance that these potential risks are identified, minimised and communicated clearly to women with epilepsy. Objectives To assess the effects of prenatal exposure to commonly prescribed AEDs on neurodevelopmental outcomes in the child and to assess the methodological quality of the evidence. Search methods We searched the Cochrane Epilepsy Group Specialized Register (May 2014), Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (2014, Issue 4), MEDLINE (via Ovid) (1946 to May 2014), EMBASE (May 2014), Pharmline (May 2014) and Reprotox (May 2014). No language restrictions were imposed. Conference abstracts from the last five years were reviewed along with reference lists from the included studies. Selection criteria Prospective cohort controlled studies, cohort studies set within pregnancy registers and randomised controlled trials were selected for inclusion. Participants were women with epilepsy taking AED treatment; the two control groups were women without epilepsy and women with epilepsy who were not taking AEDs during pregnancy. Data collection and analysis Three authors (RB, JW and JG) independently selected studies for inclusion. Data extraction and risk of bias assessments were completed by five authors (RB, JW, AS, NA, AJM). The primary outcome was global cognitive functioning. Secondary outcomes included deficits in specific cognitive domains or prevalence of neurodevelopmental disorders. Due to substantial variation in study design and outcome reporting only limited data synthesis was possible. Main results Twenty‐two prospective cohort studies were included and six registry based studies. Study quality varied. More recent studies tended to be larger and to report individual AED outcomes from blinded assessments, which indicate improved methodological quality.The developmental quotient (DQ) was lower in children exposed to carbamazepine (CBZ) (n = 50) than in children born to women without epilepsy (n = 79); mean difference (MD) of ‐5.58 (95% confidence interval (CI) ‐10.83 to ‐0.34, P = 0.04). The DQ of children exposed to CBZ (n = 163) was also lower compared to children of women with untreated epilepsy (n = 58) (MD ‐7.22, 95% CI ‐12.76 to ‐ 1.67, P = 0.01). Further analysis using a random‐effects model indicated that these results were due to variability within the studies and that there was no significant association with CBZ. The intelligence quotient (IQ) of older children exposed to CBZ (n = 150) was not lower than that of children born to women without epilepsy (n = 552) (MD ‐0.03, 95% CI ‐3.08 to 3.01, P = 0.98). Similarly, children exposed to CBZ (n = 163) were not poorer in terms of IQ in comparison to the children of women with untreated epilepsy (n = 87) (MD 1.84, 95% CI ‐2.13 to 5.80, P = 0.36). The DQ in children exposed to sodium valproate (VPA) (n = 123) was lower than the DQ in children of women with untreated epilepsy (n = 58) (MD ‐8.72, 95% ‐14.31 to ‐3.14, P = 0.002). The IQ of children exposed to VPA (n = 76) was lower than for children born to women without epilepsy (n = 552) (MD ‐8.94, 95% CI ‐11.96 to ‐5.92, P < 0.00001). Children exposed to VPA (n = 89) also had lower IQ than children born to women with untreated epilepsy (n = 87) (MD ‐8.17, 95% CI ‐12.80 to ‐3.55, P = 0.0005). In terms of drug comparisons, in younger children there was no significant difference in the DQ of children exposed to CBZ (n = 210) versus VPA (n=160) (MD 4.16, 95% CI ‐0.21 to 8.54, P = 0.06). However, the IQ of children exposed to VPA (n = 112) was significantly lower than for those exposed to CBZ (n = 191) (MD 8.69, 95% CI 5.51 to 11.87, P < 0.00001). The IQ of children exposed to CBZ (n = 78) versus lamotrigine (LTG) (n = 84) was not significantly different (MD ‐1.62, 95% CI ‐5.44 to 2.21, P = 0.41). There was no significant difference in the DQ of children exposed to CBZ (n = 172) versus phenytoin (PHT) (n = 87) (MD 3.02, 95% CI ‐2.41 to 8.46, P = 0.28). The IQ abilities of children exposed to CBZ (n = 75) were not different from the abilities of children exposed to PHT (n = 45) (MD ‐3.30, 95% CI ‐7.91 to 1.30, P = 0.16). IQ was significantly lower for children exposed to VPA (n = 74) versus LTG (n = 84) (MD ‐10.80, 95% CI ‐14.42 to ‐7.17, P < 0.00001). DQ was higher in children exposed to PHT (n = 80) versus VPA (n = 108) (MD 7.04, 95% CI 0.44 to 13.65, P = 0.04). Similarly IQ was higher in children exposed to PHT (n = 45) versus VPA (n = 61) (MD 9.25, 95% CI 4.78 to 13.72, P < 0.0001). A dose effect for VPA was reported in six studies, with higher doses (800 to 1000 mg daily or above) associated with a poorer cognitive outcome in the child. We identified no convincing evidence of a dose effect for CBZ, PHT or LTG. Studies not included in the meta‐analysis were reported narratively, the majority of which supported the findings of the meta‐analyses. Authors' conclusions The most important finding is the reduction in IQ in the VPA exposed group, which are sufficient to affect education and occupational outcomes in later life. However, for some women VPA is the most effective drug at controlling seizures. Informed treatment decisions require detailed counselling about these risks at treatment initiation and at pre‐conceptual counselling. We have insufficient data about newer AEDs, some of which are commonly prescribed, and further research is required. Most women with epilepsy should continue their medication during pregnancy as uncontrolled seizures also carries a maternal risk

Redshift distortions in one-dimensional power spectra

We present a model for one-dimensional (1D) matter power spectra in redshift space as estimated from data provided along individual lines of sight. We derive analytic expressions for these power spectra in the linear and nonlinear regimes, focusing on redshift distortions arising from peculiar velocities. In the linear regime, redshift distortions enhance the 1D power spectra only on small scales, and do not affect the power on large scales. This is in contrast to the effect of distortions on three-dimensional (3D) power spectra estimated from data in 3D space, where the enhancement is independent of scale. For CDM cosmologies, the 1D power spectra in redshift and real space are similar for wavenumbers $q<0.1h/Mpc$ where both have a spectral index close to unity, independent of the details of the 3D power spectrum. Nonlinear corrections drive the 1D power spectrum in redshift space into a nearly universal shape over scale $q<10h/Mpc$, and suppress the power on small scales as a result of the strong velocity shear and random motions. The redshift space, 1D power spectrum is mostly sensitive to the amplitude of the initial density perturbations. Our results are useful in particular for power spectra computed from the SDSS quasars sample.Comment: MNRAS in press. matches published versio

A classification scheme for OpenSTEM Labs experiments

The OpenSTEM Labs deliver authentic practical experiences to the Open University’s distance learning students in STEM subjects using real time instrumentation, data and equipment for practical enquiries over the internet. We are undertaking an eSTEeM project to understand the breadth of activities, skills and educational outcomes developed in OpenSTEM Labs experiments. In this project, a classification scheme for remote and onscreen experiments is being developed and will be used to create a database of OpenSTEM Labs experiments. The database, once populated, will help us to understand the range of experiments in our labs and will help module teams to search for existing experiments that are relevant to their needs. Several researchers have developed classification schemes for remote and onscreen laboratories. Zutin et al. (2010) classify online laboratories in terms of laboratory type (remote/ virtual/ hybrid) and experiment type (observation/ fixed/ adaptive) and Orduna et al. (2016) classify of online laboratories in five models: remote laboratories, simulations, datasets, dataset-based simulators and hybrid dataset and reality labs. Remote and online laboratory experiments have also been classified in terms of their educational outcomes. Mead and Bennett (2011) developed a framework for assessing engineering outcomes building on Bloom’s taxonomy. Brinson (2015) classified learning outcomes from remote/ onscreen laboratories using the United States ABET defined technical outcomes for Engineering Accreditation; and Feisel & Rosa (2005) developed a set of 13 learning objectives that can be used to assess the effectiveness of laboratories in distance education. This paper will review previous classification schemes for remote and online laboratories from the literature and propose a new classification scheme for OpenSTEM Labs activities that includes attributes for both laboratory types and educational outcomes

Sparse spectral-tau method for the three-dimensional helically reduced wave equation on two-center domains

We describe a multidomain spectral-tau method for solving the three-dimensional helically reduced wave equation on the type of two-center domain that arises when modeling compact binary objects in astrophysical applications. A global two-center domain may arise as the union of Cartesian blocks, cylindrical shells, and inner and outer spherical shells. For each such subdomain, our key objective is to realize certain (differential and multiplication) physical-space operators as matrices acting on the corresponding set of modal coefficients. We achieve sparse banded realizations through the integration "preconditioning" of Coutsias, Hagstrom, Hesthaven, and Torres. Since ours is the first three-dimensional multidomain implementation of the technique, we focus on the issue of convergence for the global solver, here the alternating Schwarz method accelerated by GMRES. Our methods may prove relevant for numerical solution of other mixed-type or elliptic problems, and in particular for the generation of initial data in general relativity.Comment: 37 pages, 3 figures, 12 table

The nature of the dwarf population in Abell 868

We present the results of a study of the morphology of the dwarf galaxy population in Abell 868, a rich, intermediate redshift (z=0.154) cluster which has a galaxy luminosity function with a steep faint-end slope (alpha=-1.26 +/- 0.05). A statistical background subtraction method is employed to study the B-R colour distribution of the cluster galaxies. This distribution suggests that the galaxies contributing to the faint-end of the measured cluster LF can be split into three populations: dIrrs with B-R<1.4; dEs with 1.4<B-R<2.5; and contaminating background giant ellipticals (gEs) with B-R>2.5. The remvoal of the contribution of the background gEs from the counts only marginally lessens the faint-end slope (alpha=-1.22 +/- 0.16). However, the removal of the contribution of the dIrrs from the counts produces a flat LF (alpha=-0.91 +/- 0.16). The dEs and the dIrrs have similar spatial distributions within the cluster except that the dIrrs appear to be totally absent within a central projected radius of about 0.2 Mpc (Ho=75 km/s /Mpc). The number density of both dEs and dIrrs appear to fall off beyond a projected radius of about 0.35 Mpc. We suggest that the dE and dIrr populations of A868 have been associated with the cluster for similar timescales but that evolutionary processes such as `galaxy harassment' tend to fade the dIrr galaxies while having much less effect on the dE galaxies. The harassement would be expected to have the greatest effect on dwarfs residing in the central parts of the cluster.Comment: 6 pages, 6 figures To be published in The Monthly Notices of the Royal Astronomical Societ