Surface modification of a polyether-urethane with RGD-containing peptides for enhanced cell attachment and signalling

Abstract of article examining the chemical modification of polyurethane with RGD-containing peptides offers a means of encouraging the adhesion, spreading and proliferation of cells cultured on its surface. This study assesses the efficacy of a modification procedure using surface analysis techniques and preliminary cell culture studies

The Initial Mass Function in the Nearest Strong Lenses from SNELLS: Assessing the Consistency of Lensing, Dynamical, and Spectroscopic Constraints

We present new observations of the three nearest early-type galaxy (ETG) strong lenses discovered in the SINFONI Nearby Elliptical Lens Locator Survey (SNELLS). Based on their lensing masses, these ETGs were inferred to have a stellar initial mass function (IMF) consistent with that of the Milky Way, not the bottom-heavy IMF that has been reported as typical for high-σ ETGs based on lensing, dynamical, and stellar population synthesis techniques. We use these unique systems to test the consistency of IMF estimates derived from different methods. We first estimate the stellar M */L using lensing and stellar dynamics. We then fit high-quality optical spectra of the lenses using an updated version of the stellar population synthesis models developed by Conroy & van Dokkum. When examined individually, we find good agreement among these methods for one galaxy. The other two galaxies show 2–3σ tension with lensing estimates, depending on the dark matter contribution, when considering IMFs that extend to 0.08 M ⊙. Allowing a variable low-mass cutoff or a nonparametric form of the IMF reduces the tension among the IMF estimates to <2σ. There is moderate evidence for a reduced number of low-mass stars in the SNELLS spectra, but no such evidence in a composite spectrum of matched-σ ETGs drawn from the SDSS. Such variation in the form of the IMF at low stellar masses (m lesssim 0.3 M ⊙), if present, could reconcile lensing/dynamical and spectroscopic IMF estimates for the SNELLS lenses and account for their lighter M */L relative to the mean matched-σ ETG. We provide the spectra used in this study to facilitate future comparisons

The Australian Charter of Employment Rights: The missing dimensions

Just prior to the 2007 General Election, a group of labour lawyers and economists, broadly sympathetic to the Labor Party, produced a Charter of Employment Rights. This article examines the Charter's proposals and its underlying framework, and suggests significant aspects of work and labour have been omitted. It contends that the Charter would have been improved if it had not retained an artificially stretched definition of workers as employees, in which the only relationship worthy of inclusion in a Charter is that between the direct employer and employee. The framework and language of the Charter convey a paternalistic approach and an outdated focus on industrial labour, while ignoring aspects of the emerging global system of work linked to the concept of occupation

Role of patient-reported outcomes in postsurgical monitoring in oncology

Monitoring recovery from oncologic surgery becomes difficult following discharge. The vulnerable time between discharge and first follow up presents an opportunity for symptom management, complication avoidance, and readmission prevention. These goals may be achieved through careful postsurgical symptom monitoring using electronic patient-reported outcomes (ePROs). ePROs can identify patients at risk, provide closer monitoring when needed, and offer a mechanism to identify and treat complications before they progress. Herein, we describe the benefits of ePROs and summarize the literature of ePRO use in surgical oncology

Accurate age estimation in small-scale societies

Precise estimation of age is essential in evolutionary anthropology, especially to infer population age structures and understand the evolution of human life history diversity. However, in small-scale societies, such as hunter-gatherer populations, time is often not referred to in calendar years, and accurate age estimation remains a challenge. We address this issue by proposing a Bayesian approach that accounts for age uncertainty inherent to fieldwork data. We developed a Gibbs sampling Markov chain Monte Carlo algorithm that produces posterior distributions of ages for each individual, based on a ranking order of individuals from youngest to oldest and age ranges for each individual. We first validate our method on 65 Agta foragers from the Philippines with known ages, and show that our method generates age estimations that are superior to previously published regression-based approaches. We then use data on 587 Agta collected during recent fieldwork to demonstrate how multiple partial age ranks coming from multiple camps of hunter-gatherers can be integrated. Finally, we exemplify how the distributions generated by our method can be used to estimate important demographic parameters in small-scale societies: here, age-specific fertility patterns. Our flexible Bayesian approach will be especially useful to improve cross-cultural life history datasets for small-scale societies for which reliable age records are difficult to acquire

Stable two-dimensional dispersion-managed soliton

The existence of a dispersion-managed soliton in two-dimensional nonlinear Schr\"odinger equation with periodically varying dispersion has been explored. The averaged equations for the soliton width and chirp are obtained which successfully describe the long time evolution of the soliton. The slow dynamics of the soliton around the fixed points for the width and chirp are investigated and the corresponding frequencies are calculated. Analytical predictions are confirmed by direct PDE and ODE simulations. Application to a Bose-Einstein condensate in optical lattice is discussed. The existence of a dispersion-managed matter-wave soliton in such system is shown.Comment: 4 pages, 3 figures, Submitted to Phys. Rev.

PT Invariant Complex E (8) Root Spaces

We provide a construction procedure for complex root spaces invariant under antilinear transformations, which may be applied to any Coxeter group. The procedure is based on the factorisation of a chosen element of the Coxeter group into two factors. Each of the factors constitutes an involution and may therefore be deformed in an antilinear fashion. Having the importance of the E(8)-Coxeter group in mind, such as underlying a particular perturbation of the Ising model and the fact that for it no solution could be found previously, we exemplify the procedure for this particular case. As a concrete application of this construction we propose new generalisations of Calogero-Moser Sutherland models and affine Toda field theories based on the invariant complex root spaces and deformed complex simple roots, respectively

Standard Gamble to Derive Utility Health States for Limbal Stem Cell Deficiency

Purpose: To generate UK health-related quality-of-life (HRQoL) data for adult patients with moderate-to-severe limbal stem cell deficiency (LSCD), unilateral or bilateral, due to physical or chemical ocular burns to help inform economic evaluations of treatments. Patients and Methods: EQ-5D-3L with vision bolt-on scores was prospectively measured for one of five clinical scenarios of LSCD described in vignettes in a demographically representative population of 520 UK adults. These were converted to health state utilities using three different UK value sets. A standard gamble (SG) was then undertaken using 12 SG scenarios to examine the component drivers of health utility for the treatment of LSCD. Results: For the EQ-5D-3L scenarios, the mean disutility for LSCD with poor visual acuity, pain and disfigurement in both eyes compared to one eye was − 0.084 (range=− 0.156 to − 0.045 across the value sets). The mean disutility of bilateral LSCD with pain, disfigurement, and poor visual acuity compared to unilateral LSCD with only poor visual acuity in one eye was − 0.104 (range=− 0.151 to − 0.078). Similarly, where one eye was affected, pain and disfigurement in combination were associated with a greater mean disutility than improvements in visual acuity alone: − 0.011 (range=− 0.04 to 0.005). Mean SG utilities were within a narrow range (0.682– 0.765). Where one eye was affected, the main driver was disfigurement: mean utility was 0.731 (0.709– 0.753) compared to 0.682 (0.659– 0.704) when disfigurement was removed compared to vision restored to normal. For bilateral LSCD, mean utilities were 0.693 (0.672– 0.715) for normal vision and 0.75 (0.73– 0.771) when disfigurement and pain were removed. Conclusion: Improvements in pain and disfigurement appeared to be the main factors driving differences in health utilities associated with symptom profiles in LSCD, with improvements in visual acuity having lesser impact

Nutrient losses from manure and fertilizer applications as impacted by time to first runoff event

Nutrient losses to surface waters following fertilization contribute to eutrophication. This study was conducted to compare the impacts of fertilization with inorganic fertilizer, swine (Sus scrofa domesticus) manure or poultry (Gallus domesticus) litter on runoff water quality, and how the duration between application and the first runoff event affects resulting water quality. Fertilizers were applied at 35 kg P ha-1-, and the duration between application and the first runoff event varied between 1 and 29 days. Swine manure was the greatest risk to water quality 1 day after fertilization due to elevated phosphorus (8.4 mg P L -1) and ammonium (10.3 mg NH4-N L-1) concentrations; however, this risk decreased rapidly. Phosphorus concentrations were 2.6 mg L -1 29 days after fertilization with inorganic fertilizer. This research demonstrates that manures might be more environmentally sustainable than inorganic fertilizers, provided runoff events do not occur soon after application