Predictors of Increases in Alcohol Problems and Alcohol Use Disorders in Offspring in the San Diego Prospective Study.

BackgroundThe 35-year-long San Diego Prospective Study documented 2-fold increases in alcohol problems and alcohol use disorders (AUDs) in young-adult drinking offspring compared to rates in their fathers, the original probands. The current analyses use the same interviews and questionnaires at about the same age in members of the 2 generations to explore multiple potential contributors to the generational differences in adverse alcohol outcomes.MethodsUsing data from recent offspring interviews, multiple cross-generation differences in characteristics potentially related to alcohol problems were evaluated in 3 steps: first through direct comparisons across probands and offspring at about age 30; second by backward linear regression analyses of predictors of alcohol problems within each generation; and finally third through R-based bootstrapped linear regressions of differences in alcohol problems in randomly matched probands and offspring.ResultsThe analyses across the analytical approaches revealed 3 consistent predictors of higher alcohol problems in the second generation. These included the following: (i) a more robust relationship to alcohol problems for offspring with a low level of response to alcohol; (ii) higher offspring values for alcohol expectancies; and (iii) higher offspring impulsivity.ConclusionsThe availability of data across generations offered a unique perspective for studying characteristics that may have contributed to a general finding in the literature of substantial increases in alcohol problems and AUDs in recent generations. If replicated, these results could suggest approaches to be used by parents, healthcare workers, insurance companies, and industry in their efforts to mitigate the increasing rates of alcohol problems in younger generations

An Improved Method of Documenting Activity Patterns of Post-Emergence Polar Bears (Ursus maritimus) in Northern Alaska

Throughout their circumpolar range, pregnant female polar bears (Ursus maritimus) create snow dens in which they give birth to altricial cubs. Because polar bear neonates are born in such an undeveloped state, their survival requires a long, undisturbed period of in-den development. To mitigate human impacts on denning bears, it is necessary to understand the chronology of denning, the behaviors of denning bears, and their sensitivity to human activities. Since 2002, we have studied the den emergence behaviors of polar bears in northern Alaska; however, we moved from using on-site observers (2002 – 03) to using autonomous video systems (2005 – 08). Here we compare the duration, activity budgets, and behaviors of polar bears to see whether observation methods affected their activities. Camera systems recorded nearly 10 times the data per den recorded by human observers (526 h/den and 57 h/den respectively). We found no difference between the two study periods in emergence dates, duration at den sites, abandonment dates, or activity budgets for polar bears. We observed a 16-fold reduction in the number of bear-human interactions when using cameras instead of human observers. There was, however, a marked increase in the intensity of response when using cameras (125 m) as compared to observers in blinds (400 m). An understanding of these activity patterns can be used to manage human activities near dens so as to minimize disturbance.À l’échelle de leur aire de répartition circumpolaire, les ourses polaires (Ursus maritimus) en gestation se créent une tanière de neige pour donner naissance à leurs oursons à développement tardif. Puisque les nouveau-nés de l’ourse polaire naissent dans un état si peu développé, leur survie nécessite une longue période de développement non perturbé en tanière. Afin d’atténuer les incidences de l’être humain sur les ours en tanière, il est nécessaire de comprendre la chronologie de la mise bas, les comportements des ours en tanière et leur sensibilité à l’activité humaine. À partir de 2002, nous avons étudié les comportements de sortie des tanières des ours polaires du nord de l’Alaska, tout d’abord au moyen d’observations faites sur place (en 2002 et 2003) et ensuite, au moyen de caméras vidéo autonomes (de 2005 à 2008). Ici, nous comparons la durée, la répartition des activités et les comportements des ours polaires afin de déterminer si les méthodes d’observation ont influencé leurs activités. Les caméras ont enregistré près de dix fois plus de données par tanière que les observateurs humains (526 h/tanière et 57 h/tanière respectivement). Nous n’avons trouvé aucune différence entre les deux périodes à l’étude en ce qui a trait aux dates de sortie, aux durées de séjour en tanière, aux dates d’abandon ou à la répartition des activités des ours polaires. Lorsque nous avons utilisé des caméras par opposition à des observateurs, nous avons dénoté 16 fois moins d’interactions entre les ours et l’être humain. Cependant, nous avons remarqué une augmentation accrue sur le plan de l’intensité de la réponse lorsque nous nous sommes servis de caméras (125 m) comparativement aux observateurs dissimulés (400 m). La compréhension de ces modèles d’activités peut servir à gérer l’activité humaine à proximité des tanières afin de minimiser les perturbations

Decoupling 802.11B From the Partition Table in Erasure Coding

Many cyberneticists would agree that, had it not been for extensible epistemologies, the evaluation of superblocks might never have occurred. In this paper, authors disprove the improvement of context-free grammar, demonstrates the technical importance of distributed systems. In our research, we concentrate our efforts on showing that IPv4 and erasure coding are never incompatible

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts

Objectives: To assess the associations between both uric acid levels and hyperuricaemia, with ischaemic heart disease and blood pressure, and to explore the potentially confounding role of body mass index. Design: Mendelian randomisation analysis, using variation at specific genes (SLC2A9 (rs7442295) as an instrument for uric acid; and FTO (rs9939609), MC4R (rs17782313), and TMEM18 (rs6548238) for body mass index). Setting: Two large, prospective cohort studies in Denmark. Participants: We measured levels of uric acid and related covariables in 58 072 participants from the Copenhagen General Population Study and 10 602 from the Copenhagen City Heart Study, comprising 4890 and 2282 cases of ischaemic heart disease, respectively. Main outcome: Blood pressure and prospectively assessed ischaemic heart disease. Results: Estimates confirmed known observational associations between plasma uric acid and hyperuricaemia with risk of ischaemic heart disease and diastolic and systolic blood pressure. However, when using genotypic instruments for uric acid and hyperuricaemia, we saw no evidence for causal associations between uric acid, ischaemic heart disease, and blood pressure. We used genetic instruments to investigate body mass index as a potentially confounding factor in observational associations, and saw a causal effect on uric acid levels. Every four unit increase of body mass index saw a rise in uric acid of 0.03 mmol/L (95% confidence interval 0.02 to 0.04), and an increase in risk of hyperuricaemia of 7.5% (3.9% to 11.1%). Conclusion: By contrast with observational findings, there is no strong evidence for causal associations between uric acid and ischaemic heart disease or blood pressure. However, evidence supports a causal effect between body mass index and uric acid level and hyperuricaemia. This finding strongly suggests body mass index as a confounder in observational associations, and suggests a role for elevated body mass index or obesity in the development of uric acid related conditions

Preventing childhood malaria in Africa by protecting adults from mosquitoes with insecticide-treated nets

Malaria prevention in Africa merits particular attention as the world strives toward a better life for the poorest. Insecticide-treated nets (ITNs) represent a practical means to prevent malaria in Africa, so scaling up coverage to at least 80% of young children and pregnant women by 2010 is integral to the Millennium Development Goals (MDG). Targeting individual protection to vulnerable groups is an accepted priority, but community-level impacts of broader population coverage are largely ignored even though they may be just as important. We therefore estimated coverage thresholds for entire populations at which individual- and community-level protection are equivalent, representing rational targets for ITN coverage beyond vulnerable groups

Galaxy populations in the Antlia cluster - III. Properties of faint early-type galaxies

(Abridge) We present a new analysis of the early-type galaxy population in the central region of the Antlia cluster, focusing on the faint systems like dwarf ellipticals (dE) and dwarf spheroidals (dSph). We confirm 22 early-type galaxies as Antlia members, using GEMINI-GMOS and MAGELLAN-MIKE spectra. Among them, 2 belong to the rare type of compact ellipticals (cE), and 5 are new faint dwarfs that had never been catalogued before. In addition, we present 16 newly identified low surface brightness galaxy candidates, almost half of them displaying morphologies consistent with being Antlia's counterparts of Local Group dSphs, that extend the faint luminosity limit of our study down to MB = -10.1 (BT = 22.6) mag. We built an improved CMR in the Washington photometric system, i.e. integrated T1 magnitudes versus (C - T1) colours, which extends \sim 4 mag faintwards the limit of spectroscopically confirmed Antlia members. When only confirmed early-type members are considered, this relation extends over 10 mag in luminosity with no apparent change in slope or increase in colour dispersion towards its faint end. The intrinsic colour scatter of the relation is compared with those reported for other clusters of galaxies; we argue that it is likely that the large scatter of the CMR, usually reported at faint magnitudes, is mostly due to photometric errors along with an improper membership/morphological classification. The distinct behaviour of the luminosity versus mean effective surface brightness relation at the bright and faint ends is analyzed, while it is confirmed that dE galaxies on the same relation present a very similar effective radius, regardless of their colour. The projected spatial distribution of the member sample confirms the existence of two groups in Antlia, each one dominated by a giant elliptical galaxy and with one cE located close to each giant.Comment: 19 pages, 9 figures, 5 tables. Accepted for publication in MNRA