Intramoleculer Hydrogen Bonding In Epoxide, Thiirane, Aziridine And Phosphirane Containing Cyclopentanols

A recent computational analysis of the stabilizing intramolecular OH· · · O contact in 1,2-dialkyl-2,3-epoxycyclopentanol diastereomers has been extended to thiiriane, aziridine and phosphirane analogues. Density functional theory (DFT), second-order Møller-Plesset perturbation theory (MP2) and CCSD(T) coupled-cluster computations with simple methyl and ethyl substituents indicate that electronic energies of the cis isomers are lowered by roughly 3 to 4 kcal mol−1 when the OH group of these cyclopentanol systems forms an intramolecular contact with the O, S, N or P atom on the adjacent carbon. The results also suggest that S and P can participate in these stabilizing intramolecular interactions as effectively as O and N in constrained molecular environments. The stabilizing intramolecular OH· · · O, OH· · · S, OH· · · N and OH· · · P contacts also increase the covalent OH bond length and significantly decrease the OH stretching vibrational frequency in every system with shifts typically on the order of −41 cm−1

BioAcoustica : a free and open repository and analysis platform for bioacoustics

We describe an online open repository and analysis platform, BioAcoustica (http://bio. acousti.ca), for recordings of wildlife sounds. Recordings can be annotated using a crowdsourced approach, allowing voice introductions and sections with extraneous noise to be removed from analyses. This system is based on the Scratchpads virtual research environment, the BioVeL portal and the Taverna workflow management tool, which allows for analysis of recordings using a grid computing service. At present the analyses include spectrograms, oscillograms and dominant frequency analysis. Further analyses can be integrated to meet the needs of specific researchers or projects. Researchers can upload and annotate their recordings to supplement traditional publication

What is with all the plastic garbage everywhere and where does it go?

Despite countless efforts in recycling, awareness, and limited legislation, plastic pollution has continued to spiral out of control due to massive production/use and the inability to naturally decompose. Plastic pollution ends up accumulating in the environment in places like sediment and surface water. Unfortunately, another reservoir for plastic pollution is local compost, or decayed organic matter used for agricultural processes. A substantial amount of micro- and macro- plastics has been collected from both the local compost and along and around roads in Valparaiso. Plastic waste was collected at numerous roadside locations throughout the Salt Creek watershed in the Porter County area; it was quantified and classified by both recycling numbers and via infrared (IR) spectroscopy. Compost samples were collected and analyzed in the same manner, this time also accounting for microplastics. The compost was sieved with two and five micron sieves. A solution of zinc chloride (1.4 g/mL) was utilized to separate the microplastics via density separation. This was then further processed via H2O2/UV advanced oxidation to eliminate excessive organic matter and to isolate the microplastics and microfibers further. The results will identify the various types of plastics and their magnitude in the local environment, in both the local compost and throughout the Salt Creek watershed of Porter County, Indiana. These results can establish knowledge of how different types and sizes of plastics migrate throughout the environment, and provide citizens with ways to reduce the garbage

Stellar intensity interferometry: Experimental steps toward long-baseline observations

Experiments are in progress to prepare for intensity interferometry with arrays of air Cherenkov telescopes. At the Bonneville Seabase site, near Salt Lake City, a testbed observatory has been set up with two 3-m air Cherenkov telescopes on a 23-m baseline. Cameras are being constructed, with control electronics for either off- or online analysis of the data. At the Lund Observatory (Sweden), in Technion (Israel) and at the University of Utah (USA), laboratory intensity interferometers simulating stellar observations have been set up and experiments are in progress, using various analog and digital correlators, reaching 1.4 ns time resolution, to analyze signals from pairs of laboratory telescopes.Comment: 12 pages, 3 figur

Global distribution and diversity of ovine-associated Staphylococcus aureus

Staphylococcus aureus is an important pathogen of many species, including sheep, and impacts on both human and animal health, animal welfare, and farm productivity. Here we present the widest global diversity study of ovine-associated S. aureus to date. We analysed 97 S. aureus isolates from sheep and sheep products from the UK, Turkey, France, Norway, Australia, Canada and the USA using multilocus sequence typing (MLST) and spa typing. These were compared with 196 sheep isolates from Europe (n = 153), Africa (n = 28), South America (n = 14) and Australia (n = 1); 172 bovine, 68 caprine and 433 human S. aureus profiles. Overall there were 59 STs and 87 spa types in the 293 ovine isolates; in the 97 new ovine isolates there were 22 STs and 37 spa types, including three novel MLST alleles, four novel STs and eight novel spa types. Three main CCs (CC133, CC522 and CC700) were detected in sheep and these contained 61% of all isolates. Four spa types (t002, t1534, t2678 and t3576) contained 31% of all isolates and were associated with CC5, CC522, CC133 and CC522 respectively. spa types were consistent with MLST CCs, only one spa type (t1403) was present in multiple CCs. The three main ovine CCs have different but overlapping patterns of geographical dissemination that appear to match the location and timing of sheep domestication and selection for meat and wool production. CC133, CC522 and CC700 remained ovine-associated following the inclusion of additional host species. Ovine isolates clustered separately from human and bovine isolates and those from sheep cheeses, but closely with caprine isolates. As with cattle isolates, patterns of clonal diversification of sheep isolates differ from humans, indicative of their relatively recent host-jump

What is with all the plastic garbage everywhere and where does it go?

Despite countless efforts in recycling, awareness, and limited legislation, plastic pollution has continued to spiral out of control due to massive production/use and the inability to naturally decompose. Plastic pollution ends up accumulating in the environment in places like sediment and surface water. Unfortunately, another reservoir for plastic pollution is local compost, or decayed organic matter used for agricultural processes. A substantial amount of micro- and macro- plastics has been collected from both the local compost and along and around roads in Valparaiso. Plastic waste was collected at numerous roadside locations throughout the Salt Creek watershed in the Porter County area; it was quantified and classified by both recycling numbers and via infrared (IR) spectroscopy. Compost samples were collected and analyzed in the same manner, this time also accounting for microplastics. The compost was sieved with two and five micron sieves. A solution of zinc chloride (1.4 g/mL) was utilized to separate the microplastics via density separation. This was then further processed via H2O2/UV advanced oxidation to eliminate excessive organic matter and to isolate the microplastics and microfibers further. The results will identify the various types of plastics and their magnitude in the local environment, in both the local compost and throughout the Salt Creek watershed of Porter County, Indiana. These results can establish knowledge of how different types and sizes of plastics migrate throughout the environment, and provide citizens with ways to reduce the garbage

Psychological distress, physical illness and risk of myocardial infarction in the Caerphilly Study

Background. Studies have found associations between psychological distress (PD) and increased risk of myocardial infarction (MI). However, it is not clear whether the relationship reflects the subtle influence of pre-existing illness on both PD and MI. This study examines the association between PD and MI in a prospective epidemiological study of 1864 middle-aged men to examine if the association is explained by existing illness. Method. This study was a prospective cohort study modelling the association between PD, measured using the 30-item General Health Questionnaire (GHQ) and non-fatal myocardial infarction (NFMI) and fatal/non-fatal myocardial infarction (FNFMI).The relationship was modelled in a series of logistic regression models adjusted for age, then cigarette smoking, then social position, and finally for all sociodemographic characteristics, coronary heart disease (CHD) risk factors, and baseline CHD. Results. PD was associated with a 70% and 68% increased risk of NFMI and FNFMI in fully adjusted analysis. However, PD was not associated with an increased risk of NFMI and FNFMI in analyses excluding those with baseline CHD. Further, being psychologically distressed and physically ill was associated with a greater than twofold risk of NFMI and FNFMI, 2.37 (95% CI 1.33–4.20) and 2.33 (95% CI 1.32–4.12) respectively. Conclusion. This study suggests that PD is a moderator of the increased risk of MI associated with existing physical illness. PD in men who are physically ill is a marker of an underlying chronic physical illness. The prospective association of PD with MI is not independent of baseline physical illness

Correlating electroconvulsive therapy response to electroencephalographic markers: Study protocol

INTRODUCTION: Electroconvulsive therapy (ECT) is an effective intervention for patients with major depressive disorder (MDD). Despite longstanding use, the underlying mechanisms of ECT are unknown, and there are no objective prognostic biomarkers that are routinely used for ECT response. Two electroencephalographic (EEG) markers, sleep slow waves and sleep spindles, could address these needs. Both sleep microstructure EEG markers are associated with synaptic plasticity, implicated in memory consolidation, and have reduced expression in depressed individuals. We hypothesize that ECT alleviates depression through enhanced expression of sleep slow waves and sleep spindles, thereby facilitating synaptic reconfiguration in pathologic neural circuits. METHODS: Correlating ECT Response to EEG Markers (CET-REM) is a single-center, prospective, observational investigation. Wireless wearable headbands with dry EEG electrodes will be utilized for at-home unattended sleep studies to allow calculation of quantitative measures of sleep slow waves (EEG SWA, 0.5-4 Hz power) and sleep spindles (density in number/minute). High-density EEG data will be acquired during ECT to quantify seizure markers. DISCUSSION: This innovative study focuses on the longitudinal relationships of sleep microstructure and ECT seizure markers over the treatment course. We anticipate that the results from this study will improve our understanding of ECT

Mass balance of the ice sheets and glaciers – progress since AR5 and challenges

Recent research shows increasing decadal ice mass losses from the Greenland and Antarctic Ice Sheets and more generally from glaciers worldwide in the light of continued global warming. Here, in an update of our previous ISMASS paper (Hanna et al., 2013), we review recent observational estimates of ice sheet and glacier mass balance, and their related uncertainties, first briefly considering relevant monitoring methods. Focusing on the response to climate change during 1992-2018, and especially the post-IPCC AR5 period, we discuss recent changes in the relative contributions of ice sheets and glaciers to sea-level change. We assess recent advances in understanding of the relative importance of surface mass balance and ice dynamics in overall ice-sheet mass change. We also consider recent improvements in ice-sheet modelling, highlighting data-model linkages and the use of updated observational datasets in ice-sheet models. Finally, by identifying key deficiencies in the observations and models that hamper current understanding and limit reliability of future ice-sheet projections, we make recommendations to the research community for reducing these knowledge gaps. Our synthesis aims to provide a critical and timely review of the current state of the science in advance of the next Intergovernmental Panel on Climate Change Assessment Report that is due in 2021