Hide seek and negotiate: Alfred Cope and counter intelligence in Ireland 1919–1921

British intelligence in Ireland between 1919 and 1921 has been characterized as a toxic mix of incompetence and mendacity. This article will challenge this judgement by examining the activities, impact and consequences of a British civil servant, Alfred Cope, who between 1920 and 1921 was an Assistant Under Secretary in Dublin Castle. Using the three criteria of counter-intelligence operations: the ability to locate, identify and neutralize a target, it will be shown that within months of his posting to Dublin British intelligence, albeit inadvertently, had located and identified him as passing classified information to Sinn Fein. Political patronage meant the ability of the intelligence community to neutralize his impact was nugatory. Latterly Cope recognized the consequences of his actions reverberated beyond the period of his time in Ireland

Haldane's Mackindergarten: a radical experiment in British military education

This article critically evaluates a course that was conceived and run at the LSE by Sir Halford Mackinder for officers of the Britsh Army between 1907 and 1932.There is an examination of the nature of the syllabus,the aims and objectives of this course.An explanation is also given as to why the army cut it seven years before the outbreak of the Second World War

Military doctrine, command philosophy and the generation of fighting power: genesis and theory

Military doctrine is one of the conceptual components of war. Its raison d’être is that of a force multiplier. It enables a smaller force to take on and defeat a larger force in battle. This article’s departure point is the aphorism of Sir Julian Corbett, who described doctrine as ‘the soul of warfare’. The second dimension to creating a force multiplier effect is forging doctrine with an appropriate command philosophy. The challenge for commanders is how, in unique circumstances, to formulate, disseminate and apply an appropriate doctrine and combine it with a relevant command philosophy. This can only be achieved by policy-makers and senior commanders successfully answering the Clausewitzian question: what kind of conflict are they involved in? Once an answer has been provided, a synthesis of these two factors can be developed and applied. Doctrine has implications for all three levels of war. Tactically, doctrine does two things: first, it helps to create a tempo of operations; second, it develops a transitory quality that will produce operational effect, and ultimately facilitate the pursuit of strategic objectives. Its function is to provide both training and instruction. At the operational level instruction and understanding are critical functions. Third, at the strategic level it provides understanding and direction. Using John Gooch’s six components of doctrine, it will be argued that there is a lacunae in the theory of doctrine as these components can manifest themselves in very different ways at the three levels of war. They can in turn affect the transitory quality of tactical operations. Doctrine is pivotal to success in war. Without doctrine and the appropriate command philosophy military operations cannot be successfully concluded against an active and determined foe

The Royal Navy and organizational learning — the western approaches tactical unit and the Battle of the Atlantic

The Western Approaches Tactical Unit is a unique example of a learning organization. It was created within the bureaucratic constraints of the Admiralty yet was highly effective in changing command culture in the Royal Navy—which proved to be the deciding factor in the early days of World War II, particularly during the Battle of the Atlantic

Geopolitics, geography and strategic history

This is a book about relationships and the puzzles they present. These two issues will be explored through a trinitarian structure. Understanding the manner in which geography, history and strategy interact and have produced political outcomes that have affected the security of states is the analytical objective

Sir Halford Mackinder’s democratic ideals and reality: A centennial appreciation

Sir Halford Mackinder’s seminal contribution to classical geopolitics, Democratic Ideals and Reality: A Study in the Politics of Reconstruction, was published a century ago. The book was written to influence the British delegation to the peace conference that was beginning in Versailles. Scant evidence suggests that he succeeded in this aim. However, with the Second World War, and the United States’ participation in the conflict, Mackinder’s ideas found critical acclaim. This centennial appreciation contends that many of the concepts he coined have relevance for today. Crucially, he identified two enduring features of democratic regimes that both explain and warn. First, in times of peace and prosperity, democracies refuse to think strategically until compelled to do so. Second, political elites in these countries divorce their normative ideals for a rules-based international order from the existing and emerging geopolitical realities

The occurrence and frequency of genomic mutations that mediate Isoniazid and Rifampicin resistance in Mycobacterium tuberculosis isolates from untreated pulmonary Tuberculosis cases in urban Blantyre, Malawi

This study was funded by the Helse Nord Tuberculosis Initiative (HNTI), a College of Medicine grant supported by the Helse Nord RHF and the University of Tromso.Background The emergence and spread of drug-resistant Tuberculosis (TB) is a major public health threat. TB resistance originates in the course of treatment due to genomic mutations in Mycobacterium tuberculosis (MTB). An increase in new cases with drug-resistant TB could be an indicator of high levels of circulating resistant strains. This study was conducted to determine the occurrence and frequency of genomic mutations that mediate Isoniazid (INH) and Rifampicin (RIF) resistance among isolates from untreated TB cases in urban Blantyre, Malawi. Methods A cross-sectional retrospective study was conducted on a panel of 141(n=141) MTB clinical isolates recovered between June 2010 and January 2012 from ≥2+ Ziehl-Neelsen smear positive new pulmonary-TB patients with no history of treatment. Frozen isolates were revived using the BACTEC MGIT detection system. DNA was extracted using GenoLyse DNA extraction kit and detection of genomic mutations was carried out using the GenoType MTBDRplus Ver 2.0 assay. Results Out of the 141 isolates studied, 3 (2.1%) were found carrying mutations in the katG gene that confer resistance to Isoniazid (INH). No mutations were detected in the inhA promoter region gene that confer weak INH resistance or in the rpoB gene that confer Rifampicin resistance. All katG mutant genes had a S315T1 single point mutation, a genomic alteration that mediates high INH resistance. Conclusion The katG mutant gene conferring resistance to INH was the only genomic mutation observed among the isolates studied and the frequency of occurrence was low. Our findings suggest low levels of circulating drug-resistant MTB strains in urban Blantyre, Malawi.Publisher PDFPeer reviewe

The Dust Properties of Two Hot R Coronae Borealis Stars and a Wolf-Rayet Central Star of a Planetary Nebula: in Search of a Possible Link

We present new Spitzer/IRS spectra of two hot R Coronae Borealis (RCB) stars, one in the Galaxy,V348 Sgr, and one lying in the LMC, HV 2671. These two objects may constitute a link between the RCB stars and the late Wolf-Rayet ([WCL]) class of central stars of planetary nebula (CSPNe) such as CPD -56 8032 that has little or no hydrogen in their atmospheres. HV 2671 and V348 Sgr are members of a rare subclass that has significantly higher effective temperatures than most RCB stars, but sharing the traits of hydrogen deficiency and dust formation that define the cooler RCB stars. The [WC] CSPNe star, CPD -56 8032, displays evidence for dual-dust chemistry showing both PAHs and crystalline silicates in its mid-IR spectrum. HV 2671 shows strong PAH emission but shows no sign of having crystalline silicates. The spectrum of V348 Sgr is very different from those of CPD -56 8032 and HV 2671. The PAH emission seen strongly in the other two stars is not present. Instead, the spectrum is dominated by a broad emission centered at about 8.2 micron. The mid-IR spectrum of CPD -56 8032 shows emission features that may be associated with C60. The other two stars do not show evidence for C60. HV 2671 has also been detected by Herschel/PACS and SPIRE. V348 Sgr and CPD -56 8032 have been detected by AKARI/FIS. These data were combined with Spitzer, IRAS, 2MASS and other photometry to produce their spectral energy distributions from the visible to the far-IR. Monte Carlo radiative transfer modeling was used to study the circumstellar dust around these stars. HV 2671 and CPD -56 8032 require both a flared inner disk with warm dust and an extended diffuse envelope with cold dust to to fit their SEDs. The SED of V348 Sgr can be fit with a much smaller disk and envelope.Comment: 20 pages, 5 figures, accepted for publication in The Astronomical Journa

Receptors for Hyaluronic Acid and Poliovirus: A Combinatorial Role in Glioma Invasion?

Background: CD44 has long been associated with glioma invasion while, more recently, CD155 has been implicated in playing a similar role. Notably, these two receptors have been shown closely positioned on monocytes. Methods and Findings: In this study, an up-regulation of CD44 and CD155 was demonstrated in established and earlypassage cultures of glioblastoma. Total internal reflected fluorescence (TIRF) microscopy revealed close proximity of CD44 and CD155. CD44 antibody blocking and gene silencing (via siRNA) resulted in greater inhibition of invasion than that for CD155. Combined interference resulted in 86 % inhibition of invasion, although in these investigations no obvious evidence of synergy between CD44 and CD155 in curbing invasion was shown. Both siRNA-CD44 and siRNA-CD155 treated cells lacked processes and were rounder, while live cell imaging showed reduced motility rate compared to wild type cells. Adhesion assay demonstrated that wild type cells adhered most efficiently to laminin, whereas siRNA-treated cells (p,0.0001 for both CD44 and CD155 expression) showed decreased adhesion on several ECMs investigated. BrdU assay showed a higher proliferation of siRNA-CD44 and siRNA-CD155 cells, inversely correlated with reduced invasion. Confocal microscopy revealed overlapping of CD155 and integrins (b1, avb1 and avb3) on glioblastoma cell processes whereas siRNAtransfected cells showed consequent reduction in integrin expression with no specific staining patterns. Reduced expression of Rho GTPases, Cdc42, Rac1/2/3, RhoA and RhoB, was seen in siRNA-CD44 and siRNA-CD155 cells. In contrast t