Мультифакторное моделирование атеросклероза на крысах = Multifactorial modeling of atherosclerosis in rats

Savitskiy I. V., Sliusar A. A., Miastkovskaja I. V. Мультифакторное моделирование атеросклероза на крысах = Multifactorial modeling of atherosclerosis in rats. Journal of Education, Health and Sport. 2016;6(3):233-240. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.55402 http://ojs.ukw.edu.pl/index.php/johs/article/view/3577 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.03.2016. Revised 20.03.2016. Accepted: 23.03.2016. УДК 616-092.9 Мультифакторное моделирование атеросклероза на крысах И. В. Савицкий, А. А. Слюсарь, И. В. Мястковская Одесский национальный медицинский университет, Одесса, Украина Реферат В статье рассмотрена новая методика экспериментального атеросклероза на крысах линии Wistar, которая берет в своем начале полиэтиологическую теорию развития заболевания. Был проведен эксперимент и полученные результаты оценивали степень взаимодействия факторов нагрузки, которые заключались в одновременной постановке экспериментального гипотиреоза при помощи Мерказолила, иммуносупрессии Метилпреднизолоном на фоне гепатотоксического действия раствора этилового спирта и классической атерогенной диеты. В работе приведены предварительные данные за две недели, которые достигли границы верхней нормы у одной из групп, а так же значительное достоверное повышение уровня ЛПоНП выше нормы. Ключевые слова: экспериментальный атеросклероз, патогенез заболевания, сердечно-сосудистая патология. Multifactorial modeling of atherosclerosis in rats I. V. Savitskiy, A. A. Sliusar, I. V. Miastkovskaja Odessa National Medical University, Odessa, Ukraine Summary The article describes a new method of experimental atherosclerosis in rats of Wistar line, which originates in the theory that disease has a multifactorial ethiology. Experiment and the results can show the interaction of atherogenic factors, which consisted in the simultaneous staging of experimental hypothyroidism using Mercazolilum, methylprednisolone immunosuppression on the background of hepatotoxic action of ethyl alcohol solution and atherogenic diet. This work shows the preliminary data for two weeks, in which the upper border of biochemical rate was reached in one of the groups, as well as a significant increase in the level of VLDL above normal. Keywords: experimental atherosclerosis, the pathogenesis of the disease, cardiovascular disease

Building high availability central data catalog service powered by IBM Mainframe technology in the ukrainian national grid-infrastructure

Проведено аналіз особливостей застосування служб рівня кооперації української національної грід-інфраструктури, зокрема служби центрального каталогу даних LFC. Сформовано вимоги до реалізації високодоступного центрального каталога даних із використанням високонадійного обчислювального комплексу IBM Mainframe Z800. Показано особливості апаратної архітектури z/Architecture та програмного забезпечення проміжного рівня Nordugrid ARC, що були враховані при розробленні методики формування високодоступної служби LFC. Методику впроваджено для побудови системи з використанням мейнфрейму та обчислювального кластеру Київського національного університету імені Тараса Шевченка. Техніку формування опису грід-завдання для використання конфігурації високонадійної служби запроваджено до реалізації грід-порталу віртуальної лабораторії MolDynGrid в українській національній грід-інфраструктурі.Analysis of cooperation level service applications in Ukrainian national grid-infrastructure is conducted focusing on LFC central data catalog services. Methods for building high available central data catalog service employing IBM Z800 Mainframe installation are presented. Specialities of zSeries hardware architecture and Nordugrid ARC middleware software were taken into account for service implementation on top of the mainframe and HPC cluster of Taras Shevchenko National University of Kyiv. Grid job description generation technique for accessing high available LFC service was applied to the implementation of MolDynGrid Virtual Laboratory grid-portal in the Ukrainian national grid-infrastructure

ІНТЕГРОВАНЕ СЕРЕДОВИЩЕ ВІРТУАЛЬНОЇ ЛАБОРАТОРІЇ MolDynGrid ДЛЯ РОЗРАХУНКІВ МОЛЕКУЛЯРНОЇ ДИНАМІКИ БІОПОЛІМЕРІВ

Virtual laboratory MolDynGrid has been established in the frame of the Ukrainian academic grid infrastructure for the calculations of molecular dynamics of biological macromolecules.The integrated environment is introduced in virtual laboratory MolDynGrid for the automation of computational  calculations. А web-portal of virtual laboratory has been created (http://moldyngrid.org), which is composed of  computational, analytical and educational blocks аnd data base of molecular dynamics simulations.Виртуальная лаборатория MolDynGrid создана в рамках украинской академической грид-инфраструктуры  для проведения расчетов молекулярной динамики биологических макромолекул. В  виртуальной лаборатории MolDynGrid внедрена интегрированная среда для автоматизации компьютерных расчетов. Создан веб-портал виртуальной лаборатории (http://moldyngrid.org), который состоит из расчетного, аналитического и обучающего  блоков и базы данных траекторий молекулярной динамики.Віртуальна лабораторія MolDynGrid створена в рамках української академічної грід-інфраструктури  для проведення розрахунків молекулярної динаміки біологічних макромолекул. В  віртуальній лабораторії MolDynGrid впроваджене інтегроване середовище для автоматизації комп’ютерних розрахунків. Створено веб-портал віртуальної лабораторії, що складається з розрахункового, аналітичного і навчального блоків та бази даних траєкторій молекулярної динаміки

Performance of a small size telescope (SST-1M) camera for gamma-ray astronomy with the Cherenkov Telescope Array

The foreseen implementations of the Small Size Telescopes (SST) in CTA will provide unique insights into the highest energy gamma rays offering fundamental means to discover and under- stand the sources populating the Galaxy and our local neighborhood. Aiming at such a goal, the SST-1M is one of the three different implementations that are being prototyped and tested for CTA. SST-1M is a Davies-Cotton single mirror telescope equipped with a unique camera technology based on SiPMs with demonstrated advantages over classical photomultipliers in terms of duty-cycle. In this contribution, we describe the telescope components, the camera, and the trigger and readout system. The results of the commissioning of the camera using a dedicated test setup are then presented. The performances of the camera first prototype in terms of expected trigger rates and trigger efficiencies for different night-sky background conditions are presented, and the camera response is compared to end-to-end simulations.Comment: All CTA contributions at arXiv:1709.0348

Development of a strategy for calibrating the novel SiPM camera of the SST-1M telescope proposed for the Cherenkov Telescope Array

CTA will comprise a sub-array of up to 70 small size telescopes (SSTs) at the southern array. The SST-1M project, a 4 m-diameter Davies Cotton telescope with 9 degrees FoV and a 1296 pixels SiPM camera, is designed to meet the requirements of the next generation ground based gamma-ray observatory CTA in the energy range above 3 TeV. Silicon photomultipliers (SiPM) cameras of gamma-ray telescopes can achieve good performance even during high night sky background conditions. Defining a fully automated calibration strategy of SiPM cameras is of great importance for large scale production validation and online calibration. The SST-1M sub-consortium developed a software compatible with CTA pipeline software (CTApipe). The calibration of the SST-1M camera is based on the Camera Test Setup (CTS), a set of LED boards mounted in front of the camera. The CTS LEDs are operated in pulsed or continuous mode to emulate signal and night sky background respectively. Continuous and pulsed light data analysis allows us to extract single pixel calibration parameters to be used during CTA operation.Comment: All CTA contributions at arXiv:1709.0348

Control Software for the SST-1M Small-Size Telescope prototype for the Cherenkov Telescope Array

The SST-1M is a 4-m Davies--Cotton atmospheric Cherenkov telescope optimized to provide gamma-ray sensitivity above a few TeV. The SST-1M is proposed as part of the Small-Size Telescope array for the Cherenkov Telescope Array (CTA), the first prototype has already been deployed. The SST-1M control software of all subsystems (active mirror control, drive system, safety system, photo-detection plane, DigiCam, CCD cameras) and the whole telescope itself (master controller) uses the standard software design proposed for all CTA telescopes based on the ALMA Common Software (ACS) developed to control the Atacama Large Millimeter Array (ALMA). Each subsystem is represented by a separate ACS component, which handles the communication to and the operation of the subsystem. Interfacing with the actual hardware is performed via the OPC UA communication protocol, supported either natively by dedicated industrial standard servers (PLCs) or separate service applications developed to wrap lower level protocols (e.g. CAN bus, camera slow control) into OPC UA. Early operations of the telescope without the camera were already carried out. The camera is fully assembled and is capable to perform data acquisition using artificial light source.Comment: In Proceedings of the 35th International Cosmic Ray Conference (ICRC2017), Busan, Korea. All CTA contributions at arXiv:1709.0348

Software design for the control system for Small-Size Telescopes with single-mirror of the Cherenkov Telescope Array

The Small-Size Telescope with single-mirror (SST-1M) is a 4 m Davies-Cotton telescope and is among the proposed telescope designs for the Cherenkov Telescope Array (CTA). It is conceived to provide the high-energy ($>$ few TeV) coverage. The SST-1M contains proven technology for the telescope structure and innovative electronics and photosensors for the camera. Its design is meant to be simple, low-budget and easy-to-build industrially. Each device subsystem of an SST-1M telescope is made visible to CTA through a dedicated industrial standard server. The software is being developed in collaboration with the CTA Medium-Size Telescopes to ensure compatibility and uniformity of the array control. Early operations of the SST-1M prototype will be performed with a subset of the CTA central array control system based on the Alma Common Software (ACS). The triggered event data are time stamped, formatted and finally transmitted to the CTA data acquisition. The software system developed to control the devices of an SST-1M telescope is described, as well as the interface between the telescope abstraction to the CTA central control and the data acquisition system.Comment: In Proceedings of the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions at arXiv:1508.0589

Using muon rings for the optical throughput calibration of the SST-1M prototype for the Cherenkov Telescope Array

Imaging Atmospheric Cherenkov Telescopes (IACTs) are ground-based instruments devoted to the study of very high energy gamma-rays coming from space. The detection technique consists of observing images created by the Cherenkov light emitted when gamma rays, or more generally cosmic rays, propagate through the atmosphere. While in the case of protons or gamma-rays the images present a filled and more or less elongated shape, energetic muons penetrating the atmosphere are visualised as characteristic circular rings or arcs. A relatively simple analysis of the ring images allows the reconstruction of all the relevant parameters of the detected muons, such as the energy, the impact parameter, and the incoming direction, with the final aim to use them to calibrate the total optical throughput of the given IACT telescope. We present the results of preliminary studies on the use of images created by muons as optical throughput calibrators of the single mirror small size telescope prototype SST-1M proposed for the Cherenkov Telescope Array.Comment: In Proceedings of the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions at arXiv:1508.0589