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Мультифакторное моделирование атеросклероза на крысах = Multifactorial modeling of atherosclerosis in rats
Authors
I. V. Miastkovskaja
I. V. Savitskiy
A. A. Sliusar
Publication date
31 March 2016
Publisher
Doi
Cite
Abstract
Savitskiy I. V., Sliusar A. A., Miastkovskaja I. V. Мультифакторное моделирование атеросклероза на крысах = Multifactorial modeling of atherosclerosis in rats. Journal of Education, Health and Sport. 2016;6(3):233-240. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.55402 http://ojs.ukw.edu.pl/index.php/johs/article/view/3577 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.03.2016. Revised 20.03.2016. Accepted: 23.03.2016. УДК 616-092.9 Мультифакторное моделирование атеросклероза на крысах И. В. Савицкий, А. А. Слюсарь, И. В. Мястковская Одесский национальный медицинский университет, Одесса, Украина Реферат В статье рассмотрена новая методика экспериментального атеросклероза на крысах линии Wistar, которая берет в своем начале полиэтиологическую теорию развития заболевания. Был проведен эксперимент и полученные результаты оценивали степень взаимодействия факторов нагрузки, которые заключались в одновременной постановке экспериментального гипотиреоза при помощи Мерказолила, иммуносупрессии Метилпреднизолоном на фоне гепатотоксического действия раствора этилового спирта и классической атерогенной диеты. В работе приведены предварительные данные за две недели, которые достигли границы верхней нормы у одной из групп, а так же значительное достоверное повышение уровня ЛПоНП выше нормы. Ключевые слова: экспериментальный атеросклероз, патогенез заболевания, сердечно-сосудистая патология. Multifactorial modeling of atherosclerosis in rats I. V. Savitskiy, A. A. Sliusar, I. V. Miastkovskaja Odessa National Medical University, Odessa, Ukraine Summary The article describes a new method of experimental atherosclerosis in rats of Wistar line, which originates in the theory that disease has a multifactorial ethiology. Experiment and the results can show the interaction of atherogenic factors, which consisted in the simultaneous staging of experimental hypothyroidism using Mercazolilum, methylprednisolone immunosuppression on the background of hepatotoxic action of ethyl alcohol solution and atherogenic diet. This work shows the preliminary data for two weeks, in which the upper border of biochemical rate was reached in one of the groups, as well as a significant increase in the level of VLDL above normal. Keywords: experimental atherosclerosis, the pathogenesis of the disease, cardiovascular disease
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