Who is Worth What? Judge and Advisor Characteristics in a Paid-Advice Judgment Scenario

When making a decision, people often receive advice before settling on a particular course of action. Decision makers exhibit a spectrum of responses to advice, ranging from total rejection to complete acceptance. The purpose of this study is to examine predictors of advice use within a Judge Advisor System (JAS: Sniezek & Buckley, 1995). Prior research has examined a variety of task characteristics, advisor characteristics, and decision maker characteristics (e.g. Bonaccio, 2007; Gino & Moore, 2007; Yaniv & Kleinberger, 2000). In this study, judge characteristics including confidence, accuracy, prior task knowledge, and other individual differences are examined. Advisor characteristics such as advice cost and advisor expertise are manipulated between persons. Results indicated that judge accuracy, confidence, and prior task knowledge were all negatively related to advice utilization. Advice was weighted more heavily when the judge was told that the advice came from an expert than from a novice, but advice cost did not influence advice use. Implications and future research directions are discussed

Trust in Self, Trust in Others: The Impact of Emotions on Advice Behavior

This dissertation proposes that task-specific self-confidence, trust in motives, and trust in competency are the three main drivers for advice use and willingness to pay for advice. After developing this general argument, the paper then focuses on how emotions influence advice use and willingness to pay for advice. Furthermore, this paper argues that the influence of emotions on advice is partially mediated by task specific self-confidence, trust in motives, and trust in competency. This model elaborates on the underlying emotional mechanisms which may guide the mediation paths, and then tests this expected pattern with four different incidental emotions; regret, pride, anger, and gratitude. Four of the studies\u27 six hypotheses regarding trust, self-confidence, and advice behavior were supported. The expected relationships between incidental emotions, mediators, and outcomes did not materialize, suggesting that emotions may need to rise to a certain level of salience in order to impact advice behavior. Implications of these findings are discussed

Spirality: A Novel Way to Measure Spiral Arm Pitch Angle

We present the MATLAB code Spirality, a novel method for measuring spiral arm pitch angles by fitting galaxy images to spiral templates of known pitch. Computation time is typically on the order of 2 minutes per galaxy, assuming at least 8 GB of working memory. We tested the code using 117 synthetic spiral images with known pitches, varying both the spiral properties and the input parameters. The code yielded correct results for all synthetic spirals with galaxy-like properties. We also compared the code's results to two-dimensional Fast Fourier Transform (2DFFT) measurements for the sample of nearby galaxies defined by DMS PPak. Spirality's error bars overlapped 2DFFT's error bars for 26 of the 30 galaxies. The two methods' agreement correlates strongly with galaxy radius in pixels and also with i-band magnitude, but not with redshift, a result that is consistent with at least some galaxies' spiral structure being fully formed by z=1.2, beyond which there are few galaxies in our sample. The Spirality code package also includes GenSpiral, which produces FITS images of synthetic spirals, and SpiralArmCount, which uses a one-dimensional Fast Fourier Transform to count the spiral arms of a galaxy after its pitch is determined. The code package is freely available online; see Comments for URL.Comment: 19 pages, 9 figures, 3 tables. The code package is available at http://dafix.uark.edu/~doug/SpiralityCode

β-catenin and transforming growth factor β have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction

<p>Abstract</p> <p>Background</p> <p>β-catenin and transforming growth factor β signaling are activated in fibroblasts during wound healing. Both signaling pathways positively regulate fibroblast proliferation during this reparative process, and the effect of transforming growth factor β is partially mediated by β-catenin. Other cellular processes, such as cell motility and the induction of extracellular matrix contraction, also play important roles during wound repair. We examined the function of β-catenin and its interaction with transforming growth factor β in cell motility and the induction of collagen lattice contraction.</p> <p>Results</p> <p>Floating three dimensional collagen lattices seeded with cells expressing conditional null and stabilized β-catenin alleles, showed a modest negative relationship between β-catenin level and the degree of lattice contraction. Transforming growth factor β had a more dramatic effect, positively regulating lattice contraction. In contrast to the situation in the regulation of cell proliferation, this effect of transforming growth factor β was not mediated by β-catenin. Treating wild-type cells or primary human fibroblasts with dickkopf-1, which inhibits β-catenin, or lithium, which stimulates β-catenin produced similar results. Scratch wound assays and Boyden chamber motility studies using these same cells found that β-catenin positively regulated cell motility, while transforming growth factor β had little effect.</p> <p>Conclusion</p> <p>This data demonstrates the complexity of the interaction of various signaling pathways in the regulation of cell behavior during wound repair. Cell motility and the induction of collagen lattice contraction are not always coupled, and are likely regulated by different intracellular mechanisms. There is unlikely to be a single signaling pathway that acts as master regulator of fibroblast behavior in wound repair. β-catenin plays dominant role regulating cell motility, while transforming growth factor β plays a dominant role regulating the induction of collagen lattice contraction.</p

Direct measurement of protein-protein interactions by FLIM-FRET at UV laser-induced DNA damage sites in living cells

Protein-protein interactions are essential to ensure timely and precise recruitment of chromatin remodellers and repair factors to DNA damage sites. Conventional analyses of protein-protein interactions at a population level may mask the complexity of interaction dynamics, highlighting the need for a method that enables quantification of DNA damage-dependent interactions at a single-cell level. To this end, we integrated a pulsed UV laser on a confocal fluorescence lifetime imaging (FLIM) microscope to induce localized DNA damage. To quantify protein-protein interactions in live cells, we measured Förster resonance energy transfer (FRET) between mEGFP- and mCherry-tagged proteins, based on the fluorescence lifetime reduction of the mEGFP donor protein. The UV-FLIM-FRET system offers a unique combination of real-time and single-cell quantification of DNA damage-dependent interactions, and can distinguish between direct protein-protein interactions, as opposed to those mediated by chromatin proximity. Using the UV-FLIM-FRET system, we show the dynamic changes in the interaction between poly(ADP-ribose) polymerase 1, amplified in liver cancer 1, X-ray repair cross-complementing protein 1 and tripartite motif containing 33 after DNA damage. This new set-up complements the toolset for studying DNA damage response by providing single-cell quantitative and dynamic information about protein-protein interactions at DNA damage sites

Rewriting Modernity

This article rereads Paul Virilio, drawing on the distinctionbetween topography and topology to argue a case for Virilio as a rewriter of modernity. Invoking Jean-François Lyotard’s notion of rewriting modernity as an unbroken process of accumulation founded on affective life in “Re-writing Modernity” and “Argumentation and Presentation: The Foundation Crisis,” it enlists topology as a horizontal spatial structure that enables us to rethink space, time,and modernity outside the limits of the “squared horizon,” where the“squared horizon” is viewed as a spatial and textual metaphor for framing perspectives on the past, present, and future. The analysis deconstructs the topography of the “squared horizon” as a relationality in an unfolding continuum, where spaces exist ontologically and where the immaterial forces of the dromospheric and the atmospheric generate a relational and historical connectedness