Angiotensin-converting Enzyme Inhibitors Decrease the Risk of Cardiac Rupture after Acute Myocardial Infarction: A Meta-analysis of Randomized Controlled Trials

Background: ACEI therapy decreases mortality in patients with acute MI. However, the effects of ACEIs on CR are unclear. Methods: A comprehensive search of PUBMED, EMBASE, ISI Web of Science, MEDLINE and the Cochrane Register of Controlled Trials before July 2022 was conducted to identify all RCTs on ACEIs that recorded CR as an outcome. Review Manager 5.3 was used to analyze the data. Results: Five RCTs including 26,383 patients with MI were identified; 71 of the 13,159 patients receiving ACEIs and 107 of the 13,224 control patients were verified to have CR. ACEI therapy started within 24 hours after the onset of acute MI significantly decreased the risk of CR, by 33% (RR: 0.67, 95% CI: 0.50–0.90, P=0.008). Conclusions: Early administration of ACEIs (within 24 hours after the onset of acute MI) decreased the incidence of CR in patients with acute MI

Tectonic Proteins Are Important Players in Non-Motile Ciliopathies

Primary cilium is a ubiquitous, tiny organelle on the apex of the mammalian cells. Non-motile (primary) ciliopathies are diseases caused by the dysfunction of the primary cilium and they are characterized by diverse clinical and genetic heterogeneity. To date, nearly 200 genes have been shown to be associated with primary ciliopathies. Among them, tectonic genes are the important causative genes of ciliopathies. Tectonic proteins including TCTN1, TCTN2, and TCTN3 are important component proteins residing at the transition zone of cilia. Indeed, many ciliopathies have been reported to involve tectonics mutations, highlighting a pivotal role for tectonic proteins in ciliary functions. However, the specific functions of tectonic proteins remain largely enigmatic. Herein, we discuss the recent advances on the localization and structure of tectonic proteins and the functions of tectonic proteins. The increasing line of evidences demonstrates that tectonic proteins are required for ciliogenesis and regulate ciliary membrane composition. More importantly, Tectonic proteins play a vital role in the regulation of the Sonic Hedgehog (Shh) pathway; Tectonic deficient mice show the Shh pathway-related developmental defects. Tectonic proteins share similar functions including neural patterning and Gli3 processing but also each has a unique and indispensable role in the ciliogenesis and signaling pathways. At the same time, the mutations of tectonic genes are the causes of a serial of primary ciliopathies including Meckel-Gruber syndrome, Oral-facial-digital syndrome, and Joubert syndrome. Therefore, full understanding of functions of tectonic proteins will help to crack ciliopathies and improve life quality of patients by future gene therapy

The Orbitofrontal Cortex Gray Matter Is Associated With the Interaction Between Insomnia and Depression

Insomnia and depression are highly comorbid symptoms in both primary insomnia (PI) and major depressive disorder (MDD). In the current study, we aimed at exploring both the homogeneous and heterogeneous brain structure alteration in PI and MDD patients. Sixty-five MDD patients and 67 matched PI patients were recruited and underwent a structural MRI scan. The subjects were sub-divided into four groups, namely MDD patients with higher or lower insomnia, and PI patients with higher or lower severe depression. A general linear model was employed to explore the changes in cortical thickness and volume as a result of depression or insomnia, and their interaction. In addition, partial correlation analysis was conducted to detect the clinical significance of the altered brain structural regions. A main effect of depression on cortical thickness was seen in the superior parietal lobe, middle cingulate cortex, and parahippocampal gyrus, while a main effect of insomnia on cortical thickness was found in the posterior cingulate cortex. Importantly, the interaction between depression and insomnia was associated with decreased gray matter volume in the right orbitofrontal cortex, i.e., patients with co-occurring depression and insomnia showed smaller brain volume in the right orbitofrontal cortex when compared to patients with lower insomnia/depression. These findings highlighted the role of the orbitofrontal cortex in the neuropathology of the comorbidity of insomnia and depression. Our findings provide new insights into the understanding of the brain mechanism underlying comorbidity of insomnia and depression

Uncovering the Functional Link Between SHANK3 Deletions and Deficiency in Neurodevelopment Using iPSC-Derived Human Neurons

SHANK3 mutations, including de novo deletions, have been associated with autism spectrum disorders (ASD). However, the effects of SHANK3 loss of function on neurodevelopment remain poorly understood. Here we generated human induced pluripotent stem cells (iPSC) in vitro, followed by neuro-differentiation and lentivirus-mediated shRNA expression to evaluate how SHANK3 knockdown affects the in vitro neurodevelopmental process at multiple time points (up to 4 weeks). We found that SHANK3 knockdown impaired both early stage of neuronal development and mature neuronal function, as demonstrated by a reduction in neuronal soma size, growth cone area, neurite length and branch numbers. Notably, electrophysiology analyses showed defects in excitatory and inhibitory synaptic transmission. Furthermore, transcriptome analyses revealed that multiple biological pathways related to neuron projection, motility and regulation of neurogenesis were disrupted in cells with SHANK3 knockdown. In conclusion, utilizing a human iPSC-based neural induction model, this study presented combined morphological, electrophysiological and transcription evidence that support that SHANK3 as an intrinsic, cell autonomous factor that controls cellular function development in human neurons

The Evolution of Primate Short-Term Memory.

Short-term memory is implicated in a range of cognitive abilities and is critical for understanding primate cognitive evolution. To investigate the effects of phylogeny, ecology and sociality on short-term memory, we tested the largest and most diverse primate sample to date (421 non-human primates across 41 species) in an experimental delayed-response task. Our results confirm previous findings that longer delays decrease memory performance across species and taxa. Our analyses demonstrate a considerable contribution of phylogeny over ecological and social factors on the distribution of short-term memory performance in primates; closely related species had more similar short-term memory abilities. Overall, individuals in the branch of Hominoidea performed better compared to Cercopithecoidea, who in turn performed above Platyrrhini and Strepsirrhini. Interdependencies between phylogeny and socioecology of a given species presented an obstacle to disentangling the effects of each of these factors on the evolution of short-term memory capacity. However, this study offers an important step forward in understanding the interspecies and individual variation in short-term memory ability by providing the first phylogenetic reconstruction of this trait’s evolutionary history. The dataset constitutes a unique resource for studying the evolution of primate cognition and the role of short-term memory in other cognitive abilities.info:eu-repo/semantics/publishedVersio

The Evolution of Primate Short-Term Memory

Short-term memory is implicated in a range of cognitive abilities and is critical for understanding primate cognitive evolution. To investigate the effects of phylogeny, ecology and sociality on short-term memory, we tested the largest and most diverse primate sample to date (421 non-human primates across 41 species) in an experimental delayed-response task. Our results confirm previous findings that longer delays decrease memory performance across species and taxa. Our analyses demonstrate a considerable contribution of phylogeny over ecological and social factors on the distribution of short-term memory performance in primates; closely related species had more similar short-term memory abilities. Overall, individuals in the branch of Hominoidea performed better compared to Cercopithecoidea, who in turn performed above Platyrrhini and Strepsirrhini. Interdependencies between phylogeny and socioecology of a given species presented an obstacle to disentangling the effects of each of these factors on the evolution of short-term memory capacity. However, this study offers an important step forward in understanding the interspecies and individual variation in short-term memory ability by providing the first phylogenetic reconstruction of this trait’s evolutionary history. The dataset constitutes a unique resource for studying the evolution of primate cognition and the role of short-term memory in other cognitive abilities

Impacts of educational factors on economic growth in regions of China: a spatial econometric approach

This paper investigates the impacts of educational factors on economic growth across 31 provinces during 1996 and 2010 in China. A spatial panel estimation model is applied to study the impacts of education on economic growth taking into account the spatial spillover effects in Feder model and the cumulative effect. The results reveal that (1) educational factors are significantly spatially autocorrelated. Educational factors have spatial spillover effects. Regional differences of education impacts still exist. (2) Average schooling year has a more positive effect on economic output than capital investment and labor force. Basic education might play a more important role in economic growth. (3) Education sector also benefits non-education sectors on economic growth if “spatial effects of economic shocks” are considered. Some policies that may enhance education development and their impacts on economic growth are proposed. First published online: 21 Sep 201

Efficient approximating the most-probable-point trajectory method for time-variant reliability analysis

When solving complex time-variant reliability analysis（TRA）problems，the traditional TRA methods have the problem of low solving efficiency. Based on the approximating most-probable-points trajectory （AMPPT）method，the efficient approximating the most-probable-point trajectory（EAMPPT）method for TRA is proposed. According to the characteristics that the reliability of weakest part of the system determines the reliability of the system，EAMPPT takes full account of prediction values and their errors in the process of approximating the most-probable-point trajectory. The mathematical example is used to verify the effectiveness of the adaptive sampling method. EAMPPT is applied to solve TRA problems involving hydrokinetic turbine blades and the wing of the reusable aerospace during reenter. The results show that the calculation accuracy of the proposed EAMPPT and time-discretization based TRA method is similar，but the number of performance function evaluations of EAMPPT is less than 3% of traditional TDTRA

Structure characteristics and formation mechanism of the RCEP manufacturing trade network: an ERGM analysis

The entry into force of the Regional Comprehensive Economic Partnership (RCEP) on January 1st, 2022 marked the official launch of the world's largest free trade area. The RCEP agreement will gradually release its strengths to the regional trade development and finally become one of the most important economic growth polarities. In this article, the complex network theory was introduced in the analysis of regional trade patterns and the investigation of trade relation-formation mechanisms. Based on the RCEP agreement, we constructed the manufacturing trade networks at both national and industrial levels, meanwhile, we explored the node and network characteristics combining with centrality, density, reciprocity, and distance indicators. Furthermore, by using the significance testing of the three-node motifs, we recognized the main trade patterns of the RCEP manufacturing trade. Finally, we established the exponential random graph model(ERGM) and performed an empirical analysis to conduct the formation mechanisms of the RCEP manufacturing trade networks. The results provided that the integrated trade pattern had a strong positive effect on the relation formation, while the imbalanced trade pattern was not easy to form the trading relationship

Perceptual Grouping for War and Peace

In a ground war, achieving peace is challenging even when both sides suffer. Here we demonstrate that when humans jointly viewed a battlefield as perceptually grouped by colors, a factor irrelevant to the rules of land-war games, they waged fewer wars and accumulated more wealth due to the perceptual border’s constraint on their aggression. This facilitation of peace arose from perceptual grouping that serves as a visual common sense shared by humans, as a mismatched perceptual grouping between players failed to limit war. Moreover, it relies on the geopolitical principles that make ground wars destructive and disappeared when these principles were violated. Together, we show that perceptual grouping limits human ground war as it is a mutually acknowledged “rallying point” where expectations of peace converge