Malignant Metastatic Insulinoma in a Dog

Background: Insulinomas are tumors of the pancreatic islet beta cells that secreting insulin. They are malignant neoplasms and rarely seen in dogs. Because insulinomas secrete excessive insulin and hypoglycemia occur. The most common clinical symptoms are seizures, extreme weakness, and other neurological abnormalities. The tumors typically release insulin episodically, with clinical signs being seen intermittently as a result. These are most often associated with prolonged starvation or prolonged periods of exertion. Insulinoma occurs most often in middle-aged and older dogs, averaging nine years in age. They affect both sexes and are more likely in larger breeds. The most commonly afflicted breeds are German Shepherds, Irish Setters, Boxers, Golden Retrievers and Terriers. Case: In this study, a case of malignant insulinoma with multiorgan metastasis in a 7-year-old hunting dog that brought to the clinic with complaints of constipation and inappetence were evaluated by clinical, cytological, histopathological and immunohistochemical fndings. Owner stated that the animal suffers from constipation for 4 days, but no vomitus or nervous symptoms were present. Clinical efforts not solved the constipation. For to the defnitive diagnosis the dog decided to underwent laparotomy. After a midline abdominal approach multiple whitish, hard and irregular metastatic tumoral masses were observed in different abdominal organs. Because of the poor prognosis and according to owner’s acceptance the dog euthanatized at the same time. At necropsy, a bloody serous fluid approximately 500 mL was found in the abdominal cavity. The intestines were hyperemic and hemorrhagic in some areas. A hemorrhagic 9x5x3 cm in diameter mass was observed on the pancreas. Mesenterial adhesions were formed due to mass between duodenum and jejunum. The mass was moderately hard and cut surface was bloody, necrosis was observed in some areas. At the gross examination, whitish color, various sized and multiple metastatic masses were noted in spleen, liver, lymph nodes and lungs. Before formalin fxation, impression smears were made from the pancreatic mass. In cytological preparations of the lesion, epithelial cells in different shapes and sizes were observed. At the histopathological examination, the tumor mass consisted of anaplastic, pleomorphic cells that have pale cytoplasm, vesicular nucleus and prominent nucleolus. Diffuse necrotic areas were noted in the mass. Similar metastatic masses were seen in liver, spleen, lungs and kidneys. The tumor cells were positive for insulin and negative for glucagon immunohistochemically. Discussion: Insulinomas generally caused nervous symptoms due to hypoglycemia. Metastasis may occur in some cases and generally lymph node metastasis occurs. Spleen metastasis are very rare in insulinoma cases. The mean age of the occurrence of insulinoma is generally older than 9-year-old. In this case, a case of malignant insulinoma with multiorgan metastasis and caused constipation due to intestinal adhesions in a dog was presented with clinical and pathological fndings. Best of the author’s knowledge insulinoma as a cause of constipation not previously reported in a dog. The aim of this study was to report a case of metastatic insulinoma without neurological symptoms but constipation in a 7 years old hunting dog by clinical, pathological, cytological and immunohistochemical fndings. Keywords: Malignant insulinoma, constipation, cytology, histopathology, immunohistochemistry, dog

The Influence of Hyperbaric Oxygen Treatment on the Healing of Experimental Defects Filled with Different Bone Graft Substitutes

To assess potential effects of hyperbaric oxygen (HBOT) on artificial bone grafts, β - Tricalcium phosphate (β-TCP) and calcium phosphate coated bovine bone (CPCBB) substitutes were applied to standard bone defects in rat tibiae. The control defects were left empty. Half of the animals received 60 minutes of 2.4 atmosphere absolute (ATA) of HBOT. Rats were sacrificed at one, two and four weeks. Bone healing was assessed histologically and histomorphometrically using light microscopy. The periosteum over the bone defects was examined ultrastructurally. Cardiac blood was collected to determine the serum osteocalcin levels. The HBOT increased new bone formation in the unfilled controls and β-TCP groups and significantly decreased cartilage matrix and fibrous tissue formations in all groups. Active osteoblasts and highly organized collagen fibrils were prominent in the periosteum of β-TCP and control groups. Serum osteocalcin levels also increased with HBOT. The healing of defects filled with CPCBB was similar to the controls and it did not respond to HBOT. These findings suggested that the HBOT had beneficial effects on the healing of unfilled bone defects and those filled with β-TCP bone substitute but not with CPCBB, indicating a material-specific influence pattern of HBOT

Behavioral aspects of regulation: A discussion on switching and demand response in Turkish electricity market

Electricity sector has been transformed from state-owned monopolistic utilities to competitive markets with an aim to promote incentives for improving efficiency, reducing costs and increasing service quality to customers. One of the cardinal assumptions of the liberalized and competitive electricity markets is the rational actor, and decision-makers are assumed to make the best decisions that maximize their utility. However, a vast literature on behavioral economics has shown the weakness of economic theory in explaining and predicting individuals’ decision-making behavior. This issue is quite important for competition in electricity markets in which consumers’ preferences have a significant role. Despite its importance, this issue has almost been neglected in Turkey, which has taken major steps in electricity sector restructuring. Therefore, this paper aims to examine switching and demand response behavior in Turkish electricity market by using multiple correspondence and panel data analysis, and findings are discussed in light of the neoclassical and behavioral economics literature. Analyses’ results show that consumers’ switching and demand response behavior is consistent with the neoclassical literature to some extent; however, behavioral factors are also affecting consumers’ decisions. Furthermore, there are systemic problems that hinder effective functioning of the electricity market and restrict competition

Malignant Metastatic Insulinoma in a Dog

Background: Insulinomas are tumors of the pancreatic islet beta cells that secreting insulin. They are malignant neoplasms and rarely seen in dogs. Because insulinomas secrete excessive insulin and hypoglycemia occur. The most common clinical symptoms are seizures, extreme weakness, and other neurological abnormalities. The tumors typically release insulin episodically, with clinical signs being seen intermittently as a result. These are most often associated with prolonged starvation or prolonged periods of exertion. Insulinoma occurs most often in middle-aged and older dogs, averaging nine years in age. They affect both sexes and are more likely in larger breeds. The most commonly afflicted breeds are German Shepherds, Irish Setters, Boxers, Golden Retrievers and Terriers. Case: In this study, a case of malignant insulinoma with multiorgan metastasis in a 7-year-old hunting dog that brought to the clinic with complaints of constipation and inappetence were evaluated by clinical, cytological, histopathological and immunohistochemical fndings. Owner stated that the animal suffers from constipation for 4 days, but no vomitus or nervous symptoms were present. Clinical efforts not solved the constipation. For to the defnitive diagnosis the dog decided to underwent laparotomy. After a midline abdominal approach multiple whitish, hard and irregular metastatic tumoral masses were observed in different abdominal organs. Because of the poor prognosis and according to owner’s acceptance the dog euthanatized at the same time. At necropsy, a bloody serous fluid approximately 500 mL was found in the abdominal cavity. The intestines were hyperemic and hemorrhagic in some areas. A hemorrhagic 9x5x3 cm in diameter mass was observed on the pancreas. Mesenterial adhesions were formed due to mass between duodenum and jejunum. The mass was moderately hard and cut surface was bloody, necrosis was observed in some areas. At the gross examination, whitish color, various sized and multiple metastatic masses were noted in spleen, liver, lymph nodes and lungs. Before formalin fxation, impression smears were made from the pancreatic mass. In cytological preparations of the lesion, epithelial cells in different shapes and sizes were observed. At the histopathological examination, the tumor mass consisted of anaplastic, pleomorphic cells that have pale cytoplasm, vesicular nucleus and prominent nucleolus. Diffuse necrotic areas were noted in the mass. Similar metastatic masses were seen in liver, spleen, lungs and kidneys. The tumor cells were positive for insulin and negative for glucagon immunohistochemically. Discussion: Insulinomas generally caused nervous symptoms due to hypoglycemia. Metastasis may occur in some cases and generally lymph node metastasis occurs. Spleen metastasis are very rare in insulinoma cases. The mean age of the occurrence of insulinoma is generally older than 9-year-old. In this case, a case of malignant insulinoma with multiorgan metastasis and caused constipation due to intestinal adhesions in a dog was presented with clinical and pathological fndings. Best of the author’s knowledge insulinoma as a cause of constipation not previously reported in a dog. The aim of this study was to report a case of metastatic insulinoma without neurological symptoms but constipation in a 7 years old hunting dog by clinical, pathological, cytological and immunohistochemical fndings. Keywords: Malignant insulinoma, constipation, cytology, histopathology, immunohistochemistry, dog

Behavioral aspects of regulation: A discussion on switching and demand response in Turkish electricity market

Electricity sector has been transformed from state-owned monopolistic utilities to competitive markets with an aim to promote incentives for improving efficiency, reducing costs and increasing service quality to customers. One of the cardinal assumptions of the liberalized and competitive electricity markets is the rational actor, and decision-makers are assumed to make the best decisions that maximize their utility. However, a vast literature on behavioral economics has shown the weakness of economic theory in explaining and predicting individuals' decision-making behavior. This issue is quite important for competition in electricity markets in which consumers' preferences have a significant role. Despite its importance, this issue has almost been neglected in Turkey, which has taken major steps in electricity sector restructuring. Therefore, this paper aims to examine switching and demand response behavior in Turkish electricity market by using multiple correspondence and panel data analysis, and findings are discussed in light of the neoclassical and behavioral economics literature. Analyses' results show that consumers' switching and demand response behavior is consistent with the neoclassical literature to some extent; however, behavioral factors are also affecting consumers' decisions. Furthermore, there are systemic problems that hinder effective functioning of the electricity market and restrict competition

An analysis of oral radiographic findings and their interpretations in women with eating disorders

Background/Purpose: Eating disorders (EDs) are life-threatening conditions that mainly affect women and can be diagnosed early by dental professionals. The aims of this study were to examine the oral radiographic status of ED patients and compare the performances of dental professionals from different backgrounds in interpreting these findings

Clinical and Surgical Evaluation of Perineal Hernia in Dogs: 41 Cases

Besalti, Omer/0000-0002-7819-9094;WOS: 000278958100007The purpose of the study was to report the clinical and surgical records of perineal hernia and associated rectal pathology with epidural morphine analgesia in 41 dogs. Fourty one dogs suffered from perineal hernia were included into the study with the age varied from 4.5 to 16 years. Eleven dogs had bilateral while the other 30 had unilateral (17 right, 13 left) perineal hernia. The clinical signs were perianal swelling (n=41), severe tenesmus (n=19), dyschesia (n=9), proctitis (n=7), fecal incontinence (n=4), stranguria (n=2) and hematuria (n=1). Associated rectal pathologies were diverticulation (n=15), dilatation (n=4), deviation (n=3) and sacculation (n=1). The rectal diverticulum was corrected by extraluminal plication (n=12) or rectal resection (n=3). Internal obturator muscle flap transposition was used to repair the hernia in all cases. Postoperative pain was subjectively evaluated and scores were "no pain" in 10 cases, mild in 28 cases, moderate in 3 cases. Mean follow-up time was 27.3 months (range 4 months to 5 years) and the recurrence was observed only in three cases postoperatively. In conclusion, combined perineal herniorraphy with internal obturator muscle transposition and rectal wall repairment can be carried out at the same time and epidural morphine administration provide adequate analgesia for these operations

Magnetic Resonance Imaging Findings of Intracranial Tumors in Dogs: A Review of 26 Cases

WOS: 000266439500003The aim of this study was to report the magnetic resonance imaging (MRI) findings of intracranial tumors in 26 dogs. The medical records of dogs admitted to the Department of Surgery, Faculty of Veterinary Medicine, Ankara University for central nervous system disorders were reviewed, and dogs with intracranial tumors that were diagnosed with MRI between November 1997 and June 2006 were included in the study. MR images were obtained as T1 weighted (T1W), T2 weighted (T2W), and contrast enhanced T1 weighted (following Gd-DTPA administration) in the transverse, coronal (dorsal), and sagittal planes. The following features were evaluated in order to characterize the lesions and to establish diagnoses based on radiological findings: site of origin, anatomic location, signal characteristics on T1W and T2W images, contrast enhancement, shape and size, number (multiple or single), and presence of edema and midline shift. The radiological diagnoses were as follows: intracranially invading sinus tumor (n = 3), meningioma (n = 7), choroid plexus tumor or ependymoma (n = 3), ependymoma (n = 1), glioma (n = 5), metastatic tumor (n = 3), astrocytoma (n = 1), astrocytoma or metastasis (n = 1), cavernoma (n = 1), and hypophyseal adenoma (n = 1). In conclusion, lesions occupying the intracranial space can be accurately diagnosed and tumor type can be predicted with MRI

An analysis of oral radiographic findings and their interpretations in women with eating disorders

AbstractBackground/PurposeEating disorders (EDs) are life-threatening conditions that mainly affect women and can be diagnosed early by dental professionals. The aims of this study were to examine the oral radiographic status of ED patients and compare the performances of dental professionals from different backgrounds in interpreting these findings.Materials and methodsIn total, 72 women with EDs and healthy controls matched by age, sex, educational status, and smoking status were included in the project. Standardized full-mouth intraoral periapical radiography with a bisecting-angle technique and digital panoramic imaging were performed in all participants. Five observers independently interpreted the tooth status, the condition of the periapical tissues, and the third molars.ResultsScores for intra- and interobserver consistency were acceptable and were 0.76 and 0.92, respectively. The ED group consumed a larger daily amount of acidic beverages (P < 0.05) than the controls, and a significant positive correlation was observed between the daily acidic-beverage intake and the frequency of vomiting (P < 0.05). In the ED group, the mean number of teeth with untreated carious lesions (P < 0. 01), particularly in the posterior mandibular region (P < 0.05) and periapical pathologies requiring treatment (P < 0.05), were significantly higher compared with healthy individuals. However, the radiographic depth-progression pattern of the carious lesions was similar in the two groups.ConclusionThe presence of radiographically detectable caries and periapical lesions makes ED patients more susceptible to the risk of losing their functional teeth over time, especially when considered together with their inadequate oral hygiene practices and acidic-beverage consumption. Nonetheless, dental professionals with different backgrounds can interpret such radiographic findings with similar efficiency