Entorno educativo digital como herramienta de cambios complejos de la actividad pedagógica del profesor

The authors of the article identified four basic functions of the use of information technology in the course of training future representatives of a profession: information and training, forming, evaluation and correction, research.  It is noted that these functions do not operate separately, but as elements of a single system, depending on the conditions determined by the features of the information EE. The analysis allows the authors of the article to assert that at this stage of the educational process evolution the main task is to create a methodology related to the use of information management technologies in the development of electronic materials of educational nature and their implementation in the context of pedagogical activity.Los autores del artículo identificaron cuatro funciones básicas del uso de la tecnología de la información en el curso de la capacitación de futuros representantes de una profesión: información y capacitación, formación, evaluación y corrección, investigación. Cabe señalar que estas funciones no funcionan por separado, sino como elementos de un solo sistema, dependiendo de las condiciones determinadas por las características de la información EE. El análisis permite a los autores del artículo afirmar que en esta etapa de la evolución del proceso educativo, la tarea principal es crear una metodología relacionada con el uso de tecnologías de gestión de la información en el desarrollo de materiales electrónicos de naturaleza educativa y su implementación en el contexto de actividad pedagógica

Efficiency analysis of seaports in Russia's Baltic basin: performance evaluation

This research presents a comprehensive analysis of the performance efficiency of Russia's Baltic seaports, taking into account various economic indicators and addressing investment planning and management issues. Special attention is given to the sustainable development goals and objectives of the seaports, considering their significance in transport and logistics systems. The primary objective of this work is to develop a system approach for conducting multi-­criteria studies on seaport performance efficiency. The findings obtained through the proposed methodology consider criteria at different levels of seaport management, offering valuable practical implications. Notably, this study fills a gap in the literature as no previous work has provided a comprehensive methodology for studying and analyzing ports from the perspectives of management, logistics, and macroeconomics. The system approach can also incorporate environmental considerations and innovative solutions in port infrastructure management. By proposing a new approach to interpreting statistics on Baltic seaports' performance and presenting empirical research on sustainable development in transport and logistics systems, this study enables a multidimensional examination of seaport performance and establishes a framework for efficiency analysis and evaluation, which is crucial for effective management. The methodological scheme and algorithm for analyzing different categories of managers further facilitate the practical application of the approach. Moreover, it can serve as a strategic tool for informing regional economic policies regarding logistics and transportation

A new polymorphic material? Structural degeneracy of ZrMn_2

Based on density functional calculations, we propose that ZrMn_2 is a polymorphic material. We predict that at low temperatures the cubic C15, and the hexagonal C14 and C36 structures of the Laves phase compound ZrMn_2 are nearly equally stable within 0.3 kJmol^{-1} or 30 K. This degeneracy occurs when the Mn atoms magnetize spontaneously in a ferromagnetic arrangement forming the states of lowest energy. From the temperature dependent free energies at T approx 160K we predict a transition from the most stable C15 to the C14 structure, which is the experimentally observed structure at elevated temperatures.Comment: 4 pages, 3 figure

The State Administration of the German Colonies of the Russian Empire in the Second Half of the Nineteenth Century

The article was submitted on 13.01.2021.Немецкая миграция в Российское государство имеет давнюю историю. В период с XVI до середины XVIII в. в России поселяются военнопленные, захваченные в ходе Ливонской войны (1558–1583), лица, приглашенные в Россию московскими великими князьями и российскими царями (Иваном III, Иваном IV, Петром I и др.). Во второй половине XVIII в. переселение немцев в Россию становится направлением миграционной политики государства, определившим судьбу одного из самых многочисленных этнических меньшинств в империи на многие десятилетия. В статье рассматривается проблема изменения мер государственного управления в отношении немецких сельских поселений в Российской империи во второй половине XIX в. Этот период является исторически важным в определении правового статуса иностранных колоний в государстве в связи с принятием Устава о колониях 1857 г., в котором подробным образом регламентировались права и обязанности иностранных колонистов. Одними из задач политических, экономических и социальных реформ 60–70‑х гг. XIX в. были унификация сельского населения и ликвидация факторов социальной исключительности иностранных колонистов. Прагматичный подход в государственной политике по использованию колонистов для заселения и рационального освоения пустующих территорий в империи принес положительные результаты по развитию этих регионов. Представленный исторический анализ позволил рассмотреть меры, принимавшиеся российской властью по упорядочиванию законодательного установления и применения норм и правил хозяйственной, административной, бытовой, духовной жизни немецких колонистов. С помощью сравнительного ана-лиза исследованы изменения государственной политики по отношению к иностранным колонистам, отмена льгот и привилегий в результате принятия закона «Высочайше утвержденные правила об устройстве поселян-собственников (бывших колонистов)» от 4 июня 1871 г. Исследование позволило оценить влияние масштабных управленческих преобразований в государстве на различные сферы жизни и деятельности отдельной категории населения Российской империи – немецких колонистов.German migration to the Russian state has a long history. Between the sixteenth and the mid-eighteenth centuries, prisoners of war captured during the Livonian War (1558–1583) and persons invited to Russia by the Muscovite grand princes and Russian tsars (Ivan III, Ivan IV, Peter I, etc.) settled in Russia. In the second half of the eighteenth century, the resettlement of Germans became part of the state’s migration policy, which determined the fate of one of the empire’s most numerous ethnic minorities for many decades. This article deals with changes to the administration of German rural settlements in the Russian Empire in the second half of the nineteenth century. This period was important for the legal status of foreign colonies due to the adoption of the Statute of Colonies of 1857, which provided detailed regulation of the rights and obligations of foreign colonists. One of the tasks of the political, economic, and social reforms of the 1860s–1870s was the unification of the rural population and the elimination of the social exclusivity of foreign colonists. A pragmatic approach regarding the use of colonists for the settlement and rational development of empty territories brought positive results for these regions. The analysis here makes it possible to consider the measures taken by the Russian authorities to streamline the legislation, norms, and rules for the economic, administrative, everyday, and spiritual life of German colonists. With the help of comparative analysis, the authors study changes in state policy towards foreign colonists and the abolition of privileges as a result of the adoption of the law “the supremely approved rules about the management of settler-owners (former colonists)” on 4 June 1871. The study makes it possible to assess the impact of large-scale administrative changes on various spheres of life and activities of the German colonists, a separate category of the Russian Empire’s population.Статья подготовлена при финансовой поддержке РФФИ и БРФФИ в рамках научного проекта № 20–59–00010 «Этнические меньшинства в Беларуси и России в условиях общественных трансформаций 19–20 вв.».The reported study was funded by RFBR and BRFBR, project number 20–59–00010 “Ethnic minorities in Belarus and Russia in the conditions of social transformations of the XIX–XX centuries”

Protonation States of Remote Residues Affect Binding-Release Dynamics of the Ligand but not the Conformation of apo Ferric Binding Protein

We have studied the apo (Fe3+ free) form of periplasmic ferric binding protein (FbpA) under different conditions and we have monitored the changes in the binding and release dynamics of H2PO4- that acts as a synergistic anion in the presence of Fe3+. Our simulations predict a dissociation constant of 2.2$\pm$0.2 mM which is in remarkable agreement with the experimentally measured value of 2.3$\pm$0.3 mM under the same ionization strength and pH conditions. We apply perturbations relevant for changes in environmental conditions as (i) different values of ionic strength (IS), and (ii) protonation of a group of residues to mimic a different pH environment. Local perturbations are also studied by protonation or mutation of a site distal to the binding region that is known to mechanically manipulate the hinge-like motions of FbpA. We find that while the average conformation of the protein is intact in all simulations, the H2PO4- dynamics may be substantially altered by the changing conditions. In particular, the bound fraction which is 20$\%$ for the wild type system is increased to 50$\%$ with a D52A mutation/protonation and further to over 90$\%$ at the protonation conditions mimicking those at pH 5.5. The change in the dynamics is traced to the altered electrostatic distribution on the surface of the protein which in turn affects hydrogen bonding patterns at the active site. The observations are quantified by rigorous free energy calculations. Our results lend clues as to how the environment versus single residue perturbations may be utilized for regulation of binding modes in hFbpA systems in the absence of conformational changes.Comment: 26 pages, 4 figure

Computational Approaches and Analysis for a Spatio-Structural-Temporal Invasive Carcinoma Model

Spatio-temporal models have long been used to describe biological systems of cancer, but it has not been until very recently that increased attention has been paid to structural dynamics of the interaction between cancer populations and the molecular mechanisms associated with local invasion. One system that is of particular interest is that of the urokinase plasminogen activator (uPA) wherein uPA binds uPA receptors on the cancer cell surface, allowing plasminogen to be cleaved into plasmin, which degrades the extracellular matrix and this way leads to enhanced cancer cell migration. In this paper, we develop a novel numerical approach and associated analysis for spatio-structuro-temporal modelling of the uPA system for up to two-spatial and two-structural dimensions. This is accompanied by analytical exploration of the numerical techniques used in simulating this system, with special consideration being given to the proof of stability within numerical regimes encapsulating a central differences approach to approximating numerical gradients. The stability analysis performed here reveals instabilities induced by the coupling of the structural binding and proliferative processes. The numerical results expound how the uPA system aids the tumour in invading the local stroma, whilst the inhibitor to this system may impede this behaviour and encourage a more sporadic pattern of invasion.PostprintPeer reviewe

Dizaj i statistička optimizacija liposfera s glipizidom pomoću metodologije odgovora površine

A 32 factorial design was employed to produce glipizide lipospheres by the emulsification phase separation technique using paraffin wax and stearic acid as retardants. The effect of critical formulation variables, namely levels of paraffin wax (X1) and proportion of stearic acid in the wax (X2) on geometric mean diameter (dg), percent encapsulation efficiency (% EE), release at the end of 12 h (rel12) and time taken for 50% of drug release (t50), were evaluated using the F-test. Mathematical models containing only the significant terms were generated for each response parameter using the multiple linear regression analysis (MLRA) and analysis of variance (ANOVA). Both formulation variables studied exerted a significant influence (p < 0.05) on the response parameters. Numerical optimization using the desirability approach was employed to develop an optimized formulation by setting constraints on the dependent and independent variables. The experimental values of dg, % EE, rel12 and t50 values for the optimized formulation were found to be 57.54 ± 1.38 µm, 86.28 ± 1.32 %, 77.23 ± 2.78 % and 5.60 ± 0.32 h, respectively, which were in close agreement with those predicted by the mathematical models. The drug release from lipospheres followed first-order kinetics and was characterized by the Higuchi diffusion model. The optimized liposphere formulation developed was found to produce sustained anti-diabetic activity following oral administration in rats.32 faktorijalni dizajn primijenjen je za pripravu liposfera s glipizidom metodom separacije pomoću emulzija koristeći parafinski vosak i starinsku kiselinu kao tvari za usporavanje. Pomoću F-testa praćen je učinak kritičnih varijabli tijekom formuliranja, tj. količina parafinskog voska (X1) i udio stearinske kiseline (X2) na srednji promjer liposfera (dg), postotak inkapsulirane ljekovite tvari (% EE), oslobađanje ljekovite tvari nakon 12 h (rel12) te vrijeme potrebno za oslobađanje 50% ljekovite tvari (t50). Pomoću multiple linearne regresijske analize (MLRA) i analize varijabli (ANOVA) za svaki su parametar načinjeni matematički modeli koji sadrže samo značajne varijable. Proučavanje varijabli na oba načina ukazalo je na njihov značajan utjecaj (p < 0,05) na parametre liposfera. Postavljanjem ograničenja na zavisne i nezavisne varijable provedena je numerička optimizacija na principu poželjnosti. Eksperimentalne vrijednosti dg, % EE, rel12 i t50 optimiziranih formulacija bile su 57,54 ± 1,38 µm, 86,28 ± 1,32%, 77,23 ± 2,78% i 5,60 ± 0,32 h. Dobivene eksperimentalne vrijednosti iznosile su vrlo slične vrijednostima predviđenim matematičkim modelima. Oslobađanje glipizida iz liposfera slijedio je kinetiku prvog reda i okarakterizirano je Higuchijevim difuzijskim modelom. Optimizirane liposfere su nakon peroralne primjene na štakorima pokazale produljeni antidijabetički učinak

Оптимизация конструкции захвата для детали «Барабан»

Грузозахватные приспособления обычно применяются при производстве работ по подъему и перемещению грузов с применением грузоподъемных машин. Использование приспособлений позволяет реализовать максимальное удобство и безопасность производственного процесса. Грузозахватные приспособления конструируются для определенного этапа технологического процесса, для конкретного изделия. При проектировании таких приспособлений необходимо учитывать основные показатели оптимальности конструкции: прочность, надежность, простота, удобство и безопасность при эксплуатации, эргономичность. Кроме того, нужно стремиться к наименьшей массе и, соответственно, металлоемкости захвата. Конструкция грузозахватного приспособления, в основном, будет зависеть от назначенных технологом поверхностей, за которые можно крепиться и от максимальной высоты подъема крюка крана. В статье описана задача по конструированию захвата для детали «Барабан¬ в новом технологическом процессе. Рассмотрена конструкция существующего захвата, взятого за прототип. Приведен анализ различных вариантов конструктивных решений, созданных в процессе проектирования. Выбран вариант конструкции захвата, который в наибольшей степени соответствует требованиям технического задания. Конструкция этого модернизированного приспособления представляет собой захват с тремя лапами, удерживающими деталь, и подвес в виде траверсы. Разработанная конструкторская документация утверждена производством и отделом промышленной безопасности