7,764 research outputs found
PM4 SMP model proposed for system reliability criticality assessment and maintainability improvement
PhyME: A probabilistic algorithm for finding motifs in sets of orthologous sequences
BACKGROUND: This paper addresses the problem of discovering transcription factor binding sites in heterogeneous sequence data, which includes regulatory sequences of one or more genes, as well as their orthologs in other species. RESULTS: We propose an algorithm that integrates two important aspects of a motif's significance β overrepresentation and cross-species conservation β into one probabilistic score. The algorithm allows the input orthologous sequences to be related by any user-specified phylogenetic tree. It is based on the Expectation-Maximization technique, and scales well with the number of species and the length of input sequences. We evaluate the algorithm on synthetic data, and also present results for data sets from yeast, fly, and human. CONCLUSIONS: The results demonstrate that the new approach improves motif discovery by exploiting multiple species information
Large Mass Diphotons From Relativistic Heavy Ion Collisions
We evaluate the production of large mass diphotons from quark annihilation at
BNL RHIC and CERN LHC energies from central collisions of gold nuclei. The
collision is assumed to lead to either a thermally and chemically equilibrated
quark gluon plasma, or a free-streaming quark gluon gas having an identical
initial entropy, or a chemically equilibrating quark gluon system, with the
same entropy at . We also obtain an estimate of hard photon pairs from
initial state quark annihilation and find that the thermal production dominates
the yield up to 4 GeV at RHIC, and up to 6 GeV at LHC. A simulation
study of decay versus thermal diphotons is presented.Comment: Latex file; to appear in Physics Letters
Contemporary visions of masculinity
ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΡΠ·Π°Π½Π° Ρ ΠΏΠ΅ΡΠ΅ΡΠΌΠΎΡΡΠΎΠΌ ΠΎΠ±ΡΠ°Π·Π° Β«Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ ΠΌΡΠΆΡΠΈΠ½ΡΒ» Π² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΠΎΠ±ΡΠ΅ΡΡΠ²Π΅. ΠΠΎ Π²ΡΠΎΡΠΎΠΉ ΠΏΠΎΠ»ΠΎΠ²ΠΈΠ½Π΅ XX Π². ΡΠ²Π½ΠΎ ΠΏΡΠΎΡΠ²Π»ΡΠ΅ΡΡΡ ΠΊΡΠΈΠ·ΠΈΡ ΠΌΠ°ΡΠΊΡΠ»ΠΈΠ½Π½ΠΎΡΡΠΈ, ΠΊΠΎΡΠΎΡΡΠΉ Π²ΡΡΠ°ΠΆΠ°Π΅ΡΡΡ Π² ΡΠ°Π·ΠΌΡΠ²Π°Π½ΠΈΠΈ/ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ΅ΡΠΈΠ²ΠΎΡΡΠΈ ΡΡΠ΅Π±ΠΎΠ²Π°Π½ΠΈΠΉ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΊΠ°Π½ΠΎΠ½Π° ΠΌΠ°ΡΠΊΡΠ»ΠΈΠ½Π½ΠΎΡΡΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ Π² ΠΎΡΡΡΡΡΡΠ²ΠΈΠΈ ΡΠ°ΠΌΠΎΠΉ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ Ρ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΌΡΠΆΡΠΈΠ½ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΎΠ²Π°ΡΡ ΠΊΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΡΠ΅Π±ΠΎΠ²Π°Π½ΠΈΡΠΌ. ΠΡΠΎ Π²Π»ΠΈΡΠ΅Ρ Π½Π° ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈ ΡΠ°ΠΌΠΎΠΎΡΡΡΠ΅Π½ΠΈΡ Π²Π·ΡΠΎΡΠ»ΡΡ
ΠΌΡΠΆΡΠΈΠ½ ΠΈ ΠΌΠ΅Π½ΡΠ΅Ρ ΠΏΡΠΎΡΠ΅ΡΡΡ ΡΠΎΡΠΈΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠΎΠ΄ΡΠ°ΡΡΠ°ΡΡΠ΅Π³ΠΎ ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΡ ΠΌΠ°Π»ΡΡΠΈΠΊΠΎΠ². ΠΠ°ΡΠ°Π΄ΠΈΠ³ΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΡΠ½ΠΎΠ²ΠΎΠΉ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²ΡΡΡΡΠΏΠ°Π΅Ρ ΡΠ΅ΠΎΡΠΈΡ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠ²ΠΈΠ·ΠΌΠ°. Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΎ Π½Π°ΠΏΠΎΠ»Π½Π΅Π½ΠΈΠΈ ΠΎΠ±ΡΠ°Π·Π° Β«ΠΌΡΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈΒ» - ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΊ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΏΠΎΠ½ΡΡΠΈΡ, Π°Π½Π°Π»ΠΈΠ·ΠΈΡΡΡΡΡΡ ΡΠ°ΠΊΡΠΎΡΡ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΡΠ΅Π½ΠΎΠΌΠ΅Π½Π° ΠΌΠ°ΡΠΊΡΠ»ΠΈΠ½Π½ΠΎΡΡΠΈ, ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡΡΡ Π΄Π°Π½Π½ΡΠ΅ ΡΠΌΠΏΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠΌΠΏΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠΎΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π² ΡΠ°ΠΌΠΊΠ°Ρ
ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΏΠ°ΡΠ°Π΄ΠΈΠ³ΠΌΡ. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄Π²Π° ΠΌΠ΅ΡΠΎΠ΄Π°: ΡΠΎΠΊΡΡ-Π³ΡΡΠΏΠΏΡ, Π³Π΄Π΅ ΠΈΠ½ΡΠΎΡΠΌΠ°Π½ΡΠ°ΠΌΠΈ Π²ΡΡΡΡΠΏΠ°Π»ΠΈ ΠΆΠ΅Π½ΡΠΈΠ½Ρ, Π²ΠΎΡΠΏΠΈΡΡΠ²Π°ΡΡΠΈΠ΅ ΡΡΠ½ΠΎΠ²Π΅ΠΉ, ΠΈ ΠΏΠΎΠ»ΡΡΡΡΡΠΊΡΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΈΠ½ΡΠ΅ΡΠ²ΡΡ Ρ ΠΌΠΎΠ»ΠΎΠ΄ΡΠΌΠΈ ΠΌΡΠΆΡΠΈΠ½Π°ΠΌΠΈ. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΎΠ±Π½Π°ΡΡΠΆΠΈΠ²Π°Π΅ΡΡΡ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ Π΅Π΄ΠΈΠ½ΡΡ
ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΠΉ ΠΎ ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π½Π°ΠΏΠΎΠ»Π½Π΅Π½Π½ΠΎΡΡΠΈ ΠΎΠ±ΡΠ°Π·Π° ΠΌΠ°ΡΠΊΡΠ»ΠΈΠ½Π½ΠΎ- ΡΡΠΈ, Π½ΠΎ ΠΈ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ Π΅Π΄ΠΈΠ½ΠΎΠ΄ΡΡΠΈΡ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ°ΠΌΠΎΠ³ΠΎ Π½Π°Π»ΠΈΡΠΈΡ ΡΡΠ³ΡΠ±ΠΎ ΠΌΡΠΆΡΠΊΠΈΡ
ΠΊΠ°ΡΠ΅ΡΡΠ². Π₯ΠΎΡΡ Π² ΡΠ΅Π»ΠΎΠΌ ΠΌΠΎΠΆΠ½ΠΎ Π²ΡΡΠ²ΠΈΡΡ Π½Π΅ΠΊΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΊΠΎΠ½Π²Π΅Π½ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ Π΄ΠΎΠ»ΠΆΠ½Ρ Π±ΡΡΡ ΡΠ²ΠΎΠΉΡΡΠ²Π΅Π½Π½Ρ Β«Π½Π°ΡΡΠΎΡΡΠΈΠΌ ΠΌΡΠΆΡΠΈΠ½Π°ΠΌΒ», Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½Π°Ρ ΡΠ°ΡΡΡ ΠΊΠ°ΡΠ΅ΡΡΠ² ΠΏΡΠΈΠ·Π½Π°Π΅ΡΡΡ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ. Π ΡΠΎΠΌΡ ΠΆΠ΅ Π°Π½Π°Π»ΠΈΠ· Π½Π΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π²ΡΡΠ²ΠΈΡΡ ΠΊΠ°ΠΊΠΈΠ΅-Π»ΠΈΠ±ΠΎ ΠΊΠ°ΡΠ΅ΡΡΠ²Π°, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΡΠΈΠ·Π½Π°ΡΡΡΡ ΠΊΠ°ΠΊ ΠΈΡΠΊΠ»ΡΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΡΠΈΠ½Π°Π΄Π»Π΅ΠΆΠ°ΡΠΈΠ΅ ΠΌΡΠΆΡΠΈΠ½Π°ΠΌ ΠΈ Π½Π΅ ΡΡΠ΅Π±ΡΡΡΠΈΠ΅ΡΡ Π΄Π»Ρ ΠΆΠ΅Π½ΡΠΈΠ½ Π² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΠΎΠ±ΡΠ΅ΡΡΠ²Π΅.Contemporary society offers a revised version of the true masculinity. The revision occurred in the second half of the XXth century and manifested itself through the internal contradictions in the canon of masculinity. These were further aggravated by sheer impossibility for men to qualify as masculine in classical sense. The situation affects both grown men's self esteem and behavior and modifies boy's socialization. Using constructivism as a framework, the authors analyse the components and interpretations of Β«masculinityΒ» and the factors transforming the latter. The data used in the article include focus-group and personal interview transcripts. The focus-groups involved single boy-raising mothers while the interviewees were young adult males. The methods revealed both the lack of coherent composition of the model masculinity and the absence of mutual opinion concerning the sheer existence of masculine qualities. Although some characteristics could be more or less consensually perceived as Β«true masculineΒ», most were recognized as at least relative. Furthermore, the analysis did not reveal any features recognized as purely masculine because of their high relevance for a successful contemporary woman
Structural and electrical properties of CuAlMo thin films prepared by magnetron sputtering
The structural and electrical properties of a low resistivity CuAlMo thin film resistor material were investigated. The thin films were grown on Al2O3 and glass substrates by direct current (dc) magnetron sputtering. The key electrical properties of sheet resistance, temperature coefficient of resistance (TCR) and resistance stability were investigated as a function of sputtering pressure and post-deposition heat treatment time and temperature. A low sputtering pressure range of 0.13 to 0.40 Pa produced CuAlMo films with sheet resistance in the range 0.1 to 0.2 Ξ©/β‘ and resistance stability of 0.45 to 0.65% with a TCR of β 90 ppm/Β°C which could be shifted to zero following annealing in air at 425 Β°C. Films grown at higher sputtering pressures of 0.53 to 0.80 Pa had increased sheet resistance in the range 0.4 to 0.6 Ξ©/β‘ and inferior stability of 0.8 to 1.7% with a more negative TCR of β 110 to β 180 ppm/Β°C which could not be shifted to zero following annealing. The stability of the films grown at 0.13 and 0.40 Pa could be further improved to < 0.25% with heat treatment, due to the formation of a protective aluminium oxide layer. A minimum dwell time of 3 h at 425 Β°C was required to stabilise the films and set the electrical properties
OPENMINDS: CREATING A MENTAL HEALTH WORKSHOP FOR TEENAGERS TO TACKLE STIGMA AND RAISE AWARENESS
As a group of four clinical medical students from Cambridge University, we undertook a Student Selected Module (SSC-
"OpenMinds") whereby we designed and delivered a workshop about mental health to year 9 pupils.
The aim of our SSC was to produce an interactive, informative lesson which addressed the complex issues of stigma and
discrimination against those suffering from a mental illness as well as teaching the pupils how to recognise mental health problems
and provide them with guidance on how to seek help. We split a fifty minute session into the following sections: tackling stigma; how
common mental illness is; celebrity examples; real life examples; role play; and small group work. To engage the pupils we used a
combination of teaching modalities targeting all learning. We delivered the workshop to four separate classes and received feedback
from the pupils after each. We used this feedback to adapt and improve our presentation and assess the efficacy. Feedback was
overwhelmingly positive with the striking results of 101/109 pupils saying that they would recommend the workshop to a friend and
68/109 pupils saying they enjoyed all aspects.
Our SSC built upon work by a contingent of trainee Psychiatrists who undertook a similar project of mental health education for
teenagers, called "Heads above the rest", in Northern Ireland with great success. By continuing their work we were able to
demonstrate that medical students can successfully complete the same project under the guidance of a Psychiatrist, thus increasing
the sustainability of the project by reducing the time burden on the Psychiatrists. Participating in the project was also valuable to
our own personal development of teaching skills
Diagnosis of Supersymmetry Breaking Mediation Schemes by Mass Reconstruction at the LHC
If supersymmetry is discovered at the LHC, the next question will be the
determination of the underlying model. While this may be challenging or even
intractable, a more optimistic question is whether we can understand the main
contours of any particular paradigm of the mediation of supersymmetry breaking.
The determination of superpartner masses through endpoint measurements of
kinematic observables arising from cascade decays is a powerful diagnostic
tool. In particular, the determination of the gaugino sector has the potential
to discriminate between certain mediation schemes (not all schemes, and not
between different UV realizations of a given scheme). We reconstruct gaugino
masses, choosing a model where anomaly contributions to supersymmetry breaking
are important (KKLT compactification), and find the gaugino unification scale.
Moreover, reconstruction of other superpartner masses allows us to solve for
the parameters defining the UV model. The analysis is performed in the stop and
stau coannihilation regions where the lightest neutralinos are mainly gauginos,
to additionally satisfy dark matter constraints. We thus develop observables to
determine stau and stop masses to verify that the coannihilation mechanism is
indeed operational, and solve for the relic density.Comment: 16 pages, 14 figures. Figure 7 updated to show top peak. Minor
changes to other figure
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