72 research outputs found
Nutrient Management for Higher Productivity of Swarna Sub1 Under Flash Floods Areas
Two field experiments were conducted at Regional Agricultural Research Station, Tarahara, Nepal during 2012 and 2013 to determine the effect of agronomic management on growth and yield of Swarna Sub1 under flash floods. The first experiment was laid out in a split plot design with three replications; and four different nutrient combinations at nursery as main plots and three age groups of rice seedlings as sub plots. The second experiment was laid out in a randomized complete block design and replicated thrice; with three post flood nutrient doses at six and 12 days after de-submergence (dad). The experiments were complete submerged at 10 days after transplanting for 12 days. The survival percentage, at 21 dad, was significantly higher in plots planted with 35 (90.25%) and 40 (91.58%) days-old seedlings compared to 30 days-old seedlings (81.75%). Plots with 35 days-old seedlings produced 5.15 t ha-1 with advantage of 18.83% over 30 days-old seedlings. Plots with 100-50-50 kg N-P2O5-K2O/ha at nursery recorded the highest grain filling of 79.41% and grain yield of 5.068 t/ha with more benefit. Post flood application of 20-20 N-K20kg/ha at 6 dad resulted in higher plant survival and taller plants, leading to significantly higher grain yield of 5.183 t/ha and straw yield of 5.315 t/ha. Hence, 35-40 days old seedlings raised with 100-50-50 kg N-P2O5-K2O /ha in nursery and the additional application of20-20 kg N-K2O /ha at 6 dad improved plant survival and enhanced yield of Swarna Sub1 under flash flood conditions. The practice has prospects of saving crop loss with getting rice yield above national average yield leading to enhanced food security in the flood prone areas of Nepal
Quenching through Dirac and semi-Dirac points in optical Lattices: Kibble-Zurek scaling for anisotropic Quantum-Critical systems
We propose that Kibble-Zurek scaling can be studied in optical lattices by
creating geometries that support, Dirac, Semi-Dirac and Quadratic Band
Crossings. On a Honeycomb lattice with fermions, as a staggered on-site
potential is varied through zero, the system crosses the gapless Dirac points,
and we show that the density of defects created scales as , where
is the inverse rate of change of the potential, in agreement with the
Kibble-Zurek relation. We generalize the result for a passage through a
semi-Dirac point in dimensions, in which spectrum is linear in parallel
directions and quadratic in rest of the perpendicular directions. We
find that the defect density is given by where
and are the dynamical exponents and the correlation
length exponents along the parallel and perpendicular directions, respectively.
The scaling relations are also generalized to the case of non-linear quenching
Pigeonpea nutrition and its improvement
Pigeonpea (Cajanus cajan [L.] Millsp.), known by several
vernacular and names such as red gram, tuar, Angola
pea. yellow dhal and oil dhal, is one of the major grain legume crops of
the tropics and sub-tropics. It is a crop of small holder dryland
fmmers because it can grow well under subsistence level of agriculture
and provides nutritive food, fodder, and fuel wood. It also improves soil
by fixing atmospheric nitrogen. India by far is the largest pigeonpea producer
it is consumed as decorticated split peas, popularly called as
'dhaL' In other countries, its consumption as whole dty and green
vegetable is popular. Its foliage is used as fodder and milling by-products
[onn an excellent feed for domestic animals. Pigeonpea seeds contain
about 20-22% protein and appreciable amounts of essential amino.acids
and minerals. DehuHing and boiling treatments of seeds get rid of the
most antinutritional factors as tannins and enzyme inhibitors. Seed
storage causes considerable losses in the quality of this legume. The seed
protein of pigeonpea has been successfully enhanced by breeding from
20-22% to 28-30%. Such lines also agronomically performed well and
have acceptable and color. The high-protein lines were found nutritionally superior to the cultivars because they would provide more
quantities of utilizable protein and sulfur-containing amino acids
Developments in high energy theory
This non-technical review article is aimed at readers with some physics
background, including beginning research students. It provides a panoramic view
of the main theoretical developments in high energy physics since its inception
more than half a century ago, a period in which experiments have spanned an
enormous range of energies, theories have been developed leading up to the
Standard Model, and proposals -- including the radical paradigm of String
Theory -- have been made to go beyond the Standard Model. The list of
references provided here is not intended to properly credit all original work
but rather to supply the reader with a few pointers to the literature,
specifically highlighting work done by Indian authors.Comment: 52 pages, 14 figures, corrected versio
Researching COVID to Enhance Recovery (RECOVER) Adult Study Protocol: Rationale, Objectives, and Design
IMPORTANCE: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-defined. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC in Adults (RECOVER-Adult) are to: (1) characterize PASC prevalence; (2) characterize the symptoms, organ dysfunction, natural history, and distinct phenotypes of PASC; (3) identify demographic, social and clinical risk factors for PASC onset and recovery; and (4) define the biological mechanisms underlying PASC pathogenesis.
METHODS: RECOVER-Adult is a combined prospective/retrospective cohort currently planned to enroll 14,880 adults aged ≥18 years. Eligible participants either must meet WHO criteria for suspected, probable, or confirmed infection; or must have evidence of no prior infection. Recruitment occurs at 86 sites in 33 U.S. states, Washington, DC and Puerto Rico, via facility- and community-based outreach. Participants complete quarterly questionnaires about symptoms, social determinants, vaccination status, and interim SARS-CoV-2 infections. In addition, participants contribute biospecimens and undergo physical and laboratory examinations at approximately 0, 90 and 180 days from infection or negative test date, and yearly thereafter. Some participants undergo additional testing based on specific criteria or random sampling. Patient representatives provide input on all study processes. The primary study outcome is onset of PASC, measured by signs and symptoms. A paradigm for identifying PASC cases will be defined and updated using supervised and unsupervised learning approaches with cross-validation. Logistic regression and proportional hazards regression will be conducted to investigate associations between risk factors, onset, and resolution of PASC symptoms.
DISCUSSION: RECOVER-Adult is the first national, prospective, longitudinal cohort of PASC among US adults. Results of this study are intended to inform public health, spur clinical trials, and expand treatment options
Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility
Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MRA or CT scanning from head to pelvis is recommended to establish the extent of vascular involvement. Management involves early surgical intervention, including early valve-sparing aortic root replacement, genetic counselling and close monitoring in pregnancy. Despite being caused by loss of function mutations in either TGFβ receptor, paradoxical activation of TGFβ signalling is seen, suggesting that TGFβ antagonism may confer disease modifying effects similar to those observed in MFS. TGFβ antagonism can be achieved with angiotensin antagonists, such as Losartan, which is able to delay aortic aneurysm development in preclinical models and in patients with MFS. Our case emphasizes the importance of timely recognition of vasculopathy syndromes in patients with hypermobility and the need for early surgical intervention. It also highlights their heterogeneity and the potential for late presentation. Disclosures: The authors have declared no conflicts of interes
Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study
Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life
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