984 research outputs found
Enantioselective Proton Transfer Chemistry: Asymmetric Synthesis with Chiral Lithium Amide Bases
On the interactions of lipids and proteins in the red blood cell membrane
The effects of temperature and of the action of a purified phospholipase C enzyme preparation on human red blood cell membranes has been investigated by chemical analyses, circular dichroism, and proton magnetic resonance measurements. The results indicate that a substantial fraction of the phospholipids and the proteins of the membranes can change structure independently of one another, suggesting a mosaic pattern for the organization of the lipids and proteins in membranes
Theory for Nonlinear Spectroscopy of Vibrational Polaritons
Molecular polaritons have gained considerable attention due to their
potential to control nanoscale molecular processes by harnessing
electromagnetic coherence. Although recent experiments with liquid-phase
vibrational polaritons have shown great promise for exploiting these effects,
significant challenges remain in interpreting their spectroscopic signatures.
In this letter, we develop a quantum-mechanical theory of pump-probe
spectroscopy for this class of polaritons based on the quantum Langevin
equations and the input-output theory. Comparison with recent experimental data
shows good agreement upon consideration of the various vibrational
anharmonicities that modulate the signals. Finally, a simple and intuitive
interpretation of the data based on an effective mode-coupling theory is
provided. Our work provides a solid theoretical framework to elucidate
nonlinear optical properties of molecular polaritons as well as to analyze
further multidimensional spectroscopy experiments on these systems
Magnetic flux flow and superconductor stabilization Quarterly report, 1 Jan. - 31 Mar. 1968
Magnetic flux flow and stability of superconducting niobium titanium strip
Day Ahead Electric Load Forecast: A Comprehensive LSTM-EMD Methodology and Several Diverse Case Studies
Revealing Hidden Vibration Polariton Interactions by 2D IR Spectroscopy
We report the first experimental two-dimensional infrared (2D IR) spectra of
novel molecular photonic excitations - vibrational-polaritons. The application
of advanced 2D IR spectroscopy onto novel vibrational-polariton challenges and
advances our understanding in both fields. From spectroscopy aspect, 2D IR
spectra of polaritons differ drastically from free uncoupled molecules; from
vibrational-polariton aspects, 2D IR uniquely resolves hybrid light-matter
polariton excitations and unexpected dark states in a state-selective manner
and revealed hidden interactions between them. Moreover, 2D IR signals
highlight the role of vibrational anharmonicities in generating non-linear
signals. To further advance our knowledge on 2D IR of vibrational polaritons,
we develop a new quantum-mechanical model incorporating the effects of both
nuclear and electrical anharmonicities on vibrational-polaritons and their 2D
IR signals. This work reveals polariton physics that is difficult or impossible
to probe with traditional linear spectroscopy and lays the foundation for
investigating new non-linear optics and chemistry of molecular
vibrational-polaritons
Reliable and accurate diagnostics from highly multiplexed sequencing assays
Scalable, inexpensive, and secure testing for SARS-CoV-2 infection is crucial for control of the novel coronavirus pandemic. Recently developed highly multiplexed sequencing assays (HMSAs) that rely on high-throughput sequencing can, in principle, meet these demands, and present promising alternatives to currently used RT-qPCR-based tests. However, reliable analysis, interpretation, and clinical use of HMSAs requires overcoming several computational, statistical and engineering challenges. Using recently acquired experimental data, we present and validate a computational workflow based on kallisto and bustools, that utilizes robust statistical methods and fast, memory efficient algorithms, to quickly, accurately and reliably process high-throughput sequencing data. We show that our workflow is effective at processing data from all recently proposed SARS-CoV-2 sequencing based diagnostic tests, and is generally applicable to any diagnostic HMSA
Towards energetically viable asymmetric deprotonations : selectivity at more elevated temperatures with C2-symmetric magnesium bisamides
A novel chiral magnesium bisamide has enabled the development of effective asymmetric deprotonation protocols at substantially more elevated temperatures. This new, structurally simple, C2-symmetric magnesium complex displays excellent levels of asymmetric efficiency and energy reduction in the synthesis of enantioenriched enol silane
Tropical Connections to Climatic Change in the Extratropical Southern Hemisphere: The Role of Atlantic SST Trends
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