Master of Science

thesisTerm co-occurrence data has been extensively used in many applications ranging from information retrieval to word sense disambiguation. There are two major limitations of co-occurrence data. The first limitation is known as the data sparseness problem or the zero frequency problem: For a majority of pairs, the probability that they co-occur in even a large corpus is very small. The second limitation is that in co-occurrence data, each term is considered as a meaningless symbol, or in other words, terms do not have types, or any semantic relationships with other terms. In this paper, we introduce a novel approach to address these two limitations. We create concept aware co-occurrence data wherein each term is not a symbol, but an entry in a large-scale, data-driven semantic network. We show that with concepts or types, we are able to address the data sparseness problem through generalization. Furthermore, using concept co-occurrence, we show that our approach can benefit a large range of applications, including short text understanding

The Ahlfors Lemma and Picard\u27s Theorems

The article introduces Ahlfors\u27 generalization of Schwarz\u27 lemma. With this powerful geometric tool of complex functions in one variable, we are able to prove some theorems concerning the size of images under holomorphic mappings, including celebrated Picard\u27s theorems. The article concludes with a brief insight into the theory of Kobayashi hyperbolic complex manifolds. Although this survey paper does not contain any new results, it may be useful for the beginner in complex analysis to better understands the concept of hyperbolicity in complex geometry

Casebook: a virtual patient iPad application for teaching decision-making through the use of electronic health records

BACKGROUND: Virtual Patients are a well-known and widely used form of interactive software used to simulate aspects of patient care that students are increasingly less likely to encounter during their studies. However, to take full advantage of the benefits of using Virtual Patients, students should have access to multitudes of cases. In order to promote the creation of collections of cases, a tablet application was developed which makes use of electronic health records as material for Virtual Patient cases. Because electronic health records are abundantly available on hospital information systems, this results in much material for the basis of case creation. RESULTS: An iPad-based Virtual Patient interactive software system was developed entitled Casebook. The application has been designed to read specially formatted patient cases that have been created using electronic health records, in the form of X-ray images, electrocardiograms, lab reports, and physician notes, and present these to the medical student. These health records are organised into a timeline, and the student navigates the case while answering questions regarding the patient along the way. Each health record can also be annotated with meta-information by the case designer, such as insight into the thought processes and the decision-making rationale of the physician who originally worked with the patient. Students learn decision-making skills by observing and interacting with real patient cases in this simulated environment. This paper discusses our approach in detail. CONCLUSIONS: Our group is of the opinion that Virtual Patient cases, targeted at undergraduate students, should concern patients who exhibit prototypical symptoms of the kind students may encounter when beginning their first medical jobs. Learning theory research has shown that students learn decision-making skills best when they have access to multitudes of patient cases and it is this plurality that allows students to develop their illness scripts effectively. Casebook emphasises the use of pre-existing electronic health record data as the basis for case creation, thus, it is hoped, making it easier to produce cases in larger numbers. By creating a Virtual Patient system where cases are built from abundantly available electronic health records, collections of cases can be accumulated by institutions

On the usage of health records for the design of virtual patients: a systematic review

BACKGROUND: The process of creating and designing Virtual Patients for teaching students of medicine is an expensive and time-consuming task. In order to explore potential methods of mitigating these costs, our group began exploring the possibility of creating Virtual Patients based on electronic health records. This review assesses the usage of electronic health records in the creation of interactive Virtual Patients for teaching clinical decision-making. METHODS: The PubMed database was accessed programmatically to find papers relating to Virtual Patients. The returned citations were classified and the relevant full text articles were reviewed to find Virtual Patient systems that used electronic health records to create learning modalities. RESULTS: A total of n = 362 citations were found on PubMed and subsequently classified, of which n = 28 full-text articles were reviewed. Few articles used unformatted electronic health records other than patient CT or MRI scans. The use of patient data, extracted from electronic health records or otherwise, is widespread. The use of unformatted electronic health records in their raw form is less frequent. Patient data use is broad and spans several areas, such as teaching, training, 3D visualisation, and assessment. CONCLUSIONS: Virtual Patients that are based on real patient data are widespread, yet the use of unformatted electronic health records, abundant in hospital information systems, is reported less often. The majority of teaching systems use reformatted patient data gathered from electronic health records, and do not use these electronic health records directly. Furthermore, many systems were found that used patient data in the form of CT or MRI scans. Much potential research exists regarding the use of unformatted electronic health records for the creation of Virtual Patients

New effective results in the theory of the Riemann zeta-function

Results in the present thesis are divided into four groups and are mainly effective estimates for the Riemann zeta function $\zeta(s)$ and associated functions under the assumption of the (Generalized) Riemann Hypothesis. The first group of results consists of explicit and RH estimates for the moduli of $S(t)$, i.e., the argument of \zeta(1/2+\ie t), its antiderivative $S_1(t)$ and \zeta(1/2+\ie t). We follow techniques outlined by Selberg (1944), Fujii (2004, 2006) and Soundararajan (2009). The second group of results consists of explicit and RH estimates for $\log{\frac{1}{|\zeta(s)|}}$ and $\log{|\zeta(s)|}$ to the right of the critical line by following techniques developed by Titchmarsh (1927) while using also results from the first group. Moreover, we use these bounds to obtain effective and conditional estimates for the summatory function $M(x)$ of the M\"{o}bius function and for the number of $k$-free numbers. These estimates are of Titchmarsh's (1927) and Montgomery--Vaughan's (1981) strength, respectively. The third group of results consists of GRH estimates for $\left|\log{\mathcal{L}(s)}\right|$ and $\left|\left(\mathcal{L}'/\mathcal{L}\right)(s)\right|$ in the neighbourhood of the 1-line for functions in the Selberg class with a polynomial Euler product. The shape of these bounds are that of Littlewood (1912). We provide effective estimates for $\zeta(s)$, Dirichlet $L$-functions with primitive characters and Dedekind zeta-functions, together with an improvement over a particular estimate for $M(x)$ from the second group of results. The fourth group of results consists of effective and GRH estimates for $\left|\left(L'/L\right)(\sigma,\chi)\right|$ for Dirichlet $L$-functions with primitive characters $\chi$ modulo $q$, where $1/2+1/\log{\log{q}}\leq\sigma\leq 1-1/\log{\log{q}}$ and $\sigma=1$, by combining methods from Selberg (1944) and from the theory of bandlimited functions applied to the Guinand--Weil exact formula. We also provide effective and GRH estimate for \left|\left(\zeta'/\zeta\right)(1+\ie t)\right|

The primary structure of the flavoprotein D-aspartate oxidase from beef kidney.

The complete primary structure of the peroxisomal flavoenzyme D-aspartate oxidase from beef kidney has been determined by analyses of the peptides obtained through fragmentation of the carboxymethylated protein with trypsin, CNBr, heptafluorobutyric acid/CNBr and Staphylococcus aureus V8 protease. The protein consists of a single polypeptide of 338 residues, accounting for a M(r) of 37,305 for the apoprotein. A form of the enzyme lacking Lys-338 and therefore ending with Pro-337 has been detected. The N-terminal residue is blocked. Seven cysteines and no disulfide bridges are present. Residue 228 can be either Ile or Val. Thus, D-aspartate oxidase presents two types of heterogeneity in the polypeptide chain in addition to the one already described concerning the possible content of FAD or 6-hydroxyflavin adenine dinucleotide. Comparison of the primary structure of D-aspartate oxidase with other known sequences reveals that D-aspartate oxidase is homologous with D-amino acid oxidase (another flavo-oxidase) and does not present significant sequence similarities with any other protein, including flavoenzymes

Conceptos básicos en el ganado caprino

Este manual tiene por intención explicar las técnicas básicas de manejo para productores caprinos y personal dedicado a la atención de las cabras. Tiene el espíritu de mostrar los métodos correctos de tratamiento de animales en el día a día en los corrales, los parámetros necesarios a tener en cuenta en la construcción de las instalaciones y los cuidados apropiados para mantener óptima higiene y bioseguridad, entre otros temas a desarrollar.EEA Las BreñasFil: Smeriglio, Aldo Rafael. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Las Breñas; ArgentinaFil: Simonic, Delia Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Las Breñas; ArgentinaFil: Palmero, Sebastián. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; ArgentinaFil: Bogarin, Estela Melisa. Instituto Nacional de Tecnología Agropecuaria (INTA). ProHuerta; Argentin

Projekt „Digital Skills, Knowledge and Communication für Studierende der Medizin“

Die Digitalisierung verändert alle Lebensbereiche und damit auch die Anforderungen an zukünftige Ärztinnen und Ärzte. In einem gemeinsamen Ansatz haben interuniversitäre und interdisziplinäre Arbeitsgruppen der österreichischen öffentlichen medizinischen Universitäten und Fakultäten Ausbildungselemente zur Digitalisierung in der Medizin entwickelt. In einem ersten Schritt wurden diese Elemente als Wahlfächer implementiert, die nach einer Evaluierungsphase in die Curricula integriert werden. Zukünftige Ärzt:innen erhalten damit eine Basiskompetenz für den für Patient:innen nutzbringenden Einsatz digitaler Werkzeuge

Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region

Gilles de la Tourette syndrome (GTS) is characterized by multiple motor and phonic tics and high comorbidity rates with other neurobehavioral disorders. It is hypothesized that frontal-subcortical pathways and a complex genetic background are involved in the etiopathogenesis of the disorder. The genetic basis of GTS remains elusive. However, several genomic regions have been implicated. Among them, 17q25 appears to be of special interest, as suggested by various independent investigators. In the present study, we explored the possibility that 17q25 contributes to the genetic component of GTS. The initial scan of chromosome 17 performed on two large pedigrees provided a nonparametric LOD score of 2.41 near D17S928. Fine mapping with 17 additional microsatellite markers increased the peak to 2.61 (P=.002). The original families, as well as two additional pedigrees, were genotyped for 25 single-nucleotide polymorphisms (SNPs), with a focus on three genes in the indicated region that could play a role in the development of GTS, on the basis of their function and expression profile. Multiple three-marker haplotypes spanning all three genes studied provided highly significant association results (P<.001). An independent sample of 96 small families with one or two children affected with GTS was also studied. Of the 25 SNPs, 3 were associated with GTS at a statistically significant level. The transmission/disequilibrium test for a three-site haplotype moving window again provided multiple positive results. The background linkage disequilibrium (LD) of the region was studied in eight populations of European origin. A complicated pattern was revealed, with the pairwise tests producing unexpectedly high LD values at the telomeric TBCD gene. In conclusion, our findings warrant the further investigation of 17q25 as a candidate susceptibility region for GTS