Parity dependent Josephson current through a helical Luttinger liquid

We consider a superconductor-two dimensional topological insulator- superconductor junction (S-2DTI-S) and study how the 2{\pi}- and 4{\pi}-periodic Josephson currents are affected by the electron-electron interaction. In the long-junction limit the supercurrent can by evaluated by modeling the system as a helical Luttinger liquid coupled to superconducting reservoirs. After having introduced bosonization in the presence of the parity constraint we turn to consider the limit of perfect and poor interfaces. For transparent interfaces, where perfect Andreev reflections occur at the boundaries, the Josephson current is marginally affected by the interaction. On the contrary, if strong magnetic scatterers are present in the weak link, the situation changes dramatically. Here Coulomb interaction plays a crucial role both in low and high temperature regimes. Furthermore, a phase-shift of Josephson current can be induced by changing the direction of the magnetization of the impurity

Sviluppo di strumenti per l'ottimizzazione del progetto aerodinamico di turbomacchine assiali

La tesi propone un modello throughflow inverso da impiegare durante la fase assialsimmetrica del processo di progetto di una turbomacchina. Il modello risolve con tecnica time marching le equazioni meridiane di Eulero, nelle quali un campo di forza volumica normale alle superfici medie delle pale ("blade force") ne riproduce l'azione sul flusso. La geometria delle superfici è ricavata dalla condizione di tangenza, in accordo con la componente tangenziale della "blade force" imposta come dato di progetto. La distribuzione meridiana della blade force sulle regioni palettate del flowpath è definibile attraverso un processo di ottimizzazione inversa. Le equazioni di Eulero contengono anche altri termini destinati a riprodurre gli effetti del bloccaggio delle pale e delle perdite di profilo. La tesi affronta in particolare il problema delle alte deflessioni (pale di turbina), sia sotto l'aspetto fisico, individuando le più opportune condizioni al contorno da associare alle equazioni di Eulero, sia sotto l'aspetto numerico, introducendo uno schema upwind di tipo implicito per contrastare le instabilità che quelle condizioni comportano. Lo schema si rivela molto efficiente e robusto nel generare singole schiere di apertura infinita, non altrettanto se applicato a stadi di turbina completi. Per questa ragione, la tesi indaga anche la variante diretta del modello throughflow, che valuta la "blade force" (e perciò le prestazioni della macchina) a partire da un'assegnata geometria delle superfici medie. Pur con le sue limitazioni, il solutore inverso è ugualmente introdotto in ottimizzatori esistenti, allo scopo di illustrare alcuni esempi di ottimizzazione inversa per configurazioni fortemente defless

Optimized Cooper pair pumps

In adiabatic Cooper pair pumps, operated by means of gate voltage modulation only, the quantization of the pumped charge during a cycle is limited due to the quantum coherence of the macroscopic superconducting wave function. In this work we show that it is possible to obtain very accurate pumps in the non-adiabatic regime by a suitable choice of the shape of the gate voltage pulses. We determine the shape of these pulses by applying quantum optimal control theory to this problem. In the optimal case the error, with respect to the quantized value, can be as small as of the order of (10E-6)e: the error is reduced by up to five orders of magnitude with respect to the adiabatic pumping. In order to test the experimental feasibility of this approach we consider the effect of charge noise and the deformations of the optimal pulse shapes on the accuracy of the pump. Charge noise is assumed to be induced by random background charges in the substrate, responsible for the observed 1/f noise. Inaccuracies in the pulse shaping are described by assuming a finite bandwidth for the pulse generator. In realistic cases the error increases at most of one order of magnitude as compared to the optimal case. Our results are promising for the realization of accurate and fast superconducting pumps.Comment: 9 pages, 10 figure

Hypertension, left ventricular hypertrophy and chronic kidney disease.

Left ventricular hypertrophy (LVH) is a cardiovascular complication highly prevalent in patients with chronic kidney disease (CKD) and end-stage renal disease. LVH in CKD patients has generally a negative prognostic value, because it represents an independent risk factor for the development of arrhythmias, sudden death, heart failure and ischemic heart disease. LVH in CKD patients is secondary to both pressure and volume overload. Pressure overload is secondary to preexisting hypertension, but also to a loss of elasticity of the vessels and to vascular calcifications, leading to augmented pulse pressure. Anemia and the retention of sodium and water secondary to decreased renal function are responsible for volume overload, determining a hyperdynamic state. In particular, the correction of anemia with erythropoietin in CKD patients is advantageous, since it determines LVH reduction. Other risk factors for LVH in CKD patients are documented: some are specific to CKD, as mineral metabolism disorders (hypocalcemia, hyperphosphatemia, low serum vitamin D levels and secondary hyperparathyroidism), others are non-traditional, such as increased asymmetric dimethylarginine, oxidative stress, hyperhomocysteinemia and endothelial dysfunction that, in turn, accelerates the process of atherogenesis, triggers the inflammation and pro-thrombotic state of the glomerular and the vascular endothelium and aggravates the process of both CKD and LVH

Ultralong Organic Phosphorescence in the Solid State: The Case of Triphenylene Cocrystals with Halo- and Dihalo-penta/ tetrafluorobenzene

The polycyclic aromatic hydrocarbon (PAH) triphenylene (TP) has been reacted with halo-pentafluorobenzene (XF5, X = Br, I) and 1,4-dihalo-tetrafluorobenzene (X2F4, X = Br, I) to yield the corresponding cocrystals TP·BrF5, TP·Br2F4, TP·IF5, and TP·I2F4 form I. These materials have been synthesized by dissolving TP into an excess of liquid or molten coformer, and single crystals have been grown via seeding chloroform solutions. They have been fully characterized by a combination of techniques including X-ray diffraction, Raman spectroscopy, and luminescence spectroscopy in the solid state. TP·I2F4 form I was found to undergo a single-crystal to single-crystal (SCSC) polymorphic phase transition induced by temperature (when cooled down to 100 K) leading to the new form TP·I2F4 form II, which is transformed back into the first structure when brought again at RT. This behavior was confirmed also by Raman spectroscopy. Upon cocrystallization and as a result of the external heavy atom effect, all crystalline materials exhibited bright room temperature phosphorescence clearly visible by the naked eye. The latter was almost exclusive for cocrystal TP·I2F4, whereas for TP·Br2F4 both fluorescence and phosphorescence were detected. In TP·Br2F4, the phosphorescence lifetime was on the order of 200 ms, and with the visual outcome of an orange phosphorescence lasting for a couple of seconds upon ceasing the excitation, that makes this compound classifiable as an ultralong organic phosphorescent (UOP) material. The results evidenced the role of the nature of the heavy atom in governing the phosphorescence output from organic cocrystals

Wild Micromammals as Bioindicators of Antibiotic Resistance in Ecopathology in Northern Italy

Simple Summary: In recent years, animal and human health have been linked in a “One Health” approach. Wildlife could act as a reservoir for different antibiotic-resistant pathogens, representing an issue for human and domestic animal health. The aim of this study was to evaluate the presence and circulation of antimicrobial-resistant bacterial species in wild micromammals in the province of Parma, Northern Italy. Multi-drug-resistant strains and a high prevalence of resistance to critically important antibiotics were detected. Furthermore, resistance to commonly used antibiotics was detected in a large percentage of isolates. Considering that micromammals are good bioindicators, obtained results highlighted a high prevalence of strains resistant to antimicrobials of critical importance for human and animals in the investigated areas, thus representing a public health hazard. Abstract: Antimicrobial resistance (AMR) is an increasing threat to human health and an important issue also in the natural environment. For this study, an ecopathological approach was applied to the monitoring of the antimicrobial resistance in the province of Parma, Northern Italy. Fourteen monitoring sites and seventy-four faecal samples from four species of wild micromammals (Apodemus sylvaticus, Microtus savii, Mus domesticus and Suncus etruscus) were collected. Samples were subjected to bacteriological examination and antimicrobial susceptibility testing. Antibiotics belonging to 13 different antibiotic classes were tested. Collected data showed a prevalence of multi-drug resistant (MDR) strains of 55.13% and significant differences in the prevalence of MDR strains among the different micromammal species, while sex, age and anthropization level did not significantly affected MDR strains prevalence. Moreover, a high prevalence of bacterial strains resistant to colistin (95%), gentamicin (87%) and amikacin (83%) was observed. To our knowledge, this is the first report on antibiotic resistance in wild micromammals in the province of Parma

Optimized single-qubit gates for Josephson phase qubits

In a Josephson phase qubit the coherent manipulations of the computational states are achieved by modulating an applied ac current, typically in the microwave range. In this work we show that it is possible to find optimal modulations of the bias current to achieve high-fidelity gates. We apply quantum optimal control theory to determine the form of the pulses and study in details the case of a NOT-gate. To test the efficiency of the optimized pulses in an experimental setup, we also address the effect of possible imperfections in the pulses shapes, the role of off-resonance elements in the Hamiltonian, and the effect of capacitive interaction with a second qubit.Comment: 10 pages, 13 figure

An Intramolecular Hydroaminomethylation-Based Approach to Pyrrolizidine Alkaloids under Microwave-Assisted Heating

A general method for the synthesis of pyrrolizidine derivatives using an intramolecular hydroaminomethylation protocol (HAM) under microwave (MW) dielectric heating is reported. Starting from a 3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-vinylpyrrolidine, MW-assisted intramolecular HAM in the presence of gaseous H2 and CO gave the natural alkaloid hyacinthacine A2 protected as benzyl ether. The same approach gave a lentiginosine analogue starting from the corresponding vinyl N-hydroxypyrrolidine. The nature of the reaction products and the yields were strongly influenced by the relative stereochemistry of the starting pyrrolidines, as well as by the catalyst/ligand employed. The use of ethanol as a solvent provides environmentally friendly conditions, while the ligand/catalyst system can be recovered by separating the alkaloid product with an SCX column and recycling the ethanolic solution. HAM worked up to three times with the recycled catalyst solution without any significant impact on yield

in vitro antimicrobial activity of a gel containing antimicrobial peptide amp2041 chlorhexidine digluconate and tris edta on clinical isolates of pseudomonas aeruginosa from canine otitis

Background Pseudomonas aeruginosa (PA) may cause suppurative otitis externa with severe inflammation and ulceration in dogs. Multidrug resistance is commonly reported for this organism, creating a difficult therapeutic challenge. Objective The aim of this study was to evaluate the in vitro antimicrobial activity of a gel containing 0.5 μg/mL of antimicrobial peptide AMP2041, 0.07% chlorhexidine digluconate (CLX), 0.4% Tris and 0.1% EDTA on 30 clinical isolates of PA from canine otitis externa. Materials and Methods Antimicrobial activity was evaluated through minimal bactericidal concentration (MBC). Standardized bacterial suspensions were incubated with different concentrations of the gel at 37°C for 30 min and plated for colony forming unit (CFU) counts. Time-to-kill kinetics were evaluated with the undiluted product and at MBC for each PA strain at 30 s, 1, 5, 10, 15, 30 min, 24 and 48 h. Results The MBC was 1:64 for two of 30 strains, 1:128 for 15 of 30 strains and 1:256 for 13 of 30 strains. The geometric mean was 1:165, equivalent to a concentration of 0.003 μg/mL AMP2041 + 0.0004% CLX + 0.0024%Tris + 0.0006% EDTA. Time-to-kill assays with the undiluted product showed complete bactericidal effect within 30 s for all isolates, whereas at the MBC this effect was reached within 5 min for 20 of 30 isolates and within 30 min for all isolates. Bactericidal activity was maintained after 48 h for all isolates. Conclusion This gel has shown rapid, complete and long-lasting activity against a panel of 30 PA isolates from cases of canine otitis externa

Activity of AMP2041 against human and animal multidrug resistant Pseudomonas aeruginosa clinical isolates

Background: Antimicrobial resistance is a growing threat to public health. Pseudomonas aeruginosa is a relevant pathogen causing human and animal infections, frequently displaying high levels of resistance to commonly used antimicrobials. The increasing difficulty to develop new effective antibiotics have discouraged investment in this area and only a few new antibiotics are currently under development. An approach to overcome antibiotic resistance could be based on antimicrobial peptides since they offer advantages over currently used microbicides. Methods: The antimicrobial activity of the synthetic peptide AMP2041 was evaluated against 49 P. aeruginosa clinical strains with high levels of antimicrobial resistance, isolated from humans (n = 19) and animals (n = 30). In vitro activity was evaluated by a microdilution assay for lethal dose 90% (LD90), while the activity over time was performed by time-kill assay with 12.5 μg/ml of AMP2014. Evidences for a direct membrane damage were investigated on P. aeruginosa ATCC 27853 reference strain, on animal isolate PA-VET 38 and on human isolate PA-H 24 by propidium iodide and on P. aeruginosa ATCC 27853 by scanning electron microscopy. Results: AMP2041 showed a dose-dependent activity, with a mean (SEM) LD90 of 1.69 and 3.3 μg/ml for animal and human strains, respectively. AMP2041 showed microbicidal activity on P. aeruginosa isolates from a patient with cystic fibrosis (CF) and resistance increased from first infection isolate (LD90 = 0.3 μg/ml) to the mucoid phenotype (LD90 = 10.4 μg/ml). The time-kill assay showed a time-dependent bactericidal effect of AMP2041 and LD90 was reached within 20 min for all the strains. The stain-dead assay showed an increasing of membrane permeabilization and SEM analysis revealed holes, dents and bursts throughout bacterial cell wall after 30 min of incubation with AMP2041. Conclusions: The obtained results assessed for the first time the good antimicrobial activity of AMP2041 on P. aeruginosa strains of human origin, including those deriving from a CF patient. We confirmed the excellent antimicrobial activity of AMP2041 on P. aeruginosa strains derived from dog otitis. We also assessed that AMP2041 antimicrobial activity is linked to changes of the P. aeruginosa cell wall morphology and to the increasing of membrane permeability