Foreign multinationals and domestic innovation: intra-industry effects and firm heterogeneity

This paper looks at foreign Multinational Enterprises (MNEs) investing in the UK and at their impact on the innovation performance of domestic firms active in their same sector. By employing data on Foreign Direct Investments matched with firm-level information the paper develops a direct measure of capital inflows at a three-digit industry level. In order to capture innovation in both manufacturing and services the paper relies on a broader proxy for firm innovativeness based on the Community Innovation Survey (CIS). The results suggest that domestic firms active in sectors with greater investments by MNEs show a stronger innovative performance. However, the heterogeneity across domestic firms in terms of internationalization of both their market engagement and ownership structure is the main driver of this effect

The presence of foreign multinationals in the UK boosts innovation by domestic firms

Capacity to absorb new knowledge is essential, find Ricardo Crescenzi, Luisa Gagliardi and Simona Iammarino

Offshoring and the geography of jobs in Great Britain

This paper investigates the impact of the offshoring of production activities on domestic jobs in Great Britain. The paper considers both the spatial heterogeneity across local labour markets and variations in the intensity of outward flows of investments abroad (OFDI) across industries in order to shed new light on the job creation/destruction implications of offshoring. The results suggest that offshoring may generate significant job losses in routine occupations in areas that have been more exposed to the relocation of production abroad, regardless of whether the relocation has been to developed or developing/emerging countries. Offshoring to developing/emerging countries has, by contrast, a positive effect on the generation of non-routine jobs. Efficiency gains accruing from the international reorganization of production increase in the long-run, with compensation mechanisms operating through growth of employment in higher value added activities at home. Overall, our results uncover important spatial and interpersonal inequalities in job creation, which provide new challenges for public policy

Carbon-Oxygen White Dwarf Accreting CO-Rich Matter. II. Self-Regulating Accretion Process up to the Explosive Stage

We investigate the effect of rotation on the evolution of double-degenerate white dwarf systems, which are possible progenitors of Type Ia supernovae. We assume that prior to merging, the two white dwarfs rotate synchronously at the orbital frequency and that in the merger process, the lighter white dwarf is transformed into a thick disk from which the more massive white dwarf initially accretes at a very high rate (~10-5 M☉ yr-1). Because of the lifting effect of rotation, the accreting white dwarf expands until the gravitational acceleration and centripetal acceleration required for binding at the surface become equal, initiating a Roche instability. The white dwarf continues to accrete matter from the disk, but at a rate that is determined by the balance between two competing processes operating in outer layers: (1) heating, expansion, and spin-up due to accretion and (2) cooling and contraction due to thermal diffusion. The balance produces an accretion rate such that the angular velocity of the white dwarf ωWD and the break-up angular velocity ωcr remain equal. Because of the deposition of angular momentum by accreted matter and the contraction of the accreting star, ωWD increases continuously until the rotational energy reaches about 14% of the gravitational binding energy; then, another instability sets in: the structure is forced to adopt an elliptical shape and emit gravitational waves. Thereafter, a balance between the rate of deposition of angular momentum by accreted matter and the rate of loss of angular momentum by gravitational waves produces a nearly constant or "plateau" accretion rate of ~4 × 10-7 M☉ yr-1. The mass of the accreting white dwarf can increase up to and beyond the Chandresekhar mass limit for nonrotating white dwarfs before carbon ignition occurs. Independent of the initial value of the accretion rate, the physical conditions suitable for carbon ignition are achieved at the center of the accreting white dwarf and, because of the high electron degeneracy, the final outcome is an event of SN Ia proportions. Our results apply to merged binary white dwarf systems which, at the onset of explosive carbon ignition, have a total mass in the range 1.4-1.5 M☉

Carbon-Oxygen White Dwarfs Accreting CO-Rich Matter I: A Comparison Between Rotating and Non-Rotating Models

We investigate the lifting effect of rotation on the thermal evolution of CO WDs accreting CO-rich matter. We find that rotation induces the cooling of the accreting star so that the delivered gravitational energy causes a greater expansion with respect to the standard non-rotating case. The increase in the surface radius produces a decrease in the surface value of the critical angular velocity and, therefore, the accreting WD becomes gravitationally unbound (Roche instability). This occurrence is due to an increase in the total angular momentum of the accreting WD and depends critically on the amount of specific angular momentum deposited by the accreted matter. If the specific angular momentum of the accreted matter is equal to that of the outer layers of the accreting structure, the Roche instability occurs well before the accreting WD can attain the physical conditions for C-burning. If the values of both initial angular velocity and accretion rate are small, we find that the accreting WD undergoes a secular instability when its total mass approaches 1.4 Msun. At this stage, the ratio between the rotational and the gravitational binding energy of the WD becomes of the order of 0.1, so that the star must deform by adopting an elliptical shape. In this case, since the angular velocity of the WD is as large as 1 rad/s, the anisotropic mass distribution induces the loss of rotational energy and angular momentum via GWR. We find that, independent of the braking efficiency, the WD contracts and achieves the physical conditions suitable for explosive C-burning at the center so that a type Ia supernova event is produced.Comment: 39 pages, 22 eps-figures; accepted for publication in Astrophysical Journa

Sex-Dependent Outcome of Hepatitis B and C Viruses Infections: Synergy of Sex Hormones and Immune Responses?

Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that differ in their genomic content, life cycle and molecular prognosis. HBV and HCV establish chronic lifespan infections that can evolve to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). This malignant liver cancer affects more commonly male patients than females, with a male-to-female incidence ratio of <Capword>2</Capword>:1 up to 7:1. Sex significantly contributes to shape the immune responses, contributing to differences in the pathogenesis of infectious diseases, in males and females patients. Females usually develop more intense innate, humoral and cellular immune responses to viral infections and to vaccination compared to male subjects. Sex hormones, in turn, differentially affect the immune responses to viruses, by specific binding to the hormone receptors expressed on the immune cells. In general, estrogens have immune-stimulating effect, while androgens are immune-suppressing. However, sex hormones, such as androgen, can also directly interact with HBV genome integrated into the cell nucleus and activate transcription of HBV oncoproteins. On the other side, estradiol and estrogen receptors protect liver cells from inflammatory damage, apoptosis and oxidative stress, which contribute to fibrosis and malignant transformation preceding HCC. In HCV-associated cirrhosis and HCC the decreased expression of estrogen receptor alfa (ERα) in male patients may explain the worse outcome of HCV infection in men than in women. The synergistic action of male and female sex hormones and of immune responses, together with viral factors contribute to the mechanism of sex/gender disparity in the outcome and progression of hepatitis viruses infection

Las razones del censor : control ideológico y censura de libros en la primera Edad Moderna

La col·lecció Studia Aurea Monográfica, coeditada por la Universitat Autònoma de Barcelona y la Universitat de Girona, es una colección auspiciada por Studia Aurea. Revista de Literatura Española y Teoría Literaria del Renacimiento y Siglo de Oro.La publicación de este volumen colectivo forma parte de las tareas científicas vinculadas al proyecto Poéticas cristianas y teoría de la censura en el siglo XVI (FFI2009-10704), financiado por el Ministerio de Ciencia e Innovación del Gobierno de España, y al Grup de Recerca Consolidat Poetics and Politics in Early Modern Europe (SGR 2009-0660), financiado por la Generalitat de Catalunya. Ha contado para su elaboración con la Acción Complementaria del MICINN Las razones del censor. El discurso de la intolerancia y la censura en los siglos XVI y XVII (FFI2010-12238-E) y con fondos del programa de «Ajuts a la publicació d'actes de congressos i reunions científiques» de la Universitat Autònoma de Barcelona (ACT2010-18).Los índices de libros prohibidos de los siglos xvi y xvii establecen en los prólogos que el fin principal de la censura de textos es la erradicación de la herejía y del error en materia de fe. La prohibición de impresos respondería, pues, a un propósito primario de erradicación de la heterodoxia y de depuración doctrinal; regula, para ello, la creación, impresión, edición, comercio y circulación de libros, y tiene, además, de forma secundaria, efectos disuasorios e inhibitorios sobre la lectura y escritura. Los índices expurgatorios, en cambio, sí permiten la difusión de las obras suspectas, pero sólo si previamente se hubieran sanado sus 'errores' o desviaciones, se hubiera restaurado su (supuesta) forma original o se hubiera reparado la posibilidad de un uso 'depravado' o malintencionado del texto. Una lectura atenta de los índices revela, además, otras 'razones' para la acción censoria, que, con el tiempo, no se limitaría a perseguir la herejía y el error de fe, sino que aspiraría a eliminar otras formas de contestación y a vigilar las costumbres, los usos lingüísticos, la decencia y la honestidad públicas

A New Web Score to Predict Health Status in Paediatric Patients with Chronic Diseases: Design and Development of the PENSAMI Study

Paediatric chronic diseases (CD) are characterised by their ongoing duration and the fact that they are often managed throughout the lifespan, with the need to adjust lifestyle and expectations with the limitations coming from the CD. The aim of the PENSAMI study is to not only cure the disease, but to also care for the person from a clinical and psychosocial perspective. Data will be collected from 150 paediatric patients affected by heart disease, diabetes, and asthma admitted during in-hospital stay or outpatient visits, and from 200 healthy control subjects. The protocol will consist of two phases. The first one will aim at elaborating the predictive model by detecting (clinical, anthropometric at birth, environmental, lifestyle, social context, emotional state, and mental abilities) in order to develop a model predictive of the events considered: (1) re-hospitalisation; (2) severity and progression of the disease; (3) adherence to therapy; (4) HRQoL; (5) obesity and metabolic syndrome; (6) illness-stress related; (7) school drop-out; (8) school performance. The second one will address validating the previous predictive model. This model will aim to: (1) understand, prevent, and halt the progression of childhood CD; (2) develop new and improved diagnostic tools; (3) pave the way for innovative treatments and additional therapies to traditional clinical practice; and (4) create truly personalised therapeutic and preventive strategies in various sectors, such as cardiology, diabetes, and respiratory diseases