2,490 research outputs found
New presbyter meets old priests:Conciliarism and conscience in Samuel Rutherford’s Free Disputation
Maximalising providence:Samuel Rutherford’s Augustinian transformation of Scotist scholasticism
Disputing providence in seventeenth-century Scottish universities:The conflict between Samuel Rutherford and the Aberdeen Doctors and its repercussions
The Importance of Audit Firm Characteristics and the Drivers of Auditor Change in UK Listed Companies
This paper explores the importance of audit firm characteristics and the factors motivating auditor change based on questionnaire responses from 210 listed UK companies (a response rate of 70%). Twenty-nine potentially desirable auditor characteristics are identified from the extant literature and their importance elicited. Exploratory factor analysis reduces these variables to eight uncorrelated underlying dimensions: reputation/quality; acceptability to third parties; value for money; ability to provide non-audit services; small audit firm; specialist industry knowledge; non-Big Six large audit firm; and geographical proximity. Insights into the nature of 'the Big Six factor' emerge. Two thirds of companies had recently considered changing auditors; the main reasons cited being audit fee level, dissatisfaction with audit quality and changes in top management. Of those companies that considered change, 73% did not actually do so, the main reasons cited being fee reduction by the incumbent and avoidance of disruption. Thus audit fee levels are both a key precipitator of change and a key factor in retaining the status quo
Hubble Space Telescope NICMOS Polarization Observations of Three Edge-on Massive YSOs
Massive young stellar objects (YSOs), like low-mass YSOs, appear to be
surrounded by optically thick envelopes and/or disks and have regions, often
bipolar, that are seen in polarized scattered light at near-infrared
wavelengths. We are using the 0.2'' spatial resolution of NICMOS on Hubble
Space Telescope to examine the structure of the disks and outflow regions of
massive YSOs in star-forming regions within a few kpc of the Sun. Here we
report on 2 micron polarimetry of NGC 6334 V and S255 IRS1. NGC 6334 V consists
of a double-lobed bright reflection nebula seen against a dark region, probably
an optically thick molecular cloud. Our polarization measurements show that the
illuminating star lies ~ 2'' south of the line connecting the two lobes; we do
not detect this star at 2 micron, but there are a small radio source and a
mid-infrared source at this location. S255 IRS1 consists of two YSOs (NIRS1 and
NIRS3) with overlapping scattered light lobes and luminosities corresponding to
early B stars. Included in IRS1 is a cluster of stars from whose polarization
we determine the local magnetic field direction. Neither YSO has its scattered
light lobes aligned with this magnetic field. The line connecting the scattered
light lobes of NIRS1 is twisted symmetrically around the star; the best
explanation is that the star is part of a close binary and the outflow axis of
NIRS1 is precessing as a result of non-coplanar disk and orbit. The star NIRS3
is also offset from the line connecting its two scattered light lobes. We
suggest that all three YSOs show evidence of episodic ejection of material as
they accrete from dense, optically thick envelopes.Comment: 39 pages, 7 figures, 4 tables To be published in The Astrophysical
Journa
The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances.
Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation that is resistant to embryonic reprogramming, resulting in parental origin-specific monoallelic gene expression. A subset of individuals affected by imprinting disorders (IDs) displays multi-locus imprinting disturbances (MLID), which may result from aberrant establishment of imprinted differentially methylated regions (DMRs) in gametes or their maintenance in early embryogenesis. Here we investigated the extent of MLID in a family harbouring a ZFP57 truncating variant and characterize the interactions between human ZFP57 and the KAP1 co-repressor complex. By ectopically targeting ZFP57 to reprogrammed loci in mouse embryos using a dCas9 approach, we confirm that ZFP57 recruitment is sufficient to protect oocyte-derived methylation from reprogramming. Expression profiling in human pre-implantation embryos and oocytes reveals that unlike in mice, ZFP57 is only expressed following embryonic-genome activation, implying that other KRAB-zinc finger proteins (KZNFs) recruit KAP1 prior to blastocyst formation. Furthermore, we uncover ZNF202 and ZNF445 as additional KZNFs likely to recruit KAP1 to imprinted loci during reprogramming in the absence of ZFP57. Together, these data confirm the perplexing link between KZFPs and imprint maintenance and highlight the differences between mouse and humans in this respect
Star Formation in the Central 400 pc of the Milky Way: Evidence for a Population of Massive YSOs
The central kpc of the Milky Way might be expected to differ significantly
from the rest of the Galaxy with regard to gas dynamics and the formation of
YSOs. We probe this possibility with mid-infrared observations obtained with
IRAC and MIPS on Spitzer and with MSX. We use color-color diagrams and SED fits
to explore the nature of YSO candidates (including objects with 4.5 micron
excesses possibly due to molecular emission). There is an asymmetry in the
distribution of the candidate YSOs, which tend to be found at negative Galactic
longitudes; this behavior contrasts with that of the molecular gas,
approximately 2/3 of which is at positive longitudes. The small scale height of
these objects suggests that they are within the Galactic center region and are
dynamically young. They lie between two layers of infrared dark clouds and may
have originated from these clouds. We identify new sites for this recent star
formation. The methanol masers appear to be associated with young, embedded
YSOs characterized by 4.5 micron excesses. We use the SEDs of these sources to
estimate their physical characteristics. Within the central 400x50 pc
(|l|<1.3\degr and |b|<10') the star formation rate based on the identification
of Stage I evolutionary phase of YSO candidates is about 0.14 solar mass/yr. We
suggest that a recent burst of star formation took place within the last 10^5
years. This suggestion is also consistent with estimates of star formation
rates within the last ~10^7 years showing a peak around 10^5 years ago. Lastly,
we find that the Schmidt-Kennicutt Law applies well in the central 400 pc of
the Galaxy. This implies that star formation does not appear to be dramatically
affected by the extreme physical conditions in the Galactic center region.Comment: 96 pages, ten tables, 35 figures, ApJ (in press), replaced by a
revised versio
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