Porphyrin-Based Metal-Organic Frameworks as Heterogeneous Catalysts in Oxidation Reactions

Porphyrin-based Metal-Organic Frameworks (Por-MOFs) constitute a special branch of the wide MOF family that has proven its own value and high potential in different applications. In this mini-review the application of these materials as catalysts in oxidation reactions is highlighted

Produção do melão amarelo submetido a distintos sistemas de irrigação e mulching em Petrolina-PE.

O presente estudo foi realizado no Campus Petrolina Zona Rural do IF Sertão-PE, em Petrolina-PE, com o objetivo de avaliar a produção de híbridos de melão amarelo em dois sistemas de irrigação por gotejamento e três coberturas de solo no Vale do Submédio São Francisco. O delineamento experimental foi em blocos casualizados, esquema de parcelas subsubdivididas, 2 x 2 x 3 x 6, onde: 2 ? híbridos de melão (Gladial e 10/00), 2 ? sistemas de irrigação (1 fileira de gotejadores por fileira de plantas e 2 fileiras de gotejadores por fileira de planta), 3 ? coberturas de solo (cobertura com mulching preto; cobertura com mulching cinza e sem cobertura de solo) e 6 ? blocos (repetições). Observou-se que a produtividade diferiu-se estatisticamente para nível de efeito à (P<.01), em que a cobertura de solo com mulching cinza apresentou maior produtividade mesmo não diferindo estatisticamente do mulching preto, apresentando os melhores resultados em relação ao sem cobertura de solo. Os valores de produtividade em kg ha-1 foram de 41.805,55; 36.597,22 e 27.500,00 respectivamente

Cardiospondylocarpofacial syndrome as a distinct hereditary connective tissue disorder: novel missense variant in MAP3K7 in two unrelated patients

CDKL5 deficiency disorder is a rare X-linked condition that results in early onset of impairedmotor and cognitive skills such as motor rigidity, stereotypical hand movements and deficient language acquisition aswell as recurrent seizures. It is caused by mutations in the cyclin-dependent kinase-like 5 (CDKL5) gene, which encodes a serine/threonine kinase involved in important neuronal processes such as cell signaling and neuron morphogenesis.FCT: UID/Multi/04326/2019 (CCMAR)info:eu-repo/semantics/publishedVersio

Graus-dia em diferentes fases fenológicas para a cultura do melão em Petrolina-PE.

O presente estudo foi realizado no Campus Petrolina Zona Rural do IF Sertão-PE, em Petrolina-PE, com o objetivo de quantificar os graus-dia acumulados, ou soma térmica, nos diversos estádios fenológico do cultivo de melão Gladial. O ciclo fenológico ocorreu de 30 de agosto a 08 de novembro de 2016, e os dados de temperatura do ar (média, máxima e mínima) foram obtidos de uma estação meteorológica automática instalada próxima da área experimental. Verificou-se que, em média, são necessários 1.012,96 graus-dia acumulados para o melão completar seu ciclo, sendo 153,30, 294,84, 310,44 e 254,38 graus-dia acumulados nos estádios fenológicos inicial, vegetativo, frutificação e maturação, respectivamente

Models to estimate potassium and nitrate in changes of ion concentration in soil solution in banana cultivation.

The adequate fertigation use bases on the application of nutrients by water according to crop needs throughout its cycle. The evaluation of nutrients in the soil solution may be faster if based upon soil electric conductivity and moisture by using parametric models. The objective of this study was to evaluate the sensitivity of two parametric models for estimating nitrate and potassium concentration in the soil solution under changes of ion concentration during a crop cycle. One model was that from Vogeler et al. (1996) in which ion concentration is a function of soil moisture and electrical conductivity; the other was the potential in which the concentration is a function of the electrical conductivity of the soil solution. The potential model presented a better performance compared to that of adapted from Vogeler, as for estimation of ion concentrations as for the sensitivity of this model to changes in concentration of this ion in the soil solution. The models showed greater sensitivity when fitted to data corresponding to all possible occurrences in the soil during the crop cycle. The model should consider a range of concentrations with the possible values of the soil solution along crop cycle

Substantial contribution of iodine to Arctic ozone destruction

Unlike bromine, the effect of iodine chemistry on the Arctic surface ozone budget is poorly constrained. We present ship-based measurements of halogen oxides in the high Arctic boundary layer from the sunlit period of March to October 2020 and show that iodine enhances springtime tropospheric ozone depletion. We find that chemical reactions between iodine and ozone are the second highest contributor to ozone loss over the study period, after ozone photolysis-initiated loss and ahead of bromine.Iodine chemistry plays a more important role than bromine chemistry in tropospheric ozone losses in the Arctic, according to ship-based observations of halogen oxides from March to October 2020.Peer reviewe

ALDH1A2 (RALDH2) genetic variation in human congenital heart disease

Abstract\ud \ud \ud \ud Background\ud \ud Signaling by the vitamin A-derived morphogen retinoic acid (RA) is required at multiple steps of cardiac development. Since conversion of retinaldehyde to RA by retinaldehyde dehydrogenase type II (ALDH1A2, a.k.a RALDH2) is critical for cardiac development, we screened patients with congenital heart disease (CHDs) for genetic variation at the ALDH1A2 locus.\ud \ud \ud \ud Methods\ud \ud One-hundred and thirty-three CHD patients were screened for genetic variation at the ALDH1A2 locus through bi-directional sequencing. In addition, six SNPs (rs2704188, rs1441815, rs3784259, rs1530293, rs1899430) at the same locus were studied using a TDT-based association approach in 101 CHD trios. Observed mutations were modeled through molecular mechanics (MM) simulations using the AMBER 9 package, Sander and Pmemd programs. Sequence conservation of observed mutations was evaluated through phylogenetic tree construction from ungapped alignments containing ALDH8 s, ALDH1Ls, ALDH1 s and ALDH2 s. Trees were generated by the Neighbor Joining method. Variations potentially affecting splicing mechanisms were cloned and functional assays were designed to test splicing alterations using the pSPL3 splicing assay.\ud \ud \ud \ud Results\ud \ud We describe in Tetralogy of Fallot (TOF) the mutations Ala151Ser and Ile157Thr that change non-polar to polar residues at exon 4. Exon 4 encodes part of the highly-conserved tetramerization domain, a structural motif required for ALDH oligomerization. Molecular mechanics simulation studies of the two mutations indicate that they hinder tetramerization. We determined that the SNP rs16939660, previously associated with spina bifida and observed in patients with TOF, does not affect splicing. Moreover, association studies performed with classical models and with the transmission disequilibrium test (TDT) design using single marker genotype, or haplotype information do not show differences between cases and controls.\ud \ud \ud \ud Conclusion\ud \ud In summary, our screen indicates that ALDH1A2 genetic variation is present in TOF patients, suggesting a possible causal role for this gene in rare cases of human CHD, but does not support the hypothesis that variation at the ALDH1A2 locus is a significant modifier of the risk for CHD in humans.Work supported by grants from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 01/000090; 00/030722; 01/142381; 02/113402; 03/099982; 04/116068; 04/157044 and Conselho Nacional de Desenvolvimento Científico e Tecnológico 481872/20078. We would like to thank the careful work and thoughtful suggestions of the two reviewers responsible for the reviewing editorial process.Work supported by grants from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 01/00009-0; 00/03072-2; 01/14238-1; 02/11340-2; 03/09998-2; 04/11606-8; 04/15704-4 and Conselho Nacional de Desenvolvimento Científico e Tecnológico 481872/2007-8. We would like to thank the careful work and thoughtful suggestions of the two reviewers responsible for the reviewing editorial process

Deep water inflow slowed offshore expansion of the West Antarctic Ice Sheet at the Eocene-Oligocene transition

The stability of the West Antarctic Ice Sheet is threatened by the incursion of warm Circumpolar Deepwater which flows southwards via cross-shelf troughs towards the coast there melting ice shelves. However, the onset of this oceanic forcing on the development and evolution of the West Antarctic Ice Sheet remains poorly understood. Here, we use single- and multichannel seismic reflection profiles to investigate the architecture of a sediment body on the shelf of the Amundsen Sea Embayment. We estimate the formation age of this sediment body to be around the Eocene-Oligocene Transition and find that it possesses the geometry and depositional pattern of a plastered sediment drift. We suggest this indicates a southward inflow of deep water which probably supplied heat and, thus, prevented West Antarctic Ice Sheet advance beyond the coast at this time. We conclude that the West Antarctic Ice Sheet has likely experienced a strong oceanic influence on its dynamics since its initial formation