An application of a hybrid intelligent system for diagnosing primary headaches

[Abstract] (1) Background: Modern medicine generates a great deal of information that stored in medical databases. Simultaneously, extracting useful knowledge and making scientific decisions for diagnosis and treatment of diseases becomes increasingly necessary. Headache disorders are the most prevalent of all the neurological conditions. Headaches have not only medical but also great socioeconomic significance. The aim of this research is to develop an intelligent system for diagnosing primary headache disorders. (2) Methods: This research applied various mathematical, statistical and artificial intelligence techniques, among which the most important are: Calinski-Harabasz index, Analytical Hierarchy Process, and Weighted Fuzzy C-means Clustering Algorithm. These methods, techniques and methodologies are used to create a hybrid intelligent system for diagnosing primary headache disorders. The proposed intelligent diagnostic system is tested with original real-world data set with different metrics. (3) Results: First at all, nine of 20 attributes – features from International Headache Society (IHS) criteria are selected, and then only five most important attributes from IHS criteria are selected. The calculation result based on the Calinski–Harabasz index value (178) for the optimal number of clusters is three, and they present three classes of headaches: (i) migraine, (ii) tension-type headaches (TTHs), and (iii) other primary headaches (OPHs). The proposed hybrid intelligent system shows the following quality metrics: Accuracy 75%; Precision 67% for migraine, 74% for TTHs, 86% for OPHs, and Average Precision 77%; Recall 86% for migraine, 73% for TTHs, 67% for OPHs, Average Recall 75%; F1 score 75% for migraine, 74% for TTHs, 75% for OPHs, and Average F1 score 75%. (4) Conclusions: The hybrid intelligent system presents qualitative and respectable experimental results. The implementation of existing diagnostics systems and the development of new diagnostics systems in medicine is necessary in order to help physicians make quality diagnosis and decide the best treatments for the patients.Ministerio de Ciencia e Innovación; MINECO-TIN2017-84804-RGobierno del Principado de Asturias; FCGRUPIN-IDI/2018/000226Serbia. Ministry of Education, Science and Technological Development; 451-03-68/2020-14/20015

WEED INFESTATION OF WINTER WHEAT IN DIFFERENT TILLAGE SYSTEMS AND LEVEL OF NITROGEN IN TOP DRESSING

Growing technology, especially tillage and fertilization of economically important crop species such as wheat, plays a very important role in weed control. Successful weed control in the crop in turn significantly affects the formation of grain yield, both in quantity and quality. The aim of this paper was to investigate the influence of sustainable (mulch - and no- tillage) and conventional farming system on weed infestation of winter wheat. Basic fertilization was uniform (600 kg/ha NPK 15:15:15) while weed infestation differences between three levels of nitrogen fertilization in top dressing (0, 60 and 120 kg/ha) were examined. The variety Pobeda, selected at the Institute of Field and Vegetable Crops in Novi Sad, served as the object of investigation. The examination was performed at "Radmilovac" on the experimental school property of the Faculty of Agriculture in Zemun within the four- crop rotation (maize-winter wheat-spring barley + red clover-red clover) on leached chernozem soil type in a two-year period. The system of conventional tillage showed the highest efficiency in the weed control (number of weed species and number of weed plants per species) of the two conservation systems. The next is the system of mulch tillage, which may be of interest for practice, while the system of no tillage had the lowest efficiency in the control of weeds, especially perennials. Increasing the amount of nitrogen in the top dressing reduces weeds in all tillage systems, mainly due to the stronger competitiveness of winter wheat. The highest fresh biomass of weeds was measured in the no-tillage system (especially in the second year of investigation) due to the significantly higher presence of perennial broadleaf weeds

Biomass and Protein Yields of Field Peas and Oats Intercrop Affected by Sowing Norms and Nitrogen Fertilizer at Two Different Stages of Growth

In limited growing conditions, intercropped field peas and oats can represent a significant source of forage rich in protein. If applied correctly, factors such as nitrogen fertilizer, the mowing phase, and sowing norms can significantly increase the productivity of these mixtures. Field trials were conducted to examine their productivity under different nitrogen levels (0, 40, 80 kg ha−1 ), different sowing norms/mixtures (field peas: oats—100:15%; 100:30%), and two stages of growth (full flowering, full pod formation). Nitrogen fertilizer and different sowing norms had a significant effect on the biomass, hay, and crude protein yields. On average, the highest hay yields were achieved with 80 kg ha−1 N (4.96 t ha−1 ), followed by 40 kg ha−1 N (4.27 t ha−1 ). The highest protein yields were achieved with 40 kg ha−1 N (CP—704.1 kg ha−1 ), followed by 80 kg ha−1 N (CP—637.6 kg ha−1 ). Sowing norm 100:30% achieved higher hay yields: 100:30%—4.82 t ha−1; 100:15%—4.44 t ha−1, while 100:15% achieved higher crude protein yields: 100:15%—730.4 kg ha−1; 100:30%—692.7 kg ha−1 on average. The costs were not significantly increased with the nitrogen fertilizer, but the net profits were increased by as much as 163%, depending on the nitrogen level and the mixture. Nitrogen fertilizer also achieves higher economic efficiency for the mixture 100:15% compared to the 100:30% mixture. Mixtures of field peas and oats outperform single-grown crops and provide cost-effective feed for a short time. Using optimal seed ratios and nitrogen fertilizer can significantly increase the productivity and profitability of the feed with minimal impact on the overall production costs

Biochemical and ultrastructural changes in the liver of European perch (Perca fluviatilis L.) in response to cyanobacterial bloom in the Gruža reservoir

We investigated the biochemical and ultrastructural changes in the liver of the freshwater fish, European perch (Perca fluviatilis), in response to Aphanizomenon flos-aquae bloom in the Gruža Reservoir, Serbia. The activities of total manganese- and copper zinc-containing superoxide dismutase (Tot SOD, Mn-SOD, Cu/Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST), as well as concentrations of total glutathione (GSH) and sulfhydryl (-SH) groups were examined before and during the bloom period. Mn-SOD activity was significantly higher, while the activities of Cu/Zn-SOD, CAT and GSH-Px and the concentration of the -SH groups were significantly lower during the bloom. The ultrastructure of the liver revealed necrotic and apoptotic damage to the hepatocytes during the bloom period. Our work represents the first study to report the influences of an Aphanizomenon flos-aquae bloom in the Gruža Reservoir on antioxidant biomarkers and on histopathological alterations in the liver of the freshwater fish European perch (Perca fluviatilis)

Téa Obreht’s Transnational Disremembering within the Mythical Realism of The Tiger’s Wife

This paper discusses Téa Obreht's 2010 novel The Tiger's Wife within the context of transmigrations and post-national conceptions of both the real and mythical translocality. Through analysis of Obreht’s discourse of disremembering, which is in Aleksandar Hemon’s definition a recognition of one’s own experience under the new narrative, the paper will explore the transnational dimensions of the Slavic-American identity of The Tiger’s Wife. The aim of this paper is to focus on the new understanding of transnational relationality as well as on a reconception of reality that disremembers Obreht’s or, on a larger scale, human experience within the mythical realism of The Tiger’s Wife.Keywords: transnationalism, the Slavic-American identity, disremembering, Aleksandar Hemon, Téa Obreht, The Tiger’s Wife, mythical realismTo disremember, according to Aleksandar Hemon, a celebrated Bosnian-American writer with an immigrant experience, is to recognize one’s own experience under the new narrative. He points out that it especially refers to the “people who have come through a form of actual, physical slaughter, and to the extent the construction of narrative is memory, then the narrative, for them, has to involve a quantity of amnesia. More amnesia that is involved in most narrative” (Interview by Richard Wirick). Disremembering blends non-fiction and fiction, genocide documentation and utopian imagery, and implies an alternative interpretation of reality. Hemon’s 2008 novel The Lazarus Project is a transnational project of disremembering. In The Lazarus Project, Hemon intertwines a double narrative of the multilayered parallel universes of the past and the present by following the narrator Vladimir Brik, a post-war Bosnian who lives in the United States, as he questions his life. Brik traces the story of Lazarus Averbuch, a young Jewish immigrant who is a survivor of the Kishinev pogrom in what is now Moldova, and an alleged anarchist. At the same time, Brik questions both the inner and outer aspects of his reality. In the first-person narrative, he explains that he needs to re-imagine what he could not retrieve, and to see what he could not imagine. For this reason, he disremembers his own experience within the story of Lazarus that also implies resurrection and a new birth story. This paper will analyze Téa Obreht’s evocative 2010 novel The Tiger's Wife from the point of view of a Hemonesque narrative concept of disremembering and, within the discourse, an Obrehtesque interaction of myth and truth

Hemicranial Cough-Induced Headache as a First Symptom of a Carotid-Cavernous Fistula-Case Report

Background and objectives: Spontaneous carotid-cavernous fistulas (CCFs) are rare, and they may be caused by an aneurysm rupture. Materials and Methods: A case of a man hospitalized for high-intensity hemicranial headache with sudden cough onset as part of an upper respiratory tract infection is presented. The pain was of a pulsating character, localized on the right, behind the eye, followed by nausea and vomiting. Neurological finding registered a wider rima oculi to the right and slight neck rigidity. Laboratory findings detected a mild leukocytosis with neutrophil predominance, while cytobiochemical findings of CSF and a computerized tomography (CT) scan of the endocranium were normal. Results: Magnetic resonance imaging (MRI) angiography indicated the presence of a carotid cavernous fistula with a pseudoaneurysm to the right. Digital subtraction angiography (DSA) was performed to confirm the existence of the fistula. The planned artificial embolization was not performed because a complete occlusion of the fistula occurred during angiographic examination. Patient was discharged without subjective complaints and with normal neurological findings. Conclusions: Hemicranial cough-induced headache may be the first sign of carotid cavernous fistula, which was resolved by a spontaneous thrombosis in preparation for artificial embolization

Impact of Individual Headache Types on the Work and Work Efficiency of Headache Sufferers

Background: Headaches have not only medical but also great socioeconomic significance, therefore, it is necessary to evaluate the overall impact of headaches on a patient’s life, including their work and work efficiency. The aim of this study was to determine the impact of individual headache types on work and work efficiency. Methods: This research was designed as a cross-sectional study performed by administering a questionnaire among employees. The questionnaire consisted of general questions, questions about headache features, and questions about the impact of headaches on work. Results: Monthly absence from work was mostly represented by migraine sufferers (7.1%), significantly more than with sufferers with tension-type headaches (2.23%; p = 0.019) and other headache types (2.15%; p = 0.025). Migraine sufferers (30.2%) worked in spite of a headache for more than 25 h, which was more frequent than with sufferers from tension-type and other-type headaches (13.4%). On average, headache sufferers reported work efficiency ranging from 66% to 90%. With regard to individual headache types, this range was significantly more frequent in subjects with tension-type headaches, whereas 91–100% efficiency was significantly more frequent in subjects with other headache types. Lower efficiency, i.e., 0–40% and 41–65%, was significantly more frequent with migraine sufferers. Conclusions: Headaches, especially migraines, significantly affect the work and work efficiency of headache sufferers by reducing their productivity. Loss is greater due to reduced efficiency than due to absenteeism