The global integrated world ocean assessment: linking observations to science and policy across multiple scales

In 2004, the United Nations (UN) General Assembly approved a Regular Process to report on the environmental, economic and social aspects of the world's ocean. The Regular Process for Global Reporting and Assessment of the State of the Marine Environment, including Socioeconomic Aspects produced the first global integrated assessment of the marine environment in December 2016 (known as the first World Ocean Assessment). The second assessment, to be delivered in December 2020, will build on the baselines included in the first assessment, with a focus on establishing trends in the marine environment with relevance to global reporting needs such as those associated with the UN Sustainable Development Goals. Central to the assessment process and its outputs are two components. First, is the utilization of ocean observation and monitoring outputs and research to temporally assess physical, chemical, biological, social, economic and cultural components of coastal and marine environments to establish their current state, impacts currently affecting coastal and marine environments, responses to those impacts and associated ongoing trends. Second, is the knowledge brokering of ocean observations and associated research to provide key information that can be utilized and applied to address management and policy needs at local, regional and global scales. Through identifying both knowledge gaps and capacity needs, the assessment process also provides direction to policy makers for the future development and deployment of sustained observation systems that are required for enhancing knowledge and supporting national aspirations associated with the sustainable development of coastal and marine ecosystems. Input from the ocean observation community, managers and policy makers is critical for ensuring that the vital information required for supporting the science policy interface objectives of the Regular Process is included in the assessment. This community white paper discusses developments in linking ocean observations and science with policy achieved as part of the assessment process, and those required for providing strategic linkages into the future.Agência financiadora - United Nations Division for Ocean Affairs and the Law of the Seainfo:eu-repo/semantics/publishedVersio

Chapter 1: Assessing a planet in transformation: Rationale and approach of the IPBES Global Assessment on Biodiversity and Ecosystem Services

The challenges of mitigating and adapting to climate change, achieving inclusive food, water, energy and health security, addressing urban vulnerabilities, and the unequal burdens of nature deterioration, are not only predicaments on their own right. Because they interact, often exacerbating each other, they create new risks and uncertainties for people and nature. It is now evident that the rapid deterioration of nature, including that of the global environmental commons on land, ocean, atmosphere and biosphere, upon which humanity as a whole depends, are interconnected and their cascading effects compromise societal goals and aspirations from local to global levels. Growing efforts to respond to these challenges and awareness of our dependence on nature have opened new opportunities for action and collaboration towards fairer and more sustainable futures.The global assessment on biodiversity and ecosystem services (GA) has been designed to be a comprehensive and ambitious intergovernmental integrated assessment of recent anthropogenic transformations of Earth?s living systems, the roots of such transformations, and their implications to society. In the chapters that follow, our mandate is to critically assess the state of knowledge on recent past (from the 1970s), present and possible future trends in multi-scale interactions between people and nature, taking into consideration different worldviews and knowledge systems, including those representing mainstream natural and social sciences and the humanities, and indigenous and local knowledge systems. In doing so, the GA also assesses where the world stands in relation to several international agreements related to biodiversity and sustainable development.Fil: Brondizio, Eduardo. No especifíca;Fil: Díaz, Sandra Myrna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Settele, Josef. No especifíca;Fil: Ngo, Hien. No especifíca;Fil: Guèze, Maximilien. No especifíca;Fil: Aumeeruddy-Thomas, Y. No especifíca;Fil: Bai, Xuemei. No especifíca;Fil: Geschke, Arne. No especifíca;Fil: Molnár, Zsolt. No especifíca;Fil: Niamir, Aidin. No especifíca;Fil: Pascual, Unai. No especifíca;Fil: Simcock, Alan. No especifíca;Fil: Jaureguiberry, Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Hien, Ngo,. No especifíca;Fil: Brancalion, Pedro. No especifíca;Fil: Chan, Kai M. A.. No especifíca;Fil: Dubertret, Fabrice. No especifíca;Fil: Hendry, Andrew. No especifíca;Fil: Liu, Jianguo. No especifíca;Fil: Martin, Adrian. No especifíca;Fil: Martín López, Berta. No especifíca;Fil: Midgley, Guy F.. No especifíca;Fil: Obura, David. No especifíca;Fil: Oliver, Tom. No especifíca;Fil: Scheffran, Jürgen. No especifíca;Fil: Seppelt, Ralf. No especifíca;Fil: Strassburg, Bernardo. No especifíca;Fil: Spangenberg, Joachim H.. No especifíca;Fil: Stenseke, Marie. No especifíca;Fil: Turnhout, Esther. No especifíca;Fil: Williams, Meryl J.. No especifíca;Fil: Zayas, Cynthia. No especifíca

Observational cohort study in older women with early breast cancer: Use of radiation therapy and impact on health-related quality of life and mortality

Background Radiotherapy reduces in-breast recurrence risk in early breast cancer (EBC) in older women. This benefit may be small and should be balanced against treatment effect and holistic patient assessment. This study described treatment patterns according to fitness and impact on health-related quality-of-life (HRQoL). Methods A multicentre, observational study of EBC patients aged ≥ 70 years, undergoing breast-conserving surgery (BCS) or mastectomy, was undertaken. Associations between radiotherapy use, surgery, clinico-pathological parameters, fitness based on geriatric parameters and treatment centre were determined. HRQoL was measured using the European Organisation for the Research and Treatment of Cancer (EORTC) questionnaires. Results In 2013–2018 2811 women in 56 UK study centres underwent surgery with a median follow-up of 52 months. On multivariable analysis, age and tumour risk predicted radiotherapy use. Among healthier patients (based on geriatric assessments) with high-risk tumours, 534/613 (87.1%) having BCS and 185/341 (54.2%) having mastectomy received radiotherapy. In less fit individuals with low-risk tumours undergoing BCS, 149/207 (72.0%) received radiotherapy. Radiotherapy effects on HRQoL domains, including breast symptoms and fatigue were seen, resolving by 18 months. Conclusion Radiotherapy use in EBC patients ≥ 70 years is affected by age and recurrence risk, whereas geriatric parameters have limited impact regardless of type of surgery. There was geographical variation in treatment, with some fit older women with high-risk tumours not receiving radiotherapy, and some older, low-risk, EBC patients receiving radiotherapy after BCS despite evidence of limited benefit. The impact on HRQoL is transient

Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: head and neck 5000

BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle behaviour. Observational studies are required to explore survival trends and identify outcome predictors. METHODS: We are identifying people with a new diagnosis of head and neck cancer. We obtain consent that includes agreement to collect longitudinal data, store samples and record linkage. Prior to treatment we give participants three questionnaires on health and lifestyle, quality of life and sexual history. We collect blood and saliva samples, complete a clinical data capture form and request a formalin fixed tissue sample. At four and twelve months we complete further data capture forms and send participants further quality of life questionnaires. DISCUSSION: This large clinical cohort of people with head and neck cancer brings together clinical data, patient-reported outcomes and biological samples in a single co-ordinated resource for translational and prognostic research

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Multiple loci on 8q24 associated with prostate cancer susceptibility

Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility