Parametric design velocity computation for CAD-based design optimization using adjoint methods

This paper presents an efficient optimization process, where the parameters defining the features in a feature-based CAD model are used as design variables. The process exploits adjoint methods for the computation of gradients, and as such the computational cost is essentially independent of the number of design variables, making it ideal for optimization in large design spaces. The novelty of this paper lies in linking the adjoint surface sensitivity information with geometric sensitivity values, referred to as design velocities, computed for CAD models created in commercial CAD systems (e.g. CATIA V5 or Siemens NX)

X-linked adrenoleukodystrophy in heterozygous female patients: women are not just carriers

X-linked adrenoleukodystrophy (X-ALD) is a recessive X-linked disorder associated with marked phenotypic variability. Female carriers are commonly thought to be normal or only mildly affected, but their disease still needs to be better described and systematized. Objectives: To review and systematize the clinical features of heterozygous women followed in a Neurogenetics Clinic. Methods: We reviewed the clinical, biochemical, and neuroradiological data of all women known to have X-ADL. Results: The nine women identified were classified into three groups: with severe and aggressive diseases; with slowly progressive, spastic paraplegia; and with mildly decreased vibratory sensation, brisk reflexes, and no complaints. Many of these women did not have a known family history of X-ALD. Conclusions: Heterozygous women with X-ADL have a wide spectrum of clinical manifestations, ranging from mild to severe phenotypes

Sistema de produção de leite em Terra Alta, Pará.

bitstream/item/60880/1/CPATU-Doc103.pd

Immunohistochemical expression of types I and III collagen antibodies in the temporomandibular joint disc of human foetuses

The objective was to study the morphology of the articular disc and analyse the immunohistochemical expression of types I and III collagen markers in the temporomandibular joint (TMJ) disc of human foetuses of different gestational ages. Twenty TMJ from human foetuses supplied by Universidade Federal de Uberaba with gestational ages from 17 to 24 weeks were studied. the gestational age of the foetuses was determined by measuring the crown-rump (CR) length. Macroscopically, the foetuses were fixed in 10% formalin solution and dissected by removing the skin and subcutaneous tissue and exposing the deep structures. Immunohistochemical markers of type I and III were used to characterize the existence of collagen fibres. Analysis of the immunohistochemical markers of types I and III collagen revealed the presence of heterotypical fibril networks.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo, Dept Morfol & Genet, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Patol, Lab Patol Mol, BR-04023900 São Paulo, BrazilSanta Casa São Paulo, Dept Ciencias Patol, São Paulo, BrazilUniv Complutense Madrid, Dept Anat & Embryol 2, E-28040 Madrid, SpainUniversidade Federal de São Paulo, Dept Morfol & Genet, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Patol, Lab Patol Mol, BR-04023900 São Paulo, BrazilWeb of Scienc

Transboundary cooperation and Mechanisms for Maritime Spatial Planning implementation. SIMNORAT Project

El proyecto SIMNORAT, Supporting Implementation of Maritime Spatial Planning in the Northern European Atlantic region (SIMNORAT), fue un proyecto cofundado por la UE de ordenación del espacio marítimo desarrollado en la región atlántica. Los objetivos del proyecto eran apoyar a los Estados miembros (EM) para aplicar la Directiva 2014/89/UE del Parlamento Europeo y del Consejo, de 23 de julio de 2014, por la que se establece un marco para la ordenación del espacio marítimo (OEM); y poner en marcha y llevar a cabo iniciativas concretas y transfronterizas de OEM entre los EM participantes en el proyecto (España, Francia y Portugal). Para desarrollar y probar aspectos de la ordenación del espacio marítimo con el fin de elaborar directrices y recomendaciones útiles en un contexto transfronterizo, las autoridades competentes de los países también participaron en el proyecto. Los resultados de SIMNORAT, como el desarrollo de una metodología conceptual para la ordenación del espacio marítimo transfronterizo, el análisis de las herramientas y los datos aplicados en el proceso de ordenación del espacio marítimo, la evaluación de las demandas y tendencias espaciales de los sectores marítimos, y la participación de las partes interesadas, ayudaron a identificar las mejores prácticas en los aspectos científicos, técnicos y sociales de la ordenación del espacio marítimo para una cooperación eficaz, especialmente en las áreas de estudio de casos transfronterizos, para mejorar la aplicación de la Directiva sobre ordenación del espacio marítimo en cada país con esfuerzos de colaboración y una visión común. Esto, a su vez, puede apoyar la creación del marco adecuado para desarrollar una economía azul sostenible en la región, gestionando el sistema socioecológico asociado en un entorno cambiante

Reducing Parametric Uncertainty in Limit Cycle Oscillation Computational Models

ABSTRACTThe assimilation of discrete data points with model predictions can be used to achieve a reduction in the uncertainty of the model input parameters, which generate accurate predictions. The problem investigated here involves the prediction of limit-cycle oscillations using a High-Dimensional Harmonic Balance (HDHB) method. The efficiency of the HDHB method is exploited to enable calibration of structural input parameters using a Bayesian inference technique. Markov-chain Monte Carlo is employed to sample the posterior distributions. Parameter estimation is carried out on a pitch/plunge aerofoil and two Goland wing configurations. In all cases, significant refinement was achieved in the distribution of possible structural parameters allowing better predictions of their true deterministic values. Additionally, a comparison of two approaches to extract the true values from the posterior distributions is presented.</jats:p