The Effects of Galaxy Shape and Rotation on the X-ray Haloes of Early-Type Galaxies

We present a detailed diagnostic study of the observed temperatures of the hot X-ray coronae of early-type galaxies. By extending the investigation carried out in Pellegrini (2011) with spherical models, we focus on the dependence of the energy budget and temperature of the hot gas on the galaxy structure and internal stellar kinematics. By solving the Jeans equations we construct realistic axisymmetric three-component galaxy models (stars, dark matter halo, central black hole) with different degrees of flattening and rotational support. The kinematical fields are projected along different lines of sight, and the aperture velocity dispersion is computed within a fraction of the circularized effective radius. The model parameters are chosen so that the models resemble real ETGs and lie on the Faber-Jackson and Size-Luminosity relations. For these models we compute T_* (the stellar heating contribution to the gas injection temperature) and T_gm (the temperature equivalent of the energy required for the gas escape). In particular, different degrees of thermalisation of the ordered rotational field of the galaxy are considered. We find that T_* and T_gm can vary only mildly due to a pure change of shape. Galaxy rotation instead, when not thermalised, can lead to a large decrease of T_*; this effect can be larger in flatter galaxies that can be more rotationally supported. Recent temperature measurements T_x, obtained with Chandra, are larger than, but close to, the T_* values of the models, and show a possible trend for a lower T_x in flatter and more rotationally supported galaxies; this trend can be explained by the lack of thermalisation of the whole stellar kinetic energy. Flat and rotating galaxies also show lower L_x values, and then a lower gas content, but this is unlikely to be due to the small variation of T_gm found here for them.Comment: 16 pages, 7 figures, accepted for publication in MNRA

X-ray haloes and star formation in early-type galaxies

High resolution 2D hydrodynamical simulations describing the evolution of the hot ISM in axisymmetric two-component models of early-type galaxies well reproduced the observed trends of the X-ray luminosity ($L_\mathrm{x}$) and temperature ($T_\mathrm{x}$) with galaxy shape and rotation, however they also revealed the formation of an exceedingly massive cooled gas disc in rotating systems. In a follow-up of this study, here we investigate the effects of star formation in the disc, including the consequent injection of mass, momentum and energy in the pre-existing interstellar medium. It is found that subsequent generations of stars originate one after the other in the equatorial region; the mean age of the new stars is $> 5$ Gyr, and the adopted recipe for star formation can reproduce the empirical Kennicutt-Schmidt relation. The results of the previous investigation without star formation, concerning $L_\mathrm{x}$ and $T_\mathrm{x}$ of the hot gas, and their trends with galactic shape and rotation, are confirmed. At the same time, the consumption of most of the cold gas disc into new stars leads to more realistic final systems, whose cold gas mass and star formation rate agree well with those observed in the local universe. In particular, our models could explain the observation of kinematically aligned gas in massive, fast-rotating early-type galaxies.Comment: 20 pages, 10 figures, 5 tables. Accepted for publication in MNRA

The effects of stellar dynamics on the X-ray emission of flat early-type galaxies

Observational and numerical studies gave hints that the hot gaseous haloes of ETGs may be sensitive to the galaxy internal kinematics. By using high resolution 2D hydro simulations, and realistic two-component (stars plus dark matter) axisymmetric galaxy models, we study the evolution of the hot haloes in a suite of flat ETGs of fixed mass distribution, but with variable amounts of azimuthal velocity dispersion and rotational support, including the possibility of a counter-rotating inner stellar disc. The hot halo is fed by stellar mass losses and heated by SNIa explosions and thermalization of stellar motions. We measure the value of the thermalization parameter gamma (the ratio between the heating due to the relative velocity between the stellar streaming and the ISM bulk flow, and the heating attainable by complete thermalization of the stellar streaming motions). We find that 1) the X-ray emission and the average temperature are larger in fully velocity dispersion supported systems; 2) 0.1<gamma<0.2 for isotropic rotators (with a trend for being larger for lower dark mass models); 3) systems that are isotropic rotators at large radii with an inner counter-rotating disc, or fully velocity dispersion supported systems with an inner rotating disc, have gamma=1, again with a trend to increase for lower dark mass contents. We also find that the lower X-ray luminosities of isotropic rotators cannot be explained just by their low gamma, but are due to the complicated flow structure, consequence of the angular momentum stored at large radii. X-ray emission weighted temperatures and luminosities nicely match observed values; the X-ray isophotes are boxy in case of significant galaxy rotation. Overall, it is found that rotation has an important role to explain the observational result that more rotationally supported ETGs on average show a lower X-ray emission [abridged].Comment: 22 pages, 13 figures, accepted for publication in MNRAS. Comments welcom

Disk dynamics and the X-ray emission of S0 and flat early-type galaxies

With 2D hydrodynamical simulations, we study the evolution of the hot gas flows in early-type galaxies, focussing on the effects of galaxy rotation on the thermal and dynamical status of the ISM. The galaxy is modelled as a two-component axisymmetric system (stars and dark matter), with a variable amount of azimuthal velocity dispersion and rotational support; the presence of a counter rotating stellar disk is also considered. It is found that the ISM of the rotationally supported (isotropic) model is more prone to thermal instabilities than the fully velocity dispersion counterpart, while its ISM temperature and X-ray luminosity are lower. The model with counter rotation shows an intermediate behaviour.Comment: 2 pages, 2 figures. Proceedings of the International Conference "X-ray Astronomy: towards the next 50 years!", Milan, 1-5 Oct 201

The stellar initial mass function of early type galaxies from low to high stellar velocity dispersion: homogeneous analysis of ATLAS3D^{\rm 3D} and Sloan Lens ACS galaxies

We present an investigation about the shape of the initial mass function (IMF) of early-type galaxies (ETGs), based on a joint lensing and dynamical analysis, and on stellar population synthesis models, for a sample of 55 lens ETGs identified by the Sloan Lens ACS (SLACS) Survey. We construct axisymmetric dynamical models based on the Jeans equations which allow for orbital anisotropy and include a dark matter halo. The models reproduce in detail the observed \textit{HST} photometry and are constrained by the total projected mass within the Einstein radius and the stellar velocity dispersion ($\sigma$) within the SDSS fibers. Comparing the dynamically-derived stellar mass-to-light ratios $(M_*/L)_{\rm dyn}$, obtained for an assumed halo slope $\rho_{\rm h}\propto r^{-1}$, to the stellar population ones $(M_*/L)_{\rm pop}$, derived from full-spectrum fitting and assuming a Salpeter IMF, we infer the mass normalization of the IMF. Our results confirm the previous analysis by the SLACS team that the mass normalization of the IMF of high $\sigma$ galaxies is consistent on average with a Salpeter slope. Our study allows for a fully consistent study of the trend between IMF and $\sigma$ for both the SLACS and \ATLAS samples, which explore quite different $\sigma$ ranges. The two samples are highly complementary, the first being essentially $\sigma$ selected, and the latter volume-limited and nearly mass selected. We find that the two samples merge smoothly into a single trend of the form $\log\alpha =(0.38\pm0.04)\times\log(\sigma_{\rm e}/200\,\mathrm{km~s}^{-1})+(-0.06\pm0.01)$, where $\alpha=(M_*/L)_{\rm dyn}/(M_*/L)_{\rm pop}$ and $\sigma_{\rm e}$ is the luminosity averaged $\sigma$ within one effective radius $R_{\rm e}$. This is consistent with a systematic variation of the IMF normalization from Kroupa to Salpeter in the interval $\sigma_{\rm e}\approx90-270\,\mathrm{km~s}^{-1}$.Comment: 18 pages, 8 figures. Accepted for publication in MNRA

RSA:dagli anni '70 al giorno d'oggi

In this note, after a brief historical excursus, we describe the revolution in cryptography of the 70es, due to the introduction of public key cryptography and the RSA algorithm. We also consider some contemporary applications of this algorithm. Modern cryptography has indeed become a commodity technology, which is currently used for applications ranging from e–commerce to digital television

Human induced pluripotent stem cells as a source of insulin-producing cells for cell therapy of diabetes

BACKGROUND New sources of insulin-secreting cells are strongly required for the cure of diabetes. Recent successes in differentiating embryonic stem cells, in combination with the discovery that it is possible to derive human induced pluripotent stem cells (iPSC) from somatic cells, have raised the possibility that patient-specific β cells might be derived from patients through cell reprogramming and differentiation. AIMS In this study, we aimed to obtain insulin-producing cells from human iPSC and test their ability to secrete insulin in vivo. METHODS: Human iPSC, derived from both fetal and adult fibroblasts, were differentiated in vitro into pancreas-committed cells and their ability to secrete insulin was measured. iPSCderived cells at two different stages of differentiation (posterior foregut and endocrine cells) were transplanted into immunodeficient mice to test their ability to engraft, differentiate and secrete insulin. RESULTS: IPSC were shown to differentiate into insulin-producing cells in vitro, following the stages of pancreatic organogenesis. At the end of the differentiation, the production of INSULIN mRNA was highly increased and up to 14% of the cell population became insulin-positive. Terminally differentiated cells also produced C-peptide in vitro in both basal and stimulated conditions. In vivo, mice transplanted with pancreatic cells secreted human C-peptide in response to glucose stimulus, but transplanted cells were observed to lose insulin secretion capacity during the time. At histological evaluation, the grafts were composed of a mixed population of cells containing mature pancreatic cells, but also pluripotent cells and rare neuronal cells. CONCLUSION: These data overall suggest that human iPSC have the potential to generate insulinproducing cells and that these differentiated cells can engraft and secrete insulin in vivo

(a cura di) Manuale di tecniche diagnostiche ed esami di laboratorio / Wilson Denise

Il Manuale di Tecniche Diagnostiche ed Esami di Laboratorio di McGraw-Hill illustra in maniera specifica tutto ciò che è necessario conoscere sulla corretta indicazione all'utilizzo e all'interpretazione degli esami diagnostici. Affronta inoltre il tema della preparazione del paziente nelle fasi di esecuzione e che precedono e seguono l'esame, allo scopo di fornirgli un'assistenza scrupolosa e attenta alle diverse normative relative alla sicurezza. Il Manuale, di agile formato e facile consultazione, rappresenta l'unico testo interamente pensato e costruito a partire dalle linee guida della pratica professionale basate sulle evidenze scientifiche, un valido motivo in più per utilizzarlo con successo nella pratica clinica quotidiana

Experimental in vivo models of multiple sclerosis: state of the art

Multiple sclerosis is a multifactorial and heterogeneous neurological disease; hence, several experimental animal models had to be developed to mimic the different features of human pathology. Three main classes of animal models have been developed:experimental autoimmune encephalomyelitis (EAE), cupri- zone intoxication, and Theiler’s murine encephalomyelitis virus (TMEV) infection. The EAE model is the most versatile as it allows the reproduction of different patterns of multiple sclerosis; it is mostly relevant for relapsing-remitting multiple sclerosis and has allowed the development of several first-line, disease-modifying drugs for the treatment of multiple sclerosis. The other two models are less flexi- ble than the EAE model and, to date, have not led to the discovery of any clinically relevant therapies. The cuprizone model mostly mimics the acute and chronic courses of multiple sclerosis, and it may represent a useful tool to develop novel therapies to protect oligodendrocytes and stimulate remyelination. Finally, the TMEV infection is the reference model to specifically study viral-mediated mecha- nisms of acute and primary progressive multiple sclerosis