Mejorar la salud, una cuestión ciudadana

This paper deals with the main resources of health improvement in a community from a suburban area in Zaragoza, Spain. The sample is a probabilistic form made in different points: areas, streets and houses. The local hospital wanted to know the real health situation of its population, so it designed some questions in a global health survey. We asked the people how their health could be improved. In order to systematize the answers, it was used a mixture of qualitative and quantitative research strategies. The most frequent answer was related to lifestyle (sport, tobacco, coffee, personal cares). It is presented a discussion on the results and the importance of prevention and community participation on the Primary Attention Health System

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Mejorar la salud, una cuestión ciudadana

This paper deals with the main resources of health improvement in a community from a suburban area in Zaragoza, Spain. The sample is a probabilistic form made in different points: areas, streets and houses. The local hospital wanted to know the real health situation of its population, so it designed some questions in a global health survey. We asked the people how their health could be improved. In order to systematize the answers, it was used a mixture of qualitative and quantitative research strategies. The most frequent answer was related to lifestyle (sport, tobacco, coffee, personal cares). It is presented a discussion on the results and the importance of prevention and community participation on the Primary Attention Health System

Mejorar la salud, una cuestión ciudadana

This paper deals with the main resources of health improvement in a community from a suburban area in Zaragoza, Spain. The sample is a probabilistic from made in different points: areas, streets and houses. The local hospital wanted to know the real health situation of its population, so it designed some questions in a global health survey. We asked the people how their health could be improved.   In other to systematize the answers, it was used a mixture of qualitative and quantitative research strategies.  The most frequent answers was related to lifestyle (sport, tobacco, coffee, personal cares), it is presented a discussion on the results and the importance of prevention and community participation on the Primary Attention Health System.

Los lugares del hábitat y la inclusión

Los hacedores de ciudades son hombres y mujeres cuya cultura popular, producto de las mezclas de todos aquellos que vivían y otros que han llegado a nuestros territorios, han hecho de lugares declarados como no aptos, lugares donde vivir y han creado, dentro de nuestras ciudades la extensión de lo distinto. Son hombres y mujeres cuyo trabajo, el que tienen para aportar, junto al de otros y otras de su misma condición, les ha permitido autoproducir interesantes y sin duda bellos espacios donde convivir.Presentación; Prólogo; Capítulo I. Informalidad incidente en Brasil y México; Capítulo II. Dimensiones de la exclusión; Capítulo III. Habitantes productores de hábitat y vivienda; Capítulo IV. Políticas públicas de vivienda en cuatro países de Latinoamérica; Capítulo V. Visiones panorámicas y reconocimientos (Parte 1); Capítulo VI. Visiones panorámicas y reconocimientos (Parte 2); Anexos; Autores

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field