Obsession in Edgar Allan Poe's "The Black Cat" and "The Tell-Tale Heart"

TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Comunicação e Expressão. Letras Inglês.Quando lemos os contos de Edgar Allan Poe, é possível notar que muitas de suas histórias estão repletas de personagens obsessivos, mas há poucos estudos interessados na questão da obsessão existente nos contos de Poe. Muito do que foi publicado até agora foi em relação ao conto “Berenice”, no qual o protagonista é obcecado pelos dentes de sua prima. A partir disso, o propósito deste estudo é analisar o tema da obsessão nos contos “O Gato Preto” e “O Coração Delator”, uma vez que nestes contos a obsessão parece ser uma influência central nas ações mais relevantes destas histórias. Segundo Nöel Carroll, narrativas supostamente têm que gerar certos efeitos (14). Baseado nisto, o principal objetivo deste estudo é entender como a obsessão, pode contribuir para a criação de um efeito de terror-Gótico nos dois contos. A partir disto, foi possível notar que a obsessão em “O Gato Preto” e em “O Coração Delator”, quando interpretada como o principal tema destas narrativas, cria efeitos como suspense, uma sensação de estar sendo assombrado e um efeito perturbador.While reading Edgar Allan Poe’s short stories, it is possible to notice that many of his narratives are filled with obsessive characters, but only few studies are concerned with the question of obsession in Poe’s stories. Much of what was written until now has been in relation to the short story “Berenice” in which the protagonist is obsessed with his cousin’s teeth. In this sense, the purpose of this study is to analyze the theme of obsession in Poe’s short stories “The Black Cat” and “The Tell-Tale Heart” once it seems to have a key influence in the most relevant actions in the short stories. According to Nöel Carroll, narratives are supposed to elicit a certain effect (14). Based on this, the main objective of this study is to understand how obsession, in these short stories, contribute to create a Gothic-terror effect. In this regard, it was possible to notice that obsession in “The Black Cat” and “The Tell-Tale Heart”, when interpreted as the main theme of these narratives, creates effects such as suspense, a feeling of being haunted and also an uncanny effect

Study of the HVDC dual transmission system under faults in the power converters

Trabalho apresentado no Speedam 2016, 22-24 de junho de 2016, Capri, ItáliaHVDC transmission systems based on voltage source converters have lately emerged as a good alternative to conventional AC transmission. In these transmission systems multilevel converters have become a promising energy conversion technology. The reliability of the power converters are extremely important since a fault in these equipments may lead to an unavailability for a long period of the transmission system. Thus, this paper will focuses in HVDC dual transmission system under semiconductor failure conditions. As presented in this paper this structure presents interesting characteristics under the point of view the reliability considering a power semiconductor failure. It will present the consequences for the transmission system when there is a semiconductor fault. A study for the change of the modulation system in order to ensure DC link capacitors voltage balance under a fault condition is also presented. Simulation studies are shown in order to confirm the characteristics of the proposed methodology in normal and fault condition mode.N/

Trajetórias de ensino e aprendizagem na formação inicial de professores de matemática

O objetivo deste artigo é apresentar uma discussão, à luz da educação matemática Realística, dos aspectos considerados por futuros professores na elaboração de uma Trajetória de Ensino e Aprendizagem, no âmbito de uma disciplina de Prática e Metodologia do Ensino de Matemática. Para tanto, apresentamos algumas ideias gerais da Educação Matemática Realística e das Trajetórias de Ensino e Aprendizagem. Em seguida, discutimos alguns trechos, evidenciando aspectos considerados pelos futuros professores que se relacionam a conhecimentos a respeito da prática pedagógica do professor que ensina Matemática

FORMAÇÃO PARA A PRECEPTORIA: NECESSIDADES, DESAFIOS E EXPERIÊNCIAS NO CONTEXTO INTERNACIONAL

Trata-se de uma revisão integrativa que objetivou identificar a abordagem da formação para a preceptoria, com foco nos desafios pedagógicos enfrentados pelos preceptores no ensino em serviço e as experiências de formação no contexto internacional. A busca foi realizada nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde, Scientific Electronic Library Online e Medical Literature Analysis and Retrieval System Online, com os descritores em inglês: preceptorship, internship and residency e internship, nonmedical, e português: preceptoria, internato e residência e internato não médico no período entre 2000 e 2020. Foram selecionadas 24 publicações que apresentavam atividades de preceptoria conforme desenvolvidas nos programas brasileiros, ou seja, por profissionais de saúde de nível superior, sendo incluídas publicações em português, espanhol e inglês. Os trabalhos apresentam necessidades que são geradas em um contexto de exercício da preceptoria que demanda o cruzamento das dimensões de ensino e cuidado e extrapola os saberes sobre a prática. Os desafios identificados referem-se às necessidades da prática pedagógica, com destaque para mediação do processo de ensino-aprendizagem, avaliação e uso de metodologias ativas. Foram identificadas 13 experiências de formação para a preceptoria no contexto internacional, sendo duas no Brasil. O apoio dos serviços e das instituições de ensino se mostra fundamental e as experiências de formação examinadas podem orientar o arranjo de iniciativas para formação em preceptoria, a qual necessita ser ampliada e qualificada para atender às necessidades de atenção e formação em saúde no Sistema Único de Saúde

Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model.

Molecules from animal venoms are promising candidates for the development of new drugs. Previous in vitro studies have shown that the venom of the spider Phoneutria nigriventer (PnV) is a potential source of antineoplastic components with activity in glioblastoma (GB) cell lines. In the present work, the effects of PnV on tumor development were established in vivo using a xenogeneic model. Human GB (NG97, the most responsive line in the previous study) cells were inoculated (s.c.) on the back of RAG-/- mice. PnV (100 µg/Kg) was administrated every 48 h (i.p.) for 14 days and several endpoints were evaluated: tumor growth and metabolism (by microPET/CT, using 18F-FDG), tumor weight and volume, histopathology, blood analysis, percentage and profile of macrophages, neutrophils and NK cells isolated from the spleen (by flow cytometry) and the presence of macrophages (Iba-1 positive) within/surrounding the tumor. The effect of venom was also evaluated on macrophages in vitro. Tumors from PnV-treated animals were smaller and did not uptake detectable amounts of 18F-FDG, compared to control (untreated). PnV-tumor was necrotic, lacking the histopathological characteristics typical of GB. Since in classic chemotherapies it is observed a decrease in immune response, methotrexate (MTX) was used only to compare the PnV effects on innate immune cells with a highly immunosuppressive antineoplastic drug. The venom increased monocytes, neutrophils and NK cells, and this effect was the opposite of that observed in the animals treated with MTX. PnV increased the number of macrophages in the tumor, while did not increase in the spleen, suggesting that PnV-activated macrophages were led preferentially to the tumor. Macrophages were activated in vitro by the venom, becoming more phagocytic; these results confirm that this cell is a target of PnV components. Spleen and in vitro PnV-activated macrophages were different of M1, since they did not produce pro- and anti-inflammatory cytokines. Studies in progress are selecting the venom molecules with antitumor and immunomodulatory effects and trying to better understand their mechanisms. The identification, optimization and synthesis of antineoplastic drugs from PnV molecules may lead to a new multitarget chemotherapy. Glioblastoma is associated with high morbidity and mortality; therefore, research to develop new treatments has great social relevance. Natural products and their derivatives represent over one-third of all new molecular entities approved by FDA. However, arthropod venoms are underexploited, although they are a rich source of new molecules. A recent in vitro screening of the Phoneutria nigriventer spider venom (PnV) antitumor effects by our group has shown that the venom significantly affected glioblastoma cell lines. Therefore, it would be relevant to establish the effects of PnV on tumor development in vivo, considering the complex neoplastic microenvironment. The venom was effective at impairing tumor development in murine xenogeneic model, activating the innate immune response and increasing tumor infiltrating macrophages. In addition, PnV activated macrophages in vitro for a different profile of M1. These activated PnV-macrophages have potential to fight the tumor without promoting tumorigenesis. Studies in progress are selecting the venom molecules with antitumor and immunomodulatory effects and trying to better understand their mechanisms. We aim to synthesize and carry out a formulation with these antineoplastic molecules for clinical trials. Spider venom biomolecules induced smaller and necrotic xenogeneic GB; spider venom activated the innate immune system; venom increased blood monocytes and the migration of macrophages to the tumor; activated PnV-macrophages have a profile different of M1 and have a potential to fight the tumor without promote tumorigenesis

A supervisão pedagógica no século XXI : desafios da profissionalidade docente

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