57,155 research outputs found
Dual consent? Donors' and recipients' views about involvement in decision-making on the use of embryos created by gamete donation in research
Background Reasonable disagreement about the role awarded to gamete donors in decision-making on the use of embryos created by gamete donation (EGDs) for research purposes emphasises the importance of considering the implementation of participatory, adaptive, and trustworthy policies and guidelines for consent procedures. However, the perspectives of gamete donors and recipients about decision-making regarding research with EGDs are still under-researched, which precludes the development of policies and guidelines informed by evidence. This study seeks to explore the views of donors and recipients about who should take part in consent processes for the use of EGDs in research. Methods From July 2017 to June 2018, 72 gamete donors and 175 recipients completed a self-report structured questionnaire at the Portuguese Public Bank of Gametes (response rate: 76%). Agreement with dual consent was defined as the belief that the use of EGDs in research should be consented by both donors and recipients. Results The majority of participants (74.6% of donors and 65.7% of recipients) were willing to donate embryos for research. Almost half of the donors (48.6%) and half of the recipients (46.9%) considered that a dual consent procedure is desirable. This view was more frequent among employed recipients (49.7%) than among non-employed (21.4%). Donors were less likely to believe that only recipients should be involved in giving consent for the use of EGDs in research (25.0% vs. 41.7% among recipients) and were more frequently favourable to the idea of exclusive donors' consent (26.4% vs. 11.4% among recipients). Conclusions Divergent views on dual consent among donors and recipients indicate the need to develop evidence-based and ethically sustainable policies and guidelines to protect well-being, autonomy and reproductive rights of both stakeholder groups. More empirical research and further theoretical normative analyses are needed to inform people-centred policy and guidelines for shared decision-making concerning the use of EGDs for research
Measuring the extent of convective cores in low-mass stars using Kepler data: towards a calibration of core overshooting
Our poor understanding of the boundaries of convective cores generates large
uncertainties on the extent of these cores and thus on stellar ages. Our aim is
to use asteroseismology to consistently measure the extent of convective cores
in a sample of main-sequence stars whose masses lie around the mass-limit for
having a convective core. We first test and validate a seismic diagnostic that
was proposed to probe in a model-dependent way the extent of convective cores
using the so-called ratios, which are built with and
modes. We apply this procedure to 24 low-mass stars chosen among Kepler targets
to optimize the efficiency of this diagnostic. For this purpose, we compute
grids of stellar models with both the CESAM2k and MESA evolution codes, where
the extensions of convective cores are modeled either by an instantaneous
mixing or as a diffusion process. Among the selected targets, we are able to
unambiguously detect convective cores in eight stars and we obtain seismic
measurements of the extent of the mixed core in these targets with a good
agreement between the CESAM2k and MESA codes. By performing optimizations using
the Levenberg-Marquardt algorithm, we then obtain estimates of the amount of
extra-mixing beyond the core that is required in CESAM2k to reproduce seismic
observations for these eight stars and we show that this can be used to propose
a calibration of this quantity. This calibration depends on the prescription
chosen for the extra-mixing, but we find that it should be valid also for the
code MESA, provided the same prescription is used. This study constitutes a
first step towards the calibration of the extension of convective cores in
low-mass stars, which will help reduce the uncertainties on the ages of these
stars.Comment: 27 pages, 15 figures, accepted in A&
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