1,807 research outputs found
Classification of protein interaction sentences via gaussian processes
The increase in the availability of protein interaction studies in textual format coupled with the demand for easier access to the key results has lead to a need for text mining solutions. In the text processing pipeline, classification is a key step for extraction of small sections of relevant text. Consequently, for the task of locating protein-protein interaction sentences, we examine the use of a classifier which has rarely been applied to text, the Gaussian processes (GPs). GPs are a non-parametric probabilistic analogue to the more popular support vector machines (SVMs). We find that GPs outperform the SVM and na\"ive Bayes classifiers on binary sentence data, whilst showing equivalent performance on abstract and multiclass sentence corpora. In addition, the lack of the margin parameter, which requires costly tuning, along with the principled multiclass extensions enabled by the probabilistic framework make GPs an appealing alternative worth of further adoption
Chiral phase boundary of QCD at finite temperature
We analyze the approach to chiral symmetry breaking in QCD at finite
temperature, using the functional renormalization group. We compute the running
gauge coupling in QCD for all temperatures and scales within a simple truncated
renormalization flow. At finite temperature, the coupling is governed by a
fixed point of the 3-dimensional theory for scales smaller than the
corresponding temperature. Chiral symmetry breaking is approached if the
running coupling drives the quark sector to criticality. We quantitatively
determine the phase boundary in the plane of temperature and number of flavors
and find good agreement with lattice results. As a generic and testable
prediction, we observe that our underlying IR fixed-point scenario leaves its
imprint in the shape of the phase boundary near the critical flavor number:
here, the scaling of the critical temperature is determined by the
zero-temperature IR critical exponent of the running coupling.Comment: 39 pages, 8 figure
Observational constraint on generalized Chaplygin gas model
We investigate observational constraints on the generalized Chaplygin gas
(GCG) model as the unification of dark matter and dark energy from the latest
observational data: the Union SNe Ia data, the observational Hubble data, the
SDSS baryon acoustic peak and the five-year WMAP shift parameter. It is
obtained that the best fit values of the GCG model parameters with their
confidence level are ()
, ()
. Furthermore in this model, we can see that the
evolution of equation of state (EOS) for dark energy is similar to quiessence,
and its current best-fit value is with the confidence
level .Comment: 9 pages, 5 figure
SU(3) Breaking and D0-D0bar Mixing
The main challenge in the Standard Model calculation of the mass and width
difference in the D0-D0bar system is to estimate the size of SU(3) breaking
effects. We prove that D meson mixing occurs in the Standard Model only at
second order in SU(3) violation. We consider the possibility that phase space
effects may be the dominant source of SU(3) breaking. We find that y=(Delta
Gamma)/(2Gamma) of the order of one percent is natural in the Standard Model,
potentially reducing the sensitivity to new physics of measurements of D meson
mixing.Comment: 18 pages; minor corrections, version to appear in Phys. Rev.
High-performance liquid chromatographic determination of fluconazole in plasma and its application to a bioequivalence study
A sensitive and accurate HPLC-UV method for the quantification of fluconazole (FNZ) in human plasma has been developed. The sample was prepared by liquid–liquid extraction (LLE) of FNZ from plasma using ethyl acetate. Nevirapine (NVP) was used as internal standard. The chromatographic retention times of FNZ and NVP were 3.4 and 5.7 min, respectively. The lower limit of quantitation (LLOQ) was 0.5 μg/mL, and no interferences were detected in the chromatograms. The HPLC-UV method was validated by evaluating its intra-day and inter-day precisions and accuracies in a linear concentration range between 0.5 and 8.0 μg/mL. The method was developed, validated and successfully applied to bioequivalence studies involving the oral administration of a single 150 mg FNZ capsules in healthy Brazilian male volunteers.Colegio de Farmacéuticos de la Provincia de Buenos Aire
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
PI3K activation plays a central role in the development of pulmonary inflammation and tissue remodeling. PI3K inhibitors may thus offer an improved therapeutic opportunity to treat non-resolving lung inflammation but their action is limited by unwanted on-target systemic toxicity. Here we present CL27c, a prodrug pan-PI3K inhibitor designed for local therapy, and investigate whether inhaled CL27c is effective in asthma and pulmonary fibrosis. Mice inhaling CL27c show reduced insulin-evoked Akt phosphorylation in lungs, but no change in other tissues and no increase in blood glycaemia, in line with a local action. In murine models of acute or glucocorticoid-resistant neutrophilic asthma, inhaled CL27c reduces inflammation and improves lung function. Finally, inhaled CL27c administered in a therapeutic setting protects from bleomycin-induced lung fibrosis, ultimately leading to significantly improved survival. Therefore, local delivery of a pan-PI3K inhibitor prodrug reduces systemic on-target side effects but effectively treats asthma and irreversible pulmonary fibrosis
Use of Opuntia ficus-indica (L.) Mill extracts from Brazilian Caatinga as an alternative of natural moisturizer in cosmetic formulations
Determination of Escitalopram in Human Plasma by High Performance Liquid Chromatography-Tandem Mass Spectrometry
A rapid (3.0 min) and sensitive (LLOQ 0.5 ng/mL) analytical method for the quantitation of
Escitalopram (ETP) in human plasma is described. The method is based on High-Performance Liquid
Chromatography-Tandem Mass Spectrometry (LC-MS/MS) using paroxetine as internal standard (I.S.).
Sample preparation involved precipitation extraction with acetonitrile. The chromatographic separation
was achieved on a ACE C18 (125 x 4,6 mm) reversed-phase column and a mobile phase containing acetonitrile/water (60:50 v/v, add 0.2 % formic acid), in isocratic conditions. The target analytes were transferred into a triple quadrupole mass spectrometer equipped with an electrospray ionization source for
mass detection. The ion transitions selected for MRM detection were: m/z 325.2 > 109.2 and 330.0 > 192.0
for ETP and I.S., respectively. The assay was linear in the concentration range of 0.5-50 ng/mL. The mean
recovery for ETP was 97.69 %. Intra- and inter-day precision (R.S.D.) were < 10.5 % and <8.2 %, respectively and the accuracy (R.E.) was in the range ± 12.23 %. The method was successfully applied to a single
oral dose pharmacokinetics study in 28 healthy Brazilian human volunteers.Colegio de Farmacéuticos de la Provincia de Buenos Aire
Abundances of the elements in the solar system
A review of the abundances and condensation temperatures of the elements and
their nuclides in the solar nebula and in chondritic meteorites. Abundances of
the elements in some neighboring stars are also discussed.Comment: 42 pages, 11 tables, 8 figures, chapter, In Landolt- B\"ornstein, New
Series, Vol. VI/4B, Chap. 4.4, J.E. Tr\"umper (ed.), Berlin, Heidelberg, New
York: Springer-Verlag, p. 560-63
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Measurement of Bottom versus Charm as a Function of Transverse Momentum with Electron-Hadron Correlations in p+p Collisions at sqrt(s)=200 GeV
The momentum distribution of electrons from semi-leptonic decays of charm and
bottom for mid-rapidity |y|<0.35 in p+p collisions at sqrt(s)=200 GeV is
measured by the PHENIX experiment at the Relativistic Heavy Ion Collider (RHIC)
over the transverse momentum range 2 < p_T < 7 GeV/c. The ratio of the yield of
electrons from bottom to that from charm is presented. The ratio is determined
using partial D/D^bar --> e^{+/-} K^{-/+} X (K unidentified) reconstruction. It
is found that the yield of electrons from bottom becomes significant above 4
GeV/c in p_T. A fixed-order-plus-next-to-leading-log (FONLL) perturbative
quantum chromodynamics (pQCD) calculation agrees with the data within the
theoretical and experimental uncertainties. The extracted total bottom
production cross section at this energy is \sigma_{b\b^bar}= 3.2
^{+1.2}_{-1.1}(stat) ^{+1.4}_{-1.3}(syst) micro b.Comment: 432 authors, 6 pages text, 3 figures. Submitted to Phys. Rev. Lett.
Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
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