Ambiguidade do cuidado na vivência do consumidor de drogas

RESUMO Objetivo Compreender a percepção de usuários de um Centro de Atenção Psicossocial sobre o cuidado no contexto do consumo de drogas. Métodos Estudo fundamentado na Fenomenologia de Maurice Merleau-Ponty, desenvolvido no segundo semestre do ano de 2015. Foram realizados dois encontros de Grupo Focal, com dez usuários de um Centro de Atenção Psicossocial Álcool e outras Drogas. Os dados foram submetidos à técnica Analítica da Ambiguidade. Resultados O consumo de drogas ora proporciona ao consumidor sensações de prazer, ora contribui para a ocorrência de prejuízos biopsicossociais e/ou novas possibilidades de relação com a droga. Conclusões O consumo de drogas constitui-se em um processo ambíguo, que corresponde à percepção de diferentes perfis de cuidado na relação do consumidor com a droga. Cabe aos profissionais de saúde reconhecer as diversas possibilidades de cuidado e favorecer a construção de projetos terapêuticos baseados na escuta e respeito às necessidades dos consumidores de drogas

Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT₂/5-HT₃/5-HT₄ ligands

The present study examined the effects of administering selective 5-HT antagonists and agonists to rats tested in the elevated zero-maze (EZM) model of anxiety. The EZM paradigm has advantages over the elevated plus-maze (EPM) paradigm with respect to measuring anxiety, yet has been utilized less frequently. Three experiments were conducted each with a diazepam control (0.25, 0.5 and 0.75 mg/kg). In the first experiment, we administered the 5-HT(2C) antagonist RS 102221 (0.5, 1.0, and 2.0 mg/kg) and 5-HT(2C) agonist MK-212 (0.25, 0.5 and 0.75 mg/kg); in the second experiment, we administered the 5-HT(3) antagonist Y-25130 (0.1, 1.0 and 3.0 mg/kg) and 5-HT(3) agonist SR 57227A (0.1, 1.0 and 3.0 mg/kg), and in the third experiment, we administered the 5-HT(4) antagonist RS 39604 (0.01, 0.1, 1.0 mg/kg) and 5-HT(4) agonist RS 67333 (0.01, 0.1 and 0.5 mg/kg). The administration of 5-HT(2/3/4) subtype antagonists all generated behavioral profiles indicative of anxiolytic-like effects in the EZM, which was apparent from examination of both traditional and ethological measures. While little effect was observed from 5-HT(2) and 5-HT(3) agonists, the 5-HT(4) agonist RS 67333 was found to produce a paradoxical anxiolytic-like effect similar to that produced by the 5-HT(4) antagonist RS 39604. We conclude by discussing the implications of these findings