Avellaneda y Cervantes en la formación de los lectores del Quijote

IX Congresso Brasileiro de Hispanistas realizado nos dias 22 a 25 agosto 2016En este artículo, nos interesa subrayar el carácter burlesco de la obra de Avellaneda en su tiempo y como esta lectura puede, en nuestros días, favorecer el acercamiento de jóvenes lectores al Quijote. Dicho de otro modo, actualmente, llevar a jóvenes lectores del Quijote la tríade de obras que componen la historia del caballero manchego puede volverse una oportunidad singular de enseñarles cómo vida y literatura se cruzan en los mismos caminos y ,de pronto, pueden ser inmortalizadas por la tinta de grandes escritores como fueron Cervantes y Avellaneda. En ese sentido, conocer la tríade poética y las justas literarias – y personales – que convirtieron al Quijote en un personaje disputado públicamente por escritores puede servir como un motor de interés por la lectura de la obra no sólo en el contexto escolar sino que en otros contextos. No se trata de una defensa de Avellaneda ni tampoco de achicamiento de Cervantes sino de engrandecer al Quijote evidenciando que tanto lectores del siglo XVII como del siglo XXI se divierten riéndose de las aventuras del caballero Don Quijote de la Mancha y que se encantan con la continuación “falsa” y con el hecho magistral de que Cervantes convierte a sus personajes en personas de “carne y hueso” que juzgan a la obra avellanedesca. Al poner de relieve la importancia de la lectura de Avellaneda anhelamos contribuir aún más para el enriquecimiento de la comprensión de la obra cervantina al mismo tiempo en que eso se convierte, desde el Siglo de Oro, en un aumento expresivo de interés por la lectura de las aventuras del Quijote. Por lo tanto, nuestro objetivo es señalar que participar el joven lector, en contexto escolar o académico, de la tríade quijotesca y de los misterios y justas que la conforman actúa incisivamente en la formación de este lector y lo hace comprender los motivos que erigen Don Quijote como un personaje innolvidable y a la obra cervantina como un monumento de la literatura universalUNILA­-UNIOEST

Potential interaction between presenilin and metacaspase on the Mechanism of Programed Cell Death in Leishmania infantum.

Proteases have been considered as promising targets for anti-parasitic agents, these enzymes occur in all organisms from prokaryotes to eukaryotes to viruses. The aim of the present study was to provide, through bioinformatics techniques, potential promising targets related to the apoptosis mechanism, in order to develop a vaccine and new anti-parasitic drugs.For the identifying of the hydrophobic regions, the Kyte and Doolittle methodology was utilized. The nine hydrophobic regions identified in the presenilin, based on the physicochemical properties, suggested the occurrence of transmembrane regions that were confirmed as helices scattered in the membrane by THMM. In the metacaspase structure of L. chagasi, besides the occurrence of four hydrophobic regions, the THMM analyses predicted just one helix, placed in the N-terminal portion. The analyzes of hydrophilicity through B-EpiPred Server, indicated the occurrence of several residues localized in external regions, showing that both molecules have significant numbers of fragments with high antigenic propensity. The prediction of epitopes on the tertiary structure was obtained by the I-TASSER server.In the present paper we are suggesting potential availability of a hybrid peptide originated from the presenilin and metacaspase of the Leishmania for the developing of new drugs or vaccine

Lipid-free Antigen B subunits from echinococcus granulosus: oligomerization, ligand binding, and membrane interaction properties

Background: The hydatid disease parasite Echinococcus granulosus has a restricted lipid metabolism, and needs to harvest essential lipids from the host. Antigen B (EgAgB), an abundant lipoprotein of the larval stage (hydatid cyst), is thought to be important in lipid storage and transport. It contains a wide variety of lipid classes, from highly hydrophobic compounds to phospholipids. Its protein component belongs to the cestode-specific Hydrophobic Ligand Binding Protein family, which includes five 8-kDa isoforms encoded by a multigene family (EgAgB1-EgAgB5). How lipid and protein components are assembled into EgAgB particles remains unknown. EgAgB apolipoproteins self-associate into large oligomers, but the functional contribution of lipids to oligomerization is uncertain. Furthermore, binding of fatty acids to some EgAgB subunits has been reported, but their ability to bind other lipids and transfer them to acceptor membranes has not been studied.<p></p> Methodology/Principal Findings: Lipid-free EgAgB subunits obtained by reverse-phase HPLC were used to analyse their oligomerization, ligand binding and membrane interaction properties. Size exclusion chromatography and cross-linking experiments showed that EgAgB8/2 and EgAgB8/3 can self-associate, suggesting that lipids are not required for oligomerization. Furthermore, using fluorescent probes, both subunits were found to bind fatty acids, but not cholesterol analogues. Analysis of fatty acid transfer to phospholipid vesicles demonstrated that EgAgB8/2 and EgAgB8/3 are potentially capable of transferring fatty acids to membranes, and that the efficiency of transfer is dependent on the surface charge of the vesicles.<p></p> Conclusions/Significance: We show that EgAgB apolipoproteins can oligomerize in the absence of lipids, and can bind and transfer fatty acids to phospholipid membranes. Since imported fatty acids are essential for Echinococcus granulosus, these findings provide a mechanism whereby EgAgB could engage in lipid acquisition and/or transport between parasite tissues. These results may therefore indicate vulnerabilities open to targeting by new types of drugs for hydatidosis therapy.<p></p&gt

Memory for symmetry and perceptual binding in patients with schizophrenia

The present study investigated the use of perceptual binding processes in schizophrenic (SC) patients and matched healthy controls, by examining their performance on the recall of symmetrical (vertical, horizontal and diagonal) and asymmetrical patterns varying in length between 2 and 9 items. The results showed that, although SC patients were less accurate than controls in all conditions, both groups recalled symmetrical patterns better than asymmetrical ones. The impairment of SC patients was magnified with supra-span symmetrical arrays, and they were more likely to reproduce symmetrical patterns as asymmetrical, particularly at medium and high length levels. Hierarchical regression analyses further indicated that the between-group differences in the recall of supra-span vertical and horizontal arrays, which require a greater involvement of visual pattern processes, remained significant after removing the variance associated with performance on asymmetrical patterns, which primarily reflects intrafigural spatial processes. It is proposed that schizophrenia may be associated with a specific deficit in the formation and retrieval of the global visual images of studied patterns and in the use of the on-line information about the type of symmetry being tested to guide retrieval processes. © 2013 Elsevier B.V

Conocimiento sobre complicaciones post exodoncia de terceros molares impactados en estudiantes de estomatología de la Universidad Privada Antenor Orrego, 2022

Determinar el conocimiento sobre complicaciones post exodoncia de terceros molares impactados en estudiantes de estomatología de la Universidad Privada Antenor Orrego, en mayo 2022. Materiales y métodos: Estudio de tipo observacional, de corte transversal que evaluó a 169 estudiantes del programa de estudios de estomatología entre el séptimo a décimo ciclo de pregrado. El instrumento de evaluación utilizado fue un cuestionario virtual de 20 preguntas cerradas, el cual obtuvo la validez con un valor de 0.98 en la prueba V de Aiken y la confiabilidad con un valor de 0.805 en el coeficiente Alfa de Cronbach. Resultados: Se determinó que el conocimiento fue suficiente en un 39.05%,37.28% insuficiente y 19.53% bueno. En los ciclos 7mo, 8vo, 9no se evidenció un nivel suficiente en el 39.10%, 43.24% y 45%, respectivamente y un nivel insuficiente en 10mo ciclo en un 48.83% (p= 0.9094>0.05). El sexo masculino presentó en un 44.68% un nivel suficiente y el sexo femenino un nivel insuficiente en un 42.62% (p= 0.02321<0.05). Conclusión: Existe un conocimiento suficiente respecto a complicaciones postexodoncia de terceras molares, siendo el 9º ciclo y los varones con mayor nivel de conocimientoDetermine the knowledge about post-extraction complications of impacted third molars in stomatology students of the Antenor Orrego Private University, in May 2022. Materials and methods: Observational, cross-sectional study that evaluated 169 students of stomatology study program between the seventh and tenth cycle. The evaluation instrument used was a virtual questionnaire of 20 closed questions, which obtained validity with a value of 0.98 in Aiken's V test and reliability with a value of 0.805 in Cronbach's Alpha coefficient. Results: It was determined that Knowledge was sufficient by 39.05%; 37.28% insufficient and 19.53% good. In the 7th, 8th, and 9th cycles, a sufficient level was evidenced in 39.10%, 43.24%, and 45%, respectively, and an insufficient level in the 10th cycle in 48.83% (p= 0.9094>0 .05). The male sex presented a sufficient level in 44.68% and the female sex an insufficient level in 42.62% (p= 0.02321<0.05). Conclusion: There is sufficient knowledge regarding post-extraction complications of third molars, being the 9th cycle and males with a higher level of knowledge.Tesi

Habitat related variation in reproductive traits among intertidal crabs from the southwestern Atlantic

The reproductive traits of three coastal grapsoid crabs from the southwestern Atlantic, Neohelice granulata (Dana, 1851), Cyrtograpsus angulatus Dana, 1851 and C. altimanus Rathbun, 1914, were compared under the hypothesis that more energy is diverted to maintenance (and less to reproduction) in the upper intertidal and/or in estuaries than in the lower marine intertidal or subtidal, in order to cope with the harsh, and frequently variable, environmental conditions of semiterrestrial and brackish water habitats. Each species occupies a different habitat along intertidal, as well as estuarine gradients: N. granulata lives in the upper and middle intertidal of salt marshes and mud flats, especially in estuarine waters; C. angulatus lives in the low intertidal and subtidal of estuarine and marine habitats, and C. altimanus is predominantly an intertidal and subtidal marine crab. Results suggested that energy demands imposed by the harsh environmental conditions of the estuarine and semiterrestrial habitats resulted in less energy available for reproduction in N. granulata, evidenced by a shorter breeding season, a reduced reproductive output per clutch and an increased clutch interval. The opposite occurred with C. altimanus: less energy was necessary to cope with the stable marine water, allowing the presence of a long breeding season, a higher reproductive output per clutch and a very short clutch interval. Differences observed between marine and estuarine populations of C. angulatus are comparable with differences between C. altimanus, and N. granulata.Fil: Spivak, Eduardo Daniel. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Silva, Paola Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología; ArgentinaFil: Luppi, Tomas Atilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología; Argentin

Fracaso empresarial, análisis del sector comercio mediante logit y análisis discriminante = Business failure, analysis of commerce sector through logit and discriminant analysis

El sector comercio supone un 12% del PIB español. Pese a su indiscutible importancia para la economía española, apenas hay estudios sobre fracaso empresarial centrados en este sector. Esto contrasta con la cantidad de trabajos centrados en el sector construcción, inmobiliario y financiero como consecuencia de la reciente crisis. Por ello, en este trabajo nos hemos propuesto a realizar un estudio sistemático del fracaso en el sector comercio para pymes españolas. El principal objetivo de este trabajo ha sido encontrar una serie de ratios económicos y financieros, capaces de clasificar a una empresa como sana o en concurso de acreedores. Para ello hemos analizado datos de pymes del año 2011 al 2015, mediante análisis discriminante y regresión logística, habiéndose identificado tres ratios con mayor poder clasificador. Además hemos determinado que el modelo de regresión logística se comporta de forma más adecuada que el análisis discriminant

Colecionando orquídeas, colecionando o Brasil (1930-1950)

This article analyzes the debates about the orchid collecting in Brazil from the 1930s, using both the writings of amateurs and professionals, published in the journal Orchid. We approach the conditions that gave greater evidence of this activity on the national scene, the meanings attributed to orchids, as well as practices aimed at recognizing the Orchidaceae flora as national wealth and heritage.Este artigo analisa os debates acerca do colecionismo de orquídeas no Brasil a partir da década de 1930, utilizando para tanto os escritos de amadores e profissionais, publicados no periódico&nbsp;Orquídea. Abordamos as condições que deram maior evidência a essa atividade no cenário nacional, os sentidos atribuídos as orquídeas, bem como as práticas que visavam reconhecer a flora orquidácea como riqueza nacional e patrimônio.&nbsp

PODER, CONTROLE E DISCURSO: UMA ANÁLISE SOB A ÓTICA DA ANÁLISE CRÍTICA DO DISCURSO NAS POLÍTICAS DE SERVIÇOS DO GOOGLE

Este artigo visa analisar mecanismos discursivos de poder a partir da lógica de acumulação de dados e informação pelo Google. Cabe analisar, dessa forma, práticas de dominação e controle da empresa imbricadas em um regime que está diretamente ligado a uma retórica de benefícios e opacidade em seu funcionamento. Para pôr luz a essas questões foram selecionadas construções lexicais da política de privacidade do Google analisadas a partir da perspectiva da Análise Crítica do Discurso, sob a ótica de Van Djick(2010)

TV digital novas oportunidades de negócios para o consumo jovem no Brasil

A TV digital é hoje uma realidade em diversos países. No Brasil, antes de ser implantada, a TV Digital passará por um período de transição, que devera durar de 10 a 15 anos. Neste intervalo, as emissoras transmitirão dois canais de 6 MHz, um analógico e o outro digital, simultaneamente e, a partir desse momento, o telespectador poderá optar por receber a TV analógica, ou adquirir um conversor (set top box) que permitirá receber o sinal digital e convertê-lo para um formato de vídeo e áudio compatível. Poderá, ainda, adquirir um receptor de TV que já incorpore o conversor, o que significará som e imagem de melhor qualidade viabilizando a televisão de alta definição (HDTV), e a implementação de novos recursos. Dessa forma, a TV digital proporcionará uma nova forma de conexão entre as marcas e os jovens. As tecnologias digitais tornaram o consumidor mais exigente e a principal tendência detectada é a necessidade do processo de compra ser mais interativo, uma característica do público jovem. A conversão das mídias é muito importante na conquista desses jovens, bem como no processo de compra. Enfim, a TV digital, aliada as criativas ações de comunicação, será capaz de gerar experiências reais, a ponto de provocar uma propaganda espontânea no ambiente digital com o qual esse público está acostumado a se relacionar