Modulatory antimicrobial activity of Piper arboretum extracts (Zingiberaceae)

The side effects of certain antibiotics have been a recent dilemma in the medical arena. Due this fact, the necessity of natural product discovery could provide important indications against several pharmacological targets and combat many infectious agents. Piper arboreum Aub. (Piperaceae) has been used by Brazilian traditional communities against several illnesses including rheumatism, bronchitis, sexually transmitted diseases and complaints of the urinary tract. Medicinal plants are a source of several remedies used in clinical practice to combat microbial infections. In this study, ethanol extract and fractions of Piper arboreum leaves were used to assay antimicrobial and modulatory activity. The minimum inhibitory concentration (MIC) was determined using microdilution method of ethanol extract and fractions from the leaves of P. arboreum ranging between 8 and 1024 mgmL–1. The capacity of these natural products to enhance the activity of antibiotic and antifungal drugs was also assayed. In these tests, natural products were combined with drugs. The natural products assayed did not demonstrate any clinically relevant antimicrobial activity (MIC ³ 1024 mg mL–1). However, the modulation of antibiotic activity assay observed a synergistic activity of natural products combined with antifungal (such as nystatin and amphotericin B) and antibiotic drugs (such as amikacin, gentamicin and kanamycin). According to these results, these natural products can be an interesting alternative not only to combat infectious diseases caused by bacteria or fungi, but also to combat enhanced resistance of microorganisms to antibiotic and antifungal drugs

Indicadores de saúde entre idosos ativos e insuficientemente ativos residentes em áreas rurais

Modelo do estudo: Estudo transversal. Objetivo do estudo: Analisar a associação entre indicadores de saúde em idosos ativos e insuficientemente ativos. Metodologia: Estudo realizado em indivíduos com 60 anos ou mais, residentes na área rural de Jequié – BA, Brasil, cadastrados no programa Estratégia Saúde da Família do distrito de Itajurú. Foram analisadas as características sociodemográficas, comportamentais, estado de saúde, histórico de quedas, estado cognitivo e Índice de Massa Corporal (IMC). Para análise dos dados, utilizaram-se procedimentos da estatística descritiva, testes Qui-quadrado, teste “t” para amostras independentes e U de Mann-Whitney (nível de significância utilizado pd”0,05). Resultados: Foram entrevistados 95 idosos, sendo 55 mulheres e 40 homens com idade entre 60 e 96 anos (73,5 ± 9,4). A prevalência de inatividade física foi de 40%, mostrando-se superior entre os idosos que relataram viver sozinho, que apresentaram déficit cognitivo, que não sabiam ler e escrever, e com histó- rico de quedas no último ano. Os idosos mais jovens e com menor IMC eram mais ativos, quando comparados com seus pares. Conclusão: Os idosos que não alcançaram as recomendações de níveis adequados de atividade física apresentaram condições de saúde mais desfavoráveis. Recomenda-se a implementação de políticas públicas para promoção da atividade física no intuito de melhorar as condi- ções de saúde, em especial os idosos residentes de áreas ruraisStudy design: cross-sectional study. Study objective: To examine the association between health indicators in active and insufficiently active older adults. Methodology: The study included individuals 60 years or older residing in rural Jequie - BA who were registered in the Family Health Strategy program in the district Itajurú. Sociodemographic data, behavioral characteristics, health status, history of falls, cognitive status and body mass index (BMI) were analyzed. For data analysis, we used the procedures of descriptive statistics, chi-square tests, “t” test for independent samples and the Mann-Whitney test (significance level p ≤0.05). Results: Ninety-five individuals were interviewed, including 55 women and 40 men between the ages of 60 and 96 years (73.5 ± 9.4).The prevalence of physical inactivity was 40%, being higher among the elderly who live alone reported that patients with cognitive impairment, who could not read and write with a history of falls in the last year. The older people with lower BMI were more active compared to their peers. Conclusion: The elderly who not reached the recommended adequate levels of physical activity had health conditions more unfavorable. We recommend the implementation of public policies to promote physical activity in order to improve health conditions, especially the elderly residents of rural area

Assessing the Grell-Freitas Convection Parameterization in the NASA GEOS Modeling System

We implemented and began to evaluate an alternative convection parameterization for the NASA Goddard Earth Observing System (GEOS) general circulation model (GCM). The proposed parameterization follows the mass flux approach with several closures, for equilibrium and nonequilibrium convection, and includes scale and aerosol aware functionalities. Recently, we extended the scheme to a trimodal spectral size distribution of allowed convective plumes to simulate the transition among shallow, congestus, and deep convection regimes. In addition, the inclusion of a new closure for nonequilibrium convection resulted in a substantial gain of realism in the model representation of the diurnal cycle of convection over the land. We demonstrated the scaledependence functionality with a cascade of globalscale simulations from a nominal horizontal resolution of 50 km down to 6 km. The ability to realistically simulate the diurnal cycle of precipitation over various regions of the earth was verified against several remote sensingderived intradiurnal precipitation estimates. We extended the model performance evaluation for weatherscale applications by bringing together some available operational shortrange weather forecast models and global atmospheric reanalyses. Our results demonstrate that the GEOS GCM with the alternative convective parameterization has good properties and competitive skill in comparison with stateoftheart observations and numerical simulations

The Brazilian Developments on the Regional Atmospheric Modeling System (BRAMS 5.2): An Integrated Environmental Model Tuned for Tropical Areas

We present a new version of the Brazilian developments on the Regional Atmospheric Modeling System where different previous versions for weather, chemistry and carbon cycle were unified in a single integrated software system. The new version also has a new set of state-of-the-art physical parameterizations and greater computational parallel and memory usage efficiency. Together with the description of the main features are examples of the quality of the transport scheme for scalars, radiative fluxes on surface and model simulation of rainfall systems over South America in different spatial resolutions using a scale-aware convective parameterization. Besides, the simulation of the diurnal cycle of the convection and carbon dioxide concentration over the Amazon Basin, as well as carbon dioxide fluxes from biogenic processes over a large portion of South America are shown. Atmospheric chemistry examples present model performance in simulating near-surface carbon monoxide and ozone in Amazon Basin and Rio de Janeiro megacity. For tracer transport and dispersion, it is demonstrated the model capabilities to simulate the volcanic ash 3-d redistribution associated with the eruption of a Chilean volcano. Then, the gain of computational efficiency is described with some details. BRAMS has been applied for research and operational forecasting mainly in South America. Model results from the operational weather forecast of BRAMS on 5 km grid spacing in the Center for Weather Forecasting and Climate Studies, INPE/Brazil, since 2013 are used to quantify the model skill of near surface variables and rainfall. The scores show the reliability of BRAMS for the tropical and subtropical areas of South America. Requirements for keeping this modeling system competitive regarding on its functionalities and skills are discussed. At last, we highlight the relevant contribution of this work on the building up of a South American community of model developers

The Brazilian developments on the Regional Atmospheric Modeling System (BRAMS 5.2): an integrated environmental model tuned for tropical areas

We present a new version of the Brazilian developments on the Regional Atmospheric Modeling System (BRAMS), in which different previous versions for weather, chemistry, and carbon cycle were unified in a single integrated modeling system software. This new version also has a new set of state-of-the-art physical parameterizations and greater computational parallel and memory usage efficiency. The description of the main model features includes several examples illustrating the quality of the transport scheme for scalars, radiative fluxes on surface, and model simulation of rainfall systems over South America at different spatial resolutions using a scale aware convective parameterization. Additionally, the simulation of the diurnal cycle of the convection and carbon dioxide concentration over the Amazon Basin, as well as carbon dioxide fluxes from biogenic processes over a large portion of South America, are shown. Atmospheric chemistry examples show the model performance in simulating near-surface carbon monoxide and ozone in the Amazon Basin and the megacity of Rio de Janeiro. For tracer transport and dispersion, the model capabilities to simulate the volcanic ash 3-D redistribution associated with the eruption of a Chilean volcano are demonstrated. The gain of computational efficiency is described in some detail. BRAMS has been applied for research and operational forecasting mainly in South America. Model results from the operational weather forecast of BRAMS on 5 km grid spacing in the Center for Weather Forecasting and Climate Studies, INPE/Brazil, since 2013 are used to quantify the model skill of near-surface variables and rainfall. The scores show the reliability of BRAMS for the tropical and subtropical areas of South America. Requirements for keeping this modeling system competitive regarding both its functionalities and skills are discussed. Finally, we highlight the relevant contribution of this work to building a South American community of model developers.CNPqFAPESPEarth System Research Laboratory at the National Oceanic and Atmospheric Administration (ESRL/NOAA), Boulder, USAInst Nacl Pesquisas Espaciais, Ctr Previsao Tempo & Estudos Climat, Cachoeira Paulista, SP, BrazilDiv Ciência da Computação, Instituto Tecnológico de Aeronáutica, São José dos Campos, SP, BrazilUniv Estadual Paulista Unesp, Fac Ciencias, Bauru, SP, BrazilCtr Meteorol Bauru IPMet, Bauru, SP, BrazilUniv Fed Sao Paulo, Dept Ciencias Ambientais, Diadema, SP, BrazilUniv Sao Paulo, Inst Astron Geofis & Ciencias Atmosfer, Sao Paulo, SP, BrazilUniv Fed Campina Grande, Dept Ciencias Atmosfer, Campina Grande, PB, BrazilEmbrapa Informat Agr, Campinas, SP, BrazilUniv Fed Sao Paulo, Inst Ciencia & Tecnol, Sao Jose Dos Campos, SP, BrazilUniv Fed Rio Grande do Norte, Dept Ciencias Atmosfer & Climat, Programa Pos Grad Ciencias Climat, Natal, RN, BrazilInst Nacl Pesquisas Espaciais, Ctr Ciencias Sistema, Sao Jose Dos Campos, SP, BrazilUniv Fed Sao Joao Del Rei, Dept Geociencias, Sao Joao Del Rei, MG, BrazilInst Nacl Pesquisas Espaciais, Lab Associado Computacao & Matemat Aplica, Sao Jose Dos Campos, BrazilUniv Evora, Inst Ciencias Agr & Ambientais Mediterr, Evora, PortugalUniv Lusofona Humanidades & Tecnol, Ctr Interdisciplinar Desenvolvimento Ambient Gest, Lisbon, PortugalUniv Fed Pelotas, Fac Meteorol, Pelotas, RS, BrazilUnive Tecnol Fed Parana, Londrina, PR, BrazilNASA, Goddard Space Flight Ctr, Univ Space Res Assoc, Goddard Earth Sci Technol & Res Global Modeling &, Greenbelt, MD USAUniv Fed Sao Paulo, Inst Ciencia & Tecnol, Sao Jose Dos Campos, SP, BrazilUniv Fed Sao Paulo, Inst Ciencia & Tecnol, Sao Jose Dos Campos, SP, BrazilCNPq: 306340/2011-9FAPESP: 2014/01563-1FAPESP: 2015/10206-0FAPESP: 2014/01564-8Web of Scienc