A mild and efficient method for the preparation of 3-(2'-Aminoaryl)pyrazoles from 4-chloroquinolines

We describe a mild and efficient method for the formation of 3-(2'-aminoaryl)pyrazoles in excellent yields from reactions of 4-chloroquinolines with hydrazine. These heterocyclic ring opening reactions occur under much milder conditions then previously described

Prevalence of smoking and incidence of initiation in the Latin American adult population: the PLATINO study

Background: the PLATINO project was launched in 2002 in order to study the prevalence of chronic obstructive pulmonary disease (COPD) in Latin America. Because smoking is the main risk factor for COPD, detailed data on it were obtained. the aim of this paper was to evaluate the prevalence of smoking and incidence of initiation among middle-aged and older adults (40 years or older). Special emphasis was given to the association between smoking and schooling.Methods: PLATINO is a multicenter study comprising five cross-sectional population-based surveys of approximately 1,000 individuals per site in São Paulo (Brazil), Santiago (Chile), Mexico City (Mexico), Montevideo (Uruguay) and Caracas (Venezuela). the outcome variable was smoking status (never, former or current). Current smokers were those who reported to smoke within the previous 30 days. Former smokers were those who reported to quit smoking more than 30 days before the survey. Using information on year of birth and age of smoking onset and quitting, a retrospective cohort analysis was carried out. Smoking prevalence at each period was defined as the number of subjects who started to smoke during the period plus those who were already smokers at the beginning of the period, divided by the total number of subjects. Incidence of smoking initiation was calculated as the number of subjects who started to smoke during the period divided by the number of non-smokers at its beginning. the independent variables included were sex, age and schooling.Results: Non-response rates ranged from 11.1% to 26.8%. the prevalence of smoking ranged from 23.9% (95% CI 21.3; 26.6) in São Paulo to 38.5% (95% CI 35.7; 41.2) in Santiago. Males and middle-aged adults were more likely to smoke in all sites. After adjustment for age, schooling was not associated with smoking. Using retrospective cohort analysis, it was possible to detect that the highest prevalence of smoking is found between 20-29 years, while the highest incidence is found between 10-19 years. Age of smoking onset tended to decline over time among females.Conclusion: the prevalence of smoking varied considerably across sites, but was lower among countries with national anti-smoking campaigns.Univ Fed Pelotas, Pelotas, BrazilUniv Republica, Montevideo, UruguayInst Nacl Enfermedades Resp, Mexico City, DF, MexicoUniversidade Federal de São Paulo, São Paulo, BrazilPontificia Univ Catolica Chile, Santiago, ChileCent Univ Venezuela, Caracas, VenezuelaUniversidade Federal de São Paulo, São Paulo, BrazilWeb of Scienc

Bipolar disorder and age-related functional impairment

OBJECTIVE: Although bipolar disorder is a major contributor to functional impairment worldwide, an independent impact of bipolar disorder and ageing on functioning has yet to be demonstrated. The objective of the present study was to evaluate the effect of bipolar disorder on age-related functional status using matched controls as a standard. METHOD: One-hundred patients with bipolar disorder and matched controls were evaluated for disability. Age-related effects controlled for confounders were cross-sectionally evaluated. RESULTS: Patients were significantly more impaired than controls. Regression showed effects for aging in both groups. The effect, size, however, was significantly stronger in patients. CONCLUSION: Bipolar disorder was an important effect modifier of the age impact on functioning. While a longitudinal design is needed to effectively demonstrate this different impact, this study further depicts bipolar disorder as a chronic and progressively impairing illness

Geostatistics applied to the study of soil physiochemical characteristics in seasonal deciduous forest areas

Utilizaram-se m\ue9todos da geoestat\uedstica na identifica\ue7\ue3o do tamanho e da estrutura da variabilidade espacial de alguns atributos f\uedsico-qu\uedmicos do solo em \ue1reas de Floresta Estacional Decidual as quais foram denominadas floresta madura, floresta secund\ue1ria e capoeir\ue3o. As \ue1reas, localizadas no munic\uedpio de Santa Tereza, RS, foram amostradas durante o per\uedodo de 2002 a 2003, compreendendo as classes de solo: Chernossolo Argil\ufavico, Cambissolo Ta e Neossolo Lit\uf3lico. Realizou-se amostragem sistem\ue1tica com grid de espa\ue7amento regular entre os pontos variando de 30 m para o capoeir\ue3o e 40 m para floresta madura e secund\ue1ria, totalizando oitenta pontos amostrais em uma \ue1rea total de 7,34 ha. Foram coletadas amostras de solo \u201cin situ\u201d para an\ue1lise em laborat\uf3rio dos atributos densidade do solo, argila, pH, pot\ue1ssio, mat\ue9ria org\ue2nica e f\uf3sforo. A estrutura da variabilidade espacial foi identificada por meio dos semivariogramas, definindo-se os par\ue2metros necess\ue1rios para a krigagem. O atributo mais vari\ue1vel foi a mat\ue9ria org\ue2nica, n\ue3o obtendo ajuste a nenhum modelo te\uf3rico de semivariograma, enquanto que o pH foi o menor. Na an\ue1lise de estrutura da variabilidade espacial por meio da geoestat\uedstica, a argila e densidade, ambas em \ue1rea de floresta secund\ue1ria, e o pH nas \ue1reas experimentais apresentaram a maior depend\ueancia espacial. O modelo gaussiano para o atributo argila obteve o maior alcance da depend\ueancia espacial, sendo 400 e 388 m, nas \ue1reas de floresta secund\ue1ria e madura respectivamente. A valida\ue7\ue3o cruzada mostrou acuracidade no ajuste dos modelos variogr\ue1ficos, tendo a vari\ue1vel pH apresentado o melhor desempenho, 0,87; 0,94 e 0,92 nas \ue1reas de floresta madura, secund\ue1ria e capoeir\ue3o respectivamente.Methods of geostatistics were used in the identification of size and structure of space variability of some physiochemical attributes of soils under seasonal deciduous forest areas, which were called mature forest, secondary forest and "capoeir\ue3o". The areas, located in Santa Tereza, RS, were sampled during the period of 2002 and 2003, comprising the soil classes: Argiluvic Chernosol, Cambisol Ta and Litholic Neosol. Systematic sampling was performed with regular spacing grid of points varying of 30 m for "capoeir\ue3o" and 40 m for mature and secondary forest, in an amount of 80 sample points in a total area of 7.34 ha. For each point, measurements "in situ" were made of the soil bulk density, clay content, pH, potassium, organic matter and phosphorus. The structure of space variability was identified through the variograms, being defined the needed parameters for the Kriging. The most variable attribute was the organic matter, being not adjusted to any model of variogram, while the pH was the least. In the analysis of the space variability structure through the geostatistics, the clay and bulk density, both in area of secondary forest, and pH in the experimental areas, had showed the biggest space dependence. The Gauss model for the clay attribute obtained the largest reach (a), being 400 m and 388 m in the areas of secondary and mature forest, respectively. The crossed validation showed accuracy in the variographic models adjustment, being the pH variable the one which presented the optimum performance, 0.87; 0.94 and 0.92 in the areas of mature forest, secondary forest and "capoeir\ue3o", respectively

Geoestatística aplicada ao estudo das características físico-químicas do solo em áreas de Floresta Estacional Decidual

Methods of geostatistics were used in the identification of size and structure of space variability of some physiochemical attributes of soils under seasonal deciduous forest areas, which were called mature forest, secondary forest and “capoeirão”. The areas, located in Santa Tereza, RS, were sampled during the period of 2002 and 2003, comprising the soil classes: Argiluvic Chernosol, Cambisol Ta and Litholic Neosol. Systematic sampling was performed with regular spacing grid of points varying of 30 m for “capoeirão” and 40 m for mature and secondary forest, in an amount of 80 sample points in a total area of 7.34 ha. For each point, measurements "in situ" were made of the soil bulk density, clay content, pH, potassium, organic matter and phosphorus. The structure of space variability was identified through the variograms, being defined the needed parameters for the Kriging. The most variable attribute was the organic matter, being not adjusted to any model of variogram, while the pH was the least. In the analysis of the space variability structure through the geostatistics, the clay and bulk density, both in area of secondary forest, and pH in the experimental areas, had showed the biggest space dependence. The Gauss model for the clay attribute obtained the largest reach (a), being 400 m and 388 m in the areas of secondary and mature forest, respectively. The crossed validation showed accuracy in the variographic models adjustment, being the pH variable the one which presented the optimum performance, 0.87; 0.94 and 0.92 in the areas of mature forest, secondary forest and “capoeirão”, respectively.Utilizaram-se métodos da geoestatística na identificação do tamanho e da estrutura da variabilidade espacial de alguns atributos físico-químicos do solo em áreas de Floresta Estacional Decidual as quais foram denominadas floresta madura, floresta secundária e capoeirão. As áreas, localizadas no município de Santa Tereza, RS, foram amostradas durante o período de 2002 a 2003, compreendendo as classes de solo: Chernossolo Argilúvico, Cambissolo Ta e Neossolo Litólico. Realizou-se amostragem sistemática com grid de espaçamento regular entre os pontos variando de 30 m para o capoeirão e 40 m para floresta madura e secundária, totalizando oitenta pontos amostrais em uma área total de 7,34 ha. Foram coletadas amostras de solo "in situ" para análise em laboratório dos atributos densidade do solo, argila, pH, potássio, matéria orgânica e fósforo. A estrutura da variabilidade espacial foi identificada por meio dos semivariogramas, definindo-se os parâmetros necessários para a krigagem. O atributo mais variável foi a matéria orgânica, não obtendo ajuste a nenhum modelo teórico de semivariograma, enquanto que o pH foi o menor. Na análise de estrutura da variabilidade espacial por meio da geoestatística, a argila e densidade, ambas em área de floresta secundária, e o pH nas áreas experimentais apresentaram a maior dependência espacial. O modelo gaussiano para o atributo argila obteve o maior alcance da dependência espacial, sendo 400 e 388 m, nas áreas de floresta secundária e madura respectivamente. A validação cruzada mostrou acuracidade no ajuste dos modelos variográficos, tendo a variável pH apresentado o melhor desempenho, 0,87; 0,94 e 0,92 nas áreas de floresta madura, secundária e capoeirão respectivamente

Climate seasonality limits leaf carbon assimilation and wood productivity in tropical forests

The seasonal climate drivers of the carbon cycle in tropical forests remain poorly known, although these forests account for more carbon assimilation and storage than any other terrestrial ecosystem. Based on a unique combination of seasonal pan-tropical data sets from 89 experimental sites (68 include aboveground wood productivity measurements and 35 litter productivity measurements), their associated canopy photosynthetic capacity (enhanced vegetation index, EVI) and climate, we ask how carbon assimilation and aboveground allocation are related to climate seasonality in tropical forests and how they interact in the seasonal carbon cycle. We found that canopy photosynthetic capacity seasonality responds positively to precipitation when rainfall is < 2000ĝ€-mmĝ€-yrĝ'1 (water-limited forests) and to radiation otherwise (light-limited forests). On the other hand, independent of climate limitations, wood productivity and litterfall are driven by seasonal variation in precipitation and evapotranspiration, respectively. Consequently, light-limited forests present an asynchronism between canopy photosynthetic capacity and wood productivity. First-order control by precipitation likely indicates a decrease in tropical forest productivity in a drier climate in water-limited forest, and in current light-limited forest with future rainfall < 2000ĝ€-mmĝ€-yrĝ'1. Author(s) 2016.Fil: Wagner, Fabien H.. Instituto Nacional de Pesquisas Espaciais; BrasilFil: Hérault, Bruno. Ecologie Des Forets de Guyane; BrasilFil: Bonal, Damien. Institut National de la Recherche Agronomique; FranciaFil: Stahl, Clment. Universiteit Antwerp; BélgicaFil: Anderson, Liana O.. National Center For Monitoring And Early Warning Of Natural Disasters; BrasilFil: Baker, Timothy R.. University Of Leeds; Reino UnidoFil: Sebastian Becker, Gabriel. Universidad de Hohenheim; AlemaniaFil: Beeckman, Hans. Royal Museum For Central Africa; BélgicaFil: Boanerges Souza, Danilo. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: Cesar Botosso, Paulo. Ministerio da Agricultura Pecuaria e Abastecimento de Brasil. Empresa Brasileira de Pesquisa Agropecuaria; BrasilFil: Bowman, David M. J. S.. University of Tasmania; AustraliaFil: Bräuning, Achim. Universitat Erlangen-Nuremberg; AlemaniaFil: Brede, Benjamin. Wageningen University And Research Centre; Países BajosFil: Irving Brown, Foster. Universidade Federal Do Acre; BrasilFil: Julio Camarero, Jesus. Instituto Boliviano de Investigacion Forestal Bolivia; BoliviaFil: Camargo, Plnio Barbosa. Universidade de Sao Paulo; BrasilFil: Cardoso, Fernanda C.G.. Universidade Federal do Paraná; BrasilFil: Carvalho, Fabrcio Alvim. Universidade Federal de Juiz de Fora; BrasilFil: Castro, Wendeson. Universidade Federal Do Acre; BrasilFil: Koloski Chagas, Rubens. Universidade de Sao Paulo; BrasilFil: Chave, Jrome. Centre National de la Recherche Scientifique; FranciaFil: Chidumayo, Emmanuel N.. University Of Zambia; ZambiaFil: Clark, Deborah A.. University Of Missouri-st. Louis; Estados UnidosFil: Regina Capellotto Costa, Flavia. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: Couralet, Camille. Royal Museum For Central Africa; BélgicaFil: Henrique Da Silva Mauricio, Paulo. Universidade Federal Do Acre; BrasilFil: Dalitz, Helmut. Universidad de Hohenheim; AlemaniaFil: Resende De Castro, Vinicius. Universidade Federal de Vicosa; BrasilFil: Milani, Jaanan Eloisa De Freitas. Universidade Federal do Paraná; BrasilFil: Roig Junent, Fidel Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla | Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla | Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla; Argentin