PERFIL EPIDEMIOLÓGICO DE PACIENTES COM ESQUIZOFRENIA EM USO DE ANTIPSICÓTICOS DE AÇÃO PROLONGADA

O objetivo deste artigo é descrever o perfil clínico de pacientes com esquizofrenia que utilizaram antipsicóticos de ação prolongada no Centro de Atenção Psicossocial de um município do interior de Rondônia. Trata-se de um estudo delineado pelo método quantitativo de natureza descritiva, que usou como fonte as informações contidas em prontuários. A população estudada foi constituída pelo universo de usuários de um Caps, de ambos os sexos, diagnosticados com esquizofrenia, e que tinham pelo menos um registro de retirada de antipsicóticos de ação prolongada na farmácia no ano de 2015. Os resultados demonstraram prevalência do sexo masculino, 57,1%, na faixa etária entre 31 e 40 anos de idade, com baixa escolaridade e solteiros. Quanto ao uso de antipsicóticos, constituíram maioria os que utilizam decanoato de haloperdidol associado à politerapia. Conclui-se que os antipsicóticos contribuem significativamente para a qualidade de vida da pessoa com esquizofrenia e que a compreensão do perfil desses usuários é de grande importância para a instituição de novas práticas de atendimento psicossocial nos serviços de saúde mental

Os Trabalhadores de Aplicativos Durante a Pandemia de Coronavírus em 2020: um estudo exploratório.

In this article, we present a study on the experience of app drivers, conducted during the first half of 2020, during the lockdown months due to the Covid19 pandemic. Initially, we develop a brief literature review about the transformations in the world of work, and then a preliminary study about the Brazilian occupational structure based on available statistics from the Brazilian Institute of Geography and Statistics (IBGE). In Brazil, the unemployment rate has been on the rise in recent years, and with it the level of informality, that is, the number of workers without a signed labor contract and, therefore, without the guarantee of labor rights, has also increased. We can observe in the last three years a significant increase in the number of app drivers and delivery drivers. This category, for not having labor rights, faces precariousness, because it works for multinational companies that profit a lot, without any employment ties. This reality became even more evident in periods of crisis, as in the case of the coronavirus pandemic, when these workers could not comply with the isolation rules, because if they do not work they cannot support their families. The research intends to contribute to the understanding about the changes in work relations caused by the advance of digital tools that facilitate the exchange of services. To make this possible three specific objectives were defined: i) to map the debate in the specialized literature about labor relations mediated by the popularization of service provision apps; ii) to explore the statistics available from the Brazilian Institute of Geography and Statistics (IBGE) about the theme and present an exploratory study about the profile of app drivers. Public statistics on the economically active population will be examined and information on the occupational trajectories of service providers will be collected. Further discussion is expected about how these tools of service provision relate to work and how they modify these relationships based on the historical, economic, and political moment. They will also make it possible to contribute to producing sociodemographic information about these workers, about whom we have almost no statistics.Dans cet article, nous présentons une étude sur l'expérience des conducteurs d'applis, menée au premier semestre 2020, pendant les mois de verrouillage dus à la pandémie de Covid19. Dans un premier temps, nous développons une brève revue de la littérature sur les transformations du monde du travail, puis une étude préliminaire sur la structure professionnelle brésilienne basée sur les statistiques disponibles de l'Institut brésilien de géographie et de statistique (IBGE). Au Brésil, le taux de chômage a augmenté ces dernières années, et avec lui, l'informalité a également augmenté, c'est-à-dire que le nombre de travailleurs sans contrat de travail signé a augmenté, et donc, sans la garantie des droits du travail. Nous pouvons observer au cours des trois dernières années une augmentation significative du nombre de conducteurs et de coursiers d'apps. Cette catégorie, pour ne pas avoir de droits du travail, est confrontée à la précarité, car elle travaille pour des entreprises multinationales qui profitent beaucoup, sans aucun lien d'emploi. Cette réalité est devenue encore plus évidente en période de crise, comme dans le cas de la pandémie de coronavirus, lorsque ces travailleurs ne pouvaient pas respecter les règles d'isolement, car s'ils ne travaillent pas, ils ne peuvent pas subvenir aux besoins de leur famille. La recherche vise à contribuer à la compréhension des changements dans les relations de travail causés par l'avancement des outils numériques qui facilitent l'échange de services. Pour ce faire, trois objectifs spécifiques ont été fixés : i) cartographier le débat dans la littérature spécialisée sur les relations de travail médiées par la popularisation des applications de prestation de services ; ii) explorer les statistiques disponibles auprès de l'Institut brésilien de géographie et de statistique (IBGE) sur le sujet et présenter une étude exploratoire sur le profil des moteurs d'application. Les statistiques publiques sur la population économiquement active seront examinées et des informations sur les trajectoires professionnelles des prestataires de services seront collectées. Une discussion plus approfondie est attendue sur la façon dont ces outils de prestation de services sont liés au travail et comment ils modifient ces relations à partir du moment historique, économique et politique. Ils permettront également de contribuer à la production d'informations socio-démographiques sur ces travailleurs, sur lesquels nous ne disposons pratiquement d'aucune statistique.  Dans cet article, nous présentons une étude sur l'expérience des conducteurs d'applis, menée au premier semestre 2020, pendant les mois de verrouillage dus à la pandémie de Covid19. Dans un premier temps, nous développons une brève revue de la littérature sur les transformations du monde du travail, puis une étude préliminaire sur la structure professionnelle brésilienne basée sur les statistiques disponibles de l'Institut brésilien de géographie et de statistique (IBGE). Au Brésil, le taux de chômage a augmenté ces dernières années, et avec lui, l'informalité a également augmenté, c'est-à-dire que le nombre de travailleurs sans contrat de travail signé a augmenté, et donc, sans la garantie des droits du travail. Nous pouvons observer au cours des trois dernières années une augmentation significative du nombre de conducteurs et de coursiers d'apps. Cette catégorie, pour ne pas avoir de droits du travail, est confrontée à la précarité, car elle travaille pour des entrepris

Short-term high-fat diet affects macrophages inflammatory response, early signs of a long-term problem

Obesity is a chronic inflammatory disease that affects millions of people worldwide. Most studies observe the effects of a high-fat diet (HFD) in 10–12 weeks. This work investigated the effects induced by a HFD administered for 6 weeks on the nutritional status of mice and some aspects of the inflammatory response in mouse peritoneal macrophages. Male Swiss Webster mice, 2–3 months of age, were fed a control diet or HFD for 6 weeks. After this period, the mice were euthanized, and peritoneal macrophages were collected for immunoassays and assessment of biochemical parameters. A HFD was associated with increased cholesterol, insulin resistance, C-reactive protein (CRP), leptin, and serum resistin levels. Lipopolysaccharide (LPS)- stimulated adipocyte cultures of animals subjected to a HFD showed increased production of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6). However, peritoneal macrophages of the HFD group showed no changes in the levels of these cytokines. LPS-stimulated peritoneal macrophages from HFD-treated animals showed a reduction in mRNA expression of TNF-α and IL-6, as well as a decrease in expression of the transcription factor nuclear factor-kappa B (NF-kB). In conclusion, HFD treatment for 6 weeks induces similar signs to metabolic syndrome and decreases the capacity of peritoneal macrophages to develop an appropriate inflammatory response to a bacterial component

A EDUCAÇÃO POPULAR NAS PÓS-GRADUAÇÕES PÚBLICAS DA REGIÃO NORDESTE: Serviço Social e Educação (2000- 2010)

The purpose of this paper is to present the results of the scientific initiation work plan (pibic / cnpq), whose objective was to make the "Balance of dissertations and theses that address popular education in the areas of Social Service and Education in the Northeast region (2000- 2010 ) ". This appears with the project entitled THE STATE OF ART ON POPULAR EDUCATION IN THE PUBLIC POST-GRADUATIONS OF THE SOUTHERN ANDNORTHEAST REGIONS: Social Service and (2000-2010). Methodologically, the work is exploratory and bibliographical, whose approach is qualitative and quantitative, based on the critical theoretical framework. The research was developed between 2015 and 2016.Este trabalho tem o intuito de apresentar o resultado do plano de trabalho de iniciação científica (pibic/cnpq) cujo objetivo foi fazer o “Balanço das dissertações e teses que abordam educação popular nas áreas de Serviço Social e Educação na região Nordeste (2000-2010)”. O qual surge junto ao projeto intitulado O ESTADO DA ARTE SOBRE EDUCAÇÃO POPULAR NAS PÓS-GRADUAÇÕES PÚBLICAS DAS REGIÕES SUL E NORDESTE: Serviço Social e (2000- 2010). Metodologicamente, o trabalho é do tipo exploratório e bibliográfico, cuja forma de abordagem é quali-quantitativa, fundamentado no referencial teórico crítico. A pesquisa foi desenvolvida entre os anos de 2015 e 2016

Operational performance of a small sawmill of the city of Alegre, Espírito Santo, Brazil.

AbstractSawmills are the most important wood industries in the Southern of the Espírito Santo State. The aim of this research was to analyze the operational performance of a small sawmill in Alegre, Espírito Santo state, Brazil, which process Eucalyptus sp. logs. The analysis was based on the study of lumber yield, operational efficiency and work delay ratio. The average lumber yield was 53.6% ranked as good for a small log hardwood sawmill, according to the literature. The average operational efficiency was 2.77 m³/worker/shift, and was ranked as low, even for small Brazilian sawmills, due to not classified logs, layout inadequacies, machinery bad conservation and low automation level. The average productive work was 69.6% and did not achieve the minimum rank of 75% suggested by the literature, because of the referred problems, and other ones. In general, for such sawmill the operational situation was considered poor, but it has potential to be improved. As serrarias são as principais indústrias madeireiras do sul do estado do Espírito Santo. O objetivo deste trabalho foi analisar o desempenho operacional de uma serraria de pequeno porte processadora da madeira de Eucalyptus sp. no município de Alegre, região sul do estado do Espírito Santo. Para tanto, a análise consistiu do estudo do rendimento em madeira serrada, eficiência operacional e amostragem do trabalho. O rendimento médio foi igual a 53,6% e foi considerado bom, para uma serraria que processa madeira de folhosas, quando comparado com dados da literatura. A eficiência operacional média foi igual a 2,77 m³/operário/dia, e foi considerada baixa, mesmo para serrarias brasileiras de pequeno porte, em consequência da falta de classificação da matéria-prima, inadequações de layout, mau estado de conservação do maquinário e baixo nível de automação. O trabalho produtivo médio foi de 69,6% e não atingiu o valor mínimo de 75% sugerido pela literatura, resultado dos problemas referidos, dentre outros fatores. De uma maneira geral, o desempenho operacional da serraria foi considerado ruim, de acordo com os índices avaliados, porém possui potencial para ser melhorado.AbstractOperational performance of a small sawmill of the city of Alegre, Espírito Santo, Brazil. Sawmills are the most important wood industries in the Southern of the Espírito Santo State. The aim of this research was to analyze the operational performance of a small sawmill in Alegre, Espírito Santo state, Brazil, which process Eucalyptus sp. logs. The analysis was based on the study of lumber yield, operational efficiency and work delay ratio. The average lumber yield was 53.6% ranked as good for a small log hardwood sawmill, according to the literature. The average operational efficiency was 2.77 m³/worker/shift, and was ranked as low, even for small Brazilian sawmills, due to not classified logs, layout inadequacies, machinery bad conservation and low automation level. The average productive work was 69.6% and did not achieve the minimum rank of 75% suggested by the literature, because of the referred problems, and other ones. In general, for such sawmill the operational situation was considered poor, but it has potential to be improved.Keywords: Log breakdown; lumber yield; operational efficiency; productive work

Reconstruction of the nasal columella using bilateral nasolabial flaps: case report

Introduction: The columella is an important subunit of the nose, essential for nasal architecture and facial aesthetics. The total reconstruction of the nasal columella becomes a great challenge after repairing trauma, carcinomas, and necrosis in this region. There are descriptions in the literature of numerous reconstruction techniques using different flaps, such as a frontal region flap, an infraclavicular region flap, and a unilateral and bilateral nasolabial flap. Case Report: A total reconstruction of the nasal columella after resection of basal cell carcinoma (BCC) using a bilateral nasolabial flap is reported. Conclusion: The technique proved effective for correcting the complex defect after BCC resection, with technical ease for resolution and good aesthetic and functional results

Valores de referência hematológicos e bioquímicos para camundongos das linhagens C57BL/6, Swiss Webster e BALB/c

The use of animals in scientific research has contributed significantly to the development of science, promoting various advances in understanding the metabolic machinery and the discovery of treatments and preventive measures applied to human and veterinary medicine. The development and use of alternative methods is encouraged; however, in some situations, the use of animals in accordance with ethical policies is still required. Established hematological and clinical chemistry reference values in laboratory animals are essential to evaluate functional changes; however, there are few data in the literature on these values, being fundamentally a comparative basis. The aim of this investigation was the establishment of hematological and clinical chemistry reference values in common strains/stocks of mice used in animal experimentation. Blood profile (hemogram, reticulocytes and myelogram) and clinical chemistry serum determination of total protein, albumin, glucose, cholesterol, triglycerides, calcium and phosphorus were evaluated using C57BL/6, BALB/c and Swiss Webster mice, male, 2-3 months old. The results standardize reference intervals in animals reared in Laboratory Animal Facility, reflecting the expected condition in rodents subjected to scientific research.O uso de animais na pesquisa científica tem contribuído significativamente para o desenvolvimento da ciência, promovendo vários avanços na compreensão da maquinaria metabólica, bem como a descoberta de tratamentos e medidas preventivas aplicadas à medicina humana e veterinária. O desenvolvimento e utilização de métodos alternativos é encorajado, no entanto, em algumas situações, ainda é necessária a utilização de animais em conformidade com termos éticos. Estabelecer valores de referência hematológicos e bioquímicos para animais de laboratório é essencial para avaliar alterações funcionais, no entanto, existem poucos dados na literatura sobre estes valores, sendo fundamentalmente uma base comparativa. O presente trabalho foi delineado para estabelecer valores de referência hematológicos e bioquímicos em linhagens camundongos utilizados em pesquisa científica. Foram avaliados o perfil sanguíneo (hemograma, reticulócitos e mielograma) e a determinação bioquímica sérica de proteínas totais, albumina, glicose, colesterol, triglicerídeos, cálcio e fósforo. Foram utilizados camundongos C57BL/6, BALB/c e Swiss Webster, do sexo masculino, 2-3 meses de idade. Os resultados padronizam intervalos de referência em camundongos criados em Biotério, refletindo a condição esperada nesses animais submetidos à investigação científica

Phenotypic profiling of CD8+ T cells during Plasmodium vivax blood-stage infection

Submitted by Repositório Arca ([email protected]) on 2019-04-24T17:38:50Z No. of bitstreams: 1 license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5)Approved for entry into archive by Janaína Nascimento ([email protected]) on 2019-08-13T14:21:37Z (GMT) No. of bitstreams: 2 ve_ Hojo-Souza_Natália_etal_INI_2015.pdf: 1172050 bytes, checksum: b1948378bfee8669ad90694b3aa2cb60 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5)Made available in DSpace on 2019-08-13T14:21:37Z (GMT). No. of bitstreams: 2 ve_ Hojo-Souza_Natália_etal_INI_2015.pdf: 1172050 bytes, checksum: b1948378bfee8669ad90694b3aa2cb60 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2015Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro. RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Background: For a long time, the role of CD8+ T cells in blood-stage malaria was not considered important because erythrocytes do not express major histocompatibility complex (MHC) class I proteins. While recent evidences suggest that CD8+ T cells may play an important role during the erythrocytic phase of infection by eliminating parasites, CD8+ T cells might also contribute to modulate the host response through production of regulatory cytokines. Thus, the role of CD8+ T cells during blood-stage malaria is unclear. Here, we report the phenotypic profiling of CD8+ T cells subsets from patients with uncomplicated symptomatic P. vivax malaria. Methods: Blood samples were collected from 20 Plasmodium vivax-infected individuals and 12 healthy individuals. Immunophenotyping was conducted by flow cytometry. Plasma levels of IFN-γ, TNF-α and IL-10 were determined by ELISA/CBA. Unpaired t-test or Mann–Whitney test was used depending on the data distribution. Results: P. vivax-infected subjects had lower percentages and absolute numbers of CD8+ CD45RA+ and CD8+ CD45RO+ T cells when compared to uninfected individuals (p ≤ 0.0002). A significantly lower absolute number of circulating CD8+ CD45+ CCR7+ cells (p = 0.002) was observed in P. vivax-infected individuals indicating that infection reduces the number of central memory T cells. Cytokine expression was significantly reduced in the naïve T cells from infected individuals compared with negative controls, as shown by lower numbers of IFN-γ + (p = 0.001), TNF-α+ (p < 0.0001) and IL-10+ (p < 0.0001) CD8+ T cells. Despite the reduction in the number of CD8+ memory T cells producing IFN-γ (p < 0.0001), P. vivax-infected individuals demonstrated a significant increase in memory CD8+ TNF-α+ (p = 0.016) and CD8+ IL-10+ (p = 0.004) cells. Positive correlations were observed between absolute numbers of CD8+ IL-10+ and numbers of CD8+ IFN-γ + (p < 0.001) and CD8+ TNF-α+ T cells (p ≤ 0.0001). Finally, an increase in the plasma levels of TNF-α (p = 0.017) and IL-10 (p = 0.006) and a decrease in the IFN-γ plasma level (p <0.0001) were observed in the P. vivax-infected individuals. Conclusions: P. vivax infection reduces the numbers of different subsets of CD8+ T cells, particularly the memory cells, during blood-stage of infection and enhances the number of CD8+ memory T cells expressing IL-10, which positively correlates with the number of cells expressing TNF-α and IFN-γ